Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

  • Spontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm. We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats. The individual slow wave events were used for an event-related analysis of simultaneously acquired whole-brain BOLD fMRI. We identified BOLD responses directly related to onsets of slow calcium waves, revealing a cortex-wide BOLD correlate: the entire cortex was engaged in this specific type of slow wave activity. These findings demonstrate a direct relation of defined neurophysiological events to a specific BOLD activity pattern and were confirmed for ongoing slow wave activity by independent component and seed-based analyses.
Metadaten
Author:Miriam Schwalm, Florian Schmid, Lydia Wachsmuth, Hendrik Backhaus, Andrea Kronfeld, Felipe Aedo Jury, Pierre-Hugues Prouvot, Consuelo Fois, Franziska Albers, Timo Mauritz van Alst, Cornelius Faber, Albrecht Stroh
URN:urn:nbn:de:hebis:30:3-468568
DOI:https://doi.org/10.7554/eLife.27602
ISSN:2050-084X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/28914607
Parent Title (English):eLife
Publisher:eLife Sciences Publications
Place of publication:Cambridge
Contributor(s):Jan-Marino Ramirez
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/09/15
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2018/07/05
Tag:Bold fmri; Calcium recordings; Neuroscience; Research article; Slow waves
Volume:6
Issue:e27602
Page Number:27
First Page:1
Last Page:27
Note:
Copyright Schwalm et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
HeBIS-PPN:435669508
Institutes:keine Angabe Fachbereich / keine Angabe Institut
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0