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Eugen Helmlé, 1927–2000
(2018)
Eugen Helmlé (1927–2000) war einer der verwegensten und besessensten Übersetzer seiner Zunft, der an die 150 Bücher übersetzt hat und in ganz besonderer Weise Georges Perec verbunden war, dem herausragenden französischen Autor des 1960 gegründeten Oulipo-Kreises, der gemeinsam mit seinem Übersetzer Helmlé neue formale Wege der Literaturproduktion beschritt.
Der Artikel wirft einige Schlaglichter auf die Geschichtsbilder und -vorstellungen, die im modernen muslimischen religiösen Denken seit dem späten 19. Jahrhundert zum Tragen gekommen sind. Insbesondere im Blick steht dabei die Frage nach dem Umgang mit eigener Geschichtlichkeit und mit den Konsequenzen, die sich daraus für die Ausgestaltung von Islamität ergeben. Die unterschiedlichen Gewichtungen und Verknüpfungen von Vergangenheit und Gegenwart und die Frage, ob die Bedeutung des historischen Wandels für die eigenen Erkenntnisprozesse mitreflektiert wird, entscheidet, so die These, über den Umgang des religiösen Denkens mit neuen Wissensbeständen, Epistemen und methodischen Verfahren ebenso wie darüber, ob diese als legitim angesehen werden, um als authentisch islamisch akzeptiert zu werden.
TO MAKE PROFITABLE INVESTMENT DECISIONS, INVESTORS NEED TO ASSESS THE FINANCIAL FUTURE OF FIRMS. DUE TO INVESTORS’ LACK OF INTERNAL INFORMATION ABOUT THE FIRMS’ FUTURE PROSPECTS, THEY OFTEN HAVE TO RELY ON MANAGERS’ VERBAL STATEMENTS FOR THIS TASK. HOWEVER, AS MANAGERS MIGHT HAVE AN INCENTIVE TO PRESENT POSITIVELY BIASED INFORMATION, THE VALUE OF THEIR STATEMENTS FOR INVESTORS IS NOT CLEAR.
IN THIS REPORT, WE SHOW HOW TEXTUAL ANALYSIS TOOLS CAN BE USED TO ASSESS THE VALUE OF MANAGERS’ VERBAL STATEMENTS DURING EARNINGS CONFERENCE CALLS FOR INVESTORS. WE FIND THAT IN PARTICULAR MANAGERS’ NEGATIVE STATEMENTS SIGNI FICANTLY PREDICT LOWER FUTURE EARNINGS.
The cortical networks that underlie behavior exhibit an orderly functional organization at local and global scales, which is readily evident in the visual cortex of carnivores and primates1-6. Here, neighboring columns of neurons represent the full range of stimulus orientations and contribute to distributed networks spanning several millimeters2,7-11. However, the principles governing functional interactions that bridge this fine-scale functional architecture and distant network elements are unclear, and the emergence of these network interactions during development remains unexplored. Here, by using in vivo wide-field and 2-photon calcium imaging of spontaneous activity patterns in mature ferret visual cortex, we find widespread and specific modular correlation patterns that accurately predict the local structure of visually-evoked orientation columns from the spontaneous activity of neurons that lie several millimeters away. The large-scale networks revealed by correlated spontaneous activity show abrupt ‘fractures’ in continuity that are in tight register with evoked orientation pinwheels. Chronic in vivo imaging demonstrates that these large-scale modular correlation patterns and fractures are already present at early stages of cortical development and predictive of the mature network structure. Silencing feed-forward drive through either retinal or thalamic blockade does not affect network structure suggesting a cortical origin for this large-scale correlated activity, despite the immaturity of long-range horizontal network connections in the early cortex. Using a circuit model containing only local connections, we demonstrate that such a circuit is sufficient to generate large-scale correlated activity, while also producing correlated networks showing strong fractures, a reduced dimensionality, and an elongated local correlation structure, all in close agreement with our empirical data. These results demonstrate the precise local and global organization of cortical networks revealed through correlated spontaneous activity and suggest that local connections in early cortical circuits may generate structured long-range network correlations that underlie the subsequent formation of visually-evoked distributed functional networks.
This study will consider the various aspects of the portrayal of Sultan ʿAbd al-Ḥamīd II that were emphasized in the Arab-Islamist revisionist writings about Islamic history. The focus will be especially on the writings of Anwar al-Ǧundī (1917–2002), an Egyptian Islamist writer as it was he who first adopted the process of an “Islamic revision of Islamic history”. His main academic output consisted in responding to the “Orientalist attack on Islam”, and he wrote a number of books towards this aim as as-Sulṭān ʿAbd al-Ḥamīd wa l-ḫilāfa al-islāmiyya, al-Islām fī maʿrakat at-taġrīb and al-Istiʿmār wa l-Islām.
This will be followed by an analysis of the ideological exploitation of the historical personality, and the consequences of the contemporary historical Islamist vision for the development of religious thought.
Entstanden in einem Milieu aus exklusivistischen islamischen Bewegungen, baut die Gewalttheologie der dschihadistischen Organisationen wie der al-Qa‘ida oder des IS auf eine Geschichtstheologie, welche Verfalls- und Dekadenzdiagnosen über die Situation der islamischen Welt und der Muslime mit eschatologischen Elementen verknüpft. In der Konsequenz müsse diese Dekadenz zum Zerfall der Welt und zum Anbruch der Endzeit führen, als deren kämpfende Avantgarde und notwendige Vorbedingung sich die dschihadistischen Akteure stilisieren. Videos mit identifizierbaren erzählerischen Elementen gehören dabei zu zentralen Mitteln der dschihadistischen Kommunikation. Anhand eines Fallbeispiels untersucht der Artikel die geschichts- und gewalttheologisch geprägten Strukturen der IS-Videopropaganda. Zugleich wird auf im muslimischen Spektrum generierte Alternativen zu dieser exklusivistischen Geschichtstheologie verwiesen, die nicht von einem sich in der Geschichte enthüllenden ‘Heilsplan’ Gottes ausgehen, sondern auf der Prämisse der Unabgeschlossenheit und der offenen Bewegung menschlichen Denkens beruhen und damit eine Epistemologie anbieten, die nicht Spielarten des Identitären befördert.
Im Folgenden soll ein kurzer Überblick gegeben werden über die schiitische Sicht der frühislamischen Geschichte sowie über einige Phänomene, die sich daraus ergeben haben. Sie sind Hindernisse einer islamischen Einheit und müssten, sollte ein ernsthafter Versuch einer solchen verfolgt werden, mit deutlich mehr Mut angegangen werden. Dabei geht es hier weniger darum, alle Unterschiede zwischen Schia und Sunna aufzuzeigen, als sich auf die wirklich problematischen Felder zu konzentrieren, die nicht Folgen späterer, oft zufälliger Entwicklungen sind, sondern Weichenstellungen, die in der Frühgeschichte zu verorten sind. Bisher werden diese neuralgischen Punkte bei den Versuchen einer islamischen Ökumene, um diesen sehr christlich belegten Begriff an dieser Stelle doch einmal zu verwenden, meist umgangen, weil man um ihre Brisanz und Sprengkraft weiß. Doch müsste die Auseinandersetzung mit den unterschiedlichen Geschichtsbildern erfolgen, da sie ein wichtiges innerislamisches Differenzkriterium bilden; zumindest sollte man sich klar darüber sein, dass es unterschiedliche Geschichtsbilder gibt und sie ein Differenzkriterium bilden.
Background: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied across human tissues and in genetically diverse populations. This has identified disease-relevant splicing events, as well as associations between splicing and genomic features, including sequence composition and conservation. However, variability in splicing between single cells from the same tissue or cell type and its determinants remains poorly understood.
Results: We applied parallel DNA methylation and transcriptome sequencing to differentiating human induced pluripotent stem cells to characterize splicing variation (exon skipping) and its determinants. Our results show that variation in single-cell splicing can be accurately predicted based on local sequence composition and genomic features. We observe moderate but consistent contributions from local DNA methylation profiles to splicing variation across cells. A combined model that is built based on genomic features as well as DNA methylation information accurately predicts different splicing modes of individual cassette exons. These categories include the conventional inclusion and exclusion patterns, but also more subtle modes of cell-to-cell variation in splicing. Finally, we identified and characterized associations between DNA methylation and splicing changes during cell differentiation.
Conclusions: Our study yields new insights into alternative splicing at the single-cell level and reveals a previously underappreciated link between DNA methylation variation and splicing.
Background: Alternative splicing is a key mechanism in eukaryotic cells to increase the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied both across human tissues and in genetically diverse individuals. This has identified disease-relevant splicing events, as well as associations between splicing and genomic variations, including sequence composition and conservation. However, variability in splicing between single cells from the same tissue and its determinants remain poorly understood.
Results: We applied parallel DNA methylation and transcriptome sequencing to differentiating human induced pluripotent stem cells to characterize splicing variation (exon skipping) and its determinants. Our results shows that splicing rates in single cells can be accurately predicted based on sequence composition and other genomic features. We also identified a moderate but significant contribution from DNA methylation to splicing variation across cells. By combining sequence information and DNA methylation, we derived an accurate model (AUC=0.85) for predicting different splicing modes of individual cassette exons. These explain conventional inclusion and exclusion patterns, but also more subtle modes of cell-to-cell variation in splicing. Finally, we identified and characterized associations between DNA methylation and splicing changes during cell differentiation.
Conclusions: Our study yields new insights into alternative splicing at the single-cell level and reveals a previously underappreciated component of DNA methylation variation on splicing.
Background: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied across human tissues and in genetically diverse populations. This has identified disease-relevant splicing events, as well as associations between splicing and genomic variations, including sequence composition and conservation. However, variability in splicing between single cells from the same tissue or cell type and its determinants remain poorly understood.
Results: We applied parallel DNA methylation and transcriptome sequencing to differentiating human induced pluripotent stem cells to characterize splicing variation (exon skipping) and its determinants. Our results shows that variation in single-cell splicing can be accurately predicted based on local sequence composition and genomic features. We observe moderate but consistent contributions from local DNA methylation profiles to splicing variation across cells. A combined model that is built based on sequence as well as DNA methylation information accurately predicts different splicing modes of individual cassette exons (AUC=0.85). These categories include the conventional inclusion and exclusion patterns, but also more subtle modes of cell-to-cell variation in splicing. Finally, we identified and characterized associations between DNA methylation and splicing changes during cell differentiation.
Conclusions: Our study yields new insights into alternative splicing at the single-cell level and reveals a previously underappreciated link between DNA methylation variation and splicing.