Complex multimeric [FeFe] hydrogenases : biochemistry, physiology and new opportunities for the hydrogen economy

  • Hydrogenases are key enzymes of the energy metabolism of many microorganisms. Especially in anoxic habitats where molecular hydrogen (H2) is an important intermediate, these enzymes are used to expel excess reducing power by reducing protons or they are used for the oxidation of H2 as energy and electron source. Despite the fact that hydrogenases catalyze the simplest chemical reaction of reducing two protons with two electrons it turned out that they are often parts of multimeric enzyme complexes catalyzing complex chemical reactions with a multitude of functions in the metabolism. Recent findings revealed multimeric hydrogenases with so far unknown functions particularly in bacteria from the class Clostridia. The discovery of [FeFe] hydrogenases coupled to electron bifurcating subunits solved the enigma of how the otherwise highly endergonic reduction of the electron carrier ferredoxin can be carried out and how H2 production from NADH is possible. Complexes of [FeFe] hydrogenases with formate dehydrogenases revealed a novel enzymatic coupling of the two electron carriers H2 and formate. These novel hydrogenase enzyme complex could also contribute to biotechnological H2 production and H2 storage, both processes essential for an envisaged economy based on H2 as energy carrier.

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Author:Kai Schuchmann, Nilanjan Pal Chowdhury, Volker MüllerORCiD
URN:urn:nbn:de:hebis:30:3-492819
DOI:https://doi.org/10.3389/fmicb.2018.02911
ISSN:1664-302X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30564206
Parent Title (English):Frontiers in microbiology
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Chris Greening
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/12/04
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/03/05
Tag:CO2 reduction; acetogenesis; clostridia; electron bifurcation; formate dehydrogenase; hydrogen production; hydrogen storage; hydrogenase
Volume:9
Issue:Art. 2911
Page Number:22
First Page:1
Last Page:22
Note:
Copyright © 2018 Schuchmann, Chowdhury and Müller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS-PPN:448049910
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Biowissenschaften
Licence (German):License LogoCreative Commons - Namensnennung 4.0