Refine
Year of publication
- 2010 (841) (remove)
Document Type
- Article (352)
- Book (127)
- Doctoral Thesis (101)
- Part of Periodical (98)
- Working Paper (47)
- Part of a Book (39)
- Report (33)
- Conference Proceeding (19)
- Review (11)
- diplomthesis (3)
Language
- English (841) (remove)
Is part of the Bibliography
- no (841) (remove)
Keywords
- Intonation <Linguistik> (9)
- distribution (9)
- Cape Verde Islands (8)
- Relativsatz (8)
- Phonologie (7)
- Prosodie (7)
- Tension (7)
- taxonomy (7)
- Goethe, Johann Wolfgang von (6)
- Spannung (6)
Institute
- Medizin (117)
- Physik (60)
- Biochemie und Chemie (58)
- Biowissenschaften (55)
- Geowissenschaften (45)
- Center for Financial Studies (CFS) (37)
- Wirtschaftswissenschaften (26)
- Frankfurt Institute for Advanced Studies (FIAS) (23)
- E-Finance Lab e.V. (20)
- Extern (19)
Proteins of the Omp85 family are conserved in all kingdoms of life. They mediate protein transport across or protein insertion into membranes and reside in the outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts. Omp85 proteins contain a C-terminal transmembrane β-barrel and a soluble N terminus with a varying number of polypeptide-transport-associated or POTRA domains. Here we investigate Omp85 from the cyanobacterium Anabaena sp. PCC 7120. The crystallographic three-dimensional structure of the N-terminal region shows three POTRA domains, here named P1 to P3 from the N terminus. Molecular dynamics simulations revealed a hinge between P1 and P2 but in contrast show that P2 and P3 are fixed in orientation. The P2-P3 arrangement is identical as seen for the POTRA domains from proteobacterial FhaC, suggesting this orientation is a conserved feature. Furthermore, we define interfaces for protein-protein interaction in P1 and P2. P3 possesses an extended loop unique to cyanobacteria and plantae, which influences pore properties as shown by deletion. It now becomes clear how variations in structure of individual POTRA domains, as well as the different number of POTRA domains with both rigid and flexible connections make the N termini of Omp85 proteins versatile adaptors for a plentitude of functions.
Moderately elevated levels of plasma plant sterols have been suspected to be causally involved in atherosclerosis. The aim of this study was to investigate whether plant sterols and other markers of sterol metabolism predicted all-cause and cardiovascular mortality in participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. A total of 1,257 individuals who did not use statins and at baseline had a mean (± SD) age of 62.8 (± 11.0) years were included in the present analysis. Lathosterol, cholestanol, campesterol, and sitosterol were measured to estimate cholesterol synthesis and absorption. The mean (± SD) time of the follow-up for all-cause and cardiovascular mortality was 7.32 (± 2.3) years. All-cause (P = 0.001) and cardiovascular (P = 0.006) mortality were decreased in the highest versus the lowest lathosterol to cholesterol tertile. In contrast, subjects in the third cholestanol to cholesterol tertile had increased all-cause (P < 0.001) and cardiovascular mortality (P = 0.010) compared with individuals in the first tertile. The third campesterol to cholesterol tertile was associated with increased all-cause mortality (P = 0.025). Sitosterol to cholesterol tertiles were not significantly related to all-cause or cardiovascular mortality. The data suggest that high absorption and low synthesis of cholesterol predict increased all-cause and cardiovascular mortality in LURIC participants.
Chromalveolates are a diverse group of protists that include many ecologically and medically relevant organisms such as diatoms and apicomplexan parasites. They possess plastids generally surrounded by four membranes, which evolved by engulfment of a red alga. Today, most plastid proteins must be imported, but many aspects of protein import into complex plastids are still cryptic. In particular, how proteins cross the third outermost membrane has remained unexplained. We identified a protein in the third outermost membrane of the diatom Phaeodactylum tricornutum with properties comparable to those of the Omp85 family. We demonstrate that the targeting route of P. tricornutum Omp85 parallels that of the translocation channel of the outer envelope membrane of chloroplasts, Toc75. In addition, the electrophysiological properties are similar to those of the Omp85 proteins involved in protein translocation. This supports the hypothesis that P. tricornutum Omp85 is involved in precursor protein translocation, which would close a gap in the fundamental understanding of the evolutionary origin and function of protein import in secondary plastids.
The human immunodeficiency virus (HIV) protease inhibitor saquinavir shows anticancer activity. Although its nitric oxide-modified derivative saquinavir-NO (saq-NO) was less toxic to normal cells, it exerted stronger inhibition of B16 melanoma growth in syngeneic C57BL/6 mice than saquinavir did. Saq-NO has been shown to block proliferation, upregulate p53 expression, and promote differentiation of C6 glioma and B16 cells. The anticancer activity of substances is frequently hampered by cancer cell chemoresistance mechanisms. Therefore, we here investigated the roles of p53 and the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1) in cancer cell sensitivity to saq-NO to get more information about the potential of saq-NO as anticancer drug. Saq-NO exerted anticancer effects in lower concentrations than saquinavir in a panel of human cancer cell lines. Neither p53 mutation or depletion nor expression of P-gp, MRP1, or BCRP1 affected anticancer activity of saq-NO or saquinavir. Moreover, saq-NO sensitized P-gp-, MRP1-, or BCRP1-expressing cancer cells to chemotherapy. Saq-NO induced enhanced sensitization of P-gp- or MRP1-expressing cancer cells to chemotherapy compared with saquinavir, whereas both substances similarly sensitized BCRP1-expressing cells. Washout kinetics and ABC transporter ATPase activities demonstrated that saq-NO is a substrate of P-gp as well as of MRP1. These data support the further investigation of saq-NO as an anticancer drug, especially in multidrug-resistant tumors.
Peroxisome proliferator-activated receptor γ (PPARγ) gained considerable interest as a therapeutic target during chronic inflammatory diseases. Remarkably, the pathogenesis of diseases such as multiple sclerosis or Alzheimer is associated with impaired PPARγ expression. Considering that regulation of PPARγ expression during inflammation is largely unknown, we were interested in elucidating underlying mechanisms. To this end, we initiated an inflammatory response by exposing primary human macrophages to lipopolysaccharide (LPS) and observed a rapid decline of PPARγ1 expression. Because promoter activities were not affected by LPS, we focused on mRNA stability and noticed a decreased mRNA half-life. As RNA stability is often regulated via 3′-untranslated regions (UTRs), we analyzed the impact of the PPARγ-3′-UTR by reporter assays using specific constructs. LPS significantly reduced luciferase activity of the pGL3-PPARγ-3′-UTR, suggesting that PPARγ1 mRNA is destabilized. Deletion or mutation of a potential microRNA-27a/b (miR-27a/b) binding site within the 3′-UTR restored luciferase activity. Moreover, inhibition of miR-27b, which was induced upon LPS exposure, partially reversed PPARγ1 mRNA decay, whereas miR-27b overexpression decreased PPARγ1 mRNA content. In addition, LPS further reduced this decay. The functional relevance of miR-27b-dependent PPARγ1 decrease was proven by inhibition or overexpression of miR-27b, which affected LPS-induced expression of the pro-inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin (IL)-6. We provide evidence that LPS-induced miR-27b contributes to destabilization of PPARγ1 mRNA. Understanding molecular mechanisms decreasing PPARγ might help to better appreciate inflammatory diseases.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists have been shown to control inflammatory processes, in part by inhibiting distinct proinflammatory genes (e.g. Il-1β and IFN-γ). IL-8 is a member of the proinflammatory chemokine family that is important for various functions, such as mediating the adhesion of eosinophilic granulocytes onto endothelial cells. The influence of PPARδ activators on the expression of IL-8 in noninduced quiescent endothelial cells is unclear. Therefore, we explored the influence of PPARδ activators on the expression of IL-8 in nonstimulated endothelial cells. PPARδ agonists induce IL-8 expression in human umbilical vein endothelial cells. This induction is demonstrated at the level of both protein and mRNA expression. Transcriptional activation studies using IL-8 reporter gene constructs and DNA binding assays revealed that PPARδ agonists mediated their effects via an NFκB binding site. It is well known that IL-8 is also regulated by mRNA stability. To provide further evidence for this concept, we performed mRNA stability assays and found that PPARδ agonists induce the mRNA stability of IL-8. In addition, we showed that PPARδ agonists induce the phosphorylation of ERK1/2 and p38, which are known to be involved in the increase of mRNA stability. The inhibition of these MAPK signaling pathways resulted in a significant suppression of the induced IL-8 expression and the reduced mRNA stability. Therefore, our data provide the first evidence that PPARδ induces IL-8 expression in nonstimulated endothelial cells via transcriptional as well as posttranscriptional mechanisms.
Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood, but it is unknown whether such plasticity extends throughout life. We used cognitive training, diffusion-tensor imaging (DTI), and structural MRI to investigate plasticity of the white-matter tracts that connect the left and right hemisphere of the frontal lobes. Over a period of about 180 days, 20 younger adults and 12 older adults trained for a total of one hundred and one 1-h sessions on a set of three working memory, three episodic memory, and six perceptual speed tasks. Control groups were assessed at pre- and post-test. Training affected several DTI metrics and increased the area of the anterior part of the corpus callosum. These alterations were of similar magnitude in younger and older adults. The findings indicate that experience-dependent plasticity of white-matter microstructure extends into old age and that disruptions of structural interhemispheric connectivity in old age, which are pronounced in aging, are modifiable by experience and amenable to treatment.
Human exposure to endocrine disruptors is well documented by biomonitoring data. However, this information is limited to few chemicals like bisphenol A or phthalate plasticizers. To account for so-far unidentified endocrine disruptors and potential mixture effects we employ bioassays to detect endocrine activity in foodstuff and consequently characterize the integrated exposure to endocrine active compounds. Recently, we reported a broad contamination of commercially available bottled water with estrogenic activity and presented evidence for the plastic packaging being a source of this contamination. In continuation of that work, we here compare different sample preparation methods to extract estrogen-like compounds from bottled water. These data demonstrate that inappropriate extraction methods and sample treatment may lead to false-negative results when testing water extracts in bioassays. Using an optimized sample preparation strategy, we furthermore present data on the estrogenic activity of bottled water from France, Germany, and Italy: eleven of the 18 analyzed water samples (61.1%) induced a significant estrogenic response in a bioassay employing a human carcinoma cell line (MCF7, E-Screen). The relative proliferative effects ranged from 19.8 to 50.2% corresponding to an estrogenic activity of 1.9-12.2 pg estradiol equivalents per liter bottled water. When comparing water of the same spring that is packed in glass or plastic bottles made of polyethylene terephthalate (PET), estrogenic activity is three times higher in water from plastic bottles. These data support the hypothesis that PET packaging materials are a source of estrogen-like compounds. Furthermore, the findings presented here conform to previous studies and indicate that the contamination of bottled water with endocrine disruptors is a transnational phenomenon.
ϕ-meson production in In–In collisions at Elab=158A GeV: Evidence for relics of a thermal phase
(2010)
Yields and transverse mass distributions of the ϕ-mesons reconstructed in the ϕ→μ+μ− channel in In+In collisions at Elab=158A GeV are calculated within an integrated Boltzmann+hydrodynamics hybrid approach based on the Ultrarelativistic Quantum Molecular Dynamics (UrQMD) transport model with an intermediate hydrodynamic stage. The analysis is performed for various centralities and a comparison with the corresponding NA60 data in the muon channel is presented. We find that the hybrid model, that embeds an intermediate locally equilibrated phase subsequently mapped into the transport dynamics according to thermal phase-space distributions, gives a good description of the experimental data, both in yield and slope. On the contrary, the pure transport model calculations tend to fail in catching the general properties of the ϕ meson production: not only the yield, but also the slope of the mT spectra, compare poorly with the experimental observations at top SPS energies.
We demonstrate that a Quark–Gluon Plasma (QGP) with a dilute admixture of heavy quarks has, in general, a lower speed of sound than a “pure” QGP without effects from heavy flavors. The change in the speed of sound is sensitive to the details of the theory, making the hydrodynamic response to “flavoring” a sensitive probe of the underlying microscopic dynamics. We suggest that this effect may be measured in ultrarelativistic heavy ion collisions by relating the event-by-event number of charm quarks to flow observables such as the average transverse momentum.
Inclusive transverse momentum spectra of primary charged particles in Pb–Pb collisions at √sNN=2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0–5% and 70–80% of the hadronic Pb–Pb cross section. The measured charged particle spectra in |η|<0.8 and 0.3<pT<20 GeV/c are compared to the expectation in pp collisions at the same sNN, scaled by the number of underlying nucleon–nucleon collisions. The comparison is expressed in terms of the nuclear modification factor RAA. The result indicates only weak medium effects (RAA≈0.7) in peripheral collisions. In central collisions, RAA reaches a minimum of about 0.14 at pT=6–7 GeV/c and increases significantly at larger pT. The measured suppression of high-pT particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb–Pb collisions at the LHC.
The first measurement of two-pion Bose–Einstein correlations in central Pb–Pb collisions at √sNN=2.76 TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.
The inclusive charged particle transverse momentum distribution is measured in proton–proton collisions at s=900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (|η|<0.8) over the transverse momentum range 0.15<pT<10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for |η|<0.8 is 〈pT〉INEL=0.483±0.001 (stat.)±0.007 (syst.) GeV/c and 〈pT〉NSD=0.489±0.001 (stat.)±0.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger 〈pT〉 than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET.
In this Letter we derive the gravity field equations by varying the action for an ultraviolet complete quantum gravity. Then we consider the case of a static source term and we determine an exact black hole solution. As a result we find a regular spacetime geometry: in place of the conventional curvature singularity extreme energy fluctuations of the gravitational field at small length scales provide an effective cosmological constant in a region locally described in terms of a de Sitter space. We show that the new metric coincides with the noncommutative geometry inspired Schwarzschild black hole. Indeed, we show that the ultraviolet complete quantum gravity, generated by ordinary matter is the dual theory of ordinary Einstein gravity coupled to a noncommutative smeared matter. In other words we obtain further insights about that quantum gravity mechanism which improves Einstein gravity in the vicinity of curvature singularities. This corroborates all the existing literature in the physics and phenomenology of noncommutative black holes.
In this Letter we study the radiation measured by an accelerated detector, coupled to a scalar field, in the presence of a fundamental minimal length. The latter is implemented by means of a modified momentum space Green's function. After calibrating the detector, we find that the net flux of field quanta is negligible, and that there is no Planckian spectrum. We discuss possible interpretations of this result, and we comment on experimental implications in heavy ion collisions and atomic systems.
Fuzziness at the horizon
(2010)
We study the stability of the noncommutative Schwarzschild black hole interior by analysing the propagation of a massless scalar field between the two horizons. We show that the spacetime fuzziness triggered by the field higher momenta can cure the classical exponential blue-shift divergence, suppressing the emergence of infinite energy density in a region nearby the Cauchy horizon.
In this Letter, we propose a new scenario emerging from the conjectured presence of a minimal length ℓ in the spacetime fabric, on the one side, and the existence of a new scale invariant, continuous mass spectrum, of un-particles on the other side. We introduce the concept of un-spectral dimension DU of a d-dimensional, euclidean (quantum) spacetime, as the spectral dimension measured by an “un-particle” probe. We find a general expression for the un-spectral dimension DU labelling different spacetime phases: a semi-classical phase, where ordinary spectral dimension gets contribution from the scaling dimension dU of the un-particle probe; a critical “Planckian phase”, where four-dimensional spacetime can be effectively considered two-dimensional when dU=1; a “Trans-Planckian phase”, which is accessible to un-particle probes only, where spacetime as we currently understand it looses its physical meaning.
This review critically analyzes the clinical data of patients with suspected kava hepatotoxicity and suggests recommendations for minimizing risk. Kava is a plant (Piper methysticum) of the pepper family Piperaceae, and its rhizome is used for traditional aqueous extracts in the South Pacific Islands and for commercial ethanolic and acetonic medicinal products as anxiolytic herbs in Western countries. A regulatory ban for ethanolic and acetonic kava extracts was issued in 2002 for Germany on the basis of reports connecting liver disease with the use of kava, but the regulatory causality assessment was a matter of international discussions. Based on one positive reexposure test with the kava drug, it was indeed confirmed that kava is potentially hepatotoxic. In subsequent studies using a structured, quantitative and hepatotoxicity specific causality assessment method in 14 patients with liver disease described worldwide, causality for kava ± co-medicated drugs and dietary supplements including herbal ones was highly probable (n = 1), probable (n = 4) or possible (n = 9) regarding aqueous extracts (n = 3), ethanolic extracts (n = 5), acetonic extracts (n = 4), and mixtures containing kava (n = 2). Risk factors included overdose, prolonged treatment, and comedication with synthetic drugs and dietary supplements comprizing herbal ones in most of the 14 patients. Hepatotoxicity occurred independently of the used solvent, suggesting poor kava raw material quality as additional causative factor. In conclusion, in a few individuals kava may be hepatotoxic due to overdose, prolonged treatment, comedication, and probably triggered by an unacceptable quality of the kava raw material; standardization is now required, minimizing thereby hepatotoxic risks.
ecently, pertussis has become a problem also in the adult population, with incidences even higher than in children. Pediatric health care workers (HCWs) are an important source of transmission, exposing very young and immunocompromised patients to an increased risk of potentially severe pertussis infections. Encouraging HCWs to get vaccinated can play a vital role in stopping the transmission of pertussis, thereby reducing institutional outbreaks.
In Germany, HCWs come up with all sorts of reasons for not getting pertussis vaccination. This study was meant to provide information in order to better understand the backgrounds of these attitudes.
A survey was conducted at the children's university hospital in Frankfurt, using an anonymous questionnaire. Survey results were used to design an intervention to increase the immunization rate of staff. Disappointingly, our efforts to increase the acceptance of the immunization program by providing information in advance were not yet satisfying.
Misconception about pertussis vaccination was prevalent especially among nursing staff. The main reasons for non-compliance included: unawareness of an own risk of infection, the belief that pertussis is not a serious illness, fear of side effects, the belief that the pertussis vaccine might trigger the pertussis disease itself, and skepticism about the efficacy of the pertussis vaccination.
With respect to nosocomial influenza infections, the welfare of patients is best served by high rates of staff immunity against influenza. However, data from the Centers of Disease Control (CDC) in the USA and the Robert Koch-Institute (RKI) in Germany indicate that most of health care workers (HCWs) choose not to be vaccinated. Under voluntary influenza immunization standards, institutional influenza outbreaks occur every flu season. The question about the legality of implementation mandatory flu vaccination for HCWs is an ongoing debate, which covers several different positions.
To characterize the attitudes of German HCWs toward mandatory influenza immunization, an anonymous questionnaire was offered to HCWs of the University Hospital in Frankfurt/Main / Germany. Our study showed that almost 70% of the respondents would accept mandatory influenza vaccination.
In our opinion an annual influenza vaccination should be required for HCWs who care for immunocompromised patients and residents in long-term care if there will be a failure of voluntary vaccination programs. An informed declination should be obtained from employees who decline vaccination and these HCWs ought to work in uncritical areas of patient care.
Rhinoliths are mineralised foreign bodies in the nasal cavity that are a chance finding at anterior rhinoscopy. Undiscovered, they grow appreciably in size and can cause a foul-smelling nasal discharge and breathing problems. Giant nasal stones are now a very rare occurrence, since improved diagnostic techniques, such as endoscopic/microscopic rhinoscopy, now make it possible to identify foreign bodies at an early stage of development. We report the case of a 37-year-old patient who, at the age of 5-6 years, introduced a foreign body, probably a stone, into his right nasal cavity. On presentation, he complained of difficulty in breathing through the right nostril that had persisted for the last 10 years. For the past four years a strong fetid smell from the nose had been apparent to those in his vicinity. Under general anaesthesia, the stone was removed in toto from the right nasal cavity. The possible genesis of the rhinolith is discussed, our case compared with those described in the literature, and possible differential diagnoses are considered.
Child of earth
(2010)
Child of Earth is the story of Achu, a young African boy who loses his mother when he is still a baby. He is raised by his father in a household teeming with wives and children. Then the father dies and the task of raising Achu devolves on his aunt, his father's sister, who is married to one of the richest and most powerful men in the country. But the aunt is jealous because Achu is doing better in school than her own children . . .
Intimate strangers
(2010)
Intimate Strangers tells the story of the everyday tensions of maids and madams in ways that bring together different worlds and explore various dimensions of servitude and mobility. Immaculate travels to a foreign land only to find her fiancé refusing to marry her. Operating from the margins of society, through her own ingenuity and an encounter with researcher Dr Winter-Bottom Nanny, she is able to earn some money. Will she remain at the margins or graduate into DUST - Diamond University of Science and Technology? Immaculate learns how maids struggle to make ends meet and madams wrestle to keep them in their employ. Resolved to make her disappointments blessings, she perseveres until she can take no more.
Les murmures de l'harmattan
(2010)
The author of Harmattan Whispers reproduces life in such a harmonic order enveloped with dreams carefully filtered and balanced. As a keen observer of his society, he describes with passionate fervour movements that give existence its density. Emmanuel Matateyou in this poetic cocktail of his takes the reader through an African society where Harmattan, this North East trade wind, destroys as it sweeps along the ugly, the vicissitudes and the shredded pieces of life to leave place to a new kind of drunken quest. In the flux of his words and imagery, he gives life to dreams, fantasies and the Utopian visions of this lover of life, all of which are brought to the limelight through poetically revealing correspondences all rooted in passion and hope.
This is a very engaging book based on compelling stories of human triumph over adversity coming out of Africa, Asia and America. Gideon's personal journey and his account of his mother and uncle in this book exemplify what it means to be truly resilient. The book is moving, well thought out and masterfully structured, a most riveting Read. Gideon For-mukwai draws on local wisdoms from his native Cameroon to tell a universal story. It is a book written in evidence of a mind in tune with the heart. Its stories, strategies, and metaphors provide incredible wisdom relevant to any society and explicitly remind readers that our circumstances may be different, but the strategies to overcome are the same. If a widow can make a legendary success story in Africa, then almost anybody can. What makes this book special is the fact that it is based on the stories of modest human beings.
Konglanjo : (Spears of Love without Ill-fortune) and Letters to Ethiopia with Some Random Poems
(2010)
This collection of poems evolves as a network and satellite of an expressive pursuit of justice with a difference. For, though this poetry simultaneously shapes global and grassroots smiles and tears, its corpus is no matter for laughter or weeping. In familiar but not identical voices, the poet tackles social evils as parasites while cross-examining cultural assumptions in the same vein. Triple form -title poem, Letters to Ethiopia and Some Random poems, explores nightmares of colonial mission civilisatrice by dint of two decades of inspirational events from 1965 as invitations into a more serene world emerging from post-discoveries.
The forces of nature warranted that these two English speaking poets, linguists, translators cum academics and researchers be born in Ndop, Ngoketunjia Division, in the North West Region of Cameroon. The one is based in the USA and other in Australia. Disgusted by the rotten political clime in their country as well as the political stance of politician vis-à-vis the English speaking minority, these two poets in their poetry explore the ins and outs of the problems of existence, not only of the minority English speaking Cameroonian but those of minorities in a modern world with a push for globalization. To them art is not only a weapon for survival but one for resistance.
Rock of God (Kilán ke Nyùy)
(2010)
Rock of God centres on a significant war that Nso fought with Bamoun in the 1880s, and which war resulted in a devastating defeat for the Bamouns. During this war, a major Nso combat rule was broken: the Sultan (king) of Bamoun was decapitated. Both local story tellers and historians have indicated that the Sultan was only supposed to be captured alive. The play explores some very compelling reasons for this violation. It mocks any attempt at categorization because the events involved are as historically relevant as they are anthropologically profound; as literarily dense as they are linguistically compelling. It surely stands on its own because it clearly combines concepts of docu-drama, morality play, classical theatre, historical drama, and much more. But beyond all else, it is great artistry that demonstrates the genius of experimentation.
The call of blood
(2010)
Efenze, the President of the Board of Directors of government companies and a member of the Central Committee of the Ruling Party, eliminates his erstwhile business contractor, Sancheu, with the complicity of the latter's wife. His aim is to inherit Sancheu's widow and wealth and to forge his way into the Political Bureau of the Party. The Call of Blood is a dramatization of evil in its multifaceted dimensions including treachery, infidelity, greed, hypocrisy, double-crossing and vaulting ambition in a postcolonial society where those who wield political and financial power thrive or perish by their involvement in obscure schemes. The play is enriched by a great sense of dramatic economy and poetic style evident in the preponderant use of local imagery.
Wholeness Living
(2010)
Wholeness Living is about recognizing the power that exists within us, in others and in the Higher Power. When these powers are in harmony we experience growth in the sense of physical health, high self-esteem, high social interest, and high optimism. Therefore, wholeness living is the openness to the truth about the relationship with the physical self, the psychological self, others and the Higher Power. Based on years of clinical practice, academic research and personal investigation, Dr Bonaventura Balige's approach to leading a full, rich and happy life focuses on four main areas - the physical, the psychological, the social and the spiritual - any one or more of which can be at the root of our difficulties. In this book are lessons and heartfelt advice to help us address the issues interfering with our enjoyment of life. While it is true that life is often difficult, we have the tools to deal with any situation. Dr Balige shows us that every person has the power to create the wholeness that can see us through the storms of life. Every person can find happiness by following the steps explaining what wholeness living entails.
