Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

  • In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R2 = 0.233, p = .032) and verbal memory function (∆R2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.

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Author:Nadine Caroline ConradiORCiDGND, Friederike Rosenberg, Susanne KnakeORCiDGND, Louise Biermann, Anja HaagGND, Iris GornyGND, Anke Maria HermsenGND, Viola Lara von PodewilsORCiDGND, Marion Behrens, Marianna Gurschi, Richard Klaus Frieder du Mesnil de RochemontGND, Katja MenzlerORCiD, Sebastian BauerGND, Susanne Schubert-BastORCiDGND, Christopher NimskyORCiD, Jürgen KonczallaORCiDGND, Felix RosenowORCiDGND, Adam StrzelczykORCiDGND
Parent Title (English):Scientific reports
Publisher:Macmillan Publishers Limited, part of Springer Nature
Place of publication:[London]
Document Type:Article
Date of Publication (online):2021/05/26
Date of first Publication:2021/05/26
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/10/13
Tag:Epilepsy; Neurology; Psychology
Issue:art. 10979
Article Number:10979
Page Number:10
First Page:1
Last Page:10
The authors were supported by the LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany, funded by The Hessen State Ministry for Higher Education, Research and the Arts (HMWK), and by the Detlev-Wrobel-Fonds for Epilepsy Research.
Open Access funding enabled and organized by Projekt DEAL.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International