Enhanced immune response after a second dose of an AS03-adjuvanted H1N1 influenza A vaccine in patients after hematopoietic stem cell transplantation
- Seroconversion rates following influenza vaccination in patients with hematologic malignancies after hematopoietic stem cell transplantation (HSCT) are known to be lower compared to healthy adults. The aim of our diagnostic study was to determine the rate of seroconversion after 1 or 2 doses of a novel split virion, inactivated, AS03-adjuvanted pandemic H1N1 influenza vaccine (A/California/7/2009) in HSCT recipients (ClinicalTrials.gov Identifier: NCT01017172). Blood samples were taken before and 21 days after a first dose and 21 days after a second dose of the vaccine. Antibody (AB) titers were determined by hemagglutination inhibition assay. Seroconversion was defined by either an AB titer of ≤1:10 before and ≥1:40 after or ≥1:10 before and ≥4-fold increase in AB titer 21 days after vaccination. Seventeen patients (14 allogeneic, 3 autologous HSCT) received 1 dose and 11 of these patients 2 doses of the vaccine. The rate of seroconversion was 41.2% (95% confidence interval [CI] 18.4-67.1) after the first and 81.8% (95% CI 48.2-97.7) after the second dose. Patients who failed to seroconvert after 1 dose of the vaccine were more likely to receive any immunosuppressive agent (P = .003), but time elapsed after or type of HSCT, age, sex, or chronic graft-versus-host disease was not different when compared to patients with seroconversion. In patients with hematologic malignancies after HSCT the rate of seroconversion after a first dose of an adjuvanted H1N1 influenza A vaccine was poor, but increased after a second dose.
Author: | Saskia Güller, Regina AllwinnGND, Sabine Mousset, Hans MartinORCiD, Imke WietersGND, Eva HerrmannORCiDGND, Hubert ServeORCiDGND, Markus BickelGND, Gesine BugORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-445145 |
DOI: | https://doi.org/10.1016/j.bbmt.2011.02.004 |
ISSN: | 1523-6536 |
ISSN: | 1083-8791 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/21324375 |
Parent Title (English): | Biology of blood and marrow transplantation |
Publisher: | Elsevier Health Sciences |
Place of publication: | [s. l.] |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2017/11/09 |
Year of first Publication: | 2011 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2017/11/09 |
Tag: | H1N1; HSCT; Hemagglutination inhibition assay |
Volume: | 17 |
Issue: | 10 |
Page Number: | 5 |
First Page: | 1546 |
Last Page: | 1550 |
Note: | Copyright © 2011 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. Under a Creative Commons license |
HeBIS-PPN: | 426712455 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |