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G protein-coupled receptors (GPCRs) play a crucial role in modulating physiological responses and serve as the main drug target. Specifically, salmeterol and salbutamol which are used for the treatment of pulmonary diseases, exert their effects by activating the GPCR β2-adrenergic receptor (β2AR). In our study, we employed coarse-grained molecular dynamics simulations with the Martini 3 force field to investigate the dynamics of drug molecules in membranes in presence and absence of β2AR. Our simulations reveal that in more than 50% of the flip-flop events the drug molecules use the β2AR surface to permeate the membrane. The pathway along the GPCR surface is significantly more energetically favorable for the drug molecules, which was revealed by umbrella sampling simulations along spontaneous flip-flop pathways. Furthermore, we assessed the behavior of drugs with intracellular targets, such as kinase inhibitors, whose therapeutic efficacy could benefit from this observation. In summary, our results show that β2AR surface interactions can significantly enhance membrane permeation of drugs, emphasizing their potential for consideration in future drug development strategies.
Motivated by the question of the impact of selective advantage in populations with skewed reproduction mechanims, we study a Moran model with selection. We assume that there are two types of individuals, where the reproductive success of one type is larger than the other. The higher reproductive success may stem from either more frequent reproduction, or from larger numbers of offspring, and is encoded in a measure Λ for each of the two types. Our approach consists of constructing a Λ-asymmetric Moran model in which individuals of the two populations compete, rather than considering a Moran model for each population. Under certain conditions, that we call the "partial order of adaptation", we can couple these measures. This allows us to construct the central object of this paper, the Λ−asymmetric ancestral selection graph, leading to a pathwise duality of the forward in time Λ-asymmetric Moran model with its ancestral process. Interestingly, the construction also provides a connection to the theory of optimal transport. We apply the ancestral selection graph in order to obtain scaling limits of the forward and backward processes, and note that the frequency process converges to the solution of an SDE with discontinous paths. Finally, we derive a Griffiths representation for the generator of the SDE and use it to find a semi-explicit formula for the probability of fixation of the less beneficial of the two types.
Im November durfte er seinen 77. Geburtstag feiern, von Ruhestand ist aber noch keine Spur. Gerade bereitet er sich in seinem Büro über der Neuen Mensa am alten Campus in Bockenheim mit großem Elan auf die nächste Seminarsitzung vor. »Die Lehre an der Universität wie an Fachhochschulen war mir nie eine Last. Ich habe versucht, die Studierenden zu motivieren oder bei Bedarf gar zu provozieren, um zu kommunizieren, weil wir alle viel mehr von gegenseitigem Austausch haben«, sagt Ludwig Salgo. Zahlreiche Studierende der Sozialen Arbeit, aus der Rechtswissenschaft, aber auch aus der Erziehungswissenschaft haben seine Veranstaltungen besucht; etliche Juristinnen und Juristen haben bei ihm promoviert, sich für die pädagogische oder juristische Laufbahn qualifiziert. Sein zentrales Thema in Forschung und Lehre: das Verhältnis Eltern-Kind-Staat. Anfang 2012 ging er in den Ruhestand, doch die Lehre blieb vorerst seine große Passion. Jetzt beendet er seine Seniorprofessur an der Goethe-Universität zum Semesterende nach zehn Jahren: »Nun ist es genug«, sagt er. In der Fortbildung für Jugendämter, Verfahrensbeistände und Juristen, auch in Stiftungen und Verbänden, hier vor allem im Kinderschutzbund in Frankfurt, möchte er weiterhin aktiv bleiben, auch um für das Thema Kindeswohl zu sensibilisieren. Dass er dann mehr Zeit für seine große Leidenschaft haben wird, freut ihn: »Ich leide an der Melomanie«, sagt der passionierte Freund klassischer Musik. »Wie Nietzsche treffenderweise einmal bemerkt hat, wäre das Leben ohne Musik ein Irrtum.«
Highlights
• Seed size mediates seedling recruitment in tropical forests and pastures.
• Large-seeded species recruited better than small-seeded species in the forest.
• Recruitment of large-seeded species in pastures was limited by surface temperature.
• Large-seeded species should be protected against drought in regenerating pastures.
Abstract
Seedling recruitment is a key process of plant regeneration that often depends on plant functional traits, such as seed size. To optimize forest restoration efforts, we need to better understand how seedling recruitment of different seed sizes varies along environmental gradients with strong variation in abiotic and biotic factors. To understand these interacting effects, we conducted a sowing experiment with different-sized seeds in forests and pastures in the tropical mountains of southern Ecuador. We quantified seedling recruitment in relation to temperature, soil moisture and biotic pressures. We sowed seeds of five tree species of varying seed size at three elevations (1000, 2000 and 3000 m a.s.l.) in primary forest and pastures. We tested (1) how habitat type influences the recruitment of seedlings belonging to three small- and two large-seeded species, and (2) how abiotic and biotic factors limit seedling recruitment of species with different seed sizes. We found that seedlings of the two large-seeded species recruited better than seedlings of the three small-seeded species, but only in the forest habitat. Seedling recruitment of large seeds was primarily limited by high surface temperature, which explains lower recruitment of large seeds in pastures compared to forests. Our study shows that seed size can be a key trait mediating variability in seedling recruitment in tropical ecosystems. We conclude that restoration measures should aim to mitigate extreme temperatures in tropical pastures to aid the natural regeneration of large-seeded tree species.
Highlights
• Six Newton methods for solving matrix quadratic equations in linear DSGE models.
• Compared to QZ using 99 different DSGE models including Smets and Wouters (2007).
• Newton methods more accurate than QZ with comparable computation burden.
• Apt for refining solutions from alternative methods or nearby parameterizations.
Abstract
This paper presents and compares Newton-based methods from the applied mathematics literature for solving the matrix quadratic that underlies the recursive solution of linear DSGE models. The methods are compared using nearly 100 different models from the Macroeconomic Model Data Base (MMB) and different parameterizations of the monetary policy rule in the medium-scale New Keynesian model of Smets and Wouters (2007) iteratively. We find that Newton-based methods compare favorably in solving DSGE models, providing higher accuracy as measured by the forward error of the solution at a comparable computation burden. The methods, however, suffer from their inability to guarantee convergence to a particular, e.g. unique stable, solution, but their iterative procedures lend themselves to refining solutions either from different methods or parameterizations.
The hierarchical feature regression (HFR) is a novel graph-based regularized regression estimator, which mobilizes insights from the domains of machine learning and graph theory to estimate robust parameters for a linear regression. The estimator constructs a supervised feature graph that decomposes parameters along its edges, adjusting first for common variation and successively incorporating idiosyncratic patterns into the fitting process. The graph structure has the effect of shrinking parameters towards group targets, where the extent of shrinkage is governed by a hyperparameter, and group compositions as well as shrinkage targets are determined endogenously. The method offers rich resources for the visual exploration of the latent effect structure in the data, and demonstrates good predictive accuracy and versatility when compared to a panel of commonly used regularization techniques across a range of empirical and simulated regression tasks.
SAFE Update April 2024
(2024)
The ALICE Collaboration reports a differential measurement of inclusive jet suppression using pp and Pb−Pb collision data at a center-of-mass energy per nucleon-nucleon collision sNN−−−√=5.02 TeV. Charged-particle jets are reconstructed using the anti-kT algorithm with resolution parameters R= 0.2, 0.3, 0.4, 0.5, and 0.6 in pp collisions and R= 0.2, 0.4, 0.6 in central (0−10%), semi-central (30−50%), and peripheral (60−80%) Pb−Pb collisions. A novel approach based on machine learning is employed to mitigate the influence of jet background. This enables measurements of inclusive jet suppression in new regions of phase space, including down to the lowest jet pT≥40 GeV/c at R=0.6 in central Pb−Pb collisions. This is an important step for discriminating different models of jet quenching in the quark-gluon plasma. The transverse momentum spectra, nuclear modification factors, derived cross section, and nuclear modification factor ratios for different jet resolution parameters of charged-particle jets are presented and compared to model predictions. A mild dependence of the nuclear modification factor ratios on collision centrality and resolution parameter is observed. The results are compared to a variety of jet-quenching models with varying levels of agreement.
An overview of the genus Psephenops Grouvelle (Coleoptera: Psephenidae: Psepheninae) is provided with geographic distributions of the species. The taxonomic history of Psephenops smithi Grouvelle, the type species from Grenada and St. Vincent, and junior synonym Xexanchorinus latus Grouvelle from Grenada, is discussed, and lectotypes and paralectotypes are designated for both. Photographs of the type series and a non-type specimen with illustrated male genitalia, along with new distributional information for the species, are provided. The male, female, and associated larva of Psephenops trini Barr and Shepard, new species, are described and illustrated, as is the habitat of this species in Trinidad and Tobago. The Peruvian species Psephenus robacki Spangler is transferred from Psephenus Haldeman to Psephenops as Psephenops robacki (Spangler) new combination. Photographs of the female holotype are included, and possible new distributional records from Peru are reported.
ZooBank registration. urn:lsid:zoobank.org:pub:5C9ECB63-6A77-4FF6-8391-BF0F77BE5674
Pears, Pyrus pyrifolia (Burm.f.) Nak. (Rosaceae) are one of the most widely grown fruit trees in South Korea. Approximately 11% of the total pear production in 2022 was exported to countries such as the US and Vietnam. Exported pears must be free of pest species that are considered of quarantine importance by the importing countries. Herein, a list of scale insects (Hemiptera: Coccomorpha) associated with pear trees is updated. Additionally, Spilococcus pacificus (Borchsenius) is added to the list of mealybugs affecting pears in South Korea and is briefly diagnosed based on non-type specimens and illustrated using photographs. Information on its distribution and plant hosts are also provided.
ZooBank registration. urn:lsid:zoobank.org:pub:48A93063-EB78-402F-82CE-168540C90FE2
Highlights
• High resolution profile of C. pipiens' sugar diet has been obtained using UHPLC-MS.
• Artificial feeding using ornamental plants provides similar sugar profiles as observed in field collected mosquitoes.
• Metabolomic profiling found secondary metabolites and pollutants of anthropogenic use.
Abstract: Culex pipiens (Linnaeus, 1758) mosquitoes search plant sources of sugars to cope with the energetic demand of various physiological processes. The crop as part of the digestive system is devoted to the storage of sugar-based meal obtained from various nectars sources. The profiling of sugars and metabolites in the Culex pipiens’ crop is scarce, and only few studies used Liquid Chromatography – Mass Spectrometry (LC-MS), which provides broad detection for biomonitoring environmental substances and even contaminants in the sugar diet of mosquitoes populations.
Therefore, sugar and metabolite profiling were performed on crops obtained from mosquitoes exposed to plant nectar under laboratory or natural conditions by Ultra High-Performance LC-MS (UHPLC-MS). This method allowed us a precise quantitative and qualitative identification of sugar diet and associated environmental compounds in the crop of the mosquito C. pipiens. Under laboratory condition, mosquitoes were allowed to feed on either glucose solution, commercially-available flowers or field collected flowers. In addition, we collected mosquitoes from the field to compare those crop metabolomes with metabolome patterns occurring after nectar feeding in the lab.
The sugar quantities and quality obtained from the crops of mosquitoes collected in the field were similar to those crops obtained from mosquitoes that fed on commercially-available flowers and from field collected flowers with a limit of detection of 10 μg/L for sucrose, glucose and sucrose. Next to sugar compounds, we identified 2 types of amino acids, 12 natural products, and 9 pesticides.
Next to the diversity of sugar compounds, we could confirm that secondary metabolites and environmental pollutants are typically up taken from floral nectar sources by C. pipiens. The in-depth knowledge on mosquito–plant interactions may inspire the development and further optimization of mosquito trap systems and arboviral surveillance systems.
Members of the genus Centris Fabricius (Hymenoptera: Apoidea: Anthophila) constitute a significant component of the Neotropical (including insular) bee fauna, exhibiting high species richness, a moderate to large body size, and extensive interactions with various important plant groups. Females of most species possess specialized morphology adapted for collecting oils from flowers. This study documents the presence of the genus in Cuba, recognizing six species: C. aethiops Cresson, C. cornuta Cresson, C. fulviventris Cresson, C. poecila Lepeletier, C. taina Genaro and Breto new species, and C. tarsata F. Smith. Detailed information is provided for each species, encompassing a diagnosis, natural history, floral associations, seasonal occurrence, and distribution. Centris taina new species is described from Cuba, based on both sexes, which were previously misidentified as C. versicolor (Fabr.) for females and C. fasciatus F. Smith for males due to sexual dimorphism. Centris tarsata is reported as a new national record for Cuba, possibly introduced by humans from South America and now established and widely distributed across the entire island. A key to differentiate the Cuban species of Centris is presented.
ZooBank registration. urn:lsid:zoobank.org:pub:257916DF-2129-4694-876C-49C858046BF6
The two-particle momentum correlation functions between charm mesons (D∗± and D±) and charged light-flavor mesons (π± and K±) in all charge-combinations are measured for the first time by the ALICE Collaboration in high-multiplicity proton-proton collisions at a center-of-mass energy of s√=13 TeV. For DK and D∗K pairs, the experimental results are in agreement with theoretical predictions of the residual strong interaction based on quantum chromodynamics calculations on the lattice and chiral effective field theory. In the case of Dπ and D∗π pairs, tension between the calculations including strong interactions and the measurement is observed. For all particle pairs, the data can be adequately described by Coulomb interaction only, indicating a shallow interaction between charm and light-flavor mesons. Finally, the scattering lengths governing the residual strong interaction of the Dπ and D∗π systems are determined by fitting the experimental correlation functions with a model that employs a Gaussian potential. The extracted values are small and compatible with zero.
For genus g=r(r+1)2+1, we prove that via the forgetful map, the universal Prym-Brill-Noether locus Rrg has a unique irreducible component dominating the moduli space Rg of Prym curves.
Can prediction error explain predictability effects on the N1 during picture-word verification?
(2024)
Do early effects of predictability in visual word recognition reflect prediction error? Electrophysiological research investigating word processing has demonstrated predictability effects in the N1, or first negative component of the event-related potential (ERP). However, findings regarding the magnitude of effects and potential interactions of predictability with lexical variables have been inconsistent. Moreover, past studies have typically used categorical designs with relatively small samples and relied on by-participant analyses. Nevertheless, reports have generally shown that predicted words elicit less negative-going (i.e., lower amplitude) N1s, a pattern consistent with a simple predictive coding account. In our preregistered study, we tested this account via the interaction between prediction magnitude and certainty. A picture-word verification paradigm was implemented in which pictures were followed by tightly matched picture-congruent or picture-incongruent written nouns. The predictability of target (picture-congruent) nouns was manipulated continuously based on norms of association between a picture and its name. ERPs from 68 participants revealed a pattern of effects opposite to that expected under a simple predictive coding framework.
The hippocampal-dependent memory system and striatal-dependent memory system modulate reinforcement learning depending on feedback timing in adults, but their contributions during development remain unclear. In a 2-year longitudinal study, 6-to-7-year-old children performed a reinforcement learning task in which they received feedback immediately or with a short delay following their response. Children’s learning was found to be sensitive to feedback timing modulations in their reaction time and inverse temperature parameter, which quantifies value-guided decision-making. They showed longitudinal improvements towards more optimal value-based learning, and their hippocampal volume showed protracted maturation. Better delayed model-derived learning covaried with larger hippocampal volume longitudinally, in line with the adult literature. In contrast, a larger striatal volume in children was associated with both better immediate and delayed model-derived learning longitudinally. These findings show, for the first time, an early hippocampal contribution to the dynamic development of reinforcement learning in middle childhood, with neurally less differentiated and more cooperative memory systems than in adults.
Looking beyond ESG preferences: The role of sustainable finance literacy in sustainable investing
(2024)
We assess how sustainable finance literacy affects people’s sustainable investment behavior, using a pre-registered experiment. We find that an increase in sustainable finance literacy leads to a 4 to 5% increase in the probability of investing sustainably. This effect is moderated by sustainability preferences. In the absence of moderate sustainability preferences, any additional increase in sustainable finance literacy is at minimum irrelevant, and we find some evidence that it might even reduce sustainable investments. Our findings underscore the role of knowledge in shaping sustainable investment decisions, highlighting the importance of factors beyond sustainability preferences.
Korean immigrants have migrated to New Zealand over the past three decades in search of a happier and more balanced life. While they anticipated that their children would be integrated into New Zealand society, they have primarily settled in Korean ethnic enclaves. In this context, younger Korean New Zealanders have been exposed to and influenced by New Zealand’s national and Korean ethnic cultures. This study examined success beliefs and well-being among Korean youth in New Zealand with a Third Culture Kid background (TCK K-NZ) in comparison to Korean youth in Korea (K-Korean) and European New Zealand youth (Pākehā). Results indicated that TCK K-NZ youth endorsed extrinsic success similarly to K-Korean youth, but that valuing extrinsic success predicted lowered well-being only for K-Korean youth. Conversely, valuing intrinsic success predicted higher well-being across the three groups. Results also revealed that TCK K-NZ youth's well-being levels were between those of K-Korean and Pākehā youth, potentially influenced by different structural relations between success beliefs and well-being, as well as their position as “third culture kids” in New Zealand. This study contributes to understanding cultures' roles in formulating success beliefs and the relationship between success beliefs and well-being for Korean New Zealander youth.
We provide in this paper a comprehensive comparison of various transfer learning strategies and deep learning architectures for computer-aided classification of adult-type diffuse gliomas. We evaluate the generalizability of out-of-domain ImageNet representations for a target domain of histopathological images, and study the impact of in-domain adaptation using self-supervised and multi-task learning approaches for pretraining the models using the medium-to-large scale datasets of histopathological images. A semi-supervised learning approach is furthermore proposed, where the fine-tuned models are utilized to predict the labels of unannotated regions of the whole slide images (WSI). The models are subsequently retrained using the ground-truth labels and weak labels determined in the previous step, providing superior performance in comparison to standard in-domain transfer learning with balanced accuracy of 96.91% and F1-score 97.07%, and minimizing the pathologist's efforts for annotation. Finally, we provide a visualization tool working at WSI level which generates heatmaps that highlight tumor areas; thus, providing insights to pathologists concerning the most informative parts of the WSI.
Die vorliegende Dissertation bietet eine eingehende Analyse der Entstehung und Evolution der rechtlichen Rahmenbedingungen der Arbeitnehmerüberlassung in der Volksrepublik China. Ursprünglich in den 1980er Jahren als Instrument zur Reduzierung der Arbeitslosigkeit eingeführt, hat sich die Funktion der Arbeitnehmerüberlassung im Laufe der Zeit gewandelt. Diese Entwicklung wird in der Arbeit sorgfältig nachgezeichnet.
Die Studie skizziert die legislative Entwicklung von der anfänglichen Konzeption bis zur formellen Legalisierung im Jahr 2007 und untersucht die geltenden gesetzlichen Bestimmungen zur Arbeitnehmerüberlassung. Dabei werden die spezifischen Aspekte der chinesischen Gesetzgebung herausgestellt, bei der die Arbeitnehmerüberlassung vornehmlich als komplementäre Beschäftigungsform angesehen wird. Die Arbeit beleuchtet die Rechte und Pflichten aller Akteure. Obwohl nicht umfassend rechtsvergleichend angelegt, wird doch immer wieder ein Blick auf die Rechtslage in Deutschland geworfen, sodass die unterschiedlichen regulatorischen Ansätze deutlich hervortreten. Zugleich werden die besonderen Herausforderungen behandelt, denen diese Beschäftigungsform im chinesischen Kontext begegnet.
Programm Sommersemester 2024, Frankfurter Bürger-Universität, Goethe-Universität Frankfurt am Main
(2024)
• Mexican and German populations of L. sericata differ in their development times.
• Mexican L. sericata had a shorter development time at 20°C than German flies.
• At 30 °C, German L. sericata pupariated and eclosed earlier than the Mexican flies.
• Differences in study design make the comparison of developmental studies difficult.
Abstract
The cosmopolitan blow fly Lucilia sericata is often used in forensic case work for estimating the minimum postmortem interval (PMImin). For this, the age of immature specimens developing on the dead body is calculated by measuring the time taken to reach the sampled developmental stage at a given temperature. To test whether regional developmental data of L. sericata is valid on a global scale, the time taken to reach different developmental stages was compared between a population from Mexico and one from Germany at two different constant temperatures.
The German population of L. sericata was collected in Frankfurt/Main, while the Mexican population originated near Oaxaca de Juarez and was transported to Germany in the larval stage. Only the F1 generation was used to avoid adaption of the Mexican flies. Eggs were immediately placed at 20 °C and 30 °C. Five times 30 freshly eclosed larvae per replicate (n = 5) were then transferred to a cup of minced meat in separate containers. The larvae were checked every 8 h for migration, pupariation or emergence of adult flies. The time at which the first individual and 50 % of the specimens per container entered each of these stages, was recorded.
Significant differences in the time of development between the two populations were observed at both temperatures. At 20 °C, the first specimens of the Mexican population reached all developmental stages a little (< 1 day to < 2 days) earlier than the German L. sericata. At 30 °C, the Mexican flies also reached the post-feeding stage slightly earlier (0.2 days). However, at 30 °C, the German flies started pupariation significantly earlier (after 5 days) than the Mexican flies (6.9 days) and the adults from Germany also emerged earlier (10.5 days compared to 13.1 days). The same pattern was observed when looking at 50 % of the total number of specimens per container. A comparison with previously published developmental studies was difficult as the experimental design varied widely between studies. However, the results were within the range of most studies. Our study has shown that age estimation can vary widely depending on the population on which the reference data used for the calculations are based. This highlights the importance of using local and population-specific developmental data for estimating the age of blow flies in case work.
In a year marked by challenging market dynamics, the importance of ESG investments remains unwavering. But the wave of ESG regulations and requests generates a demand for more scalable ways to collect and analyze ESG data. The rise of AI could mark a turning point in an industry heavily burdened by reporting requirements, and unlock the true potential of ESG for businesses and investors alike.
For genus g=2i≥4 and the length g−1 partition μ=(4,2,…,2,−2,…,−2) of 0, we compute the first coefficients of the class of D¯¯¯¯(μ) in PicQ(R¯¯¯¯g), where D(μ) is the divisor consisting of pairs [C,η]∈Rg with η≅OC(2x1+x2+⋯+xi−1−xi−⋯−x2i−1) for some points x1,…,x2i−1 on C. We further provide several enumerative results that will be used for this computation.
Yes, they are. The securities services industry is at a tipping point of its digital transformation and will now see industry solutions to scale. We identify three fundamental drivers being adopted more broadly: cloud migration, data, and digitization. This triage also drives the scaling of Clearstream’s digital infrastructure D7, one of the leading digital infrastructures globally.
This study explores high-frequency cross-asset lead-lag relationships for various market microstructure dimensions. Utilizing data from stocks, futures, and exchange traded products, the findings uncover significant lead-lag patterns, particularly among fundamentally related instruments. Our results demonstrate that knowledge about lead-lag relationships can be leveraged for forecasting short-term changes in financial markets.
Nowadays, firms lack information to derive the share of wallet, a vital metric that identifies how much additional spending a firm could capture from each customer. However, decoding Blockchain data enables observing all transactions of each wallet, respectively customer, on the Ethereum NFT market. To shed light on the share of wallet, we analyzed 22.7 million transactions from over 1.3 million customers across eight competing firms on the Ethereum NFT market.
Diese Forschungsarbeit analysiert die Rolle des Superblock-Konzepts in neoliberalen Stadtpolitiken am Beispiel der Stadt Offenbach am Main. Die Stadt, einst von industrieller Bedeutung, kämpft seit dem Ende des Fordismus mit finanziellen Schwierigkeiten, die zu einer restriktiven Austeritätspolitik geführt haben. Auf der Suche nach einer positiven Imageveränderung und im Wettbewerb um einkommensstarke Bevölkerungsschichten und Unternehmen initiierte Offenbach verschiedene Strategiepapiere und neue Stadtentwicklungsprojekte. Die Idee, den Offenbacher Stadtteil Nordend im Stile eines Superblocks umzugestalten, wird seit kurzem von verschiedenen Akteur*innen in der Stadt diskutiert. Bei Superblocks handelt es sich um eine grundlegende Transformation des Straßenraumes durch die Neugestaltung des Verkehrs in kleinteilige Abschnitte. Der motorisierte Individualverkehr wird umgeleitet und Freiflächen für die kollektive Nutzung entstehen. Die Forschungsarbeit basiert auf sechs qualitativen Expert*innen-Interviews mit verschiedenen Akteur*innen aus Offenbach. Durch die Interviews konnten die Einschätzungen der Expert*innen zum Superblock-Konzept sowie dessen Verhältnis zur Stadtentwicklungspolitik Offenbachs analysiert werden. Sie betonen die grundsätzliche Eignung des Nordends für die Implementierung des Superblock-Konzepts. Als Instrument der Mobilitätswende könnten Superblocks den öffentlichen Raum transformieren, die Lebensqualität steigern und speziell den im Nordend lebenden einkommensschwachen Haushalten zugutekommen. Dennoch zeigt sich in den Interviews eine Ambivalenz zum Superblock-Konzept im Kontext der Stadtentwicklungspolitik, insbesondere im Hinblick auf finanzielle Herausforderungen und Probleme der Umsetzung. Deutlich wird die prekäre finanzielle Situation Offenbachs im Kontext der Neoliberalisierung des Städtischen, deren Auswirkungen sich an den Aushandlungen über das Konzept der Superblocks exemplarisch äußert. Die Studie zeigt die Widersprüchlichkeiten eines innovativen Mobilitätskonzeptes innerhalb neoliberaler Stadtpolitiken auf und fragt nach dem Zusammenhang von Mobilitätsforschung und kritischer Stadtforschung.
• Mexican and German populations of L. sericata differ in their development times.
• Mexican L. sericata had a shorter development time at 20°C than German flies.
• At 30 °C, German L. sericata pupariated and eclosed earlier than the Mexican flies.
• Differences in study design make the comparison of developmental studies difficult.
Abstract
The cosmopolitan blow fly Lucilia sericata is often used in forensic case work for estimating the minimum postmortem interval (PMImin). For this, the age of immature specimens developing on the dead body is calculated by measuring the time taken to reach the sampled developmental stage at a given temperature. To test whether regional developmental data of L. sericata is valid on a global scale, the time taken to reach different developmental stages was compared between a population from Mexico and one from Germany at two different constant temperatures.
The German population of L. sericata was collected in Frankfurt/Main, while the Mexican population originated near Oaxaca de Juarez and was transported to Germany in the larval stage. Only the F1 generation was used to avoid adaption of the Mexican flies. Eggs were immediately placed at 20 °C and 30 °C. Five times 30 freshly eclosed larvae per replicate (n = 5) were then transferred to a cup of minced meat in separate containers. The larvae were checked every 8 h for migration, pupariation or emergence of adult flies. The time at which the first individual and 50 % of the specimens per container entered each of these stages, was recorded.
Significant differences in the time of development between the two populations were observed at both temperatures. At 20 °C, the first specimens of the Mexican population reached all developmental stages a little (< 1 day to < 2 days) earlier than the German L. sericata. At 30 °C, the Mexican flies also reached the post-feeding stage slightly earlier (0.2 days). However, at 30 °C, the German flies started pupariation significantly earlier (after 5 days) than the Mexican flies (6.9 days) and the adults from Germany also emerged earlier (10.5 days compared to 13.1 days). The same pattern was observed when looking at 50 % of the total number of specimens per container. A comparison with previously published developmental studies was difficult as the experimental design varied widely between studies. However, the results were within the range of most studies. Our study has shown that age estimation can vary widely depending on the population on which the reference data used for the calculations are based. This highlights the importance of using local and population-specific developmental data for estimating the age of blow flies in case work.
Marjan van den Akker, Gesundheitswissenschaftlerin und Epidemiologin : Goethe, Deine Forscher
(2024)
Die Welt im Wasserstress
(2024)
Wie haben sich die Wasserresourcen in den letzten 120 Jahren verändert? Und was passiert, wenn es bis Ende des 21. Jahrhunderts noch einmal zwei Grad wärmer wird als heute? Fragen wie diese beantwortet das globale Wasser-Modell WaterGAP, das maßgeblich vom Institut für Physische Geographie der Goethe-Universität und von der Ruhr-Universität Bochum entwickelt wird. Bislang ließen sich die damit erzeugten Daten nur von Expertinnen und Experten nutzen. Eine neue Web-App ändert das nun. Entwickelt wurde sie von dem französischen Geodaten-Unternehmen Ageoce, das dafür mit der Goethe-Universität kooperierte.
Wissen angezapft: unterhaltsam, informativ – und ziemlich schräg : Frankfurter Bürgeruniversität
(2024)
Studieren kann man lernen – so lautet das Motto der »Schlüsselkompetenzen im Studium«. Dieses Angebot hilft Studierenden dabei, die vielen Anforderungen, die das Studieren mit sich bringt, zu meistern. Neben dem bisherigen Workshopangebot können Studierende jetzt auch jederzeit und von überall online auf Selbstlernmaterialien zugreifen, die im Projekt »Erfolgreich Lehren und Lernen – Vielfalt und Internationales im Studium« (ELLVIS) erstellt wurden.
Thomas Bowrey, who was an employee of the British colonial government, visited the Malay-speaking region at the end of the 17th century and published a dictionary of Malay (1701) which consists of 12,683 headwords. It is one of the oldest and largest collections of data on this language, which was the first language of the people he came into contact with while travelling through the Malay Peninsula, spending most of his time in harbours along its west coast. Malay, which was spoken in the various trading centres of this area (e.g. Penang, Malacca), had long previously begun to develop into a form of lingua franca during Bowrey’s stay there due to the fact that traders, especially those from Arabic countries (beginning in the 12th century), China (from the 15th century onwards), Portugal (since 1511), the Netherlands (since 1641), and less so from England, came into contact with Malays speaking their local dialects in the various trading posts in Malaya and probably began to become acquainted with the trade-language variant. Thus, Bowrey must have observed and recorded elements of both.
The data he collected is not limited to Malay variants spoken in coastal areas, but includes material from dialects which he encountered during his travels throughout the Malay Peninsula, though without, however, describing the locations in which he took notes on the lexicon and clauses. Not all of his material was written into manuscript form during his stay in Southeast Asia. A large part of his notes taken in situ were prepared for publication during his long journey home. His notes, which were used to print his dictionary, are in part kept in British libraries. Most of the material accessible to the public was studied during the preparation of this thesis.
Earlier works on this dictionary are quite limited in scope. They deal with very specific aspects such as the meanings of headwords found between the letters A and C (Rahim Aman, 1997 & 1998), and the work of Nor Azizah, who deals with the lexical change found in Bowrey’s dictionary between D and F, and syntactic and sociolinguistic aspects (Mashudi Kader, 2009), and collective nouns by Tarmizi Hasrah (2010). This study will discuss Bowrey’s dictionary as a whole in order to describe its contribution to our knowledge of linguistic and non-linguistic facts in 17th century Malaya. Besides analysing Malay synchronically, this thesis also deals with historical-comparative questions and asks whether Bowrey contributes to our knowledge of the changes to the Malay language between the 17th and 21st centuries.
In order to answer the research questions, this study not only relies on the dictionary in its entirety, but also on the notes found in British libraries as well as other material on early Malay, such as the Pigafetta list (1523), Houtman (1598–1603), and the Wilkinson dictionary (1901) as a complement to Bowrey’s dictionary; at the same time, the Malay Concordance Project (online), the SEAlang Project (online), Kamus Besar Bahasa Indonesia (online), and Kamus Dewan Edisi Keempat (2007) will represent modern Malay. It should be borne in mind that in contrast to the Thomas Bowrey dictionary (TBD), Kamus Dewan Edisi Keempat (KDE4) does not hold information on colloquial forms of Malay, many of which reflect features of lingua franca Malay. This study is divided into two different branches, namely the consideration of synchronic aspects and historical comparative aspects.
Finally, this study concludes that the Malay language in Thomas Bowrey’s dictionary is heavily influenced by both external and internal factors prevalent to the 17th century. The Malay language recorded in the Thomas Bowrey dictionary is very similar to modern Malay. The similarities between the Malay language of the 17th century and the Malay language of today are considerable, even though there are, of course, still some notable variances.
Metahumans ist ein innovatives Framework für die Unreal Engine, das hochgradig realistische digitale Charaktere zur Verfügung stellt. Metahumans zeichnen sich durch eine vollständige Control Rig aus, die es Entwicklern ermöglicht, vorgefertigte Animationen zu nutzen und sie nach Bedarf anzupassen und zu erweitern.
Im Rahmen dieser wissenschaftlichen Arbeit wird die Anwendung von Metahumans in der virtuellen Umgebung der Unreal Engine 5 untersucht. Das Hauptziel besteht darin, die Fähigkeit eines Metahumans zu untersuchen, mittels eines herkömmlichen Virtual Reality Headsets mithilfe von Motion Tracking gesteuert und animiert zu werden. Dabei wird speziell auf die Verwendung von Inverse Kinematics als Methode zur Erzeugung möglichst natürlicher Bewegungsabläufe eingegangen. Zusätzlich wird angestrebt, die Interaktion zwischen verschiedenen Metahuman-Avataren in einer Online-Sitzung zu ermöglichen.
Um den Einfluss auf das Immersionserlebnis der Benutzerinnen und Benutzer zu analysieren, werden Probandinnen und Probanden eingeladen, ihre Nutzererfahrungen zu evaluieren. Zu diesem Zweck werden zwei vergleichbare Level erstellt: eines in der Unreal Engine mit Metahumans und das andere in Unity mit den Meta Avataren von Oculus.
Diese wissenschaftliche Untersuchung zielt darauf ab, ein umfassendes Verständnis für die Leistungsfähigkeit von Metahumans zu erlangen, insbesondere im Vergleich zu anderen Avatar-Systemen.
Wir untersuchen die regulatorischen Änderungen in der EU, die die Transparenz bei nachhaltigen Investitionen erhöhen sollen. Durch eine Untersuchung der Unterschiede zwischen ESG-Ratingagenturen bewerten wir Herausforderungen für Standardisierung und Konsens von Ratings. Unsere Analyse unterstreicht die Dringlichkeit klarerer ESG-Ratings für eine nachhaltige Invesitionslandschaft.
We delve into the EU's regulatory changes aimed at boosting transparency in sustainable investments. By examining disparities among ESG rating agencies, we assess how these differences challenge standardization and consensus. Our analysis underscores the critical need for clearer ESG assessments to guide the sustainable investment landscape.
