Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings

  • Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence from non-invasive recordings has remained inconclusive. Here, we measure endogenous spindle and theta activity intracranially in humans during low-frequency tACS and find no stable entrainment of spindle power during non-REM sleep, nor of theta power during resting wakefulness. As positive controls, we find robust entrainment of spindle activity to endogenous slow-wave activity in 66% of electrodes as well as entrainment to rhythmic noise-burst acoustic stimulation in 14% of electrodes. We conclude that low-frequency tACS at common stimulation intensities neither acutely modulates spindle activity during sleep nor theta activity during waking rest, likely because of the attenuated electrical fields reaching the cortical surface.
Metadaten
Author:Belen Lafon, Simon Henin, Yu Huang, Daniel Friedman, Lucia Melloni, Thomas Thesen, Werner Doyle, György Buzsáki, Orrin Devinsky, Lucas Cristobal Parra, Anli Liu
URN:urn:nbn:de:hebis:30:3-483717
DOI:https://doi.org/10.1038/s41467-017-01045-x
ISSN:2041-1723
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29084960
Parent Title (English):Nature Communications
Publisher:Nature Publishing Group UK
Place of publication:[London]
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/10/31
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/11/22
Tag:Consolidation; Electroencephalography – EEG; EpilepsyNon-REM sleep; Non-REM sleep
Volume:8
Issue:1, Art. 1199
Page Number:14
First Page:1
Last Page:14
Note:
Rights and permissions: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Note:
Erratum erschienen in: Nature Communications, 9.2018, Nr. 1, Art. 949, doi:10.1038/s41467-018-03392-9
HeBIS-PPN:440044278
Institutes:Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Angeschlossene und kooperierende Institutionen / MPI für empirische Ästhetik
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 50 Naturwissenschaften / 500 Naturwissenschaften und Mathematik
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0