The S-adenosylmethionine dependent O-methyltransferase PaMTH1 : a longevity assurance factor protecting Podospora anserina against oxidative stress

  • PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about the function of the protein in the protection against metal induced oxidative stress. Deletion of PaMth1 was found to lead to a decreased resistance against exogenous oxidative stress and to a shortened lifespan suggesting a role of PaMTH1 as a longevity assurance factor in a new molecular pathway involved in lifespan control. Key words: Podospora anserina, knock-out, reactive oxygen species, flavonoids, ageing, O-methyltransferase

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Author:Birgit Kunstmann, Heinz D. OsiewaczORCiDGND
Pubmed Id:
Parent Title (English):Aging
Publisher:Impact Journals, LLC
Place of publication:[s. l.]
Document Type:Article
Date of Publication (online):2010/10/26
Year of first Publication:2009
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/10/26
Tag:O-methyltransferase; Podospora anserina; ageing; flavonoids; knock-out; reactive oxygen species
Page Number:7
First Page:328
Last Page:334
Copyright: © 2009 Kunstmann and Osiewacz. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Source:AGING, Vol 1, No 3, pp 328-334 ;
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):License LogoCreative Commons - Namensnennung 3.0