Uni-Highlights Februar 2024 : Einladungen zu ausgewählten Veranstaltungen der Goethe-Universität
(2024)
Unter Experten in Sachen Übersetzungsgeschichte ist Johann Diederich Gries kein Unbekannter. Er zählt z. B. zu den zehn "bedeutende[n] Übersetzerpersönlichkeiten von der frühen Neuzeit bis heute", deren Leben und Werk in der Europäischen Übersetzungsgeschichte von Jörn Albrecht und Iris Plack dargestellt wird. Friedmar Apels von Gottsched und Bode bis Dedecius und Enzensberger reichende "Leseliste zur Geschichte des Übersetzens in Deutschland" umfasst 60 Übersetzer, von Gries werden dessen Calderón- und Tasso-Übersetzungen zur Lektüre empfohlen.
Dorothea Gotfurt, 1907–1995
(2024)
Dorothea Gotfurt kam 1935 als Exilantin nach England. Dort wurde sie zur Übersetzerin. Zwischen 1955 und 1970 veröffentlichte sie vor allem im Scherz-Verlag (Bern), aber auch bei Fischer (Frankfurt/M.), Rowohlt (Reinbek) oder Szolnay (Wien) über dreißig von ihr ins Deutsche gebrachte Romane aus der zeitgenössischen englischsprachigen Literatur.
Die Bibliographie nennt alle in der Deutschen Nationalbibliothek vorhandenen Bücher Grete Fischers. Die Titel wurden mit Ausnahme der drei 1945/46 in Glasgow erschienenen Bücher autoptisch überprüft. Als Verlagslektorin hat sie durch mehrere Jahrzehnte an deutschen und englischen Übersetzungen mitgewirkt, die sich bisher jedoch bibliographisch nicht nachweisen ließen.
Auf Initiative des Schwerpunktes Ökotoxikologie im Masterstudiengang Umweltwissenschaften an der Justus-Liebig-Universität Gießen wurde eine neue Plattform für die Begegnung und Vernetzung der Studierenden untereinander eingerichtet, der sich nun zum ersten Mal jährt. Um mehr Einblicke in das praktische Versuchswesen und Studienangebote anderer Hochschulen zu geben, organisiert der Schwerpunkt Angebotsformate, die über die Vorlesungen hinausgehen. Der »Mittelhessische Tag der Ökotoxikologie« bringt Studierende der Technischen Hochschule Mittelhessen, der Goethe-Universität Frankfurt, der Philipps-Universität Marburg, jüngst auch der Universität Kassel und der JLU am FNU in Homberg (Ohm) zusammen und erlaubt ihnen Einblicke in die ökotoxikologische Forschung und Praxis.
Die Arbeitsgruppe Generative KI erforscht die Folgen von KI für die Goethe-Universität. Die beiden studiumdigitale-Mitarbeiter*innen der AG Julia Schmitt und Dr. David Weiß, der zugleich auch der Leiter der AG ist, geben Auskunft darüber, warum TechnologieAusrollen allein nicht reicht und es wichtig ist, im KI-Hype nicht die Ruhe zu verlieren.
In der Bibliographie sind alle bisher ermittelten Publikationen von und über Curt SigmarGutkind verzeichnet. Belegexemplare der von ihm verfassten Aufsätze und Zeitungsbeiträge(Rezensionen, Theaterkritiken usw.) befinden sich in seinem im Mannheimer Stadtarchivaufbewahrten Nachlass. Alle Einträge wurden autoptisch geprüft.
Von A bis Å. (Fast) alles über die Frankfurter Skandinavistik. Ausgabe 8 ; Sommeremester 2024
(2024)
Kinder und Jugendliche beschäftigen sich gerne mit audiovisuellen, auditiven und interaktiven Medien. Das Buch gerät im Mediengeflecht zunehmend in den Hintergrund. Um für die junge Zielgruppe attraktiv zu sein, setzen Verlage auf Bücher, die Themen, Geschichten und Darstellungsweisen aus anderen Medien aufgreifen. Dazu gehören auch die sogenannten Medienbegleitbücher, die in Bezug zu einem Film, einer Serie, einem Hörspiel oder einem digitalen Spiel stehen. Diese Bücher ermöglichen Kindern aufgrund der bereits bekannten Geschichten, Charaktere und Dialoge einen erleichterten Zugang zu Literatur und locken mit besonderen Gratifikationen, die vorlagenfreie Bücher nicht zu bieten haben. Daher sind sie als Lesestoffe auch für die Leseförderung interessant.
Diese Arbeit untersucht daher, welche Stellung Medienbegleitbücher im Kinder- und Jugendbuchmarkt sowie in der Leseförderung haben. Im ersten Teil liegt der Fokus auf der Produktion und Distribution von Begleitbüchern. Mithilfe einer Recherche im Katalog der Deutschen Nationalbibliothek wurden das Marktangebot erarbeitet und Rückschlüsse auf die Entwicklung des Genres gezogen. Jahresbestsellerlisten des Buchreport geben einen Eindruck vom Verkauf der Bücher. Forschungsliteratur zum Thema Lizenzen und Kommunikationspolitik in Verlagen ergänzt den Marktüberblick durch die Perspektive von Handel und Herstellung.
Im folgenden Kapitel werden unter Zuhilfenahme von Forschungsliteratur und Studien die Potenziale der Begleitbücher geschildert. Rezensionen und Bewertungen zu Medienbegleitbüchern auf LovelyBooks und Amazon geben Aufschluss über die Einstellung der Leser*innen und Beiträge in Zeitschriften der Kinder- und Jugendliteratur zeigen die Meinung der Vermittler*innen zu Begleitbüchern.
Der letzte Abschnitt der Arbeit beschäftigt sich mit dem Einsatz der Medienbegleitbücher in der Leseförderung. Stellvertretend für Angebote in der Familie und in Kindertagesstätten wurde die Arbeit der Stiftung Lesen Mainz betrachtet. Eine Analyse der Angebote und ein Experten-Interview geben nähere Einblicke in die Einbindung von Medienbegleitbüchern. Die Didaktik-Forschung gibt Auskunft über die Integration von Medienbegleitbüchern und Medienverbünden in den Unterricht. Im Bereich der außerschulischen Leseförderung wurde der Einsatz von Medienbegleitbüchern in den Lesestunden von Mentor e.V. Mainz mit einer Online-Umfrage unter den Mentor*innen untersucht. Der Katalog der Anna Seghers Bücherei Mainz zeigt das Angebot an Medienbegleitbüchern in Büchereien auf. Der Instagram-Account der Bücherei lässt Rückschlüsse über den Einsatz von Begleitbüchern in Aktionen zu.
Zusammenfassend konnte festgehalten werden, dass Medienbegleitbücher ein wichtiges Segment des Kinder- und Jugendbuchmarktes darstellen, hohe Umsätze generieren können und für den Handel von Bedeutung sind. Aufgrund des vielfältigen Angebots und der verschiedenen Vertriebswege können viele Zielgruppen angesprochen und erreicht sowie Barrieren zum Medium Buch abgebaut werden. Obwohl die Erfahrungen von Familienangehörigen und Mentor*innen belegen, dass sich Begleitbücher positiv auf die Lesemotivation und das Leseverhalten von Kindern und Jugendlichen auswirken können, werden sie in der Leseförderung bislang eher am Rande berücksichtigt. Sie werden zwar empfohlen, aber Konzepte für und Evaluationen von Projekten fehlen. Die Potenziale der Medienbegleitbücher und ihrer Medienverbünde werden daher nicht ausgeschöpft. Medienbegleitbücher sollten zunehmend in den Fokus gerückt und als Chance wahrgenommen werden, Heranwachsende für Bücher zu begeistern und ihre Lesefreude zu wecken.
Evidence of predation pressure on sensitive species by raccoons based on parasitological studies
(2024)
Highlights
• Parasitological analyses were carried out on 108 free-ranging raccoons in Germany.
• Three endoparasite species were newly discovered, alongside 13 parasites already known.
• A high prevalence of the pathogenic nematode Baylisascaris procyonis was identified.
• Uncovering endoparasites provides insights into predation events from the past.
• Stomach contents show serious negative impact of raccoons on native amphibians.
Abstract
To demonstrate predation and potential impacts of raccoons on various species, a total of 108 raccoons from aquatic-associated nature reserves and natural areas in three federal states of Germany, Hesse (n = 36), Saxony-Anhalt (n = 36) and Brandenburg (n = 36), were investigated from a dietary ecological perspective in the present study. Fecal analyses and stomach content examinations were conducted for this purpose. Additionally, as a supplementary method for analyzing the dietary spectrum of raccoons, the parasite fauna was considered, as metazoan parasites, in particular, can serve as indicators for the species and origin of food organisms. While stomach content analyses allow for a detailed recording of trophic relationships solely at the time of sampling, parasitological examinations enable inferences about more distant interaction processes. With their different developmental stages and heteroxenous life cycles involving specific, sometimes obligate, intermediate hosts, they utilize the food web to reach their definitive host. The results of this study clearly demonstrate that spawning areas of amphibians and reptiles were predominantly utilized as food resources by raccoons in the study areas. Thus, common toad (Bufo bufo), common newt (Lissotriton vulgaris), grass frog (Rana temporaria), and grass snake (Natrix natrix) were identified as food organisms for raccoons. The detection of the parasite species Euryhelmis squamula, Isthmiophora melis, and Physocephalus sexalatus with partially high infestation rates also suggests that both amphibians and reptiles belong to the established dietary components of raccoons from an ecological perspective, as amphibians and reptiles are obligate intermediate hosts in the respective parasitic life cycles of the detected parasites. The study clearly demonstrates that raccoons have a significant impact on occurrence-sensitive animal species in certain areas and, as an invasive species, can exert a negative influence on native species and ecosystems.