This book is the first comprehensive contribution to understanding the character of important societal transitions in Tanzania during Benjamin Mkapa's presidency (1995- 2005). The analyses of the trajectory of these transitions are conducted against the background of the development model of Tanzanian's first president, Julius Nyerere (1961-1985), a model with lasting influence on the country. This approach enables an understanding of continuities and discontinuities in Tanzania over time in areas such as development strategy an ideology, agrarian-land, gender and forestry issues, economic liberalization, development assistance, corruption and political change. The period of Mkapa's presidency is particularly important because it represents the first phase of Tanzania's multi- party political system. Mkapa's government initially faced a gloomy economic situation. Although Mkapa's crusade against corruption lost direction, his presidency was characterised by relatively high growth rates and a stable macro-economy. Rural and agrarian transitions were dominated by diversification rather than productivity growth and transformation. Rural attitudes in favour of land markets emerged only slowly but formal land disputes showed more respect for women's rights. Some space emerged for widening local participation in forest management, but rural dynamics was mainly found in trading settlements feeding on economic liberalization and artisanal mining. The transitions documented and analysed of Mkapa's presidency, however, indicate only limited transformational change. Rural poverty is therefore likely to remain deep and the sustainability of economic development to be at risk in the future. Mkapa was, however, able to protect the legacy of peace and political stability of Nyerere, but there were nevertheless important challenges to the first multiparty elections and governance, and particularly in Zanzibar. The post- script (covering 2005 2010), indicates that the incumbent president, Jakaya Kikwete, has yet to prove that he can change this legacy of Mkapa. Co-published with the Nordic Africa Institute and the Sokoine University of Agriculture, the contributions to the eleven chapters of this book are evenly shared between Tanzanian, Nordic and other European researchers with a long-term commitment to Tanzanian development research. he book is dedicated to the youth of Tanzania.
Conflict in Northern Ghana appears to be increasing in amplitude and frequency and its effects are getting more devastating. It is the view of this book that the Government of Ghana and civil society organisations involved in aspects of conflict management have approached peace issues in the region with an inadequate understanding of the local issues that divide and unite the people, or using sufficient resources to preempt conflict. In 2003 The Mole V summit was held in Damongo to discuss strategic directions for comprehensive development and poverty reduction in Northern Ghana as a mechanism for supporting conflict management. It is the aim of this publication to contribute to the proposed plan by suggesting past and current conflict management resources and mechanisms which could be employed. The suggestions are informed by surveys, which are oulined in the book, of particular conflicts in the three northern Regions of Ghana between 2006 and 2008 - their histories, causes and effects and their resolution.
he name Dar es Salaam comes from the Arabic phrase meaning house of peace. A popular but erroneous translation is haven of peace resulting from a mix-up of the Arabic words 'dar' (house) and 'bandar' (harbour). Named in 1867 by the Sultan of Zanzibar, the town has for a long time benefitted from a reputation of being a place of tranquility. The tropical drowsiness is a comfort to the socialist poverty and under-equipment that causes an unending anxiety to reign over the town. Today, for the Tanzanian, the town has become Bongoland, that is, a place where survival is a matter of cunning and intelligence (bongo means brain in Kiswahili). Far from being an anecdote, this slide into toponomy records the mutations that affect the links that Tanzanians maintain with their principal city and the manner in which it represents them. This book takes into account the changes by departing from the hypothesis that they reveal a process of territorialisation. What are the processesenvisaged as spatial investmentswhich, by producing exclusivity, demarcations and exclusions, fragment the urban space and its social fabric? Do the practices and discussions of the urban dwellers construct limited spaces, appropriated, identified and managed by communities (in other words, territories)? Dar es Salaam is often described as a diversified, relatively homogenous and integrating place. However, is it not more appropriate to describe it as fragmented? As territorialisation can only occur through frequenting, management and localised investment, it is therefore through certain placesfirst shelter and residential area, then the school, daladala station, the fire hydrant and the quaysthat the town is observed. This led to broach the question in the geographical sense of urban policy carried out since German colonisation to date. At the same time, the analysis of these developments allows for an evaluation of the role of the urban crisis and the responses it brings. In sum, the aim of this approach is to measure the impact of the uniqueness of the place on the current changes. On one hand, this is linked to its long-term insertion in the Swahili civilisation, and on the other, to its colonisation by Germany and later Britain and finally, to the singularity of the post-colonial path. This latter is marked by an alternation of Ujamaa with Structural Adjustment Plans applied since 1987. How does this remarkable political culture take part in the emerging city today?
This book is a compilation of oral histories about the movement of Luo and some Bantu-speaking peoples. It includes histories of many clans or ethnic groups, and how drought, warfare, disease, and competition over pastoral resources in western Kenya forced them to look for a land that they could call their own. Highly entertaining, the stories cross over from pre-colonial to post-colonial eras, with tales of fooling the colonial officers, winning battles and producing miracles. Although warriors and chiefs play a critical part in the stories so too do unlikely actors such as women, prophets, and common farmers. As one of the elders put it, 'Without history you are like wild animals' you need to know where you came from and who you are.' People with kinship connections to the ethnic groups represented here will delight in the references to places, people, kin groups and events. Residents of western Kenya will be able to trace some of their genealogies to North Mara and vice versa. Historians and anthropologists will find in this book a rich primary source for their own research. Those interested in cultural change will find this a fascinating case of Luo assimilation: events chronicled in this book are still underway and observable in communities today. Producing the text in both Swahili and English ensures that local people will have access to these histories for their own learning and on-going discussions about the past.
