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The paper analyses the linkages from financial developments to public finances. It maps and discusses the transmission channels to fiscal variables. These channels include asset prices, financing conditions, balance sheets of banks, non-banks and central banks and international linkages. The study argues that the fiscal effects via each and all these channels can be very serious in magnitude and can put the sustainability of public finances at risk. However, there is an only limited in-depth analysis of these channels and risks.
Im Frühjahr 2018 wurde innerhalb des vom Bundesministerium für Bildung und Forschung geförderten Projektes „QuartierMobil“ eine Haushaltsbefragung im innenstadtnahen Stadtteil Frankfurt-Bornheim durchgeführt (N = 1027). Für die Stichprobenauswahl wurden das Random-Route-Verfahren und die Last-Birthday-Methode angewendet. Der Fragebogen wurde in Abstimmung mit den Projektpartner*innen, dem Referat Mobilitäts- und Verkehrsplanung der Stadt Frankfurt sowie dem Planungsbüro Planersocietät, entwickelt. Ziel der Befragung war es, die Dynamiken und Präferenzen der Bewohnenden des Quartiers hinsichtlich ihrer Alltagsmobilität, Verkehrsmittelnutzung und Einstellungen zu Konfliktsituationen zu erhalten. Der Schwerpunkt der Befragung lag auf dem Parken im urbanen Quartier und möglichen Gestaltungsoptionen des städtischen Parkraummanagements hin zu einer nachhaltigeren Mobilität und einer Erhöhung der Aufenthalts- und Lebensqualität im Quartier.
We present a model for the autonomous and simultaneous learning of active binocular and motion vision. The model is based on the Active Efficient Coding (AEC) framework, a recent generalization of classic efficient coding theories to active perception. The model learns how to efficiently encode the incoming visual signals generated by an object moving in 3-D through sparse coding. Simultaneously, it learns how to produce eye movements that further improve the efficiency of the sensory coding. This learning is driven by an intrinsic motivation to maximize the system's coding efficiency. We test our approach on the humanoid robot iCub using simulations. The model demonstrates self-calibration of accurate object fixation and tracking of moving objects. Our results show that the model keeps improving until it hits physical constraints such as camera or motor resolution, or limits on its internal coding capacity. Furthermore, we show that the emerging sensory tuning properties are in line with results on disparity, motion, and motion-in-depth tuning in the visual cortex of mammals. The model suggests that vergence and tracking eye movements can be viewed as fundamentally having the same objective of maximizing the coding efficiency of the visual system and that they can be learned and calibrated jointly through AEC.
Fährt man in den Urlaub, weiß man eigentlich schon vorab, dass man als Reisende ob der eigenen Unwissenheit mehr bezahlt als die ortskundigen Locals. Man weiß, dass die meisten europäischen Urlaubsorte vom Tourismus leben und drückt im Stillen sein Einverständnis damit aus, indem man überhaupt reist. Gelegentlich aber zahlt man nicht nur etwas mehr, sondern wird beim Rückweg zum Flughafen von einem Taxifahrer, der kein Englisch spricht oder auch nur so tut, um die halbe Insel gefahren, obwohl man vom Beifahrersitz in sein Handy schaut und einem Google Maps einen wesentlich kürzeren Weg angezeigt hat. Man könnte sich aufregen, mit Hand und Fuß mit dem Taxifahrer schimpfen, die Türen des Wagens zuknallen und so dem eigenen Unmut Ausdruck verschaffen. Man kann aber auch ruhig bleiben, dem Taxifahrer thank you for showing us the whole island zurufen, zurückfliegen und eine Ausstellung organisieren, wie Cemile Deniz Alibas, Dominika Bednarsky, Un-Zu Ha-Nul Lee und Lena Stewens es getan haben. ...
Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain incompletely understood, and predictive biomarkers for HMA efficacy are lacking. Here, we show that the bioactive metabolite decitabine triphosphate, but not azacytidine triphosphate, functions as activator and substrate of the triphosphohydrolase SAMHD1 and is subject to SAMHD1-mediated inactivation. Retrospective immunohistochemical analysis of bone marrow specimens from AML patients at diagnosis revealed that SAMHD1 expression in leukemic cells inversely correlates with clinical response to decitabine, but not to azacytidine. SAMHD1 ablation increases the antileukemic activity of decitabine in AML cell lines, primary leukemic blasts, and xenograft models. AML cells acquire resistance to decitabine partly by SAMHD1 up-regulation. Together, our data suggest that SAMHD1 is a biomarker for the stratified use of hypomethylating agents in AML patients and a potential target for the treatment of decitabine-resistant leukemia.
Causes of maladaptation
(2019)
Evolutionary biologists tend to approach the study of the natural world within a framework of adaptation, inspired perhaps by the power of natural selection to produce fitness advantages that drive population persistence and biological diversity. In contrast, evolution has rarely been studied through the lens of adaptation's complement, maladaptation. This contrast is surprising because maladaptation is a prevalent feature of evolution: population trait values are rarely distributed optimally; local populations often have lower fitness than imported ones; populations decline; and local and global extinctions are common. Yet we lack a general framework for understanding maladaptation; for instance in terms of distribution, severity, and dynamics. Similar uncertainties apply to the causes of maladaptation. We suggest that incorporating maladaptation‐based perspectives into evolutionary biology would facilitate better understanding of the natural world. Approaches within a maladaptation framework might be especially profitable in applied evolution contexts – where reductions in fitness are common. Toward advancing a more balanced study of evolution, here we present a conceptual framework describing causes of maladaptation. As the introductory article for a Special Feature on maladaptation, we also summarize the studies in this Issue, highlighting the causes of maladaptation in each study. We hope that our framework and the papers in this Special Issue will help catalyze the study of maladaptation in applied evolution, supporting greater understanding of evolutionary dynamics in our rapidly changing world.
Multitasking is ubiquitous in our everyday life. Accordingly, situations in which two or more tasks need to be handled concurrently or in close temporal succession have been studied intensely. Different paradigms have been developed in that context (Koch et al., 2018). Over the last decades, the psychological refractory period (PRP) paradigm has dominated dual-task research, because it allows quantitative predictions of reaction time increases coupled to stimulus onset asynchrony. Part of the success of this paradigm is grounded in the fact that most of the studies are run under strict experimental control with very elementary tasks, mostly characterized by a definite start and ending. However, it remains unclear whether these limited settings sufficiently reflect the range of eventualities we find in real life. Rather, there is accumulating evidence that important factors modulating multitask performance are not sufficiently captured by the PRP approach. Here we focus on evidence that motor responses that involve continuous interaction with the environment may engage processes that alter the coordination of concurrently performed tasks in fundamental ways. ...
Among the causality assessment methods used for the diagnosis of drug-induced liver injury (DILI), Roussel Uclaf Causality Assessment Method (RUCAM) remains the most widely used not only for individual cases but also for prospective and retrospective studies worldwide. This first place is justified by the characteristics of the method such as precise definition and classification of the liver injury, which determines the right scale in the scoring system, precise definition of the seven criteria, and the validation approach based on cases with positive rechallenge. RUCAM is used not only for any types of drugs but also for herbal medicines causing herb-induced liver injury, (HILI) and dietary supplements. In 2016, the updated RUCAM provided further specifications of criteria and instructions to improve interobserver variability. Although this method was criticized for criteria such as the age and alcohol consumption, recent consensus meeting of experts has recognized their value and recommended their incorporation into any method. While early studies searching for DILI in large databases especially in electronic medical records were based on codes of diseases or natural language without causality assessment, the recommendation is now to include RUCAM in the search for DILI/HILI. There are still studies on DILI detection or the identification of biomarkers that take into consideration the cases assessed as “possible,” although it is well known that these cases reduce the strength of the association between the cases and the offending compound or the new biomarker to be validated. Attempts to build electronic RUCAM or automatized application of this method were successful despite some weaknesses to be corrected. In the future, more reflections are needed on an expert system to standardize the exclusion of alternative causes according to the clinical context. Education and training on RUCAM should be encouraged to improve the results of the studies and the day-to-day work in pharmacovigilance departments in companies or in regulatory agencies. It is also expected to improve RUCAM with biomarkers or other criteria provided that the validation process replaces expert opinion by robust standards such as those used for the original method.