Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk
- Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A2 and prostaglandin (PG)E2, generated from arachidonic acid (AA) by the activity of cyclooxygenase (COX)-1], granule content, including ADP and growth factors, chemokines, proteases and Wnt proteins. Moreover, activated platelets shed different vesicles, such as microparticles (MPs) and exosomes (rich in genetic material such as mRNAs and miRNAs). These platelet-derived products induce several phenotypic changes in cancer cells which confer high metastatic capacity. A central event involves an aberrant expression of COX-2 which influences cell-cycle progression and contribute to the acquisition of a cell migratory phenotype through the induction of epithelial mesenchymal transition genes and down-regulation of E-cadherin expression. The identification of novel molecular determinants involved in the cross-talk between platelets and cancer cells has led to identify novel targets for anti-cancer drug development.
Author: | Melania Dovizio, Sara Alberti, Angela Sacco, Paloma Guillem-Llobat, Simone Schiavone, Thorsten Jürgen MaierGND, Dieter SteinhilberORCiDGND, Paola PatrignaniORCiD |
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URN: | urn:nbn:de:hebis:30:3-403383 |
DOI: | https://doi.org/10.1042/BST20140322 |
Parent Title (English): | Biochemical Society Transactions |
Publisher: | Portland Press |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Year of Completion: | 2015 |
Year of first Publication: | 2015 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2016/06/02 |
Tag: | colon cancer cells; cyclooxygenase 1 (COX-1); cyclooxygenase 2 (COX-2); epithelial mesenchymal transition; metastasis; platelets |
Volume: | 43 |
Issue: | 4 |
Page Number: | 8 |
First Page: | 707 |
Last Page: | 714 |
HeBIS-PPN: | 427808596 |
Institutes: | Medizin / Medizin |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 3.0 |