A developmental stretch-and-fill process that optimises dendritic wiring

  • The way in which dendrites spread within neural tissue determines the resulting circuit connectivity and computation. However, a general theory describing the dynamics of this growth process does not exist. Here we obtain the first time-lapse reconstructions of neurons in living fly larvae over the entirety of their developmental stages. We show that these neurons expand in a remarkably regular stretching process that conserves their shape. Newly available space is filled optimally, a direct consequence of constraining the total amount of dendritic cable. We derive a mathematical model that predicts one time point from the previous and use this model to predict dendrite morphology of other cell types and species. In summary, we formulate a novel theory of dendrite growth based on detailed developmental experimental data that optimises wiring and space filling and serves as a basis to better understand aspects of coverage and connectivity for neural circuit formation.

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Metadaten
Author:Lothar Gunnar BaltruschatGND, Gaia TavosanisORCiDGND, Hermann CuntzORCiDGND
URN:urn:nbn:de:hebis:30:3-727879
DOI:https://doi.org/10.1101/2020.07.07.191064
Parent Title (English):bioRxiv
Document Type:Preprint
Language:English
Date of Publication (online):2020/07/07
Date of first Publication:2020/07/07
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/03/24
Issue:2020.07.07.191064
Page Number:44
HeBIS-PPN:509985270
Institutes:Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International