Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding

  • Spatial navigation requires landmark coding from two perspectives, relying on viewpoint-invariant and self-referenced representations. The brain encodes information within each reference frame but their interactions and functional dependency remains unclear. Here we investigate the relationship between neurons in the rat's retrosplenial cortex (RSC) and entorhinal cortex (MEC) that increase firing near boundaries of space. Border cells in RSC specifically encode walls, but not objects, and are sensitive to the animal’s direction to nearby borders. These egocentric representations are generated independent of visual or whisker sensation but are affected by inputs from MEC that contains allocentric spatial cells. Pharmaco- and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vice versa, indicating allocentric-to-egocentric transformation. Finally, RSC border cells fire prospective to the animal’s next motion, unlike those in MEC, revealing the MEC-RSC pathway as an extended border coding circuit that implements coordinate transformation to guide navigation behavior.

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Author:Joeri B. G. van WijngaardenORCiDGND, Susanne BablORCiDGND, Hiroshi T. ItoORCiD
Parent Title (German):eLife
Publisher:eLife Sciences Publications
Place of publication:Cambridge
Document Type:Article
Date of Publication (online):2020/11/03
Date of first Publication:2020/11/03
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/05/16
Page Number:25
Angeschlossene und kooperierende Institutionen / MPI für Hirnforschung
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International