G protein‐coupled receptor 40 expression in human melanoma – correlation with tumour thickness, AJCC stage and survival

  • Background In melanoma, preclinical data suggest a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G protein-coupled receptor GPR40, was identified in melanoma cells. Objectives The aim of this study was to investigate GPR40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker. Methods and Results A total of 114 tissue sections of naevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti-GPR40. The staining was evaluated, using the immunoreactivity scoring system. Compared to naevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR40 (P < 0.05). In primary melanoma, GPR40 expression positively correlated with tumour thickness (P = 0.044) and AJCC level (P = 0.017) and in melanoma metastasis with AJCC level (P = 0.035). Primary melanoma patients with high levels of GPR40 had a significantly poorer overall survival (P = 0.004) and shorter disease-free survival (0.040). Conclusion The present study identified GPR40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumour progression and metastases was found, and it could be demonstrated that GPR40 expression is negatively correlated with patient’s survival.

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Author:Johannes KleemannORCiDGND, Igor HrgovicORCiDGND, Pia Kleimann, Jan Wilhelm Ter‐Nedden, Melanie Glaser, Katja Steinhorst, Katja Härle, Jutta Müller, Roland KaufmannGND, Stefan KippenbergerORCiDGND, Markus MeissnerORCiDGND
Parent Title (English):Journal of the European Academy of Dermatology and Venereology
Place of publication:Oxford [u.a.]
Document Type:Article
Date of Publication (online):2019/08/29
Date of first Publication:2019/08/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/09
Page Number:8
First Page:285
Last Page:292
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0