Mitochondrial composition and function under the control of hypoxia
- Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.
Author: | Dominik Christian FuhrmannORCiDGND, Bernhard BrüneORCiD |
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URN: | urn:nbn:de:hebis:30:3-430171 |
DOI: | https://doi.org/10.1016/j.redox.2017.02.012 |
ISSN: | 2213-2317 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28259101 |
Parent Title (English): | Redox Biology |
Publisher: | Elsevier |
Place of publication: | Amsterdam [u. a.] |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2017/03/09 |
Date of first Publication: | 2017/02/24 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2017/03/09 |
Tag: | HIF; Hypoxia; Mitochondria; ROS; Respiratory chain |
Volume: | 12 |
Page Number: | 8 |
First Page: | 208 |
Last Page: | 215 |
Note: | © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). |
Institutes: | Medizin / Medizin |
Wissenschaftliche Zentren und koordinierte Programme / Sonderforschungsbereiche / Forschungskollegs | |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (English): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |