Role of tristetraprolin in the resolution of inflammation
- Inflammation is a crucial part of immune responses towards invading pathogens or tissue damage. While inflammatory reactions are aimed at removing the triggering stimulus, it is important that these processes are terminated in a coordinate manner to prevent excessive tissue damage due to the highly reactive inflammatory environment. Initiation of inflammatory responses was proposed to be regulated predominantly at a transcriptional level, whereas post-transcriptional modes of regulation appear to be crucial for resolution of inflammation. The RNA-binding protein tristetraprolin (TTP) interacts with AU-rich elements in the 3′ untranslated region of mRNAs, recruits deadenylase complexes and thereby facilitates degradation of its targets. As TTP regulates the mRNA stability of numerous inflammatory mediators, it was put forward as a crucial post-transcriptional regulator of inflammation. Here, we summarize the current understanding of the function of TTP with a specific focus on its role in adding to resolution of inflammation.
Verfasserangaben: | Peter RapplGND, Bernhard BrüneORCiD, Tobias SchmidORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-577900 |
DOI: | https://doi.org/10.3390/biology10010066 |
ISSN: | 2079-7737 |
Titel des übergeordneten Werkes (Englisch): | Biology |
Verlag: | MDPI |
Verlagsort: | Basel |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Veröffentlichung (online): | 19.01.2021 |
Datum der Erstveröffentlichung: | 19.01.2021 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 21.01.2021 |
Freies Schlagwort / Tag: | AU-rich element; RNA-binding protein; mRNA stability; post-transcriptional regulation |
Jahrgang: | 10 |
Ausgabe / Heft: | 66 |
Seitenzahl: | 12 |
Erste Seite: | 1 |
Letzte Seite: | 12 |
Bemerkung: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/ |
HeBIS-PPN: | 476072859 |
Institute: | Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Open-Access-Publikationsfonds: | Medizin |
Lizenz (Deutsch): | Creative Commons - Namensnennung 4.0 |