L'obiettivo del presente articolo è quello di offrire una visione complementare a quella abituale del romanzo "Die Entdeckung der Currywurst" di Uwe Timm in cui vengano privilegiati gli aspetti del romanzo che lo identificano come opera di World Literature. Se fino ad ora il romanzo è stato principalmente letto come un romanzo tedesco di guerra, con questa lettura si intende far emergere gli aspetti che di esso oltrepassano i confini nazionali e linguistici. Per fare questo si osserveranno in breve i punti di contatto fra la WL e la letteratura postcoloniale, dalla quale la WL stessa ha origine. In particolare si concentrerà l'attenzione sugli elementi del romanzo che evidenziano il rapporto con le letterature e culture di oltre confine, come la cornice narrativa, in cui la narrazione principale si iscrive; le contaminazioni letterarie che emergono dal racconto e infine i numerosi esempi di relazione fra centro e periferia. Inoltre, verrà evidenziato come il periodo storico in cui il romanzo è ambientato, ovvero quello della 'Stunde Null', abbia esso stesso dei contatti intrinseci con le teorie postcoloniali. Si mostrerà come la tesi dell'afferenza del presente romanzo alla WL, sia sostenuta dal fatto che anche attraverso romanzi precedenti, Uwe Timm mostra un interesse spiccato nei confronti delle realtà degli altri paesi e continenti e dell’eredità coloniale dell'Europa.
Arbeit und Spiel fungieren im allgemeinen Sprachgebrauch als Gegensätze. Spielen wird im Kontext dieser Oppositionsbeziehung als autotelische Handlung, also als eine freiwillige Beschäftigung mit unproduktivem Charakter, definiert, die primär der Freude oder Entspannung dient. Arbeiten hingegen wird als zweckorientierte Tätigkeit gefasst, die mit Ernsthaftigkeit und Mühsal assoziiert wird. In einer sich verändernden Arbeitswelt lösen sich diese binären Zuordnungen, sofern sie in dieser Schärfe überhaupt jemals bestanden haben, jedoch zunehmend auf. Arbeit und Spiel verschränken sich, sie bilden Hybridformen aus, bei denen sich Verschiebungen von Spielenden zu Arbeitenden und umgekehrt beobachten lassen. Die Etablierung der Spieleindustrie als Wirtschaftsbranche oder die Professionalisierung des Wettkampfsports bringen beispielsweise Formen des Play-as-Work hervor: "Sämtliche Tätigkeiten mit einer unterstellten Wirkabsicht können demnach als Arbeit begriffen werden. Daher können auch aus traditionellen Gründen oder aus Unterhaltungs- und Zerstreuungsgründen ausgeführte Tätigkeiten nunmehr als Arbeit verstanden werden, wenn ihnen eine Wirkabsicht unterstellt werden kann." Zudem werden in Arbeitsbereichen der postfordistischen Wissensökonomie ludische Elemente wie Kreativität, Improvisation oder Risikobereitschaft in einer Abwendung von der normierten Rationalisierung von Arbeit des Taylorismus aufgewertet und spielhaftes Arbeiten ohne kodifizierte Regeln (wieder) als Mittel wirtschaftlicher Produktivität erkannt. Seit den 1990er Jahren lassen sich ferner Tendenzen einer zunehmenden Entgrenzung und Subjektivierung von Erwerbstätigkeit ausmachen; hierbei wird die mit der Industrialisierung entstandene Trennung von Arbeit und Leben abgeschwächt und das Konzept Arbeit neu definiert, denn diese wird nun nicht mehr vornehmlich negativ als Plage oder göttliche Strafe gerahmt, sondern positiv als Mittel der Selbstverwirklichung konnotiert. Arbeit soll infolgedessen spielend von der Hand gehen und Vergnügen bereiten. Auf diese Weise wird eine work-as-play-Mentalität erzeugt, die die Differenz von Ernst und Spiel in der Betrachtungsweise der Handlung festmacht: Es hängt vom Ausführenden ab, ob eine Tätigkeit als Spiel oder als Arbeit klassifiziert wird. So kann letztlich jede Aktivität einfach zum Spiel erklärt werden. [...] Im Fokus dieses Artikels soll jedoch eine andere Form der Hybridisierung von Arbeit und Spiel stehen: die Repräsentation von Büroarbeit im Computerspiel. [...] Untersucht werden soll im Folgenden, welche Inszenierungsstrategien und Spielmechaniken eingesetzt werden, um das Büro spielbar zu machen. Wie wird das Setting für das Gameplay funktionalisiert und wie werden Arbeitsprozesse ludifiziert? Zu welcher Form des Spiels lädt das Büro ein? Welche Aspekte des Büroalltags werden aufgegriffen und welche Erzählungen sowie Figuren werden mit dem Schauplatz verbunden? Des Weiteren soll analysiert werden, wie über die räumliche Ästhetik inhaltliche Aussagen über die kulturelle Bedeutung und gesellschaftliche Wahrnehmung des Büros transportiert werden.
Der Begriff der Verblendung, ein oft implizit immer wiederkehrendes Thema in der Literatur, Philosophie, und auch in der Religion, hat eine komplexe Bedeutungsebene, die es vielleicht wohl zu bewahren gilt, anstatt sie zu fixieren und damit die Lesemöglichkeiten, die er eröffnen kann, zu reduzieren. Das Wort, das Offenes (etwa eine Hingabe an einen Glauben, die auch eine Selbsttäuschung, ein Fehler sein kann, aber auch Mut bedeuten kann) und Verborgenes (eine mehr oder weniger bewusste Täuschung anderer) zugleich andeutet, entzieht sich durch diese doppelte Struktur von 'Oberfläche' und 'Hintergrund' in gewisser Weise, ohnehin einer festen BeDeutungsgebung. In besonderer Weise bleibt der Begriff mit dem als 'Verliebtheit' umschriebenen Zustand als einer ambivalenten un/wahren, irrational und affektiv besetzten, relationalen, inneren Vorstellung und äußeren Projektion des Selbst und eines Anderen verbunden. Der Begriff kann die Hingabe an eine (trügerische) Romantik oder eine (trügerische) Hingabe an eine Romantik meinen, der ein Selbst und ein Anderes in eine affektive Beziehung zueinander setzt, und so auch die Möglichkeit des Unheimlichen, das Hineinbrechen eines Trug(-Bild)-es kennzeichnen. Dies wiederum ist engstens mit Angst und Wut, den oft als destruktiv dargestellten Affekten und affektiv besetzten Effekten verbunden. Verblendung ist somit auch ein Begriff, der Vorstellungen von 'Rationalität' und (affektiv-besetzter) 'Irrationalität', von 'Richtigkeit' und 'Falschheit' beinhaltet.
This paper relies on an unedited and unpublished nineteenth century love correspondence of a heterosexual couple from the German speaking area. The aim of this study is to contribute to the knowledge regarding the nineteenth century love experience of ordinary and unknown lovers. In fact, while there are plenty of books on love correspondences of famous personalities, little research has been dedicated to love letters and romantic experiences of 'ordinary and unknown' people. For this reason the main aim of this article is to shed light on love stories and love experiences that otherwise will fall into the abyss of oblivion. A new theory regarding the love experience in the nineteenth will be proposed: in this century love was perceived more in its material than in its abstract nature; I argue that in the nineteenth love was more about what people did, than to what they said. Lovers are in constant need of material and 'seeable' proof in order to perceive the love of their partners as real and authentic. The examples extrapolated from the following correspondence will corroborate this statement. Furthermore, this article has the purpose to underline the great value of love letters not only from an historical perspective (being evidence of past lives and dynamics), but also and more importantly from a cultural and societal one: analyzing love letters means to acquire knowledge not only about cultural and societal dynamics, but also and more importantly to add knowledge to the love discourse. In fact, they say a lot about the way people talked, expressed and materialized love in their daily lives. Correspondences without any publication in view are the most precious ones because they represent an unregulated and more spontaneous expression 'of the language of the heart'.