Despite being a large capital city in Africa in terms of size and its regional role, Nairobi is an unrecognised entity. For the majority of its inhabitants, the capital of Kenya is a transit point rather than a dwelling place. Since its origins, Nairobi has been a city of migrants, more predisposed to their rural roots than to their current city status. It is a non-conforming town, which conceals its urbanity more than it claims it, and whose identity remains evasive. Nairobi presents itself as a mosaic of residential areas which bring to mind the cityís history. The racial segregation that stratified the development of the colonial city has today disappeared, but it has given way to a form of social segregation. One must, therefore, not seek a unique identity in Nairobi, but rather, several identities - those of different communities that comprise the city and whose dynamics are seen at village and residential estate level. However, Nairobi is also a city that is contradictory. This East African capital city is often associated with slums and crime, and their increase and growth stigmatises the failure of urban policies. Therefore, it is at these cracks and fringes of the city that we should seek out the identities and dynamics that have shaped the city for a century. Nairobi is a fragmented city that can be understood in steps. The 13 contributory articles in Nairobi Today thus reveal the city. This multidisciplinary collective work invites us to gain entry into certain areas of the city, to visit its communities and to familiarise ourselves with its formal and informal institutions. This is a requirement in order to fully understand what makes Nairobi what it is today.
The importance of watercourses to human life and development cannot be overemphasised. From communication, trade, agriculture and the location of human settlements, they have played an immeasurable role. Almost 60% of Africa lies within shared rivers and lake basins. The Nile is shared by more than seven nations, the Zambezi by six, and the Congo by nine. With populations on the rise, many countries have been labeled water scarce nations, and in fifteen years it is predicted that many people on earth will be exposed to water shortage consequences such as famine and disease. Thirteen African nations already suffer water stress and soon another twelve will join the list unless something is done to thwart the problem. On March 20, 2009 in Nairobi, Hekima College collaborated with Jesuit Hakimani Centre and the French Institute for Research in Africa (IFRA) to host the Hekima College Water Day Academic Seminar with the theme Shared Waters, Shared Opportunities. This book is the result of critical research and presentations by internationally renowned scholars, researchers and experts, and students of the Institute of Peace Studies and International RelationsHekima College. For most of 2009 Kenya suffered severe problems caused by flooding which took many lives and destroyed homes and important infrastructures. It highlighted the issues of water management and water conflicts, not only in Kenya but in other parts of East Africa, as it was made abundantly clear that not only scarcity of water, but excess water, incorrectly managed, can be disastrous. This timely, scholarly book presents discussions of the issues which underlie the major water crises in the region. They open the debate into the water problems of Kenya and East Africa in an effort to join the global campaign to find solutions to these difficulties.
Cheche, a radical, socialist student magazine at the University of Dares Salaam, first came out in 1969. Featuring incisive analyses of key societal issues by prominent progressives, it gained national and international recognition in a short while. Because it was independent of authority, and spoke without fear or favor, it was banned after just a year of existence. The former editors and associates of Cheche revive that salutory episode of student activism in this book with fast-flowing, humor spiced stories, and astute socio-economic analyses. Issues covered include social and technical aspects of low-budget magazine production, travails of student life and activism, contents and philosophy of higher education, socialism in Tanzania, African liberation, gender politics and global affairs. They also reflect on the relevance of past student activism to the modern era. If your interests cover higher education in Africa, political and development studies, journalism, African affairs, socialism and capitalism, or if you just seek elucidation of student activism in a nation then at the center of the African struggle for liberation, this book presents the topic in a lively but unorthodox and ethically engaging manner.
Sitting on the terrace of the royal plantation Frederiksgave, his favourite retreat, Governor Edward Carstensen came to see the inevitable: Denmark had to give up her 'possessions' in Africa. As fate would have it, he came to be the instrument by which two centuries of Danish involvement on the Gold Coast was terminated, thereby making way for the emergence of the colonial system that developed there. After the abolition of the slave trade, Denmark had struggled to find ways and means to legitimate her continued stay at the Coast. At an early stage the Danes initiated a number of attempts to establish experimental plantations to cultivate export crops such as cotton, coffee and sugar. But a transition from slave trade to 'legitimate' products required stability and peace, and a need for control, which the rather limited Danish presence was not able to maintain. Closing the Books comprises a compilation of the official reports that the last Danish Governor sent home during his term of office at the Gold Coast. The reports reflect his personal views regarding the economic and political situations there, as well as his ideas on the 'civilization of Africa'.
This book brings together articles and conference papers on the Zambezi River and Kariba Dam written by Dr. Tumbare between 1998-2010. Part I discusses issues of river basin and integrated water resources management and Part II contains papers in infrastructure development in the water and energy sectors.
