Geometrically repatterned immunological synapses uncover formation mechanisms

  • The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases. The surface molecules of the cells form a characteristic spatial pattern whose formation mechanisms and function are largely unknown. We perform computer simulations of recent experiments on geometrically repatterned immunological synapses and explain the emerging structure as well as the formation dynamics. Only the combination of in vitro experiments and computer simulations has the potential to pinpoint the kind of interactions involved. The presented simulations make clear predictions for the structure of the immunological synapse and elucidate the role of a self-organizing attraction between complexes of T cell receptor and peptide–MHC molecule, versus a centrally directed motion of these complexes.

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Author:Marc Thilo Figge, Michael Meyer-Hermann
URN:urn:nbn:de:hebis:30-33205
DOI:https://doi.org/10.1371/journal.pcbi.0020171
ISSN:1553-7358
Parent Title (English):PLoS Computational Biology
Publisher:PLoS
Place of publication:Lawrence, Kan.
Document Type:Article
Language:English
Date of Publication (online):2006/11/10
Date of first Publication:2006/11/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2006/11/16
Volume:2
Issue:(11): e171
Page Number:8
First Page:1377
Last Page:1384
Note:
© 2006 Figge and Meyer-Hermann. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HeBIS-PPN:190084456
Institutes:Physik / Physik
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0