Relation between acute GVHD and NK cell subset reconstitution following allogeneic stem cell transplantation

  • One of the major challenges of allogeneic stem cell transplantation (allo-SCT) is to reduce the risk of graft-versus-host disease (GVHD) while boosting the graft-versus-leukemia (GVL) effect. The reconstitution of natural killer (NK) cells following allo-SCT is of notable interest due to their known capability to induce GVL without GVHD. Here, in this study, we investigate the association between the incidence and severity of acute graft-versus-host disease (aGVHD) and the early reconstitution of NK cell subsets following allo-SCT. We analyzed 342 samples from 107 patients using flow cytometry, with a focus on immature CD56high and mature cytotoxic CD56dim NK cells. Longitudinal analysis of immune reconstitution after allo-SCT showed that the incidence of aGVHD was associated with a delayed expansion of the entire NK cell population, in particular the CD56high subset. Notably, the disturbed reconstitution of the CD56high NK cells also correlated with the severity of aGVHD.

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Author:Evelyn UllrichORCiDGND, Emilia Salzmann-Manrique, Shahrzad BakhtiarGND, Melanie BremmGND, Stephanie Gerstner, Eva HerrmannORCiDGND, Peter BaderORCiDGND, Petra Hoffmann, Ernst Holler, Matthias Edinger, Daniel Wolff
Pubmed Id:
Parent Title (English):Frontiers in immunology
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Antoine Touber
Document Type:Article
Year of Completion:2016
Date of first Publication:2016/12/22
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/02/03
Tag:GVHD; NK cell; NK cell subset; SCT; immune reconstitution
Issue:Art. 595
Page Number:8
First Page:1
Last Page:8
Copyright: © 2016 Ullrich, Salzmann-Manrique, Bakhtiar, Bremm, Gerstner, Herrmann, Bader, Hoffmann, Holler, Edinger and Wolff. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0