Impact of DMEK on visual quality in patients with Fuchs' endothelial dystrophy

  • Purpose: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). Methods: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessment included the Quality of Vision (QoV) questionnaire preoperatively, at 1 month, and 3 months after surgery. Secondary outcome measures were anterior segment parameters acquired by Scheimpflug imaging, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). Results: Glare, hazy vision, blurred vision, and daily fluctuation in vision were the symptoms mostly reported preoperatively. All symptoms demonstrated a significant reduction of item scores for severity, frequency, and bothersome in the course after DMEK (P < 0.01). Glare and fluctuation in vision remained to some extent during the follow-up period (median score = 1). Preoperatively, corneal densitometry correlated moderately to weakly with severity of hazy vision (rs = 0.39; P = 0.03) and frequency (rs = 0.26; P = 0.02) as well as severity (rs = 0.27; P = 0.03) of blurry vision. CDVA and central corneal thickness (CCT) did not correlate with visual complains. Conclusions: Following DMEK for FED, patient-reported visual symptoms assessed by the QoV questionnaire represent a useful tool providing valuable information on the impact of DMEK on visual quality that cannot be directly estimated by morphological parameters and visual acuity only.
Author:Vanessa Ademmer, Bishr AghaGND, Mehdi ShajariGND, Thomas KohnenORCiDGND, Ingo SchmackORCiDGND
Parent Title (English):Graefe's archive for clinical and experimental ophthalmology
Place of publication:Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2021/09/16
Date of first Publication:2021/09/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/01/11
Tag:DMEK; Fuchs endothelial dystrophy; Scheimpflug imaging; Visual quality
Issue:online version before inclusion in an issue
Page Number:8
Early View: Online Version before inclusion in an issue.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0