Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues
- In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
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| Author: | Abdelaaziz Ouahrouch, Moha Taourirte, Joachim W. EngelsORCiDGND, Soumaya Benjelloun, Hassan B. Lazrek |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-343083 |
| DOI: | https://doi.org/10.3390/molecules19033638 |
| ISSN: | 1420-3049 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24662079 |
| Parent Title (English): | Molecules |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2014/11/22 |
| Date of first Publication: | 2014/03/24 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2014/11/22 |
| Tag: | 1,2,3-triazole-acyclonucleosides; HCV; Huisgen cycloaddition; quinazoline ribonucleosides; quinazolinone alkylation |
| Volume: | 19 |
| Issue: | 3 |
| Page Number: | 16 |
| First Page: | 3638 |
| Last Page: | 3653 |
| Note: | © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| HeBIS-PPN: | 366536400 |
| Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
