Dynamic mRNP remodeling in response to internal and external stimuli
- Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.
Author: | Katharina ZarnackORCiDGND, Sureshkumar Balasubramanian, Michael P. Gantier, Vladislav Kunetsky, Michael Kracht, M. Lienhard Schmitz, Katja SträßerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-563094 |
DOI: | https://doi.org/10.3390/biom10091310 |
ISSN: | 2218-273X |
Parent Title (English): | Biomolecules |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Year of Completion: | 2020 |
Year of first Publication: | 2020 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2020/10/18 |
Tag: | RNA-binding proteins (RBPs); extracellular stimuli; intracellular stimuli; messenger ribonucleoprotein particles (mRNPs); post-transcriptional gene regulation; signal transduction; stress |
Volume: | 10 |
Issue: | (9), 1310 |
Page Number: | 32 |
HeBIS-PPN: | 471417289 |
Institutes: | Biowissenschaften / Biowissenschaften |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |