Dennis Alexander Eichenauer, Ina Bühnen, Stefanie Kreissl, Helen Goergen, Michael Fuchs, Bastian von Tresckow, Andreas Rosenwald, Wolfram Klapper, Martin-Leo Hansmann, Peter Möller, Heinz-Wolfram Bernd, Alfred C. Feller, Andreas Engert, Peter Borchmann, Sylvia Hartmann
- We retrospectively investigated histopathological growth patterns in individuals with advanced nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) treated within the randomized HD18 study. In all, 35/60 patients (58%) presented with atypical growth patterns. Patients with atypical growth patterns more often had stage IV disease (P = 0·0354) and splenic involvement (P = 0·0048) than patients with typical growth patterns; a positive positron emission tomography after two cycles of chemotherapy (PET-2) tended to be more common (P = 0·1078). Five-year progression-free survival [hazard ratio (HR) = 0·86; 95% confidence interval (CI) = 0·49–1·47] and overall survival (HR = 0·85; 95% CI = 0·49–1·51) did not differ between the groups after study treatment with PET-2-guided escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). Thus, advanced NLPHL is often associated with atypical growth patterns but their prognostic impact is compensated by PET-2-guided escalated BEACOPP.
MetadatenAuthor: | Dennis Alexander Eichenauer, Ina Bühnen, Stefanie Kreissl, Helen Goergen, Michael Fuchs, Bastian von Tresckow, Andreas RosenwaldGND, Wolfram KlapperORCiDGND, Martin-Leo HansmannGND, Peter Möller, Heinz-Wolfram BerndGND, Alfred C. Feller, Andreas Engert, Peter Borchmann, Sylvia HartmannORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-639552 |
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DOI: | https://doi.org/10.1111/bjh.17770 |
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ISSN: | 1365-2141 |
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Parent Title (English): | British journal of haematology |
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Publisher: | Wiley-Blackwell |
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Place of publication: | Oxford [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/08/15 |
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Date of first Publication: | 2021/08/15 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/03/10 |
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Tag: | BEACOPP; histopathological growth pattern; interim positron emissiontomography; nodular lymphocyte-predominant Hodgkin lymphoma |
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Volume: | 196 |
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Issue: | 1 |
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Page Number: | 6 |
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First Page: | 99 |
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Last Page: | 104 |
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Note: | SH is supported by the Deutsche Forschungsgemeinschaft (grant HA6145/3-1). |
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HeBIS-PPN: | 493479325 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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