Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals

  • During the sleep-wake cycle, the brain undergoes profound dynamical changes, which manifest subjectively as transitions between conscious experience and unconsciousness. Yet, neurophysiological signatures that can objectively distinguish different consciousness states based are scarce. Here, we show that differences in the level of brain-wide signals can reliably distinguish different stages of sleep and anesthesia from the awake state in human and monkey fMRI resting state data. Moreover, a whole-brain computational model can faithfully reproduce changes in global synchronization and other metrics such as functional connectivity, structure-function relationship, integration and segregation across vigilance states. We demonstrate that the awake brain is close to a Hopf bifurcation, which naturally coincides with the emergence of globally correlated fMRI signals. Furthermore, simulating lesions of individual brain areas highlights the importance of connectivity hubs in the posterior brain and subcortical nuclei for maintaining the model in the awake state, as predicted by graph-theoretical analyses of structural data.

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Author:Gerald Hahn, Gorka Zamora-LópezORCiDGND, Lynn UhrigORCiD, Enzo TagliazucchiORCiDGND, Helmut LaufsORCiDGND, Dante MantiniORCiDGND, Morten L. KringelbachORCiDGND, Bechir JarrayaORCiD, Gustavo DecoORCiDGND
Parent Title (English):NeuroImage
Place of publication:Amsterdam [u.a.]
Document Type:Article
Date of Publication (online):2020/11/01
Date of first Publication:2020/11/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/11
Page Number:16
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0