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The first measurement of ϕ-meson production in p-Pb collisions at a nucleon-nucleon centre-of-mass energy sNN−−−√ = 5.02 TeV has been performed with the ALICE apparatus at the LHC. The ϕ-mesons have been identified in the dimuon decay channel in the transverse momentum (pT) range 1<pT<7 GeV/c, both in the p-going (2.03<y<3.53) and the Pb-going (−4.46<y<−2.96) directions, where y stands for the rapidity in the nucleon-nucleon centre-of-mass. Differential cross sections as a function of transverse momentum and rapidity are presented. The forward-backward asymmetry for ϕ-meson production is measured for 2.96<|y|<3.53, resulting in a factor ∼0.5 with no significant pT dependence within the uncertainties. The pT dependence of the ϕ nuclear modification factor RpPb exhibits an enhancement up to a factor 1.6 at pT = 3-4 GeV/c in the Pb-going direction. The pT dependence of the ϕ-meson cross section in pp collisions at s√ = 2.76 TeV, which is used to determine a reference for the p-Pb results, is also presented here for 1<pT<5 GeV/c and 2.5<y<4.
Zimbabwe: The Urgency of Now
(2015)
Zimbabwe: The Urgency of Now, is a follow-up creative non-fiction book to Zimbabwe: The Blame Game. It goes further than The Blame Game and focuses on Zimbabwe in the GNU entity, the 2013 elections, post elections and post GNU Zimbabwe, and Now. They are a myriad number of problems, issues, limitations that still unbundles Zimbabwe's push towards multiparty democracy, social justice, economic sanity and growth, and The Urgency of Now focuses on the solutions to these. It also tackles the land reform in South Africa, how this could be its biggest problem going forward. It goes further and tackles the larger Africa problem toward democracy, growth, stability and unity, and why the progress towards the United States of Africa has been moribund.
The function of RNA is subtly modulated by post-transcriptional modifications. Here, we report an important crosstalk in the covalent modification of two classes of RNAs. We demonstrate that yeast Kre33 and human NAT10 are RNA cytosine acetyltransferases with, surprisingly, specificity toward both 18S rRNA and tRNAs. tRNA acetylation requires the intervention of a specific and conserved adaptor: yeast Tan1/human THUMPD1. In budding and fission yeasts, and in human cells, we found two acetylated cytosines on 18S rRNA, one in helix 34 important for translation accuracy and another in helix 45 near the decoding site. Efficient 18S rRNA acetylation in helix 45 involves, in human cells, the vertebrate-specific box C/D snoRNA U13, which, we suggest, exposes the substrate cytosine to modification through Watson–Crick base pairing with 18S rRNA precursors during small subunit biogenesis. Finally, while Kre33 and NAT10 are essential for pre-rRNA processing reactions leading to 18S rRNA synthesis, we demonstrate that rRNA acetylation is dispensable to yeast cells growth. The inactivation of NAT10 was suggested to suppress nuclear morphological defects observed in laminopathic patient cells through loss of microtubules modification and cytoskeleton reorganization. We rather propose the effects of NAT10 on laminopathic cells are due to reduced ribosome biogenesis or function.
Seed production varies from year-to-year in most species. Factors influencing this variation can include pollination and dispersal mechanisms, seed predation and resource availability. Here we examine a long-term (12– year) photographic record of seed cone production for the Australian endemic conifer Wollemia nobilis (Araucariaceae). Coefficient of variation (a commonly used measure of variation in seed production) was low for the two trees analysed, compared with published values for other polycarpic plants. Nevertheless, cone production decreased with increasing spring minimum temperatures (during pollination) and increased with summer total rainfall (during cone initiation). Hence, Wollemia nobilis cone production was correlated with weather, in line with the resource-matching hypothesis. Impacts of variation in cone production on the Wollemia nobilis population are likely to be buffered by the shade-tolerant, slow-growing juvenile life stage of Wollemia nobilis.
Writing Mystery and Mayhem
(2015)
This eighth anthology of twelve short stories from Weaver Press reveals again the range and variety, compassion and humour, irony and tragedy with which Zimbabwean writers observe the world around them. Several writers adopt a tongue-in-cheek approach to the subject: Naishe Nyamubaya takes us behind graphic newspaper headlines with a story of goblins, Jonathan Brakarsh turns the world inside out by constantly reversing our expectations, and Lawrence Hoba draws a situation both 'collateral and incompatible'. It is a characteristic of crime fiction to defy expectation, as Farai Mudzingwa, Bongani Sibanda and Valerie Tagwira do in exploring the ramifications of sudden death. But if we are surprised by some stories, we can only be moved those which draw on the pain and vulnerablity of both the victims and those left behind. Godess Bvukutwa, Isabella Matambanadzo and Donna Kirstein help us to reflect on injustice and loss. Reading this collection of stories, with subjects ranging from tokolosh to tsunami, and from ghosts to goldfish, reminds us that the world is crazier than we think.
Previous research on working memory (WM) in children with poor mathematical skills has yielded heterogeneous results, possibly due to inconsistent consideration of the IQ-achievement discrepancy and additional reading and spelling difficulties. To examine the impact of both, the WM of 68 average-achieving and 68 low-achieving third-graders in mathematics was assessed. Preliminary analyses showed that poor mathematical skills were associated with poor WM. Afterwards, children with isolated mathematical difficulties were separated from those with additional reading and spelling difficulties. Half of each group fulfilled the IQ-achievement discrepancy, resulting in a 2 (additional reading and spelling difficulties: yes/no) by 2 (IQ-achievement discrepancy: yes/no) factorial design. Analyses revealed that not fulfilling the IQ achievement discrepancy was associated with poor visual WM, whereas additional reading and spelling difficulties were associated with poor central executive functioning in children fulfilling the IQ-achievement discrepancy. Therefore, WM in children with poor mathematical skills differs according to the IQ-achievement discrepancy and additional reading and spelling difficulties.
Witch Girl
(2015)
This is modern Lusaka, Zambia, where the line between magic and religion is blurred, the arcane and the mundane muddle and nothing is what it seems. Luse is a sharp street child combing the gang-ridden city in a desperate search for Doctor Georgia Shapiro who she hopes can offer her a way back into her once-bright past. The doctor is trying to unravel the mystery of a friend's sudden death while attending to the AIDS crisis laying waste to the country around her. Meanwhile The Blood Of Christ Church and its enigmatic leader Priestess Selena Clark gain popularity with their murky promises of salvation and violent clandestine rituals. A small silver box links them in ways they cannot foretell. It will force Luse and Georgia to question who they trust, who they are and for whom they fight. Tanvi Bush's Witch girl is a crime thriller that juggles the past and the present effortlessly, blending AIDS activism, witchcraft, religious extremism and romance to create a well-paced narrative. Luse is so feisty, charming and resourceful that you'll miss her after you finish the book.
This paper investigates whether exchanging the Social Security delayed retirement credit, currently paid as an increase in lifetime annuity benefits, for a lump sum would induce later claiming and additional work. We show that people would voluntarily claim about half a year later if the lump sum were paid for claiming any time after the Early Retirement Age, and about two-thirds of a year later if the lump sum were paid only for those claiming after their Full Retirement Age. Overall, people will work one-third to one-half of the additional months, compared to the status quo. Those who would currently claim at the youngest ages are likely to be most responsive to the offer of a lump sum benefit.
This paper provides a theoretical assessment of gestures in the context of authoring image-related hypertexts by example of the museum information system WikiNect. To this end, a first implementation of gestural writing based on image schemata is provided (Lakoff in Women, fire, and dangerous things: what categories reveal about the mind. University of Chicago Press, Chicago, 1987). Gestural writing is defined as a sort of coding in which propositions are only expressed by means of gestures. In this respect, it is shown that image schemata allow for bridging between natural language predicates and gestural manifestations. Further, it is demonstrated that gestural writing primarily focuses on the perceptual level of image descriptions (Hollink et al. in Int J Hum Comput Stud 61(5):601–626, 2004). By exploring the metaphorical potential of image schemata, it is finally illustrated how to extend the expressiveness of gestural writing in order to reach the conceptual level of image descriptions. In this context, the paper paves the way for implementing museum information systems like WikiNect as systems of kinetic hypertext authoring based on full-fledged gestural writing.
Last November, the media organisation of the „Islamic State“ (IS) published a video, the sole purpose of which was to prove that the „caliphate“ which the IS has established in June 2014 was in fact a proper state. The video highlighted a host of institutions in order to drive home the claim of real statehood, including examples like a working judiciary, a prison administration, a schooling system, and so on. At one point in the video, the IS claimed that it was also financially independent and had apt resources at its disposal, namely oil and gas.
However, while it is true that the IS controls a number of oil and gas fields in Syria as well as in Iraq, we have by now enough evidence to be rather sure that the economic base of the „caliphate“ is by no means sustainable...
The prefix cyber, prepended onto terms like war, peace, security, and so on, results in interesting word combinations which we construct with our spoken language. Many scholars, from political to social science, have discussed the terms and the semantics of it in order to understand the problem and to create some scientific value out of it. But this article will not be another endless discussion on whether cyberfoo exists somewhere in any computer network at the moment or not...
'In Who's Afraid of Mongo Wa Swolenka? a book launch is planned which, from information given to His Royal Excellency Gbadarango Binyambutu Buthablaisi, by a traitorous intellectual seeking preferment; and by his security agents, is a campaign led by disgruntled writers and intellectuals of Nubialand for the return of their exiled colleague and international award winner, Professor Mongo Wa Swolenka. How the celebrated leader of Nubialand and master of gunocratic politics responds to the prevailing circumstances is the nerve centre of dialogue, action and morality in the play.' - John Nkemngong Nkengasong, Writer and critic, University of Yaounde I, Cameroon
Even in the absence of sensory stimulation the brain is spontaneously active. This background “noise” seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN), which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network's spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network's behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural responses can be accounted for by a simple deterministic recurrent neural network which learns a predictive model of its sensory environment via a combination of generic neural plasticity mechanisms.
Mesenchymal stem/stromal cells (MSCs) feature promising potential for cellular therapies, yet significant progress in development of MSC therapeutics and assays is hampered because of remarkable MSC heterogeneity in vivo and in vitro. This heterogeneity poses challenges for standardization of MSC characterization and potency assays as well as for MSC study comparability and manufacturing. This review discusses promising marker combinations for prospective MSC subpopulation enrichment and expansion, and reflects MSC phenotype changes due to environment and age. In order to address animal modelling in MSC biology, comparison of mouse and human MSC markers highlights current common ground of MSCs between species.
We consider the continuous-time portfolio optimization problem of an investor with constant relative risk aversion who maximizes expected utility of terminal wealth. The risky asset follows a jump-diffusion model with a diffusion state variable. We propose an approximation method that replaces the jumps by a diffusion and solve the resulting problem analytically. Furthermore, we provide explicit bounds on the true optimal strategy and the relative wealth equivalent loss that do not rely on quantities known only in the true model. We apply our method to a calibrated affine model. Our findings are threefold: Jumps matter more, i.e. our approximation is less accurate, if (i) the expected jump size or (ii) the jump intensity is large. Fixing the average impact of jumps, we find that (iii) rare, but severe jumps matter more than frequent, but small jumps.
After five years of the Syrian war, we can recognize “four” conflicting parties on the ground – Assad, ISIS, rebel groups and the Kurds. Each one of these conflicting parties has regional and international backers, who ironically do not agree with each other about whom they are fighting for or against. The Syrian regime is backed by Iran, Russia, Hezbollah and Iraqi militias. ISIS is backed by the flood of global Jihadists from all over the world. Rebel groups are backed by Gulf States, Turkey, Jordan and the US. The Kurds are supported by the US. While in the media, we always say “the Syrian conflict, crisis or war”, I wonder what makes this war that much Syrian. It is rather a war on the land of Syria, in which more than 50% of Syria’s population have been displaced, over 220 thousand have been killed, and many more have been injured or imprisoned. According to Amnesty international, more than 12.8 million Syrian people are in “urgent need of humanitarian assistance”. In addition to this humanitarian catastrophe, most of the Syrian land and infrastructure have been destroyed. So what is that Syrian about the Syrian “war”?...