Dopamine in fear extinction

  • The ability to extinguish fear memories when threats are no longer present is critical for adaptive behavior. Fear extinction represents a new learning process that eventually leads to the formation of extinction memories. Understanding the neural basis of fear extinction has considerable clinical significance as deficits in extinction learning are the hallmark of human anxiety disorders. In recent years, the dopamine (DA) system has emerged as one of the key regulators of fear extinction. In this review article, we highlight recent advances that have demonstrated the crucial role DA plays in mediating different phases of fear extinction. Emerging concepts and outstanding questions for future research are also discussed.

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Author:Ximena I. Salinas-Hernández, Sevil Duvarci
Parent Title (English):Frontiers in synaptic neuroscience
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2021/03/01
Date of first Publication:2021/03/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/09/08
Tag:amygdala; dopamine; fear extinction; medial prefrontal cortex; nucleus accumbens
Issue:art. 635879
Page Number:8
First Page:1
Last Page:8
This work was supported by the Deutsche Forschungsgemeinschaft [DFG SFB1193 Grants INST247/852-1 and INST 247/858-1 (subprojects B01 and C02) to SD].
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0