- Purpose: To correlate inflammatory and proangiogenic key cytokines from undiluted vitreous of treatment-naïve central retinal vein occlusion (CRVO) patients with SD-OCT parameters.
Methods: Thirty-five patients (age 71.1 years, 24 phakic, 30 nonischemic) underwent intravitreal combination therapy, including a single-site 23-gauge core vitrectomy. Twenty-eight samples from patients with idiopathic, non-uveitis floaterectomy served as controls. Interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF-A) levels were correlated with the visual acuity (logMar), category of CRVO (ischemic or nonischemic) and morphologic parameters, such as central macular thickness-CMT, thickness of neurosensory retina-TNeuro, extent of serous retinal detachment-SRT and disintegrity of the IS/OS and others.
Results: The mean IL-6 was 64.7pg/ml (SD ± 115.8), MCP-1 1015.7 ( ± 970.1), and VEGF-A 278.4 ( ± 512.8), which was significantly higher than the control IL-6 6.2 ± 3.4pg/ml (P=0.06), MCP-1 253.2 ± 73.5 (P<0.0000001) and VEGF-A 7.0 ± 4.9 (P<0.0006). All cytokines correlated highly with one another (correlation coefficient r=0.82 for IL-6 and MCP-1; r=0.68 for Il-6 and VEGF-A; r=0.64 for MCP-1 and VEGF-A). IL-6 correlated significantly with CMT, TRT, SRT, dIS/OS, and dELM. MCP-1 correlated significantly with SRT, dIS/OS, and dELM. VEGF-A correlated not with changes in SD-OCT, while it had a trend to be higher in the ischemic versus the nonischemic CRVO group (P=0.09).
Conclusions: The inflammatory cytokines were more often correlated with morphologic changes assessed by SD-OCT, whereas VEGF-A did not correlate with CRVO-associated changes in SD-OCT. VEGF inhibition alone may not be sufficient in decreasing the inflammatory response in CRVO therapy.
MetadatenAuthor: | Michael Janusz KossORCiDGND, Marcel PfisterGND, Florian RothweilerGND, Robert Rejdak, Ramiro M. Ribeiro, Jindrich CinatlORCiDGND, Ralf SchubertORCiDGND, Thomas KohnenORCiDGND, Frank H. KochORCiD |
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URN: | urn:nbn:de:hebis:30:3-298650 |
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URL: | http://benthamscience.com/open/openaccess.php?toophtj/articles/V007/11TOOPHTJ.htm |
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DOI: | https://doi.org/10.2174/1874364101307010011 |
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ISSN: | 1874-3641 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23560031 |
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Parent Title (English): | The open ophthalmology journal |
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Publisher: | Bentham Open |
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Place of publication: | Sharjah [u.a.] |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2013 |
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Date of first Publication: | 2013/03/08 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2013/05/10 |
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Tag: | CBA; CRVO; IL-6; MCP-1; SD-OCT; VEGF; Vitreous samples |
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Volume: | 7 |
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Page Number: | 7 |
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First Page: | 11 |
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Last Page: | 17 |
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Note: | © Koss et al.; Licensee Bentham Open. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
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HeBIS-PPN: | 33920799X |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell 3.0 |
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