Mitogen-activated protein (MAP) kinase scaffolding proteins: a recount

  • The mitogen-activated protein kinase (MAPK) pathway is the canonical signaling pathway for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor. Downstream of the receptors, this pathway involves the activation of a kinase cascade that culminates in a transcriptional response and affects processes, such as cell migration and adhesion. In addition, the strength and duration of the upstream signal also influence the mode of the cellular response that is switched on. Thus, the same components can in principle coordinate opposite responses, such as proliferation and differentiation. In recent years, it has become evident that MAPK signaling is regulated and fine-tuned by proteins that can bind to several MAPK signaling proteins simultaneously and, thereby, affect their function. These so-called MAPK scaffolding proteins are, thus, important coordinators of the signaling response in cells. In this review, we summarize the recent advances in the research on MAPK/extracellular signal-regulated kinase (ERK) pathway scaffolders. We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer.

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Metadaten
Author:Melanie Meister, Ana Tomasovic, Antje Banning, Ritva TikkanenORCiDGND
URN:urn:nbn:de:hebis:30:3-543676
DOI:https://doi.org/10.3390/ijms14034854
ISSN:1422-0067
Parent Title (German):International journal of molecular sciences
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2013/03/01
Date of first Publication:2013/03/01
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2020/04/24
Tag:cancer; growth factor; mitogen-activated protein kinase; receptor tyrosine kinase; scaffolding proteins; signal transduction
Volume:14
Issue:3
Page Number:31
First Page:4854
Last Page:4884
Note:
This is an open access article distributed under the Creative Commons Attribution License https://creativecommons.org/licenses/by-nc-sa/3.0/
HeBIS-PPN:465082750
Institutes:Medizin / Medizin
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Keine kommerzielle Nutzung-Weitergabe unter gleichen Bedingungen