Keep a little fire burning - the delicate balance of targeting sphingosine-1-phosphate in cancer immunity
- The sphingolipid sphingosine-1-phosphate (S1P) promotes tumor development through a variety of mechanisms including promoting proliferation, survival, and migration of cancer cells. Moreover, S1P emerged as an important regulator of tumor microenvironmental cell function by modulating, among other mechanisms, tumor angiogenesis. Therefore, S1P was proposed as a target for anti-tumor therapy. The clinical success of current cancer immunotherapy suggests that future anti-tumor therapy needs to consider its impact on the tumor-associated immune system. Hereby, S1P may have divergent effects. On the one hand, S1P gradients control leukocyte trafficking throughout the body, which is clinically exploited to suppress auto-immune reactions. On the other hand, S1P promotes pro-tumor activation of a diverse range of immune cells. In this review, we summarize the current literature describing the role of S1P in tumor-associated immunity, and we discuss strategies for how to target S1P for anti-tumor therapy without causing immune paralysis.
Author: | Catherine OleschORCiDGND, Bernhard BrüneORCiD, Andreas WeigertORCiDGND |
---|---|
URN: | urn:nbn:de:hebis:30:3-814723 |
DOI: | https://doi.org/10.3390/ijms23031289 |
ISSN: | 1422-0067 |
Parent Title (English): | International journal of molecular sciences |
Publisher: | Molecular Diversity Preservation International |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/01/24 |
Date of first Publication: | 2022/01/24 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/02/02 |
Tag: | cancer; immunity; inflammation; lipids; sphingosine-1-phosphate |
Volume: | 23 |
Issue: | 3, art. 1289 |
Article Number: | 1289 |
Page Number: | 22 |
First Page: | 1 |
Last Page: | 22 |
Note: | This work was supported by Deutsche Forschungsgemeinschaft (SFB 1039, TP B04 and B06, GRK 2336, TP1 and 6, FOR 2438), Deutsche Krebshilfe (70112451), Wilhelm-Sander Foundation (2019.082.01), the Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz (LOEWE), LOEWE Center for Translational Medicine and Pharmacology, and the LOEWE Center Frankfurt Cancer Institute (FCI), funded by the Hessen State Ministry for Higher Education, Research and the Arts. |
Institutes: | Medizin |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |