Expression of interleukin-18 receptor in fibroblast-like synoviocytes

  • An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R alpha-chain and beta-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA. Open Access: Published: 14 November 2001 © 2002 Möller et al., licensee BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913)

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Author:Burkhard Möller, Uta Kessler, Stefan RehartORCiDGND, Uwe Kalina, Oliver G. OttmannORCiDGND, Joachim Peter KaltwasserGND, Dieter HoelzerGND, Natasa Kukoc-Zivojnov
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Parent Title (English):Arthritis Research & Therapy
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2005/06/22
Date of first Publication:2001/11/14
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2005/06/22
Tag:fibroblast; interleukin-18; receptor; rheumatoid arthritis; synoviocyte
Issue:2, Art. 139
Page Number:8
First Page:139
Last Page:144
© 2002 Möller et al., licensee BioMed Central Ltd
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoDeutsches Urheberrecht