Occupational risk of tuberculosis transmission in a low incidence area

  • Background: To investigate the occupational risk of tuberculosis (TB) infection in a low-incidence setting, data from a prospective study of patients with culture-confirmed TB conducted in Hamburg, Germany, from 1997 to 2002 were evaluated. Methods: M. tuberculosis isolates were genotyped by IS6110 RFLP analysis. Results of contact tracing and additional patient interviews were used for further epidemiological analyses. Results: Out of 848 cases included in the cluster analysis, 286 (33.7%) were classified into 76 clusters comprising 2 to 39 patients. In total, two patients in the non-cluster and eight patients in the cluster group were health-care workers. Logistic regression analysis confirmed work in the health-care sector as the strongest predictor for clustering (OR 17.9). However, only two of the eight transmission links among the eight clusters involving health-care workers had been detected previously. Overall, conventional contact tracing performed before genotyping had identified only 26 (25.2%) of the 103 contact persons with the disease among the clustered cases whose transmission links were epidemiologically verified. Conclusion: Recent transmission was found to be strongly associated with health-care work in a setting with low incidence of TB. Conventional contact tracing alone was shown to be insufficient to discover recent transmission chains. The data presented also indicate the need for establishing improved TB control strategies in health-care settings.

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Author:Roland Diel, Andreas SeidlerORCiDGND, Albert Nienhaus, Sabine Rüsch-Gerdes, Stefan Niemann
URN:urn:nbn:de:hebis:30-11571
DOI:https://doi.org/10.1186/1465-9921-6-35
ISSN:1465-993X
ISSN:1465-9921
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/15831092
Parent Title (English):Respiratory research
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Language:English
Date of Publication (online):2005/06/22
Date of first Publication:2005/04/14
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2005/06/22
Tag:tuberculosis epidemiology
Volume:6
Issue:Art. 35
Page Number:11
First Page:1
Last Page:11
Note:
This article is available from: http://respiratory-research.com/content/6/1/35 © 2005 Diel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source:Respiratory Research 2005, 6:35 , http://respiratory-research.com/content/pdf/1465-9921-6-35.pdf
HeBIS-PPN:188841342
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0