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Two new species of the genus Pahamunaya Schmid (Trichoptera: Polycentropodidae), P. talon sp. n. and P. spinifera sp. n., from Vietnam are described and illustrated. Examination of the holotype male of P. khoii Oláh and Johanson, in combination with an additional specimen of the same species, revealed new characters. New illustrations for this species are provided.
Two species of the genus Sisyra Burmeister (Neuroptera: Sisyridae), S. cameroonensis, n. sp., and S. gruwelli, n. sp., are described from the African Republic of Cameroon. Sisyra pallida Meinander is synonymized with Sisyra delicata Smithers, new synonymy, after comparison of the types of the former with topotypic paratypes of the latter. Type material of Sisyra nilotica Tjeder appears to be lost. Examples of Sisyra are recorded from Nigeria, Ethiopia and Uganda. A second species of the endemic African genus, Sisyborina, Monserrat, S. scitula, n. sp., is described from Cameroon, Guinea, and Zambia.
Significant new host and distribution records are presented for Hylesinus mexicanus (Wood) (Coleoptera: Curculionidae: Scolytinae), including its pest potential on cultivated olives. Hylesinus mexicanus is similar to H. fasciatus LeConte and information presented here suggests that the distinctiveness of these two species needs to be re-examined.
The chilopod, Cryptops hortensis (Donovan, 1810) (Scolopendromorpha: Cryptopidae), and the diplopods, Pseudospirobolellus avernus (Butler, 1876) (Spirobolida: Pseudospirobolellidae) and Oxidus gracilis (C. L. Koch, 1847) (Polydesmida: Paradoxosomatidae), are newly recorded from Saba Island, Lesser Antilles, which also harbors one additional scolopendromorph and four more chilognath millipeds. Except for the plausibly native scolopendrid centipede, Scolopendra alternans Leach, 1813, all are human introductions. Concentrated sampling is needed in the cloud/elfin forest atop Mt. Scenery, where indigenous millipeds may reside, and with extraction techniques throughout the island, to potentially document the diplopod subclass Penicillata. Nine small Caribbean islands in addition to Saba have been incorrectly reported as lacking diplopod records because publications citing them were overlooked by past authors. Works documenting myriapods from small Caribbean islands are consolidated.
Extreme economic effects globally of various populations of the whitefly Bemisia tabaci (Gennadius)
(Hemiptera: Aleyrodidae) led to an in depth study of the morphology of that species as well as that of
numerous other species of whiteflies in the genus Bemisia Quaintance and Baker and other similar appearing
species. The data collected are presented here as illustrations of the puparia (fourth instar nymphal stages)
and discussions of morphology as it relates to species and generic separations within this closely knit group
of insects. A brief history of the pest outbreaks of B. tabaci is given and an overview of the important
morphological characteristics of aleyrodine whiteflies is provided. Each of the eighty illustrations is
accompanied by a discussion of the more important aspects of morphology.
A new genus and species of armored scale insect (Hemiptera: Diaspididae), Protomorgania koebelei.
Dooley and Evans, is described and illustrated from specimens collected by Albert Koebele on Pittosporum sp.
(Pittosporaceae) in Australia around the year 1900. A key to the genera of armored scale insects similar to Protomorgania
and known to occur in Australia is provided.
The taxonomic position of Onthophagus (Palaeonthophagus) lemuroides d’Orbigny, 1898 and Onthophagus
(Palaeonthophagus) fortigibber Reitter, 1909 is discussed (Coleoptera: Scarabaeidae: Scarabaeinae: Onthophagini).
A key to the species is given. Photos of type specimens of the two taxa and significant chromatic varieties, and
drawings of aedeagi are presented.
Essentially any behavior in simple and complex animals depends on neuronal network function. Currently, the best-defined system to study neuronal circuits is the nematode Caenorhabditis elegans, as the connectivity of its 302 neurons is exactly known. Individual neurons can be activated by photostimulation of Channelrhodopsin-2 (ChR2) using blue light, allowing to directly probe the importance of a particular neuron for the respective behavioral output of the network under study. In analogy, other excitable cells can be inhibited by expressing Halorhodopsin from Natronomonas pharaonis (NpHR) and subsequent illumination with yellow light. However, inhibiting C. elegans neurons using NpHR is difficult. Recently, proton pumps from various sources were established as valuable alternative hyperpolarizers. Here we show that archaerhodopsin-3 (Arch) from Halorubrum sodomense and a proton pump from the fungus Leptosphaeria maculans (Mac) can be utilized to effectively inhibit excitable cells in C. elegans. Arch is the most powerful hyperpolarizer when illuminated with yellow or green light while the action spectrum of Mac is more blue-shifted, as analyzed by light-evoked behaviors and electrophysiology. This allows these tools to be combined in various ways with ChR2 to analyze different subsets of neurons within a circuit. We exemplify this by means of the polymodal aversive sensory ASH neurons, and the downstream command interneurons to which ASH neurons signal to trigger a reversal followed by a directional turn. Photostimulating ASH and subsequently inhibiting command interneurons using two-color illumination of different body segments, allows investigating temporal aspects of signaling downstream of ASH.
Background: Valvular aortic stenosis is a common disease in the elderly, often in multimorbid patients. It is often associated with coronary artery disease and peripheral artery disease. In this situation, the risk of conventional open-heart surgery is too high, and other treatment strategies have to be evaluated.
Case report: A 79-year-old female patient with severe aortic stenosis, coronary artery disease and end-stage chronic obstructive pulmonary disease suffering from dyspnea at rest and permanently dependent on oxygen was treated in three steps. Firstly, her pulmonary infection was treated with antibiotics for 7 days. Then, the left anterior descending artery was stented (bare-metal stent). In the same session, valvuloplasty of the aortic valve was performed. She was sent to rehabilitation to improve her pulmonary condition and took clopidogrel for 4 weeks. Finally, she underwent transapical aortic valve replacement. She was released to rehabilitation on postoperative day 12.
Conclusion: A combination of modern interventional and minimally invasive surgical techniques to treat aortic stenosis and coronary heart disease can be a viable option for multimorbid patients with extremely high risk in conventional open-heart surgery.
Objective: Sensorineural hearing loss leads to the progressive degeneration of spiral ganglion cells (SGC). Next to postoperative fibrous tissue growth, which should be suppressed to assure a close nerve–electrode interaction, the density of healthy SGC is one factor that influences the efficiency of cochlear implants (CI), the choice of treatment for affected patients. Rolipram, a phosphodiesterase-4 inhibitor, has proven neuroprotective and anti-inflammatory effects and might also reduce SGC degeneration and fibrosis, but it has to pass the cellular membrane to be biologically active.
Methods: Lipidic nanocapsules (LNC) can be used as biodegradable drug carriers to increase the efficacy of conventional application methods. We examined the biological effects of rolipram and LNC's core encapsulated rolipram on SGC and dendritic cell (DC) tumor necrosis factor-α (TNF-α) production in vitro and on SGC survival in systemically-deafened guinea pigs in vivo.
Results: Our results prove that rolipram does not have a beneficial effect on cultured SGC. Incorporation of rolipram in LNC increased the survival of SGC significantly. In the DC study, rolipram significantly inhibited TNF-α in a dose-dependent manner. The rolipram-loaded LNC provided a significant cytokine inhibition as well. In vivo data do not confirm the in vitro results.
Conclusion: By transporting rolipram into the SGC cytoplasm, LNC enabled the neuroprotective effect of rolipram in vitro, but not in vivo. This might be due to dilution of test substances by perilymph or an inadequate release of rolipram based on differing in vivo and in vitro conditions. Nevertheless, based on in vitro results, proving a significantly increased neuronal survival when using LNC-rolipram compared to pure rolipram and pure LNC application, we believe that the combination of rolipram and LNC can potentially reduce neuronal degeneration and fibrosis after CI implantation. We conclude that rolipram is a promising drug that can be used in inner ear therapy and that LNC have potential as an inner ear drug-delivery system. Further experiments with modified conditions might reveal in vivo biological effects.
Bei der Information und Sensibilisierung von Eigenheimbesitzer/innen für das Thema
Energie und CO2-Einsparung im Gebäudesektor stehen bislang vor allem breitenwirksame
Instrumente zur Verfügung. Dialogische Kommunikationsangebote, die in anderen
Bereichen des Nachhaltigkeitsmarketing eingesetzt werden, sind bislang nur wenig
verbreitet.
In dem vorliegenden Arbeitspapier werden die Bausteine einer integrierten Kommunikationsstrategie
für eine energetische Gebäudesanierung beleuchtet. Nach dem Verständnis
der Autor/innen umfasst eine solche Strategie monologisches und dialogisches
Marketing, Energieberatung sowie Markenbildung. Gestützt auf konzeptionelle
Überlegungen und empirische Ergebnisse werden im ersten Teil grundlegende Ziele
und Elemente einer dialogischen Kommunikationsstrategie für eine energetische Sanierung
erläutert. Im zweiten Teil illustrieren konkrete Beispiele, wie unter anderem
eine dialogische Kommunikation für unterschiedliche Sanierungsanlässe in der Praxis
gestaltet werden kann.
Im Projekt OPTUM wurde untersucht, welche Umweltentlastungen durch Elektrofahrzeuge in Zukunft erzielt werden könnten. Hierzu wurde ein integrativer Ansatz verfolgt, der neben der fahrzeugseitigen Betrachtung auch die Interaktionen mit dem Strommarkt berücksichtigt. Im Einzelnen fanden Analysen zu den folgenden zentralen Aspekten statt: Akzeptanz und Attraktivität von Elektrofahrzeugen, Marktpotenziale für Elektrofahrzeuge, Interaktion von Elektrofahrzeugen mit dem Stromsektor, CO2-Minderungspotenziale von Elektromobilität, Ökonomische Betrachtung der Speichermedien und Ressourceneffizienz des Systems Elektromobilität. In diesem Studientext werden die Forschungsergebnisse zur Frage nach der Attraktivität und Akzeptanz von Elektroautos vorgestellt. Dabei wird auf Ergebnisse aus zwei empirischen Untersuchungen eingegangen, die in OPTUM zur Ermittlung der Attraktivität und Akzeptanz von Elektrofahrzeugen durchgeführt wurden. Bei diesen Untersuchungen handelt es sich zum einen um eine qualitative Untersuchung mittels Fokusgruppen und zum anderen um eine standardisierte Erhebung, bei der NeuwagenkäuferInnen befragt wurden. Mit der standardisierten Befragung wurde eine Conjoint-Analyse zur Fahrzeugwahl gekoppelt, bei der sich die Befragten zwischen Fahrzeugen mit Verbrennungsmotor, Plug-in-Hybrid-Antrieb und voll-elektrischem Antrieb entscheiden mussten. Die empirischen Analysen verdeutlichen, dass es ein erhebliches Akzeptanzpotenzial für die beiden Elektrofahrzeugkonzepte – Plug-in-Hybride und vollelektrische Fahrzeuge – gibt. Speziell für voll-elektrische Fahrzeuge existiert je nach Szenario und Fahrzeugklasse ein Akzeptanzpotenzial von 12 bis 25 Prozent. Des Weiteren liefern beide empirischen Erhebungen Hinweise, wie dieses Akzeptanzpotenzial ausgeschöpft oder gar vergrößert werden kann.
Wir leben in einer Welt voller Bilder. Unser Denken funktioniert in Bildern, die menschliche Kommunikation bedient sich verschiedener Sprachbilder und das mediale Zeitalter überrollt uns mit einer wahren Flut aus bewegten und unbewegten Bildern. Die Moderne greift dabei nicht nur auf den reichen Bilderschatz vergangener Jahrhunderte zurück, sondern es werden auch traditionelle Motive variiert, verändert und verworfen. Das ursprüngliche Bild wird ergänzt durch Gegenbilder und Alternativkonzepte. Letztlich ringen sie alle, Bilder und ihre Gegenbilder, um die Deutungshoheit. Die Veranstalter Corina Erk, M.A., und Christoph Naumann, M.A., eröffneten als Promovierendenvertreter der Bamberger Graduiertenschule für Literatur, Kultur und Medien den Workshop „Gegenbilder – literarisch/filmisch/fotografisch“ und stellten das anspruchsvolle Tagungsprogramm vor, das sich in fünf Sektionen gliederte. Jedes Panel näherte sich aus einer anderen Perspektive dem Themenbündel „Gegenbild“ an.
A preliminary checklist of the Cerambycidae, Disteniidae, and Vesperidae (Coleoptera) of Peru is presented. Within Cerambycidae, we record five subfamilies, 55 tribes, 345 genera and subgenera, and 714 species. Within Disteniidae, we record one tribe, six genera, and 11 species. We also record one subfamily, one tribe, one genus, and two species within Vesperidae. Four new country records are recorded: one species in the tribe Anacolini (Cerambycidae: Prioninae): Cycloprionus flavus Tippmann, 1953; and three species in the tribe Onciderini (Cerambycidae: Lamiinae): Cacostola simplex (Pascoe, 1859); Marensis simplex (Bates, 1865); Trachysomus cavigibba Martins, 1975. In addition, 161 species recorded are known only from Peru.
The Caribbean Islands (or the West Indies) are recognized as one of the leading global biodiversity hot
spots. This is based on data on species, genus, and family diversity for vascular plants and non-marine vertebrates. This
paper presents data on genus level endemicity for the most speciose (but less well publicised) group of terrestrial
animals: the beetles, with 205 genera (in 25 families) now recognized as being endemic (restricted) to the West Indies.
The predominant families with endemic genera are Cerambycidae (41), Chrysomelidae (28), Curculionidae (26), and
Staphylinidae (25). This high level of beetle generic endemicity can be extrapolated to suggest that a total of about
700 genera of all insects could be endemic to the West Indies. This far surpasses the total of 269 endemic genera of all
plants and non-marine vertebrates, and reinforces the biodiversity richness of the insect fauna of the West Indies.
The mirine plant bug Tropidosteptes forestierae, new species (Hemiptera: Miridae) is described from
Collier County, Florida, where it was found causing serious injury to an extensive ornamental hedge of Florida swampprivet, Forestiera segregata (Jacq.) Krug and Urb. (Oleaceae). Adult male and female, fifth instar, and egg are described. Color images of the adults, nymph, egg, and injury; scanning photomicrographs of selected adult structures; and illustrations of male genitalia are provided. A key to help distinguish the 16 species of Tropidosteptes known to occur in the southeastern United States is given.
We provide the first records of six species of biting midges (Diptera: Ceratopogonidae) in the genus
Culicoides Latreille from Mexico: C. baueri Hoffman, C. castillae Fox, C. debilipalpis Lutz, C. iriartei Fox, C. leoni
Barbosa and C. pusilloides Wirth and Blanton. In addition, C. leopoldoi Ortiz is confirmed from Mexico, and new
records are included for 25 other species previously recorded in Mexico: C. arubae Fox and Hoffman, C. blantoni Vargas
and Wirth, C. crepuscularis Malloch, C. daedalus Macfie, C. diabolicus Hoffman, C. foxi Ortiz, C. furens (Poey), C.
gabaldoni Ortiz, C. haematopotus Malloch, C. hylas Macfie, C. insignis Lutz, C. jamaicensis Edwards, C. luteovenus
Root and Hoffman, C. neopulicaris Wirth, C. nigrigenus Wirth and Blanton, C. pampoikilus Macfie, C. panamensis
Barbosa, C. paraensis (Goeldi), C. phlebotomus (Williston), C. poikilonotus Macfie, C. pusillus Lutz, C. stigmalis Wirth,
and all three species in the C. (Monoculicoides) variipennis complex, C. variipennis (Coquillett), C. occidentalis Wirth
and Jones, and C. sonorensis Wirth and Jones.
Evidence is presented that the subspecies Chrysobothris thoracica guadeloupensis Descarpentries, 1981
(Coleoptera: Buprestidae) should be recognized at the species level. Character evidence is provided to separate C.
guadeloupensis, new status, from C. thoracica Fabricius, 1798. Both species are illustrated with habitus photographs
and images of the male genitalia.
Chalcosicya maya, new species, (Coleoptera: Chrysomelidae: Eumolpinae) is described and the species
key of Blake (1951) is modified to accommodate it. This is the first known mainland species of this previously
Antillean genus. Sclerotized rods in the apical segment of the ovipositor of Chalcosicya Blake and related genera
are shown to be useful systematic characters within the eumolpine tribe Adoxini. Relationships with other genera
suggest that Chalcosicya belongs to a clade derived from ancestors with a western Tethyian distribution.
Das Ecological Research Network (Ecornet) ist online ++ Memorandum zur sozial-ökologischen Forschung: jetzt unterzeichnen ++ BMBF-Delegation besucht CuveWaters-Pilotprojekte ++ Abkommen zu Forschungszentrum in Namibia unterzeichnet ++ Neue Kooperationsmodelle zwischen Afrika und Europa ++ Artikel zu Transdisziplinarität in Ecological Economics erschienen ++ Beim Hauskauf schon ans Sanieren denken – Projekt EiMap beginnt ++ Neue Kommunikationsangebote für eine energetische Sanierung ++ Fahrradförderseminare im Projekt mobile2020 gestartet ++ Mobilitätsstile der Zukunft auf der Frankfurt Global Business Week ++ Survey zu Migration und Umweltveränderungen im Projekt micle ++ ISOE-Expertin bei der Forschungsbörse ++ Safe the date: ISOE-Tagung zum Wissenschaftsjahr im November ++ Termine ++ Publikationen
The long sought molecular function of membrane raft-associated flotillin proteins is slowly becoming resolved, partially owing to the increasing knowledge about their interaction partners. Being ubiquitously expressed and evolutionarily highly conserved, flotillins carry out important cellular functions, one of which is the regulation of signal transduction pathways. This study shows that the signaling adaptor protein fibroblast growth factor receptor substrate 2 (FRS2) directly interacts both in vivo and in vitro with flotillin-1 (flot-1). FRS2 is an important docking protein of many receptor tyrosine kinases. It regulates downstream signaling by forming molecular complexes with other adaptor proteins and tyrosine phosphatases, and seems to be a critical mediator of sustained extracellular signal regulated kinase (ERK) activity. Flot-1 has also been implicated in the regulation of ERK activity upon EGF and FGF stimuli. Furthermore, flot-1 forms signalosomes with EGFR and the downstream components of the MAP kinase pathway. The newly discovered interaction between FRS2 and flot-1 was shown to be mediated by the phosphotyrosine binding (PTB) domain and, to a lesser extent, the C-terminus (CT) of FRS2 and by the C-terminus of flot-1. Flot-1 coprecipitated together with FRS2 from murine tissues and cell lysates, demonstrating that this interaction also takes place in vivo. Interestingly, flot-2, which shows a high homology to flot-1 and forms stable oligomeric complexes with it, does not appear to directly interact with FRS2. Novel insights into the functional role of the interaction between flot-1 and FRS2 were provided by the results showing that depletion of flot-1 affects the cellular localization of FRS2. In hepatocytes stably depleted of flot-1, FRS2 appeared to be more soluble. Furthermore, upon pervanadate stimulation of the cells, a small fraction of FRS2 was recruited into detergent resistant membranes, but the recruitment did not take place in the absence of flot-1. Triggered by the same stimulus, a fraction of FRS2 was translocated to the nucleus independently of flot-1. Overexpression of FRS2 has previously been shown to result in increased ERK activation. However, in cells depleted of flot-1, FRS2 was not able to compensate for the compromised ERK activation after EGF or FGF stimulation. This might imply that FRS2 and flot-1 are functionally interconnected and that FRS2 resides upstream of flot-1. Taken together, the results presented here indicate that this complex may be involved in the control of signaling downstream of receptor tyrosine kinases and is important for ensuring a proper signaling response. In the absence of flot-1, increased Tyr phosphorylation of FRS2 was observed. It is known that Tyr and Thr phosphorylation of FRS2 are reciprocally regulated. Since ERK is a known executor of the FRS2 Thr phosphorylation, and ERK activity was shown to be severely diminished upon flot-1 depletion, the increased Tyr phosphorylation of FRS2 was in agreement with this and might be a direct consequence of a decreased ERK activity upon flot-1 depletion. FRS2 owes its name to the major and the first described function of this protein as a substrate for FGFR. PTB domain of FRS2 was published to constitutively bind the juxtamembrane domain of FGFR. In this study, the PTB domain was mapped to be involved in the constitutive interaction with flot-1 and the competition was shown to exist between flot-1 and FGFR1 for binding to FRS2. Another novel interaction partner of FRS2 was discovered in the present study. Cbl-associated protein (CAP) is an adaptor protein with three SH3 domains and it plays a role during insulin signaling by recruiting the signaling complex to lipid rafts. CAP was previously shown to interact with flot-1 via the SoHo domain, and this interaction was found to be crucial for the lipid raft recruitment of other signaling components. Both the PTB domain and CT of FRS2 were found to mediate the interaction with CAP, whereas in CAP, the SoHo domain, together with the third SH3 domain, seems to bind to FRS2. SH3 domains mediate the assembly of specific protein complexes by binding to proline rich sequences, several of which are present in FRS2. Due to overlapping interaction domains, FRS2 and flot-1 competed for the binding to CAP. However, the interaction with neither CAP nor flot-1 was necessary for the observed nuclear translocation of FRS2. Since CAP is expressed as several tissue- and developmental stage-specific isoforms, a further aim of this study was to analyze the expression of its isoforms in mouse embryonic fibroblasts (MEFs). Many new isoforms were discovered here which have not been described in the literature so far. They all contain the SoHo domain and three SH3 domains, but differ among themselves by the presence and length of a proline-rich region that preceeds the SoHo domain and by a novel 20-amino acid (AA) stretch between the second and the third SH3 domain. The length of the proline-rich region turned out to be an important factor determining the strength of the interaction with FRS2. The interaction was found to be weakened by the increasing length of this region. The new isoforms possessing the 20-AA stretch are specifically expressed in murine muscular tissues, with the highest level in the heart. During adipogenesis, we observed a shift in the abundance of the isoforms, in that only the isoforms without the insertion were shown to be upregulated on mRNA level. However, during myogenesis, preferentially expressed isoforms were those with the insertion. The collected data implicate that isoforms with the 20-AA insertion might be more ubiquitous in nondifferentiated/embryonic cells and that the observed "isoform-switch" might be dependent on the cell fate and differentiation state.
In der modernen Festkörperphysik spielen elektronisch stark korrelierte Systeme mit ihrem komplexen Vielteilchenverhalten eine zentrale Rolle. Insbesondere das Wechselspiel zwischen thermischen und Quantenfluktuationen in den Ladungs- und Spinfreiheitsgraden führt zur Entstehung verschiedenster neuartiger Grundzustände.
Die vorliegende Dissertation „Ultrasonic and Magnetic Investigations in frustrated Lowdimensional Spin Systems“ beschäftigt sich mit den besonderen physikalischen Eigenschaften niedrig dimensionaler Spinsysteme. Diese Materialklasse, die auch zu den stark korrelierten Systemen zählt, wird seit vielen Jahren intensiv sowohl experimentell als auch theoretisch untersucht. Auf theoretischer Seite sind die niedrigdimensionalen Spinsysteme besonders interessant, da sie als Modellsysteme die exakte Beschreibung des Grundzustandes und des Anregungsspektrums ermöglichen. Von experimenteller Seite ist es in den letzten Jahrzehnten gelungen, verschiedenste Materialklassen niedrigdimensionaler Spinsysteme zu synthetisieren.
In der vorliegenden Arbeit werden die grundlegenden Theorien und physikalischen Konzepte niedrigdimensionaler Spinsysteme diskutiert. Insbesondere auch die Spin-Phonon-Wechselwirkung dieser Materialien, die für die hier beobachteten elastischen Anomalien verantwortlich ist. Weiterhin wird auch das elastische Verhalten bei magnetischen Phasenübergängen beschrieben.
Da die Ultraschallexperimente einen Schwerpunkt dieser Arbeit bilden, wird der Versuchsaufbau zur phasenempfindlichen Detektion von Schallgeschwindigkeit und Ultraschalldämfung ausführlich beschrieben. Diese Messmethode ist ideal zur Untersuchung der Spin-Phonon Wechselwirkung geeignet.
Conceptual design of an ALICE Tier-2 centre integrated into a multi-purpose computing facility
(2012)
This thesis discusses the issues and challenges associated with the design and operation of a data analysis facility for a high-energy physics experiment at a multi-purpose computing centre. At the spotlight is a Tier-2 centre of the distributed computing model of the ALICE experiment at the Large Hadron Collider at CERN in Geneva, Switzerland. The design steps, examined in the thesis, include analysis and optimization of the I/O access patterns of the user workload, integration of the storage resources, and development of the techniques for effective system administration and operation of the facility in a shared computing environment. A number of I/O access performance issues on multiple levels of the I/O subsystem, introduced by utilization of hard disks for data storage, have been addressed by the means of exhaustive benchmarking and thorough analysis of the I/O of the user applications in the ALICE software framework. Defining the set of requirements to the storage system, describing the potential performance bottlenecks and single points of failure and examining possible ways to avoid them allows one to develop guidelines for selecting the way how to integrate the storage resources. The solution, how to preserve a specific software stack for the experiment in a shared environment, is presented along with its effects on the user workload performance. The proposal for a flexible model to deploy and operate the ALICE Tier-2 infrastructure and applications in a virtual environment through adoption of the cloud computing technology and the 'Infrastructure as Code' concept completes the thesis. Scientific software applications can be efficiently computed in a virtual environment, and there is an urgent need to adapt the infrastructure for effective usage of cloud resources.
La Reserva de la Biosfera de Chamela-Cuixmala se localiza en la costa del Pacífico del estado mexicano de Jalisco. La Reserva fue fundada en 1993 y se extiende por 13142 hectáreas. Es una de las pocas reservas en México creada para la protección de la selva tropical caducifolia (seca) y sistemas asociados. Cinco especies de ciempiés han sido registradas previamente para la Reserva: Cormocephalus impressus Porat, 1876; Dendrothereua linceci (Wood, 1867); Ectonocryptoides quadrimeropus Shelley y Mercurio, 2005; Scolopendra polymorpha (Wood, 1861) y Scolopendra viridis Say, 1821. A partir de julio de 2010 se inició con el primer estudio formal de la fauna de ciempiés en la Reserva. Después de un año de muestreos, ocho morfoespecies de ciempiés se han determinado para la Reserva: Cryptops (Haplocryptops) cf. acapulcensis Verhoeff, 1934; Cryptops sp.; Rhysida immarginata (Porat, 1876); Scolopendra morsitans Linnaeus, 1758; Polycricus sp.; Sogona sp.; Orphnaeus sp.; y Straberax sp. Esta es la primera vez que Cryptops (Haplocryptops) cf. acapulcensis es encontrada en otra localidad distinta de su localidad tipo. Estudios previos han determinado el papel de los ciempiés como parte de la dieta de mamíferos y componente de la fauna del suelo.
The milliped genus Euryurus Koch, 1847, and the species, E. leachii (Gray, 1832) (Polydesmida: Euryuridae), are recorded from three sites on the northern part of Crowley’s Ridge (Cross, Lee, and Poinsett counties), Arkansas, where the only prior familial records are of Auturus evides (Bollman, 1887). Coupled with the published locality of E. leachii in Phillips Co., at the southern extremity of the Ridge, the only known occurrences of both the genus and species in Arkansas and west of the Mississippi River are in this physiographic feature. The Arkansas population is geographically peripheral but anatomically intermediate between the two recognized subspecies, E. l. leachii and E. l. fraternus Hoffman, 1978, and we do not assign it to a race. Molecular investigations seem necessary to resolve relationships in the “E. leachii complex.”
Among the four oriental genera of the tribe Helluonini, Omphra Dejean (Coleoptera: Carabidae), is unique for its endemism to the Indian subcontinent and aptery. High intraspecies variability in morphological characters and limited diagnostic information makes species differentiation of the genus Omphra a complicated task. The present study provides a description of a new species, Omphra drumonti n. sp. from the Western Ghats, redescriptions and a key to the species of Omphra, details of intraspecies variation, discussion of relationships between taxa and distributional patterns of the genus. Based on the distributional patterns in the Indian subcontinent and flightlessness of the genus, inability to cross the physical barrier of the Ganges–Brahmaputra delta between north and peninsular India is indicated as the reason for its absence in the northeastern Indian subcontinent and endemism to the lower Indian subcontinent.
Innerhalb der vorliegenden Arbeit wurden verschiedene Teilaspekte des S1P-Signalsystems näher untersucht. Der erste Teil der Arbeit geht der Frage nach, welche Störungen das Ausschalten der S1P-Lyase in der Ca2+-Homöostase verursacht. Die Messung der zellulären Lipidkonzentrationen ergab in Sgpl1-/--MEFs einen sechsfach höherer Wert für S1P und einen doppelt so hohen Wert für Sphingosin als in den Sgpl1+/+-MEFs. [Ca2+]i wurde an Einzelzellen mit Hilfe des Proteinfarbstoffs Cameleon untersucht, wobei [Ca2+]i-Anstiege durch den SERCA-Inhibitor Thapsigargin induziert wurden. So konnte gezeigt werden, dass sowohl in Sgpl1+/+-MEFs als auch in Sgpl1-/--MEFs zwei verschiedene Subtypen existieren, die sich hinsichtlich Geschwindigkeit und Ausmaß des [Ca2+]i-Anstiegs unterscheiden. Die basale [Ca2+]i war im Subtyp der Sgpl1-/--MEFs mit einem schnellen und kurzen [Ca2+]i-Anstieg signifikant erhöht, während das Maximum des Thapsigargin-induzierten [Ca2+]i-Anstiegs im Subtyp der Sgpl1-/--MEFs mit einem langsamen und langen [Ca2+]i-Anstieg signifikant erhöht war. Die AUC des Zeitverlaufs nach der Stimulation mit Thapsigargin war in beiden Subtypen der Sgpl1-/--MEFs signifikant erhöht, was bedeutet, dass der Ca2+-Gehalt der Thapsigargin-sensitiven Speicher in Sgpl1-/--MEFs höher als in Wildtyp-MEFs war.
Im zweiten Teil der Arbeit wurden Aspekte der Modulation des S1P-Signalsystems durch das Sphingosin-Analogon cis-4-Methylsphingosin näher untersucht. Die Messung der Lipidkonzentrationen von cis-4-Methylsphingosin und dem Phosphorylierungsprodukt cis-4-Methyl-S1P erfolgte dabei in HEK-293-Zellen und deren Überständen mittels LC-MS/MS. Hierbei wurde erstmals cis-4-Methyl-S1P im Zellkulturüberstand nachgewiesen, was bedeutet, dass cis-4-Methylsphingosin nach der intrazellulären Phosphorylierung sezerniert werden kann. Dieser Mechanismus bildet die Grundlage dafür, dass cis-4-Methylsphingosin nicht nur intrazellulär wirken, sondern ebenso wie FTY720 als S1P-Rezeptor-Modulator fungieren kann. Der dritte und umfangreichste Teil der Arbeit befasst sich mit der Regulation der SK1 durch G-Protein-gekoppelte Rezeptoren. Um die Rolle von Gαq/11-Proteinen bei der Ansteuerung der SK1 durch G-Protein-gekoppelte Rezeptoren weiter zu analysieren, wurde zunächst die Rezeptor-induzierte Translokation der SK1 in MEFs untersucht, die sowohl in Gαq als auch in seinem Homolog Gα11 doppelt defizient waren (Gαq/11 -/--MEFs). Die SK1-Translokation war nur nach Transfektion mit Gαq möglich. Um Hinweise auf die strukturellen Erfordernisse für die SK1-Ansteuerung durch Gαq zu erhalten, wurde der Einfluss verschiedener Gαq-Mutanten auf die Translokationshalbwertszeit der SK1 untersucht. So waren alle untersuchten Mutanten in der Lage, die SK1-Translokation in Gαq/11-/--MEFs zu vermitteln. Die Expression der Gαq-W263D-Mutante führte dabei zu einer signifikant verlangsamten SK1-Translokation. Die durch Gαq-T257E-vermittelte Translokation war erst nach mehreren Minuten feststellbar. Die Abhängigkeit der SK1-Translokation von Gαq wurde auf zellulärer Ebene durch Coexpression einer katalytisch inaktiven Mutante der G-Protein gekoppelter Rezeptorkinase 2 (GRK2) als Gαq-scavenger in HEK3-Zellen nachgewiesen. Dies führte zu einer vollständigen Inhibierung der Carbachol-induzierten SK1-Translokation. Hingegen führte die Überexpression der SK1 in den M3-Rezeptor exprimierenden HEK-293-Zellen zu einer reduzierten Carbachol-induzierten Aktivierung der PLCβ. Dieser Effekt war unabhängig von der katalytischen Aktivität der SK1. Daraus lässt sich schlussfolgern, dass die SK1 mit den Effektoren GRK2 und PLCβ um gemeinsame Bindungsstellen der aktivierten G-Protein Untereinheit Gαq konkurriert. Zusätzlich wurde die direkte Interaktion zwischen Gαq und SK1 auf Proteinebene mittels optischer Thermophorese nachgewiesen. Dazu wurde die humane SK1 als N-terminal getaggtes His6-MBP-Fusionsprotein exprimiert, aufgereinigt und charakterisiert. So konnte gezeigt werden, dass die mit dem Fluoreszenzfarbstoff NT647-markierte hSK1 (hSK1*) mit dem TNF Rezeptor-assoziiertem Faktor 2 (TRAF2), nicht jedoch mit dem N-terminalen Fragment des TRAF family member-associated NF-kappa-B activator (TANK) interagierte. Sowohl inaktives Gαq als auch [AlF4]--aktiviertes Gαq interagierten mit der hSK1* mit einem vergleichbaren kD-Wert. Auch mit NT-647-markiertes Gαq interagierte mit der hSK1 sowohl in der inaktiven als auch in der [AlF4]--aktivierten Form, wohingegen es nicht mit TANK oder TRAF2 interagierte.
Insgesamt zeigen die erhaltenen Daten, dass die SK1 ein direktes Target von Gαq ist und sie an genau dieselben Gαq-Reste bindet, an die auch die klassischen Effektoren PLCβ, p63RhoGEF und GRK2 binden.
Die nicht-konventionelle Hefe P. ciferrii produziert große Mengen der tetra-acetylierten Sphingoidbase Phytosphingosin (TAPS). Sphingoidbasen sind essentielle Komponenten des stratum corneums, der multilamellaren Barriere der menschlichen Haut, und daher in der Kosmetik-Industrie von großem Interesse. Im Rahmen dieser Arbeit sollte die biotechnologische Produktion der Sphingoidbasen Phytosphingosin, Sphinganin und Sphingosin auf molekularbiologischer Ebene in P. ciferrii charakterisiert und optimiert werden. Die Hefe P. ciferrii konnte durch Etablierung einer einfachen und hoch-effizienten Transformations-Methode auf genetischer Ebene leicht zugänglich gemacht werden. Durch Inaktivierung des für NHEJ essentiellen PcLIG4 Gens konnte die Effizienz zielgerichteter genomischer Integrationen von transformierten DNA-Konstrukten von 1 % auf 87 % erhöht werden. Die Etablierung des Cre-loxP Systems erlaubte das mehrfache Verwenden eines Selektions-Markers wodurch sukzessiv mehrere genomische Integrationen in einem Stamm ermöglicht wurden. Durch diese Errungenschaften konnte das Ziel „Optimierung der Sphingoidbasen-Produktion der nicht-konventionellen Hefe P. ciferrii“ im Folgenden erfolgreich verfolgt werden. Der initiale Schritt der Sphingoidbasen-Biosynthese ist die von der Serin-Palmitoyl-Transferase katalysierte Kondensation von L-Serin und Palmitoyl-CoA. Durch die Deletion von Genen, die am L-Serin-Katabolismus von P. ciferrii beteiligt sind (PcSHM1, PcSHM2und PcCHA1), konnte die de novo Sphingoidbasen-Biosynthese optimiert werden und führte in einem lig4? Stamm zu einer etwa dreifachen Erhöhung der TAPS-Produktion. Weitere Ansätze den (vermutlich durch L-Serin feed back regulierten) L-Serin-Biosyntheseweg bzw. die in vivo L-Serin-Verfügbarkeit zu optimieren, führten nicht zu einer gesteigerten TAPS-Produktion. Durch weitere Deletion und Überexpression von Genen des Sphingolipid-Stoffwechsels konnte die TAPS-Produktion jedoch um ein Vielfaches verbessert werden. So konnte ein Stamm konstruiert werden, der die Gene PcLCB1, PcLCB2 und PcSYR2 überexprimiert und Deletionen der Gene PcSHM1, PcSHM2, PcCHA1, PcLCB4 und PcORM12 trägt. Dieser Stamm (CSS.L4.O.L2.L1.S2) wies eine mehr als fünffach erhöhte maximale spezifische TAPS-Produktbildungsrate (q Pmax ) auf und produzierte mit 2 g * L rund siebenmal mehr TAPS als der lig4? Ausgangsstamm, weshalb ein Einsatz dieses Stammes für die industrielle TAPS-Produktion denkbar wäre. Ausgehend von einem für die TAPS- (und somit Sphingoidbasen-) Produktion optimierten Stamm sollten Stämme mit optimierter TriASa- oder TriASo-Produktion für industrielle Zwecke generiert werden. Es stellte sich allerding heraus, dass erhöhte Mengen dieser Sphingoidbasen wahrscheinlich wachstumshemmend für P. ciferrii sind, weshalb eine weitere Produktions-Optimierung nicht ohne Weiteres möglich ist. In einem Laborstamm gelang es jedoch, durch Konstruktion und anschließende Transformation eines optimierten integrativen Plasmids (trägt die Gene, die für die Produktion von Sphingosin bzw. TriASo nötig sind) eine TriASo-Produktion von bis zu 30 mg * g (BTM) zu erzielen, wobei gleichzeitig die Bildung des Nebenprodukts TriASa auf weniger als 4 mg * g (BTM)reduziert wurde. Weiterhin konnte durch Deletion von PcSCS7 in einem TriASo-Produktionsstamm die TriASa-Produktion mehr als vierfach reduziert werden. Die Bildung eines weiteren von P. ciferrii gebildeten Nebenproduktes [Tri-Acetyl-Sphingadienin (TriASd)] konnte durch Deletion des PcSLD1 Gens unterbunden werden. Nach Inaktivierung von PcSCH9 konnte eine fast 20 %ige Verbesserung der TriASo-Produktion erreicht werden. Es konnten zwei putative Acetyl-Transferasen identifiziert werden (PcAft2 und PcSli1), die an der Acetylierung von Phytosphingosin (zu TAPS), Sphinganin (zu TriASa) und Sphingosin (zu TriASo) beteiligt sind. Die Aufklärung und Optimierung dieser von PcAtf2 und PcSli1 katalysierten Schritte sind vielversprechende Ansatzpunkte die Sphingoidbasen-Produktion in P. ciferrii weiter zu optimieren.
A biodiversity inventory of the Lepidoptera of Pico Bonito National Park and vicinity, in the Department of Atlantida of northern Honduras, was initiated in 2009 to obtain baseline data. We present a revised checklist of Honduran butterfly species (updated from the initial 1967 lists), as well as the first comprehensive list of Honduran moths. Our updated list includes 550 species of Papilionoidea, 311 Hesperioidea, and 1,441 moth species.
Self-organized complexity and Coherent Infomax from the viewpoint of Jaynes’s probability theory
(2012)
This paper discusses concepts of self-organized complexity and the theory of Coherent Infomax in the light of Jaynes’s probability theory. Coherent Infomax, shows, in principle, how adaptively self-organized complexity can be preserved and improved by using probabilistic inference that is context-sensitive. It argues that neural systems do this by combining local reliability with flexible, holistic, context-sensitivity. Jaynes argued that the logic of probabilistic inference shows it to be based upon Bayesian and Maximum Entropy methods or special cases of them. He presented his probability theory as the logic of science; here it is considered as the logic of life. It is concluded that the theory of Coherent Infomax specifies a general objective for probabilistic inference, and that contextual interactions in neural systems perform functions required of the scientist within Jaynes’s theory.
The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
Molecules of the title compound, C20H14O2, show approximate C s symmetry with the approximate mirror plane perpendicular to the central ring. The torsion angles about the acyclic bonds are 30.05 (15) and 30.77 (15)° in one half compared to −36.62 (14) and −18.60 (15)° in the other half of the molecule. The central aromatic ring makes dihedral angles of 47.78 (4) and 51.68 (3)° with the two terminal rings.
Objective: Betahistine is a histamine H1-receptor agonist and H3-receptor antagonist that is administered to treat Menière’s disease. Despite widespread use, its pharmacological mode of action has not been entirely elucidated. This study investigated the effect of betahistine on guinea pigs at dosages corresponding to clinically used doses for cochlear microcirculation.
Methods: Thirty healthy Dunkin-Hartley guinea pigs were randomly assigned to five groups to receive betahistine dihydrochloride in a dose of 1,000 mg/kg b. w. (milligram per kilogram body weight), 0.100 mg/kg b. w., 0.010 mg/kg b. w., 0.001 mg/kg b. w. in NaCl 0.9% or NaCl 0.9% alone as placebo. Cochlear blood flow and mean arterial pressure were continuously monitored by intravital fluorescence microscopy and invasive blood pressure measurements 3 minutes before and 15 minutes after administration of betahistine.
Results: When betahistine was administered in a dose of 1.000 mg/kg b. w. cochlear blood flow was increased to a peak value of 1.340 arbitrary units (SD: 0.246; range: 0.933–1.546 arb. units) compared to baseline (p<0.05; Two Way Repeated Measures ANOVA/Bonferroni t-test). The lowest dosage of 0.001 mg/kg b. w. betahistine or NaCl 0.9% had the same effect as placebo. Nonlinear regression revealed that there was a sigmoid correlation between increase in blood flow and dosages.
Conclusions: Betahistine has a dose-dependent effect on the increase of blood flow in cochlear capillaries. The effects of the dosage range of betahistine on cochlear microcirculation corresponded well to clinically used single dosages to treat Menière’s disease. Our data suggest that the improved effects of higher doses of betahistine in the treatment of Menière’s disease might be due to a corresponding increase of cochlear blood flow.
The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target. In donor organs hypoxia and ischemia induce a broad spectrum of pathologic molecular mechanisms favoring primary graft dysfunction (PGD) after transplantation. Increased hypoxia-induced transcriptional activity leads to increased vascular permeability which in turn is the soil of a reperfusion edema and the enhancement of a pro-inflammatory response in the graft after reperfusion. We hypothesize that inhibition of the respiration chain in mitochondria and thus inhibition of the hypoxia induced mechanisms might reduce reperfusion edema and consecutively improve survival in vivo. In this study we demonstrate that the rotenoid Deguelin reduces the expression of hypoxia induced target genes, and especially VEGF-A, dose-dependently in hypoxic human lung derived cells. Furthermore, Deguelin significantly suppresses the mRNA expression of the HIF target genes VEGF-A, the pro-inflammatory CXCR4 and ICAM-1 in ischemic lungs vs. control lungs. After lung transplantation, the VEGF-A induced reperfusion-edema is significantly lower in Deguelin-treated animals than in controls. Deguelin-treated rats exhibit a significantly increased survival-rate after transplantation. Additionally, a downregulation of the pro-inflammatory molecules ICAM-1 and CXCR4 and an increase in the recruitment of immunomodulatory monocytes (CD163+ and CD68+) to the transplanted organ involving the IL4 pathway was observed. Therefore, we conclude that ischemic periods preceding reperfusion are mainly responsible for the increased vascular permeability via upregulation of VEGF. Together with this, the resulting endothelial dysfunction also enhances inflammation and consequently lung dysfunction. Deguelin significantly decreases a VEGF-A induced reperfusion edema, induces the recruitment of immunomodulatory monocytes and thus improves organ function and survival after lung transplantation by interfering with hypoxia induced signaling.
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes. Breast (MDA-MB-231), lung (NCI-H358), and colon (HCT 116) carcinoma cells were transduced with shRNA to downregulate SK-1 expression or treated with a pharmacologic SK-1 inhibitor. The effects of SK-1 targeting were investigated by measuring the level of intracellular sphingosine, the activity of protein kinase C (PKC) and cell cycle regulators, and the mitotic index. Functional assays included measurement of cell proliferation, colony formation, apoptosis, and cell cycle analysis. Downregulation of SK-1 or its pharmacologic inhibition increased intracellular sphingosine and decreased PKC activity as shown by reduced phosphorylation of PKC substrates. In MDA-MB-231 cells this effect was most pronounced and reduced cell proliferation and colony formation, which could be mimicked using exogenous sphingosine or the PKC inhibitor RO 31-8220. SK-1 downregulation in MDA-MB-231 cells increased the number of cells with 4N and 8N DNA content, and similar effects were observed upon treatment with sphingosine or inhibitors of SK-1 or PKC. Examination of cell cycle regulators unveiled decreased cdc2 activity and expression of Chk1, which may compromise spindle checkpoint function and cytokinesis. Indeed, SK-1 kd cells entered mitosis but failed to divide, and in the presence of taxol also failed to sustain mitotic arrest, resulting in further increased endoreduplication and apoptosis. Our findings delineate an intriguing link between SK-1, PKC and components of the cell cycle machinery, which underlines the significance of SK-1 as a target for cancer therapy.
Race has been a term avoided in the Swedish debates, while at the same time, protections with respect to unlawful discrimination on the basis of race or ethnic origins have not been vigilantly upheld by the courts. This paper looks at the treatment of race by the Swedish legislature, as well as the treatment by the courts, specifically the Labour Court, with respect to claims of unlawful discrimination in employment on the basis of ethnic origins, against the background of Critical Race Theory. The disparities between the intent of the legislature and the outcome of the cases brought to the Swedish courts can be in least in part explained through the lens of Critical Race Theory, particularly with respect to the liberal approach taken by the courts when applying the law.
Es wird eine Verbindung zwischen dem von Antiphon entwickelten infinitesimalen Berechnungsverfahren, der Theorie Verteilungsgerechtigkeit von Aristoteles, des Hebelgesetzes, der eben radialen Figuren und der Verteilung hergestellt.
Die Problemstellung stellt sich wie folgt dar: dem Kennenlernen der Gründe, die Antiphon mutmaßen ließ, die Exhaustionsmethode als ein Mittel der Bildung des Quadratur des Kreises anzusehen, Beziehungen von grundsätzlicher und historischer Art zwischen der Verteilungsgerechtigkeit und den Hebelgesetz herzustellen, ein Model der Verteilungsgerechtigkeit, basierend auf der modernen Mathematik der Verteilung, von multipler Partizipierung zu konstruieren.
Die Zielsetzungen sind:
Die These zu erstellen, dass die Exhaustionsmethode aus der Gerichtspraxis stammt; dass das Hebelgesetz und die Theorie der Proportionen von Eudoxos Modelle der Verteilungsgerechtigkeit von Aristoteles sind; weiter soll gezeigt werden, dass die ebene Verteilung der materiellen Partikel auch ein Modell der Verteilungsgerechtigkeit ist.
Das Modell der Mehrteiligkeit der Verteilung, das vorgestellt wurde, enthält zwei Arten von Freiheitsgraden, einen für den Wert der zu verteilenden Güter an jeweils einen der Beteiligten und einen zweiter Freiheitsgrad für die verschieden Ebene zwischen den Beteiligten im Falle der Ungleichheit.
Keywords: Exhaustionsmethode, Hebelgesetz, Verteilungsgerechtigkeit, Verteilung.
In order to understand the impact of new technologies on the law through the science of law, it is essential to observe how Law researches are done. This paper pursues the following models of legal science: analytical (theory of formal rule); hermeneutics (interpretation theory) and empirical (decision theory) to appraise methodological procedures used in monograph researches in some Brazilian Law courses. This study was to detect which model of law science was used in the development of Law researches. The study was conducted, through Juris Doctors’ interviews. All of these respondents have written a monograph, which is a requirement to complete a Law course in Brazil. The main conclusions of this study were the following: 1) most of the monographs produced do not specify the methodology used for developing the work; 2) when the papers indicate the methodology used, the analytical model was prevalent. In these cases, the science of law appears as a systematization of rules for obtaining possible decisions. 3) Hermeneutic and empirical models were also used, but on a smaller scale. These researches revealed the inaccuracy of the methodological tools used to apprehend the reality. However, these strategies are significant to define the objects of study of law in the contemporary time. Answering the question about how Law researches are done in some Brazilian Law schools, this paper discusses the construction of classical models of science of law, which were taken as the theoretical framework of this work before the hypercomplex current problems.
This article considers the Brazilian Legal System and the requirements of an act performed by public administration. To do so, it presents six main chapters. The first one considers Brazilian Constitution as it regards State form, legal and judicial systems. The second chapter presents the public administration stated in the Constitution. The requirements of a public administration act are presented in the third chapter. The improbity law, which determines how public administration acts should be performed, is presented on the fourth chapter. How one of the main judicial courts of Brazil has understood this law is the topic of the fifth chapter. The sixth chapter presents a proposal of how could be Phronesis used to solve misunderstandings about improbity in the Brazilian Legal System.
This paper aims to present the similarities and differences between Posner's defense of Law and Economics (LAE) and Holmes' pragmatism. The investigation is centered in the arguments of economic consequences of judicial decisions. Law and Economics tend to emphasize these arguments as a determinant characterization of legal pragmatism. These arguments involve some dilemmas: Is it possible to eliminate a rule, or reinterpret it according to the effect of its application in practical life? May these economic consequences serve as argument for a replacement of traditional interpretation? To what extent can we rule out the law with arguments of consequence? Despite the influence, LAE has some important differences with respect Holmes' legal pragmatism. Posner's LAE involves the economic principle of wealth maximization and its relations with utilitarianism and economic liberalism. Consequentialism in Holmes, by contrast, is based on a teleological interpretation of existing rules. It is important that the judge does not decide based on a specific economic theory. Also, legal pragmatism does not advocate abandoning the tenets of positivism that form the basis for the rule of law. Holmes defends a judicial restraint. Accordingly, the argument of consequence must have previous limits in precedents and statutes. However, both legal pragmatism and LAE are connected by the idea that the adaptation of the law to a reasonable end can not be absent from the canons of interpretation and adjudication.
This paper traces the development of National Socialist cultural and legal policy towards the arts. It examines the role of censure in this development starting with Hitler's first attempts at power in the Weimar republic. It then looks more closely into aspects of the development of new policies in and after 1933 and their implementation in institutions of the totalitarian state. As the paper shows, policies were carried out within a legal framework that included parliament and constitutional law but they were often also accompanied by aggressive political actions. Racial and nationalistic ideologies were at the heart of the National Socialist discourse about culture. This discourse quickly established modernity as its principal enemy and saw modernist culture (in the broad sense of the word), and especially art criticism, as being under Jewish domination. True German Kultur was set against this; Hitler himself promoted German art both through exhibitions and through policies which included the removal of un-German art and the exclusion of writers and artists who did not conform the cultural ideal. As Jewish artists and intellectuals in modernist culture posed the greatest threat to the establishment of a new German culture, Nazi policies towards the arts embarked on a process of censure, exclusion and annihilation. The purpose of these policies was nothing less than the elimination of all modernist (Jewish and ‘degenerate’) culture and any memory of it.
In his works, Hans Kelsen elaborates several objections to the so-called “doctrine of natural law”, especially in his essay The Natural-Law Doctrine Before the Tribunal of Science. Kelsen argues that natural law theorists, searching for an absolute criterion for justice, try to deduce from nature the rules of human behavior. Robert P. George, in the essay Kelsen and Aquinas on the ‘Natural Law Doctrine’ examines his criticism and concludes that what Kelsen understands as the Natural-law doctrine does not include the natural law theory elaborated by Thomas Aquinas. In this paper, we will try to corroborate George’s theses and try to show how Aquinas’ natural law theory can be vindicated against Kelsens criticisms.
Abstract of the German original article “Rechtssubjekte und Teilrechtssubjekte des elektronischen Geschäftsverkehrs“, to be published in S. Beck (ed.): Jenseits von Mensch und Maschine: Moralische und rechtliche Aspekte des Umgangs mit Robotern, Künstlicher Intelligenz und Cyborgs. Baden-Baden: Nomos, 2012.
Jurisprudence under the perspective of the new media and its effect on the communication of law
(2012)
Despite the law knowledge presumption, Jurisprudence has not always considered the effects introduced by the communication of law in the transition from the print to the electric revolution, using here concepts and ideas of McLuhan´s theory.
The use of Internet by Brazilian Courts (on line transmission of trials, the digital process, transformation of courts in source of news on what concerns their decisions) is an interesting example of how the new medium interferes in the substance of the message of law, since the movement of the messages must be considered to understand the epistemological domain of law. New elements are introduced by the new media and interact with the old meanings, concepts and processes of law and of the old media and can themselves bring new conflicts that are relevant to the comprehension of the complete and real dynamics of Law.
The process of finding evidence of what truthfully happened in a conflictive situation interests jurists and journalists but in different ways. When the work of journalists and judges are concerned the paradox is at stake. Both categories must tell a story about a conflict must listen to all involved, must inform what happened to the general public. Although both categories must use the freedom must use the freedom of speech their point of view about something with objectivity, their timing is different as well as the process and the effect of fulfilling their task. That question that should be made is what happen to law when it becomes the subject matter to the news in the world of full information? In what measurement journalists also pass judgements and how this affects the formal processes of law? The effort to answer these questions and the ones related to them is important to understand some of the problems that must be approached in order to establish the ways of law and of the mass media technological society.
A Privacy Impact Assessment (PIA) is a systematic risk assessment tool, enabling organizations to maintain compliance with data protection regulations, to manage privacy risks and to provide public benefits through the success of privacy-by-design efforts. An actual practical implementation of a PIA framework has been realized in the context of RFID applications encompassing detailed steps for the PIA process; a first successful review has been completed. The PIA also allows to introduce a pro-active mitigation of privacy risks through technical and organizational controls. The better the precautionary measures realize the relevant privacy objectives, the less likely will occur with the PIA process afterwards. The recent proposal for a far-reaching revision of the EU Data Protection Directive envisages to state a specific requirement to implement a PIA process. Indeed, since risks for privacy and non-disclosure of personal data are different in not identical circumstances, the protection measures should also be different, i.e. technology should assist in trying to achieve the (at least) second-best solution for the implementation of the data protection regime by a PIA. Insofar, privacy rules can be individualized and matched with the concrete needs in the given environment.
Axiomatic method and the law
(2012)
This paper seeks to analyse the debate on equality between women and men found in the claims against the subjects related to Education for Citizenship. These claims were resolved in the Spanish Supreme Court and High Courts of the Autonomous Communities. In this debate, there is a strong rejection of antidiscrimination law assumptions, namely that the different roles and social roles of women and men have a cultural and social base and it is unnatural, as evidenced by the concept of gender. But many appellants and judgments defend the difference between women and men as if it was informed and legitimated on human nature. Hence gender is considered an ideology, that is, a category of analysis by means of which the reality of true human nature can be concealed or distorted. But these arguments are opposed to recent legal reforms since they are questioning its normative value, by prioritizing certain moral principles against these laws. We are talking about the Organic Law for Effective Equality between Women and Men, the Law on Integrated Protection Measures against Gender Violence and the Law on Education. However their arguments are not fully justified.
The normative position of the judiciary under the traditional conception of democracy as self-legislation by the people is too weak to protect in an effective way the rights of suspects in the global War on Terror. Drawing on arguments elaborated by Hans Kelsen and Karl Popper, we shall attempt to devise in this paper an alternative democracy conception that could serve as a much more solid foundation for the judicial branch of government in a democratic state. Through this jurisprudential strategy, we hope to be able to maintain the balance of normative power among the Trias Politica, which, in turn, may contribute to the preservation of the legal rights of every person during the struggle against terrorists.
This paper intends to discuss some contemporary issues on human rights and democracy related to the concept of justice. Is the set of individual rights that is assumed by western democracies really universal? If so, how are they supposed to be interpreted? On the other side if I take into account the “other” and pluralism in a serious way how to conciliate different concepts of justice? Taking Jacques Derrida’s approach of justice as its standpoint this paper aims to stress the difficulty to achieve a unique concept of justice as well as to think justice in the sphere of international law and the problem of ensuring human rights in the international order. Western democracies has becoming more and more multiethnic and multicultural and the set of rights that is at the center of the legal order has to be interpreted in a dialogical sense, one that assumes difference and plurality as its starting point. The plurality of conceptions of the good and the impossibility of establishing a unique concept of justice demands the re-creation of a democratic sphere where the dissent and the conflict could be experienced and, at the same time, the legal order needs to ensure individual and group rights against majority’s dictatorship. The main goal of this paper is to re-think the interpretation of law in a multicultural scenario in which it is not possible to have only one criteria of justice and difference and pluralism are envisaged are values themselves.
The bare life and (the) modern law : a journey to some key concepts or conceptions of Agamben
(2012)
This text is imitating a journey which tries to explore what is completely unknown. It starts Homo Sacer and traces some key concepts namely der Muselmann, bare life, state of exception, sovereignty and nihilism in law. Doing so, it hopes to reach a general picture of biopolitics or biopower according to Agamben. So, first part of this text generally tries to clarify some fundamental concepts or conceptions in order to use them for its aim. The second part suggests an alternative reading of Agamben, centered around his concept of der Muselmann which is the ultimate figure defined by Primo Levi and Agamben chooses the term because of its resemblance to or representation of Homo Sacer. Der Muselmann was a derogatory term in its origin and very meaning has still been unclear today. So, the second part tries to clarify the meaning of der Muselmann (and unbaptized babies) from a different outlook, not from outside but inside of the referred concept. It tries to show a Muslim’s image of a non Muslim world in order to reveal what are the very meanings of sovereignty, law and biopolitics. So at the end of the journey, this text hopes to reach a different picture of modern life and a modern law.
Abstract/Keywords: Theory of communicative action, ontology of the sentence, systems, subsystems, role, function, crime of breach of duty, compensation, general and special prevention, rule of law, breach of communicative rationality, institutional rivalry and competition for organization, lord of the fact, the duty of guarantor, facticity and validity, counterfactual assertion, public use of reason, prosecution, transcendental ego, self, idealism, voyage, cognitive subject, object of knowledge, hermeneutics of criminal conduct and public servant
Free riders play fair
(2012)
After the demise of the social contract theory, the argument from fair play, which employs the principle of fair play, has been widely acknowledged as one of the most promising ways of justifying political obligation. First, I articulate the most promising version of the principle of fair play. Then, I show that free riders play fair, that is, that their moral fault lies not in unfairness but in the violation of a rule by appealing to the example of three-in-a-boat. Finally, I conclude that even the most promising version is false because those who have accepted benefits from a social cooperative scheme do not owe an obligation of fair play.
In assessing the aftermath of the fraudulent presidential election of 2009 in Iran, one question has received less critical analysis than other complexities of this event: What can explain the remarkable non-violent character of the Green Movement in Iran? I propose that the answer, inter alia, lies with the following three learning experiences: 1) The experience of loss brought about by the Iran/Iraq war; 2) the experience of relative opening during Khatami’s presidency; and 3) the experience of modernization of faith in the work of the post-Islamist thinkers that aimed to make political Islam compatible with democracy. Together, these learning processes fostered a new mode of thinking that is civil and non-violent in character.
What is it that makes the subject of bioethics autonomous? The problem that this research tries to clarify is What is it that makes the subject of bioethics autonomous? This question is answered from an applied ethics, bioethics. This article will show a new methodological approach to study the subject of bioethics.
The principal objetives of this research that is presented here, are related to the relationship between: 1) Autonomy and information; 2) Autonomy and responsability; 3) Autonomy and freedom; and 4) Autonomy and social ties or social links.
The rule of law is unique establishment that had taken place in historical context, as politico-legal edifice of capitalist society. To the extent that any legal system was established in historical context, its form and functioning are cannot be channelled by reflections or professional commitments of lawyers and legal philosophers. The rule of law emerged in certain conditions that we say “classical liberalism”, of power allocation where we diversify political power and legal power in the milieu of political society, enunciated as republic or commonwealth. Contrary to earlier forms of legal order, capitalism was unique that its super structure was articulated according to the pivotal role of legal machinery. There was an actual equilibrium between legal and political domains that they moderately matched with public and private dichotomy. After monopoly capitalism, social setting of liberalism was dramatically incurred some major modifications which were firstly dislocation of liberal individual, incited by monopoly capital and secondly, political achievement of the working classes obtained political equality, as drastic consequence of mass society. Hence, the rule of law altered as depoliticsation of democratised mass society, instead of modus vivendi of liberal individuals, which demarcated the rule of law according to welfare society or sozialrechtsstaat. The neo-liberal globalisation after 1980’s, republican model of political society faded away that it has been transformed by transnational capital where markets, hierarchies, regionalism and communal settings crosscut inner equilibrium between politics and law. Finally, the newborn articulation of power structure undermined necessary basement of the rule of law.
This paper expands on the concept of legal machine which was presented first at IRIS 2011 in Salzburg. The research subjects are (1) the creation of institutional facts by machines, and (2)
multimodal communication of legal content to humans. Simple examples are traffic lights and vending machines. Complicated examples are computer-based information systems in organisations, form proceedings workflows, and machines which replace officials in organisations. The actions performed by machines have legal importance and draw legal consequences. Machines similarly as humans can be imposed status-functions of legal actors. The analogy of machines with humans is in the focus of this paper. Legal content can be communicated by machines and can be perceived by all of our senses. The content can be expressed in multimodal languages: textual, visual, acoustic, gestures, aircraft manoeuvres, etc. The concept of encapsulatation of human into machine is proposed. Herein humanintended actions are communicated through the machine’s output channel. Encapsulations can be compared with deities and mythical creatures that can send gods’ messages to people through the human mouth. This paper also aims to identify law production patterns by machines.
In this article I advance an account of human rights as individual claims that can be justified within the conceptual framework of social contract theories. The contractarian approach at issue here aims, initially, at a justification of morality at large, and then at the specific domain of morality which contains human rights concepts. The contractarian approach to human rights has to deal with the problem of universality, i.e. how can human rights be ‘universal’? I deal with this problem by examining the relationship between moral dispositions and what I call ‘diffuse legal structure’.
Communist regimes in general and especially the one in Albania destroyed almost every aspect of political, social, cultural and economic life, including the notion of pluralism and intellectual elite of the country. In Albania, the transition into democracy in 90’ was done through extrication which means that the authoritarian government was weakened, but not as thoroughly as in a transition by defeat. As a consequence, the former Communist elite was able to negotiate crucial features of the transition and was very quickly transformed into the new pluralist political class. This position enabled the communist elite to be rehabilitated and together with the new emerged communist elite to remain a strong influential actor in new emerged democracy and de facto to run in continuance the country. The purpose of the new emerged communist elite to maintain control was favored inter alia by the absence of a new strong intellectual elite and was done merely by sharing the power among its members divided into different political parties and also by using the ‘pluralist’ law as a tool for social control over new emerging intellectual elites. The use of law as a tool for social control by the political class has severely damaged people's understanding and expectations on the law, its relations with the state as well as international community. Indeed, such experience of the use of law by the political class for its own narrow interests, has made people lose confidence in law and state as well as has severely weakened the law enforcement in the country. To conclude, the overall purpose of this paper would be the analysis of law in general and its understandings and development in a post-communist society such as Albania from different points of view.
Die brasilianische Verfassung hat ein System detaillierter materieller und prozessualer Rechte etabliert und damit die richterliche Kontrolle hoheitlicher Akte in fast allen politisch relevanten Bereichen ermöglicht. Auf dem Gebiet der ökologischen und sozialen Rechte, wo eine intensive Positivierung individueller und kollektiver Ansprüche stattgefunden hat, ist die wachsende Judizialisierung der staatlichen Programme nicht als übertriebene Einmischung der Gerichte in politische Fragen anzusehen, sondern fördert die Ausbildung des gesellschaftlichen Bewusstseins. Die Gesetzestexte enthalten kaum konkrete materielle Anforderungen oder Richtlinien zur Gewichtung von Gütern und Werten, sondern setzen lediglich Verbote fest oder regeln die föderativen Zuständigkeiten bzw. das Verwaltungsverfahren. Deswegen kann die Genehmigung umweltgefährdender Aktivitäten kaum auf der Grundlage dogmatisch abgeklärter Rechtsbegriffe erfolgen. Die fachliche Qualifikation vieler Verwaltungsbeamter und Richter entspricht noch nicht den Herausforderungen einer korrekten Gesetzesauslegung. Die akademische Diskussion konzentriert sich derweilen auf Themen wie die philosophische Hermeneutik, Semiotik oder Systemtheorie und unterschätzt dabei die Wichtigkeit des juristischen Methodenkanons, weswegen es ihr nicht gelingt, den Praktikern gangbare Direktiven zur Herstellung richtiger und gut begründeter Entscheidungen anzubieten. Nötig ist daher eine mehr pragmatisch orientierte Debatte über den angemessenen Gebrauch der traditionellen und modernen Methoden und Techniken der Rechtsfindung, um die dogmatische Basis des Umweltrechts in Brasilien zu stärken und es an das Modell eines Umweltstaats heranzuführen.
Democratic rule of law has been struggling with the occurring problem of pluralism of values. It is therefore still faced with the dilemma of ordering the relationship of law and ethics, namely with the question whether in the issue of legal solutions the priority is granted to ethics or to law. In the case of dominance of the positivist paradigm, it is all the more important because the ethical issue is marginalized in it. It turns out that the same authority, deciding on similar issues, at the junction of two areas: ethics and law, can make mutually contradictory decisions: once giving priority to ethics, whereas - at different times - to positive law. On a closer analysis, this contradiction proves illusory because under the guise of protection of a positive paradigm, the hidden fact is that the axiological decision underlies the resolution concerning law. This decision protects the values that have priority in the scale of preferential value of decision-making body. The example considered in the article concerns the interface between ethical and legal norms against selected rulings of the Constitutional Court. The doubts that arise in this context may be in future avoided or perhaps, if necessary, resolved by adopting a two-aspect model of legal norm. This model in its vertical approach has an evaluative element. This allows to deem the seemingly contradictory decision in similar cases as justified one. It also shows that in practice the rightness of the resolution takes precedence both over ethics as well as over law.
The concept of biopolitics has its origin on the Michel Foucault works developped since 1975 to 1979. In this period, the author introduced the foundations for a new approach about the modern government, based in both crescent enpowerment on individuals and the control of populations. The theme has attracted the attentions of some critical political studies, with many practical uses. However, I believe there is not enough consolidation about biopolitics as a concept and a comprehensive theory of the new political mechanisms. This uncertainness is more evident when the very role of Law is questioned in a biopolitical model, due to the archaic nature that Foucault gives to it. So the aim of the paper is to identify the theorical comprehension of biopolitics in a contemporary author as Giorgio Agamben to demonstrate his oppositions and proximities from the original idea of Michel Foucault. I propose that Agamben has the same difficulties of Foucault to deal with legal theory and Law inside biopolitics. Nevertheless, after a critical review on the works of this two authors, my conclusion is that a settlement of the concepts of Law and biopolitics depends of the surpassing of the Foucaldian version of Law as sovereignity, a clear delimitation of a common core between the authors and their differences and the research and affirmation of the concept of Law in Agamben, more well-refined than Foucault's one.
E-democracy as the frame of networked public discourse : information, consensus and complexity
(2012)
The quest for democracy and the political reflection about its future are to be understood nowadays in the horizon of the networked information revolution. Hence, it seems difficult to speak of democracy without speaking of e-democracy, the key issue of which is the re-configuration of models of information production and concentration of attention, which are to be investigated both from a political and an epistemological standpoint. In this perspective, our paper aims at analyzing the multi-agent dimension of networked public discourse, by envisaging two competing models of structuring this discourse (those of dialogue and of claim) and by suggesting to endorse the epistemic idea of complementarity as a guidance principle for elaborating a form of partnership between traditional and electronic media.
Judicial review reflects the level of commitment between constitutionalism and democracy in contemporary States. Yet democracy as the sovereign government of the people implies a tension with constitutionalism as the rule of law. That is, people ruling themselves or the government by the people – majority government - is limited by the law of law making, the constitution. In Brazil, the improvement of judicial review is nowadays related to increase the number of decisions given by the Brazilian Supreme Court or rather to the capability of this latter in deciding a large number of constitutional lawsuits no matter the form and content of its arguments. For, the Court is nowadays driven by numbers and to accomplish its goals in terms of numbers (of decisions) it applies to technological solutions such as the digitalization of legal proceedings. It means that as many decision as Supreme Court issues -with the help of technology- the better it is. Relating the numbers of decisions issued by the Court to the improvement of Brazilian judicial review or Brazilian constitutionalism and democracy is a great mistake and a false statement as far as it does not face the main problem of the system, which is the lack of reasons of Supreme Court’s decision. The point is that, in this case, technology is just a tool –among others- in order to render legal proceedings faster yet not a qualitative sign of Supreme Court’s decisions.
The main Question of this paper is: how can we tackle the global warming in accordance with the economical growth especially in emerging countries?
K. W. Kapp, “The Social Costs of Private Enterprise” (1950), defines the social costs as direct or indirect damages which are not compensated by the producer, but added to the third parties. An example might be the disaster of the BP plant in April 2010, in which the polluter can hardly cover all the damages so as to make the seawater clean, to regenerate the harmed natural lives and to recover the jobs and the everyday life of the residents on site.
The Club of Rome, “The Limits to Growth” (1972), makes us aware of the five conditions which set the limits to growth: population, industrialization, pollution, consumption of food and natural resources, which tendentiously increase in a exponential progression. The GDP growth 10% a year means that it will be 2.59 times as large in ten years, whereas technology could resolve problematic concerning five elements at highest in arithmetical progression.
Remarkable would be that the modern industrial civilization has brought social damages in form of global warming. Developed nations have not payed for it yet. All the people in the world should have right to economical growth at any rate, which would however be limited by those five conditions. Conclusion: the developed nations should give up the consumption lifestyle for the sake of equal right of every citizen in the world to reasonable standard of living.
The development of laboratory animal science and animal care of legislation and the consummation
(2012)
Laboratory animal science is the use of non-human animals in experiments to obtain new knowledge and new technologies in biomedical research and testing. In order to develop science and technology, the human carried out a large number of animal experiments, these experiments greatly expanded the vision of related research field, and make a great contribution to human beings. Meanwhile, animal experiments also bring us a certain extent of negative effects. Countries around the world have adopted legislative measures to regulate behavior of animal experiments, but in the process of legislation and enforcement are not wholly satisfactory. On the basis of present situation of laboratory animal science and existing problems, with the comparison of animal welfare act between Europe and China, the author puts forward the ideas of perfecting experimental animals’ laws and its enforcement proposals.
Biopower, governmentality, and capitalism through the lenses of freedom: a conceptual enquiry
(2012)
In this paper I propose a framework to understand the transition in Foucault’s work from the disciplinary model to the governmentality model. Foucault’s work on power emerges within the general context of an expression of capitalist rationality and the nature of freedom and power within it. I argue that, thus understood, Foucault’s transition to the governmentality model can be seen simultaneously as a deepening recognition of what capitalism is and how it works, but also the recognition of the changing historical nature of the actually existing capitalisms and their specifically situated historical needs. I then argue that the disciplinary model should be understood as a contingent response to the demands of early capitalism, and argue that with the maturation of the capitalist enterprise many of those responses no longer are necessary. New realities require new responses; although this does not necessarily result in the abandonment of the earlier disciplinary model, it does require their reconfiguration according to the changed situation and the new imperatives following from it.
This work intends to analysis the philosophy of history and to discuss the consequences of this death to the Critical Theory. The concept of reason and the devices of democracy and human rights are discussed in a revision of the historical debate about the end of history operates the life in the interior of the modern society, especially about the intellectual condition at the information society.
Making use of United Nations (U.N.) materials and documents, Anja Matwijkiw and Bronik Matwijkiw argue that the organization – in 2004 – converted to a stakeholder jurisprudence for human rights. However, references to “stakeholders” may both be made in the context of narrow stakeholder theory and broad stakeholder theory. Since the U.N. does not specify its commitment by naming the theory it credits for its conversion, the authors of the article embark on a comparative analysis, so as to be able to try the two frameworks for fit. The hypothesis is that it is the philosophy and methodology of broad stakeholder theory that best matches the norms and strategies of the U.N. While this is the case, certain challenges nevertheless present themselves. As a consequence of these, the U.N. has to – as a minimum – take things under renewed consideration.
The improvement of accident prevention technology in many fields of social life has spurred new challenges to the doctrinal tools of fault and strict based civil liability in the law of torts. Amid these challenges lies the identification of the proper scope of the respective criteria of liability in a changing factual environment, their suitability as doctrinal tools, as well as their actual application to concrete cases given the amount of information which would be needed to render adequate judgments. Precedents and old laws should be assessed with caution, taking into account the tacit cost-benefit analysis embedded in them, for they may or may not serve the interests of welfare maximization in an environment with constantly renewed accident prevention technology.
In this thesis, we have investigated strongly correlated bosonic gases in an optical lattice, mostly based on a bosonic version of dynamical mean field theory and its real-space extension. Emphasis is put on possible novel quantum phenomena of these many-body systems and their corresponding underlying physics, including quantum magnetism, pair-superfluidity, thermodynamics, many-body cooling, new quantum phases in the presence of long-range interactions, and excitational properties. Our motivation is to simulate manybody phenomena relevant to strongly correlated materials with ultracold lattice gases, which provide an excellent playground for investigating quantum systems with an unprecedented level of precision and controllability. Due to their high controllability, ultracold gases can be regarded as a quantum simulator of many-body systems in solid-state physics, high energy astrophysics, and quantum optics. In this thesis, specifically, we have explored possible novel quantum phases, thermodynamic properties, many-body cooling schemes, and the spectroscopy of strongly correlated many-body quantum systems. The results presented in this thesis provide theoretical benchmarks for exploring quantum magnetism in upcoming experiments, and an important step towards studying quantum phenomena of ultracold gases in the presence of long-range interactions.
As is well known, the 2nd Spanish Republic (1931-1936) was toppled by a military uprising which, after a cruel Civil War, set up an autocratic regime led by General Franco which lasted until his natural death in 1975. According to the contemporary theory of the legal system, a legal order exists on the sole condition that it is efficient in general terms and this was the case for both the Republic and the Dictatorship. In turn, the validity of the legal norms of all legal orders is based on its respective rules of recognition. Thus, neither the existence of the legal order nor the validity of its respective legal norms depends on moral considerations. In this paper, we call this affirmation into question on the base of the fact that the compensatory methods adopted from the Transition to Democracy show an evident concern to repair the damage of taking away a person’s basic rights (life, health, freedom, expression, association etc) although the Spanish Constitution, with its catalogue of fundamental rights was not in force at that time. But these measures would not have much sense if, as Raz says, there was no shared content which is common to all legal systems. Like Nino, we claim that one must discriminate between a democratic legal order and an autocratic one to establish the level of validity of its respective legal norms. Thus it can be assigned a presumption of justice to democratic norms. Finally, we state that the criteria to weigh up the justice or injustice of legal norms, as that of legal orders, takes root in the level of respect they show towards human rights.
Introduction: aims and points of departure. 1. The problem of the knowledge of law: whether previous general rules may support a casuistic decision. 2. The problem of legal ethics: whether there are autonomous rights, which do not depend on positive law. 3. The ways of modern dogmatics to deal with these problems. 4. The question remains the same.
From chaos to chaos theory, from the primordial perception of the world as disorderly to the scientific research of disorder a long distance has been covered. This path implies openness of mind and scientific boldness which connect mythological perceptions of the world with philosophical and scientific interpretations of phenomena throughout the world in a quite distinctive way resting on the creation of a model and application of computing. Owing to this, for the first time instead of asking What awaits us in the future? we can ask What can be done in the future? and get a reliable scientific answer to the question.
In reconsideration of the composition and operation of European law, it is the description of its underlying mentality that may cast best light on the query whether European law is the extension of domestic laws or a sui generis product. As to its action, European law is destructive upon the survival of traditions of legal positivism, for it recalls post modern clichés rather. Like a solar system with planets, it is two-centred from the beginning, commissioning both implementation and judicial check to member states. As part of global post modernism, a) European law stems from artificial reality construction freed from particular historical experience and, indeed, anything given hic et nunc. By its operation, b) it dynamises large structures and sets in motion that what is chaos itself. It is owing to reconstructive human intent solely that any outcome can at all be seen as fitting to some ideal of order, albeit neither operation nor daily management strives for implementing any systemicity. This is the way in which the European law becomes adequate reflection of the underlying (macro) economic basis, which it is to serve as superstructure. Accordingly, c) the entire construct is operated (as integrated into one well-working unit) within the framework of an artificially animated dynamism. With its “order out of chaos” philosophy it assures member states’ standing involvement and competition, achieving a flexibly self-adapting (and unprecedentedly high degree of) conformity.
Die Hauptthese dieses Papers geht von dem Konzept der normativen Verfassung der Nachkriegzeit aus und setzt sich kritisch mit dem Konzept des 19. Jahrhunderts „Verfassungswandlung“ auseinander. Das Konzept des Verfassungswandels ist mit der Verfassungsdemokratie inkompatibel. Statt von einem Verfassungswandel zu sprechen, sollte man die Entwicklung des Sinns der Normen in der Zeit als dynamische Interpretation bezeichnen.
There is an increasing interest in incorporating significant citizen participation into the law-making process by developing the use of the internet in the public sphere. However, no well-accepted e-participation model has prevailed. This article points out that, to be successful, we need critical reflection of legal theory and we also need further institutional construction based on the theoretical reflection.
Contemporary dominant legal theories demonstrate too strong an internal legal point of view to empower the informal, social normative development on the internet. Regardless of whether we see the law as a body of rules or principles, the social aspect is always part of people’s background and attracts little attention. In this article, it is advocated that the procedural legal paradigm advanced by Jürgen Habermas represents an important breakthrough in this regard.
Further, Habermas’s co-originality thesis reveals a neglected internal relationship between public autonomy and private autonomy. I believe the co-originality theory provides the essential basis on which a connecting infrastructure between the legal and the social could be developed. In terms of the development of the internet to include the public sphere, co-originality can also help us direct the emphasis on the formation of public opinion away from the national legislative level towards the local level; that is, the network of governance.1
This article is divided into two sections. The focus of Part One is to reconstruct the co-originality thesis (section 2, 3). This paper uses the application of discourse in the adjudication theory of Habermas as an example. It argues that Habermas would be more coherent, in terms of his insistence on real communication in his discourse theory, if he allowed his judges to initiate improved interaction with the society. This change is essential if the internal connection between public autonomy and private autonomy in the sense of court adjudication is to be truly enabled.
In order to demonstrate such improved co-original relationships, the empowering character of the state-made law is instrumental in initiating the mobilization of legal intermediaries, both individual and institutional. A mutually enhanced relationship is thus formed; between the formal, official organization and its governance counterpart aided by its associated ‘local’ public sphere. Referring to Susan Sturm, the Harris v Forklift Systems Inc. (1930) decision of the Supreme Court of the United States in the field of sexual harassment is used as an example.
Using only one institutional example to illustrate how the co-originality thesis can be improved is not sufficient to rebuild the thesis but this is as much as can be achieved in this article.
In Part Two, the paper examines, still at the institutional level, how Sturm develops an overlooked sense of impartiality, especially in the derivation of social norms; i.e. multi-partiality instead of neutral detachment (section 4). These two ideas should be combined as the criterion for impartiality to evaluate the legitimacy of the joint decision-making processes of both the formal official organization and ‘local’ public sphere.
Sturm’s emphasis on the deployment of intermediaries, both institutional and individual, can also enlighten the discourse theory. Intermediaries are essential for connecting the disassociated social networks, especially when a breakdown of communication occurs due to a lack of data, information, knowledge, or disparity of value orientation, all of which can affect social networks. If intermediaries are used, further communication will not be blocked as a result of the lack of critical data, information, knowledge or misunderstandings due to disparity of value orientation or other causes.
The institutional impact of the newly constructed co-originality thesis is also discussed in Part Two. Landwehr’s work on institutional design and assessment for deliberative interaction is first discussed. This article concludes with an indication of how the ‘local’ public sphere, through e-rulemaking or online dispute resolution, for example, can be constructed in light of the discussion of this article.
Principles can be directly expressed by law or may be found in jurisprudence, philosophy or literature. Often the principles are contradictory, as in the case of transparency and the taboo of state information disclosure. At the individual level, transparency and taboo, the sense and purpose of privacy may compliment each other. Moreover the rise of cyberspace has blurred the distinction between privacy and public. The taboo is widening. The development of the internet and of the social networks can alter the once apparently stable legal situation, bringing a new dynamic into play in both state and individual spheres. In the context of the internet it is as though the secret workings of the state are projected on its "walls and facades", reminding us of Plato's "Myth of the Cave". As Plato described, disillusionment and reflexive defensiveness can follow.
In the intersection between law, science and technology lies the debate on the overcoming of the boundaries of the biological structure of the human being and its implications on the idea of human rights, on the concept of person and on the conception of equality – being the latter a fundamental tenet of a democracy.
Posthumanism assumes a biological inadequacy of the human body regarding the quantity, complexity and quality of information which it can muster. The same occurs with the needs of accuracy, speed or strength demanded by the contemporary environment. Under such perspective, the body is considered to be an inefficient structure, with a short lifespan, easy to break and hard to fix.
The body, always seen as the locus for the definition of human, emerges as the object of a commodification process that seeks to exonerate men from their burden - by declination towards a virtual existence, totally free and rational - or to enhance them with bionic devices or drugs.
This issue has already been the subject of attention by many scholars like Savulescu, Rodotà, Broston, Fukuyama and even Habermas.
Therefore, the aim of this paper is to seek, by criticism and revision of the positions on the foreseen problems of this process, an adequate theoretical approach on issues like the concept of person and its connection with the idea of human rights in order to promote the fundamental statement that all men are equal without disregard to the values of diversity and personal identity.
Der zweifache Urteilsspruch des Europäischen Gerichtshofs für Menschenrechte im Fall “Lautsi gegen Italien” hat sich zum Paradigma der Schwierigkeiten entwickelt, welche Europa bei der adäquaten Ansiedlung der Religion im öffentlichen Bereich erfährt. Die Lösung kann sich ändern, wenn, anstatt dem politischen Problem (wann ist die Ausübung von Macht erlaubt) einzuräumen, die Möglichkeit einer praktischen Vernunft und ihre Verträglichkeit mit dem religiösen Glauben zum Ausgangspunkt gemacht wird. Diese würde zweifelsfrei zu einer politischen Fragestellung zu einer Präsenz der Religion im öffentlichen Bereich einladen, die auf eine positive Laizität mehr Rücksicht nimmt, dabei den Laizismus ablehnt, der darauf drängt, die Rationalität zur Macht auch einen nicht kognitivistischen Code zu reduzieren.
When judges are authorised to invalidate legal acts for being unconstitutional, the competence of the legislator is directly concerned. The question raises, if thus judges do not usurp legislative power. In the traditional doctrine of the separation of powers the parliament is the first power, based on its direct democratic legitimacy. Yet cancelling legal acts completely or partially does evoke more irritations in the public that could be expected. The people seem to have more confidence to the assumed impartiality of the judges than to the results of the parliamentary work which seems to be dominated by the struggles of the parties. The necessity of judicial review mainly is based on the consideration that individual rights even in an authentic democratic system may be violated by a legal act of the parliament. In this case constitutional courts have the very task to defend individual rights, principles of liberty and authentic equality. Therefore it is justified to speak of the “jurisdiction of liberty”, as the Italian constitutional expert Cappelletti has said. But also without such legitimacy in many countries the Courts intervene in the field of the legislator. The courts themselves discuss the limits of judicial interventions, emphasising themselves, that they have to respect the legislative decisions principally, but do not abide always by their own proclaimed principles. In Spanish recent publications it is spoken of the principle “in dubio pro legislatore”, (in case of doubt in favour the legislator), reminding of “in dubio pro reo”, in order to treat the legislative power not worse than the defendant in a criminal process..
Human rights and climate policy – toward a new concept of freedom, protection rights, and balancing
(2012)
Neither the scope of “protection obligations” which are based on fundamental rights nor the theory of constitutional balancing nor the issue of “absolute” minimum standards (fundamental rights nuclei, “Grundrechtskerne”), which have to be preserved in the balancing of fundamental rights, can be considered satisfactorily resolved–in spite of intensive, long-standing debates. On closer analysis, the common case law definitions turn out to be not always consistent. This is generally true and with respect to environmental fundamental rights at the national, European, and international level. Regarding the theory of balancing, for the purpose of a clear balance of powers the usual principle of proportionality also proves specifiable. This allows a new analysis, whether fundamental rights have absolute cores. This question is does not only apply to human dignity and the German Aviation Security Act, but even if environmental policy accepts death, e.g. regarding climate change. Overall, it turns out that an interpretation of fundamental rights which is more multipolar and considers the conditions for freedom more heavily–as well as the freedom of future generations and of people in other parts of the world–develops a greater commitment to climate protection.
The structure of the title compound, C14H12N2O2 {systematic name: 2,2′-[hydrazinediylidenebis(methanylylidene)]diphenol}, has already been determined in the triclinic space group P An external file that holds a picture, illustration, etc. Object name is e-68-0o255-efi1.jpg with Z = 4 [El-Medani, Aboaly, Abdalla & Ramadan (2004 [triangle]). Spectrosc. Lett. 37, 619–632]. However, the correct space group should be P21/c with Z = 4. This structure is a new polymorph of the already known monoclinic polymorph of salicyladehyde azine, which crystallizes in space group P21/n with Z = 2. The benzene rings form a dihedral angle of 46.12 (9)°. Two intramolucular O—H[cdots, three dots, centered]N hydrogen bonds occur.
In the title compound, [Ag(BF4)(C14H12N2O4)]n, the coordination of the Ag+ ion is trigonal–bipyramidal with the N atoms of two ethane-1,2-diyl bis(pyridine-3-carboxylate) ligands in the apical positions and three F atoms belonging to different tetrafluoridoborate anions in the equatorial plane. The material consists of infinite chains of [Ag(C14H12N2O4)] units running along [001], held together by BF4 − bridging anions.