Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Robert Benedikt Höh, Zhe Tian, Shahrokh F. Shariat, Fred Saad, Alberto Briganti, Markus Graefen, Felix Preißer, Andreas Becker, Philipp Mandel, Felix Chun, Pierre I. Karakiewicz
- Background: To test the effect of race/ethnicity on cancer-specific mortality (CSM) after salvage radical prostatectomy (SRP).
Material and methods: We relied on the Surveillance, Epidemiology and End Results database (SEER, 2004–2016) to identify SRP patients of all race/ethnicity background. Univariate and multivariate Cox regression models addressed CSM according to race/ethnicity.
Results: Of 426 assessable SRP patients, Caucasians accounted for 299 (69.9%) vs. 68 (15.9%) African-Americans vs. 39 (9.1%) Hispanics vs. 20 (4.7%) Asians. At diagnosis, African-Americans (64 years) were younger than Caucasians (66 years), but not younger than Hispanics (66 years) and Asians (67 years). PSA at diagnosis was significantly higher in African-Americans (13.2 ng/ml), Hispanics (13.0 ng/ml), and Asians (12.2 ng/ml) than in Caucasians (7.8 ng/ml, p = 0.01). Moreover, the distribution of African-Americans (10.3%–36.6%) and Hispanics (0%–15.8%) varied according to SEER region. The 10-year CSM was 46.5% in African-Americans vs. 22.4% in Caucasians vs. 15.4% in Hispanics vs. 15.0% in Asians. After multivariate adjustment (for age, clinical T stage, lymph node dissection status), African-American race/ethnicity was an independent predictor of higher CSM (HR: 2.2, p < 0.01), but not Hispanic or Asian race/ethnicity. The independent effect of African-American race/ethnicity did not persist after further adjustment for PSA.
Conclusion: African-Americans treated with SRP are at higher risk of CSM than other racial/ethnic groups and also exhibited the highest baseline PSA. The independent effect of African-American race/ethnicity on higher CSM no longer applies after PSA adjustment since higher PSA represents a distinguishing feature in African-American patients.
MetadatenAuthor: | Mike WenzelORCiDGND, Christoph WürnschimmelORCiDGND, Luigi NoceraORCiD, Claudia Collà RuvoloORCiD, Robert Benedikt HöhORCiDGND, Zhe Tian, Shahrokh F. ShariatORCiDGND, Fred SaadORCiDGND, Alberto BrigantiORCiD, Markus GraefenGND, Felix PreißerORCiDGND, Andreas BeckerGND, Philipp MandelORCiDGND, Felix ChunORCiDGND, Pierre I. Karakiewicz |
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URN: | urn:nbn:de:hebis:30:3-862281 |
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DOI: | https://doi.org/10.3389/fonc.2022.874945 |
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ISSN: | 2234-943X |
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Parent Title (English): | Frontiers in oncology |
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Publisher: | Frontiers Media |
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Place of publication: | Lausanne |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/08/19 |
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Date of first Publication: | 2022/08/19 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/07/17 |
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Tag: | cancer specific survival; ethnicity; post-radiotherapy recurrence; prostate cancer; race; salvage radical prostatectomy |
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Volume: | 12 |
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Issue: | art. 874945 |
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Article Number: | 874945 |
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Page Number: | 9 |
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First Page: | 1 |
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Last Page: | 9 |
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Note: | Gefördert durch den Open-Access-Publikationsfonds der Goethe-Universität. |
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HeBIS-PPN: | 521043409 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Open-Access-Publikationsfonds: | Medizin |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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