E.T.A. Hoffmanns Erzählung "Der Sandmann" ist dank Freuds Interpretation zu einem seiner wichtigsten Werke geworden. Die Novelle, die die Leser mit dem jungen Studenten Nathanael, der mit sich ein Kindheitstrauma trägt, bekannt macht, ist ein komplexes Werk, das auch den weltbekannten Mediziner fasziniert hat. Diese Arbeit befasst sich mit der schon erwähnten Novelle, mit Freuds Artikel "Das Unheimliche" und mit der sehr relevanten Verfilmung aus dem Jahr 2012. Das Motiv des Unheimlichen kommt in dieser Arbeit als eine Kontaktstelle vor, die auf drei verschiedenen Ebenen interpretiert wird: aus der Perspektive des Unheimlichen in der Novelle, aus Sigmund Freuds Perspektive und wie es im Film auftaucht. Ziel dieser Arbeit ist es zu beweisen, dass das Motiv des Unheimlichen in der Verfilmung anders als im Buch begriffen werden kann, d.h. dass Freuds Motiv des Unheimlichen im Text als gruseliger und verwirrender empfunden werden kann.
Der interdisziplinäre Sammelband eröffnet neue Perspektiven auf den Stil als bislang unterkonturierte literaturwissenschaftliche Leitkategorie unter transnationalen, wissens-, gattungs- und sprachgeschichtlichen Gesichtspunkten. Im 18. Jahrhundert zeichnet sich im Nachdenken über Schreibarten eine Neujustierung der Stilkategorie ab, die den Stil zur Reflexionsgröße für ästhetische Diskurse macht. Der Band sondiert die Pluralisierung, Historisierung und Individualisierung der Stilkategorie, die ihr neue literatur- und kulturtheoretische Anwendungsbereiche eröffnet. Die Bewegungen zwischen den Sprachen, Literaturen, Medien und semantischen Feldern erschließt die Publikation, indem sie europäische Vergleichshorizonte eröffnet und literatur- ebenso wie sprachwissenschaftliche Ansätze präsentiert. Damit leistet sie einen Beitrag zum Feld der komparatistisch ausgerichteten Germanistik, insbesondere der Literatur- und Kulturgeschichte des 18. Jahrhunderts und des europäischen Kulturtransfers.
Beyond well-established difficulties with working memory in individuals with attention deficit hyperactivity disorder (ADHD), evidence is emerging that other memory processes may also be affected. We investigated, first, which memory processes show differences in adults and adolescents with ADHD in comparison to control participants, focusing on working and short-term memory, initial learning, interference, delayed and recognition memory. Second, we investigated whether ADHD severity, co-occurring depressive symptoms, IQ and physical fitness are associated with the memory performance in the individuals with ADHD.
We assessed 205 participants with ADHD (mean age 25.8 years, SD 7.99) and 50 control participants (mean age 21.1 years, SD 5.07) on cognitive tasks including the digit span forward (DSF) and backward (DSB), the Rey Auditory Verbal Learning Test (RAVLT), and the vocabulary and matrix reasoning subtests of the Wechsler Abbreviated Scale of Intelligence. Participants with ADHD were additionally assessed on ADHD severity, depression symptoms and cardiorespiratory fitness. A series of regressions were run, with sensitivity analyses performed when variables were skewed.
ADHD-control comparisons were significant for DSF, DSB, delayed and recognition memory, with people with ADHD performing less well than the control participants. The result for recognition memory was no longer significant in sensitivity analysis. Memory performance was not associated with greater ADHD or depression symptoms severity. IQ was positively associated with all memory variables except DSF. Cardiorespiratory fitness was negatively associated with the majority of RAVLT variables.
Individuals with ADHD showed difficulties with working memory, short-term memory and delayed memory, as well as a potential difficulty with recognition memory, despite preserved initial learning.
Targeted protein degradation (TPD) has recently emerged as an exciting new drug modality. However, the strategy of developing small molecule-based protein degraders has evolved over the past two decades and has now established molecular tags that are already in clinical use, as well as chimeric molecules, PROteolysis TArgeting Chimeras (PROTACs), based mainly on ligand systems developed for the two E3 ligases CRBN and VHL. The large size of the human E3 ligase family suggests that PROTACs can be developed by targeting a large diversity of E3 ligases, some of which have restricted expression patterns with the potential to design disease- or tissue-specific degraders. Indeed, many new E3 ligands have been published recently, confirming the druggability of E3 ligases. This review summarises recent data on E3 ligases and highlights the challenges in developing these molecules into efficient PROTACs rivalling the established degrader systems.
Isothermal titration calorimetry (ITC) is a widely used technique for the characterization of protein-protein and protein-ligand interactions. It provides information on the stoichiometry, affinity, and the thermodynamic driving forces of interactions. This chapter exemplifies the use of ITC to investigate interactions between human autophagy modifiers (LC3/GABARAP proteins) and their interaction partners, the LIR motif containing sequences. The purpose of this report is to present a detailed protocol for the production of LC3/GABARAP-interacting LIR peptides using E. coli expression systems. In addition, we outline the design of ITC experiments using the LC3/GABARAP:peptide interactions as an example. Comprehensive troubleshooting notes are provided to facilitate the adaptation of these protocols to different ligand-receptor systems. The methodology outlined for studying protein-ligand interactions will help to avoid common errors and misinterpretations of experimental results.
Die Lincoln-Siedlung in der Wissenschaftsstadt Darmstadt ist sowohl bundesweites Modellprojekt in Sachen nachhaltiger Mobilität als auch Gegenstand verschiedener Forschungsprojekte. Im Projekt NaMoLi II wird die Zufriedenheit der Bewohnenden in der Lincoln-Siedlung mit dem Mobilitätskonzept und seiner Umsetzung analysiert. Des Weiteren wird geprüft, ob und in welcher Form die vorhandenen Rahmenbedingungen eine nachhaltige Mobilität fördern und wie sich die im Quartier bzw. im Umfeld vorhandenen Angebote der Versorgung und sozialen Infrastruktur auf das Mobilitätsverhalten insbesondere neu Zugezogener auswirken. Hierzu hat eine ausgewählte Bevölkerungsgruppe aus der Lincoln-Siedlung über einen Zeitraum von einer Woche Tagebuchprotokolle ihrer täglichen Mobilität geführt. Teilgenommen haben 14 Haushalte mit insgesamt 28 Personen, die zum Zeitpunkt der Erhebung maximal 15 Monate im Quartier gelebt haben. Die Protokolle wurden von allen Haushaltsangehörigen ab dem Grundschulalter geführt, jüngere Kinder sind in den Tagebüchern der Eltern erfasst. Notiert wurden Wegezwecke und Wegeziele, das genutzte Verkehrsmittel, Start- und Ankunftszeit sowie die (geschätzte) Entfernung. Des Weiteren wurden Kennwerte zur Haushaltsstruktur erhoben, zu geänderten Gewohnheiten nach dem Umzug in die Lincoln-Siedlung sowie nach Problemen in der Alltagsmobilität gefragt. Die Ergebnisse der Mobilitätstagebücher bieten einen interessanten Einblick in den Mobilitätsalltag einer spezifischen Teilnahmegruppe, die ein besonderes Interesse an Mobilitätsthemen gezeigt hat und die sich weitgehend nachhaltig in ihrem Alltag bewegt. Das Fahrrad ist das wichtigste Verkehrsmittel, gefolgt von den eigenen Füßen. Die Mehrzahl der Wegeziele liegt innerhalb eines Radius von bis zu zwei Kilometer. Die multimodalen Angebote im Quartier werden gut genutzt. Es hat sich gezeigt, dass die Methode der Tagebuchprotokolle über einen längeren Zeitraum zielführend ist, um Hinweise für die Alltagstauglichkeit des Mobilitätskonzeptes sowie zu dessen Weiterentwicklung bzw. Nachsteuerung zu erlangen.
This study analyses potential consequences of exiting the Targeted Long-Term Refinancing Operations (TLTRO) of the European Central Bank (ECB). Thanks to its asset purchase programs, the Eurosystem still holds plenty of reserves even with a full exit from the TLTROs. This explains why voluntary and mandatory repayments of TLTRO III borrowing went smoothly. Nevertheless, the more liquidity is drained from the banking system, the more important becomes interbank market borrowing and lending, ideally between euro area member states. Right now, the usual fault lines of the euro area show up. The German banking system has plenty of reserves while there are first signs of aggregate scarcity in the Italian banking system. This does not need to be a source of concern if the interbank market can be sufficiently reactivated. Moreover, the ECB has several tools to address possible future liquidity shortages.
This document was provided/prepared by the Economic Governance and EMU scrutiny Unit at the request of the ECON Committee.
Das Ziel der BMBF-finanzierten Forschungsprojekte „Nachhaltige Mobilität in Lincoln 1“ und „Nachhaltige Mobilität in Lincoln 2“ ist es, Erkenntnisse zu Veränderungen im Mobilitätsverhalten von Personen zu erlangen, die in ein autoreduziertes Quartier umziehen. Dazu wurden zwei aufeinander aufbauende Vollbefragungen der erwachsenen Bewohner*innen der autoreduzierten Lincoln-Siedlung in Darmstadt durchgeführt. Im Rahmen der ersten Befragung im Jahr 2020 wurden 1.140, im Rahmen der zweiten Befragungswelle, 2021, 1.614 Fragebögen verteilt. Der Rücklauf belief sich 2020 auf n = 166 (14,6 %), in 2021 auf n = 231 (14,3 %). Der vorliegende Bericht beschreibt das methodische Vorgehen im Rahmen der Befragungen. Hierfür wird auf das besondere Panel-Design der Studie eingegangen. Dieses ermöglicht sowohl Einblicke in den Umzug in die Siedlung, als auch in das Leben in der Siedlung im Verlauf eines Jahres, und die damit einhergehenden Veränderungen im individuelle Mobilitätsverhalten. Der Bericht stellt dazu die zentralen Inhalte des Fragebogens vor und erläutert die Durchführung der Befragungen. In deren Rahmen wurden die Bewohner*innen der Lincoln-Siedlung insgesamt dreimal kontaktiert. Um die Bereitschaft zur Teilnahme zu steigern, wurden im Vorfeld der Erhebungen mittels einer Pressemitteilung auf die Befragung aufmerksam gemacht und Ankündigungsschreiben in die Briefkästen der Bewohner*innen verteilt. Eine Woche nach der eigentlichen Fragebogenverteilung wurden Erinnerungsschreiben verteilt. Ferner geht der Methodenbericht auf den Umgang mit dem Rücklauf sowie auf die Datenaufbereitung und - eingabe ein, bevor die soziodemographischen Daten der Teilnehmer*innen auf ihre Repräsentativität geprüft werden.
Almost ten years after the European Commission action plan on building a capital markets union (CMU) and despite incremental progress, e.g. in the form of the EU Listing Act, the picture looks dire. Stock exchanges, securities markets, and supervisory authorities remain largely national, and, in many cases, European companies have decided to exclusively list overseas. Notwithstanding the economic and financial benefits of market integration, CMU has become a geopolitical necessity. A unified capital market can bolster resilience, strategic autonomy, and economic sovereignty, reduce dependence on external funding, and may foster economic cooperation between member states.
The reason for the persistent stand-still in Europe’s CMU development is not so much the conflict between market- and state-based integration, but rather the hesitancy of national regulatory and supervisory bodies to relinquish powers. If EU member states wanted to get real about CMU (as they say, and as they should), they need to openly accept the loss of sovereignty that follows from a true unified capital market. Building on economic as well as historical evidence, the paper offers viable proposals on how to design competent institutions within the current European framework.
This note outlines the case for speedy capital market integration and for the adoption of a common regulatory framework and single supervisory authority from a political economy perspective. We also show the alternative case for harmonization and centralization via regulatory competition, elaborating how competition between EU jurisdictions by way of full mutual recognition may lead to a (cost-)efficient and standardized legal framework for capital markets. Lastly, the note addresses the political economy conflict that underpins the implementation of both models for integrating capital markets. We point out that, in both cases, national authorities experience a loss of legislative and jurisdictional competence at the national level. We predict that any plan to foster a stronger capital market union, following an institution based or a market-based strategy, will face opposition from powerful national stakeholders.
The economic rise of China has changed the global economy. The authors explore China’s transformation from a low-cost manufacturing hub to an increasingly innovation- and service-driven economy. Major growth drivers for the period 2010-2025 are analysed, including the paradigms of “Made in China” and the “Dual Circulation Strategy”. The export intensity of China’s economy is declining overall, with a tendency towards greater regional diversification and a gradual decoupling from North America and the European Union. At the same time, trade and investment activities are increasingly geared to the Belt and Road Initiative. Furthermore, labour and energy cost advantages for manufacturing operations in China are likely to diminish in the coming years, calling into question China’s attractiveness as a global manufacturing hub. In this regard, the further development of regional and industrial clusters is pivotal for China to enhance its global competitiveness and remain an attractive destination for foreign direct investment (FDI) in the medium term. On the other hand, high productivity in science and technology and rich deposits of critical minerals put China in a favourable position in advanced industries. Important challenges include the still wide development gap between rural and urban areas, the structural mismatch in the labour market, with persistently high youth unemployment, and the race to achieve carbon neutrality by 2060.
Highlights
• Family structure transitions decrease academic school track attendance among children of less educated parents.
• Children of highly educated fathers in single-mother families also have lower outcomes.
• Reduced income and increased exposure to poverty are relevant mediators.
• There is no cumulative disadvantage linked to a further transition to a stepfamily.
• Previous parental separation does not affect educational outcomes for children residing with a highly educated stepfather.
Abstract
Recent research has documented that the effect of parental separation on children’s educational outcomes depends on socioeconomic background. Yet, parental separation could lead to a stable single-parent family or to a further transition to a stepfamily. Little is known about how the effect of family structure transitions on educational outcomes depends on the education of parents and stepparents, and there has been limited empirical research into the mechanisms that explain heterogeneity in the effects of family transitions. Using longitudinal data from the German Socio-Economic Panel and models with entropy balancing and sibling fixed effects, I explore the heterogeneous effects of family transitions during early and middle childhood on academic secondary school track attendance, grades and aspirations. I find that family transitions only reduce the academic school track attendance among children of less educated parents living in stepfamilies or with a single mother after parental separation, and among children of highly educated fathers living in single-mother families. The mechanisms that partly explain these effects relate to reduced income and exposure to poverty after parental separation. The findings underscore the importance of considering the stepparent's educational level, indicating that the adverse consequences of parental separation on educational outcomes are mitigated when a highly educated stepfather becomes part of the family. Overall, these findings align more closely with the resource perspective than the family stability perspective.
Highlights
• Pre-service teachershave stereotypes towards pupils with autism, Down syndrome and dyslexia.
• Pupils with Down syndrome, autism and dyslexia are associated with distinctive stereotypes.
• These stereotypes can be classified in three resp. four different dimensions.
Abstract
Stereotypes about pupils with special educational needs are prevalent both in society and among pre- and in-service teachers. However, little is known about the specific stereotypes pre-service teachers associate with autistic pupils, pupils with Down syndrome, and pupils with dyslexia. We explored these in two studies. Study 1 (N=13) involved qualitative interviews to identify potential stereotype content. Study 2 (N=213) used these findings to create a questionnaire to quantify these stereotypes. We found distinct stereotypes associated with all three groups of pupils. For successful inclusion, teachers must recognize the uniqueness of each pupil, including those with different diagnoses.
Research around the “glass escalator” demonstrates that men receive promotions faster than women in women-dominated occupations. However, it remains unclear how overall establishment composition affects the glass escalator. We use German longitudinal linked employer-employee data (LIAB) between 2012 and 2019 to examine how occupational and establishment gender composition shape gender differences in promotions to management. Establishment gender composition moderates the glass escalator, meaning women's mobility disadvantages in women-dominated jobs are most pronounced in men-dominated establishments. We hypothesize that changing occupational status is a central mechanism: When occupations mirror the composition of the establishment, their status increases locally. Higher occupational status offsets lower leadership expectations attributed to women and increases women's promotion odds relative to their male colleagues.
PET probes targeting fibroblasts are frequently used for varying applications in oncology. In recent years, the clinical spectrum has been expanded towards cardiovascular medicine, e.g., after myocardial infarction, in aortic stenosis or as a non-invasive read-out of atherosclerosis. We herein provide a brief overview of the current status of this PET radiotracer in the context of cardiovascular disease, including translational and clinical evidence. In addition, we will also briefly discuss future applications, e.g., the use of fibroblast-targeting PET to investigate bilateral organ function along the cardiorenal axis.
Interferon-stimulated gene-15 (ISG15) is an interferon-induced protein with two ubiquitin-like (Ubl) domains linked by a short peptide chain, and the conjugated protein of the ISGylation system. Similar to ubiquitin and other Ubls, ISG15 is ligated to its target proteins with a series of E1, E2, and E3 enzymes known as Uba7, Ube2L6/UbcH8, and HERC5, respectively. Ube2L6/UbcH8 plays a literal central role in ISGylation, underscoring it as an important drug target for boosting innate antiviral immunity. Depending on the type of conjugated protein and the ultimate target protein, E2 enzymes have been shown to function as monomers, dimers, or both. UbcH8 has been crystalized in both monomeric and dimeric forms, but the functional state is unclear. Here, we used a combined approach of small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) spectroscopy to characterize UbcH8′s oligomeric state in solution. SAXS revealed a dimeric UbcH8 structure that could be dissociated when fused with an N-terminal glutathione S-transferase molecule. NMR spectroscopy validated the presence of a concentration-dependent monomer-dimer equilibrium and suggested a backside dimerization interface. Chemical shift perturbation and peak intensity analysis further suggest dimer-induced conformational dynamics at ISG15 and E3 interfaces - providing hypotheses for the protein′s functional mechanisms. Our study highlights the power of combining NMR and SAXS techniques in providing structural information about proteins in solution.