Dissecting sholl analysis into its functional components

  • Sholl analysis has been an important technique in dendritic anatomy for more than 60 years. The Sholl intersection profile is obtained by counting the number of dendritic branches at a given distance from the soma and is a key measure of dendritic complexity; it has applications from evaluating the changes in structure induced by pathologies to estimating the expected number of anatomical synaptic contacts. We find that the Sholl intersection profiles of most neurons can be reproduced from three basic, functional measures: the domain spanned by the dendritic arbor, the total length of the dendrite, and the angular distribution of how far dendritic segments deviate from a direct path to the soma (i.e., the root angle distribution). The first two measures are determined by axon location and hence microcircuit structure; the third arises from optimal wiring and represents a branching statistic estimating the need for conduction speed in a neuron.

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Metadaten
Author:Alex D. BirdORCiD, Hermann CuntzORCiDGND
URN:urn:nbn:de:hebis:30:3-775047
DOI:https://doi.org/10.1016/j.celrep.2019.04.097
ISSN:2211-1247
Parent Title (English):Cell Reports
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Date of Publication (online):2019/06/04
Date of first Publication:2019/06/04
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/10/30
Tag:Sholl analysis; connectivity; dendrite; morphology; root angle
Volume:27
Issue:10
Page Number:309596920
First Page:3081
Last Page:3096.e5
HeBIS-PPN:515832731
Institutes:Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International