The last text on the geography of Uganda was written in 1975 by Professor Brian Langlands. Since the last publication, Uganda has undergone numerous changes. The population has more than tripled from less than 10 million to almost 30 million. The district boundaries have changed and the number of districts increases every year. New districts are created every year. Economic productivity has also shifted over the years. Furthermore, new and emerging diseases have surfaced in Uganda. This book addresses the need for an updated document on the geography of Uganda. This book was written by a joint group of Ugandan geographers. The contributors authored chapters in their areas of specialization. There are a total of twelve chapters in the book. These chapters are based on the most current data available.
The Cold War period witnessed competition from political, economic, ideological, diplomatic, military and social dimensions between the United States of America (USA), and the then Union of Soviet Socialist Republics (USSR). In the superpower rivalries, India and Africa were adversely affected in many ways. The situation did not change for the better in the post-Cold War period, which has witnessed the domination of the world by the US and its allies, the Group of Eight (G-8) industrialised countries. This domination has been characterised by the process of Americanization of the worlds, otherwise termed globalisation, in virtually all spheres of life. USA, India, Africa During and After the Cold War demonstrates that both the United States and The Soviet Union used African States, India and other Third World countries for their own geopolitical considerations; that the foreign policy and foreign relations of the US were meant to subject Africa and India to the dictates of US imperialism. The book assesses the impact of the Cold War and the post-Cold War order on Africa, India and the entire world and argues that the Non Aligned Movement is still relevant to the Third World countries despite the demise of the Cold War. The book analyses issues from the African point of view as opposed to hitherto Western view points but provides a balanced appreciation of the complex forces that shape foreign policies and foreign relations globally. It is a valuable contribution to modern diplomatic history and targets university students, researchers, foreign affairs ministries, and practising diplomats.
This books is the result of concerted teamwork among the academia staff of the Department of Religious Studies, University of Nairobi between 1986 and 1990. The Project was prompted by the necessity to produce relevant and comprehensive textbooks for the undergraduate degree programme. The book has remained in demand, confirming the relevance and quality of its content covering the whole range of major religions of the world with extensive geographical and historical acope. It includes a specific section on African Religion, thus placing the African Religious Heritage within the mainstream of the comparative study of the world's religions.
Reproductive Health, Economic Growth and Poverty Reduction in Africa : Frameworks of Analysis
(2010)
This volume contains framework papers prepared for a collaborative research project on Reproductive Health, Economic Growth and Poverty Reduction in Africa, an initiative of the African Economic Research Consortium (AERC). Taken together, the chapters in this book make a compelling argument that improvement in reproductive health is key to raising household incomes and to reducing poverty. the books reveals that the triple phenomena of better reproductive health, economic growth, and declining poverty, are likely to be found in an environment in which labour and product markets function. Further, a macroeconomic framework that encourages domestic and foreign investments and promotes social protection for current and future generations is essential.
A woman yearns for self-assurance to be a woman of dreams, of song and poetry. The feel of life, buried by over socialisation and domestication processes, oppressed by the surrounding culture and dealing with a problem without a name, is lifted in the process of dreaming, singing songs and reciting poetry. That is the woman Wanjira becomes when she narrates stories. She reclaims her dreams through her stories. She reclaims her wellness, hope, independence and strength. You see the sparkle in her eyes when she talks abut dances, courtship, beauty, children, love, courage, determination, joy, and womanhood. Reclaiming My Dreams: Stories by Wanjira wa Rukenya is thus, an individual artist's work. It goes a long way in helping students appreciate the narrative genre and understand the creative role of individual artists. This understanding demystifies the idea that anybody and everybody in the African society is a storyteller; an assertion that has belittled the artistry of African Oral Literature. The book makes us appreciate our cultural heritage. Students of literature in Secondary Schools and in higher institutions of learning will find this book useful.
Jean Hartley, born in Kenya, is acknowledged as being the first to legitimise fixing for wildlife film crews. Over the last 25 years, she has worked on over a thousand films, the vast majority being about wildlife and nature. She features five of the great film makers who all started their careers in Kenya in the1950s, legends whom she is proud to call personal friends. Watching all of their films, and many more, she became fascinated by the history of film making in Kenya and determined to find out when it all started. In this insightful book, she traces the roots of wildlife film back a hundred years, drawing on accounts of the original film makers and the professional hunters who guided those early safaris. She tracks the changes from those grainy, speeded up, silent films through to the technologically perfect High Definition and 3D films that are being made today.
This book seeks to help African Christian leaders to follow the notions of biblical leadership as servanthood and to train men and women with biblical and academic knowledge, which will be critical, practical, pastoral and applicable in the Kenyan context and participate in the discovery, transmission and preservation of knowledge and stimulate the intellectual life and cultural development of Kenya.
This text broadly and comprehensively covers the area of law of succession in Kenya. It exposes the substantive succession legal regime applying in Kenya as well as the Kenyan probate practice. It is tailored specifically for the legal practitioner, the Magistrate and Judge and the law student William Musyoka holds L.L.B and LL.M degrees from the University of Nairobi. He is an Advocate of the High Court of Kenya and a law lecturer. He has taught the law of succession at the Kenya School of Law and is currently teaching the subject at the School of Law, University of Nairobi.
Written in a clear, concise and engaging style this book presents the entire criminal process in a simple, yet authoritative and informative way. The core principles that underpin the criminal procedure, their rationale and assumptions are well articulated and critiqued. In addition the book presents by way of illustration a comprehensive range of the latest local judicial decisions.