Precise slow oscillation-spindle coupling promotes memory consolidation in younger and older adults
- Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO) and sleep spindles (SP) and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that the fine-tuned SO–SP coupling that is present in younger adults diffuses with advanced age and shifts both in time and frequency. Crucially, we show that the tight precision of SO–SP coupling promotes memory consolidation in younger and older adults, and that brain integrity in source regions for the generation of SOs and SPs reinforces this beneficial SO–SP coupling in old age. Our results reveal age-related differences in SO–SP coupling in healthy elderly individuals. Furthermore, they broaden our understanding of the conditions and the functional significance of SO–SP coupling across the entire adult lifespan.
Author: | Beate Elisabeth MühlrothORCiDGND, Myriam Christine SanderORCiDGND, Yana FandakovaORCiDGND, Thomas H. GrandyORCiDGND, Björn RaschORCiDGND, Yee Lee ShingORCiDGND, Markus Werkle-BergnerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-724887 |
DOI: | https://doi.org/10.1101/268474 |
Parent Title (English): | bioRxiv |
Document Type: | Preprint |
Language: | English |
Date of Publication (online): | 2018/07/30 |
Date of first Publication: | 2018/07/30 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/07/20 |
Issue: | 268474 |
Page Number: | 37 |
HeBIS-PPN: | 510553133 |
Institutes: | Psychologie und Sportwissenschaften / Psychologie |
Dewey Decimal Classification: | 1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |