Hanna Kische, Jürgen Hoyer, Lars Pieper, John Venz, Jens Klotsche, Winfried März, Uwe Koch-Gromus, David Pittrow, Hendrik Lehnert, Sigmund Silber, Günter K. Stalla, Andreas M. Zeiher, Hans-Ulrich Wittchen, Robin Haring
- Background: Previous experimental research on testosterone (T) and psychological traits is inconclusive. Thus, we performed the first large-scale observational study of the association between T and dispositional optimism / pessimism.
Methods: We used prospective data from 6,493 primary-care patients (3,840 women) of the DETECT study (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment), including repeated immunoassay-based measurement of serum T and optimism / pessimism assessed by the revised Life-Orientation Test (LOT-R). Cross-sectional and longitudinal associations of baseline T and one-year change in T with optimism and pessimism were investigated using age- and multivariable-adjusted regression models.
Results: Cross-sectional analyses showed no association of T with optimism or pessimism in both sexes. Longitudinal analyses also showed no association of baseline T with optimism or pessimism at four-year follow-up. Multivariable analyses of total LOT-R score yielded similarly non-significant results (β-coefficient per unit change in T for men: -0.01 (95% CI: -0.24–0.22), women: 0.08 (-0.03–0.20)). Furthermore, change in T was not related to optimism or pessimism at four-year follow-up.
Conclusions: The present observational study of a large-scale prospective sample showed no association of T with optimism or pessimism. Integrating further experimental and interventional evidence from alternative methodological approaches would strengthen this conclusion and establish stronger evidence about the potential hormonal basis of psychological traits.
MetadatenAuthor: | Hanna Kische, Jürgen Hoyer, Lars Pieper, John Venz, Jens KlotscheORCiDGND, Winfried MärzORCiDGND, Uwe Koch-Gromus, David PittrowORCiDGND, Hendrik Lehnert, Sigmund Silber, Günter K. Stalla, Andreas M. ZeiherORCiDGND, Hans-Ulrich WittchenORCiDGND, Robin Haring |
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URN: | urn:nbn:de:hebis:30:3-484266 |
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DOI: | https://doi.org/10.1371/journal.pone.0207870 |
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ISSN: | 1932-6203 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30496216 |
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Parent Title (English): | PLoS one |
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Publisher: | PLoS |
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Place of publication: | Lawrence, Kan. |
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Contributor(s): | Peter Karl Jonason |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2018 |
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Date of first Publication: | 2018/11/29 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2018/12/04 |
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Tag: | Alcohol consumption; Blood pressure; Decision making; Depression; Emotions; Mental health and psychiatry; Observational studies; Testosterone |
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Volume: | 13 |
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Issue: | (11): e0207870 |
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Page Number: | 8 |
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First Page: | 1 |
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Last Page: | 8 |
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Note: | Copyright: © 2018 Kische et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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HeBIS-PPN: | 439902541 |
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Institutes: | Medizin / Medizin |
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| Exzellenzcluster / Exzellenzcluster Herz-Lungen-System |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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