High-frequency oscillations and the neurobiology of schizophrenia
- Neural oscillations at low- and high-frequency ranges are a fundamental feature of large-scale networks. Recent evidence has indicated that schizophrenia is associated with abnormal amplitude and synchrony of oscillatory activity, in particular, at high (beta/gamma) frequencies. These abnormalities are observed during task-related and spontaneous neuronal activity which may be important for understanding the pathophysiology of the syndrome. In this paper, we shall review the current evidence for impaired beta/gamma-band oscillations and their involvement in cognitive functions and certain symptoms of the disorder. In the first part, we will provide an update on neural oscillations during normal brain functions and discuss underlying mechanisms. This will be followed by a review of studies that have examined high-frequency oscillatory activity in schizophrenia and discuss evidence that relates abnormalities of oscillatory activity to disturbed excitatory/inhibitory (E/I) balance. Finally, we shall identify critical issues for future research in this area.
Author: | Peter J. UhlhaasORCiDGND, Wolf SingerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-345147 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24174902 |
Parent Title (German): | Dialogues in clinical neuroscience |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2016/02/23 |
Year of first Publication: | 2013 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2016/11/11 |
Tag: | cognition; gamma; neurobiology; oscillations; schizophrenia; synchrony |
Volume: | 15 |
Page Number: | 13 |
First Page: | 301 |
Last Page: | 313 |
Note: | Copyright : © 2013 Institut la Conférence Hippocrate - Servier Research Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
HeBIS-PPN: | 43246364X |
Institutes: | Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS) |
Angeschlossene und kooperierende Institutionen / MPI für Hirnforschung | |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |