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Transverse momentum spectra of π±, K± and p(p¯) up to pT = 20 GeV/c at mid-rapidity in pp and Pb-Pb collisions at sNN−−−√= 2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pion ratios both show a distinct peak at pT≈3GeV/c in central Pb-Pb collisions. Below the peak, pT < 3 GeV/c, both ratios are in good agreement with hydrodynamical calculations, suggesting that the peak itself is dominantly the result of radial flow rather than anomalous hadronization processes. For pT > 10 GeV/c particle ratios in pp and Pb-Pb collisions are in agreement and the nuclear modification factors for π±, K± and p(p¯) indicate that, within the systematic and statistical uncertainties, the suppression is the same. This suggests that the chemical composition of leading particles from jets in the medium is similar to that of vacuum jets.
We study forward-backward charge fluctuations to probe the correlations among produced particles in ultra relativistic heavy ion collisions. We develop a model that describes the forward-backward dynamical fluctuations and apply it to interpret the recent PHOBOS data. Within the present model, the dynamical fluctuations are related to the particle production mechanism via cluster decay and to long range correlations between the forward and backward rapidity hemispheres. We argue that with a tight centrality cut, PHOBOS may see a strong decrease of the dynamical fluctuations. Within the present model, this deterioration of the correlation among the produced hadrons can be interpreted as a sign for the production of a hot, dense and interacting medium.
Bacterial biosynthetic assembly lines, such as non-ribosomal peptide synthetases (NRPS) and polyketide synthases, are often subject of synthetic biology – because they produce a variety of natural products invaluable for modern pharmacotherapy. Acquiring the ability to engineer these biosynthetic assembly lines allows the production of artificial non-ribosomal peptides (NRP), polyketides, and hybrids thereof with new or improved properties. However, traditional bioengineering approaches have suffered for decades from their very limited applicability and, unlike combinatorial chemistry, are stigmatized as inefficient because they cannot be linked to the high-throughput screening platforms of the pharmaceutical industry. Although combinatorial chemistry can generate new molecules cheaper, faster, and in greater numbers than traditional natural product discovery and bioengineering approaches, it does not meet current medical needs because it covers only a limited biologically relevant chemical space. Hence, methods for high-throughput generation of new natural product-like compound libraries could provide a new avenue towards the identification of new lead compounds. To this end, prior to this work, we introduced an artificial synthetic NRPS type, referred to as type S NRPS, to provide a first-of-its-kind bicombinatorial approach to parallelized high-throughput NRP library generation. However, a bottleneck of these first two generations of type S NRPS was a significant drop in production yields. To address this issue, we applied an iterative optimization process that enabled titer increases of up to 55-fold compared to the non-optimized equivalents, restoring them to wild-type levels and beyond.
Welches der vielen Internet-Bezahlsysteme sich am Markt durchsetzen wird, hängt entscheidend von der „gefühlten Sicherheit“ bei den Kunden ab. Dieses Fazit konnte man Ende Juni 2002 zum Abschluss des Symposiums „Digitales Geld“ im Institut für Telematik ziehen. Weitere Voraussetzungen für den wirtschaftlichen Erfolg sind einfache Bedienung, transparente und bequeme Abwicklung sowie niedrige Kosten für Verbraucher und Anbieter, waren sich die 14 Referenten aus Wissenschaft, Wirtschaft und Verbänden einig. Das Symposium zur Sicherheit von Internet-Bezahlsystemen verfolgten rund 30 Teilnehmer vor Ort und mehr als 100 durch Live-Übertragung im World Wide Web. Die technischen Probleme - so wurde klar - sind mehr oder weniger alle gelöst. Offen bleibt die Frage, wie für das Verträgeschließen und Bezahlen im Internet mehr gesellschaftliche Akzeptanz und juristische Absicherung erreicht werden kann. Nach dem übereinstimmenden Urteil der meisten Referenten sind Internet-Bezahlsysteme „selbst für die technische Avantgarde“ noch zu kompliziert zu bedienen. Verständlich sei der Wunsch nach einheitlichen Standards. Noch immer stellten für die Kunden die Überweisung nach Rechnung (fast 90% der Internet- Käufer), die Lastschriftabbuchung (über 70%) und die Nachnahme-Zahlung (rund 65%) die beliebtesten Zahlverfahren beim Online-Shopping dar, betonten Marktforscher und Verbraucherschützer. Den größten Bedarf für neue Verfahren, die sinnvollerweise auf den vorhandenen Abrechnungsmechanismen aufbauen sollten, sahen die Symposiums-Teilnehmer im Bereich der Abrechnung von Klein(st)-Beträgen, wie sie beim Kauf digitaler Güter (Software, Musik, elektronische Dokumente usw.) anfallen. Um rentabel arbeiten zu können, seien hier aber die Sicherheitsanforderungen geringer. Mobiles Bezahlen per Handy werde sich in Zukunft immer mehr durchsetzen. Das Sicherheitsproblem liege hier in der „Luftschnittstelle“, so ein Experte, denn das Abhören von Mobilfunkverkehr sei in Europa besonders weit verbreitet. In jedem Fall - so hochrangige Vertreter der Finanzwirtschaft - haben Verfahren im E- und M-Commerce dann eine Chance, wenn sie auf den weltweit bewährten Transaktionsmechanismen beruhen.
We report about the properties of the underlying event measured with ALICE at the LHC in pp and p−Pb collisions at sNN−−−√=5.02 TeV. The event activity, quantified by charged-particle number and summed-pT densities, is measured as a function of the leading-particle transverse momentum (ptrigT). These quantities are studied in three azimuthal-angle regions relative to the leading particle in the event: toward, away, and transverse. Results are presented for three different pT thresholds (0.15, 0.5, and 1 GeV/c) at mid-pseudorapidity (|η|<0.8). The event activity in the transverse region, which is the most sensitive to the underlying event, exhibits similar behaviour in both pp and p−Pb collisions, namely, a steep increase with ptrigT for low ptrigT, followed by a saturation at ptrigT≈5 GeV/c. The results from pp collisions are compared with existing measurements at other centre-of-mass energies. The quantities in the toward and away regions are also analyzed after the subtraction of the contribution measured in the transverse region. The remaining jet-like particle densities are consistent in pp and p−Pb collisions for ptrigT>10 GeV/c, whereas for lower ptrigT values the event activity is slightly higher in p−Pb than in pp collisions. The measurements are compared with predictions from the PYTHIA 8 and EPOS LHC Monte Carlo event generators.
The ALICE collaboration at the LHC reports measurement of the inclusive production cross section of electrons from semi-leptonic decays of beauty hadrons with rapidity |y|<0.8 and transverse momentum 1<pT<10 GeV/c, in pp collisions at s√= 2.76 TeV. Electrons not originating from semi-electronic decay of beauty hadrons are suppressed using the impact parameter of the corresponding tracks. The production cross section of beauty decay electrons is compared to the result obtained with an alternative method which uses the distribution of the azimuthal angle between heavy-flavour decay electrons and charged hadrons. Perturbative QCD calculations agree with the measured cross section within the experimental and theoretical uncertainties. The integrated visible cross section, σb→e=3.47±0.40(stat)+1.12−1.33(sys)±0.07(norm)μb, was extrapolated to full phase space using Fixed Order plus Next-to-Leading Log (FONLL) predictions to obtain the total bb¯ production cross section, σbb¯=130±15.1(stat)+42.1−49.8(sys)+3.4−3.1(extr)±2.5(norm)±4.4(BR)μb.
The azimuthal (Δφ) correlation distributions between heavy-flavor decay electrons and associated charged particles are measured in pp and p−Pb collisions at sNN−−−√=5.02 TeV. Results are reported for electrons with transverse momentum 4<pT<16 GeV/c and pseudorapidity |η|<0.6. The associated charged particles are selected with transverse momentum 1<pT<7 GeV/c, and relative pseudorapidity separation with the leading electron |Δη|<1. The correlation measurements are performed to study and characterize the fragmentation and hadronization of heavy quarks. The correlation structures are fitted with a constant and two von Mises functions to obtain the baseline and the near- and away-side peaks, respectively. The results from p−Pb collisions are compared with those from pp collisions to study the effects of cold nuclear matter. In the measured trigger electron and associated particle kinematic regions, the two collision systems give consistent results. The Δφ distribution and the peak observables in pp and p−Pb collisions are compared with calculations from various Monte Carlo event generators.
The first measurement of the e+e− pair production at low lepton pair transverse momentum (pT,ee) and low invariant mass (mee) in non-central Pb−Pb collisions at sNN−−−√=5.02 TeV at the LHC is presented. The dielectron production is studied with the ALICE detector at midrapidity (|ηe|<0.8) as a function of invariant mass (0.4≤mee<2.7 GeV/c2) in the 50−70% and 70−90% centrality classes for pT,ee<0.1 GeV/c, and as a function of pT,ee in three mee intervals in the most peripheral Pb−Pb collisions. Below a pT,ee of 0.1 GeV/c, a clear excess of e+e− pairs is found compared to the expectations from known hadronic sources and predictions of thermal radiation from the medium. The mee excess spectra are reproduced, within uncertainties, by different predictions of the photon−photon production of dielectrons, where the photons originate from the extremely strong electromagnetic fields generated by the highly Lorentz-contracted Pb nuclei. Lowest-order quantum electrodynamic (QED) calculations, as well as a model that takes into account the impact-parameter dependence of the average transverse momentum of the photons, also provide a good description of the pT,ee spectra. The measured ⟨p2T,ee⟩−−−−−√ of the excess pT,ee spectrum in peripheral Pb−Pb collisions is found to be comparable to the values observed previously at RHIC in a similar phase-space region.
The measurement of the production of charm jets, identified by the presence of a D0 meson in the jet constituents, is presented in proton-proton collisions at centre-of-mass energies of s√ = 5.02 and 13 TeV with the ALICE detector at the CERN LHC. The D0 mesons were reconstructed from their hadronic decay D0→K−π+ and the respective charge conjugate. Jets were reconstructed from D0-meson candidates and charged particles using the anti-kT algorithm, in the jet transverse momentum range 5<pT;chjet<50 GeV/c, pseudorapidity |ηjet|<0.9−R, and with the jet resolution parameters R = 0.2, 0.4, 0.6. The distribution of the jet momentum fraction carried by a D0 meson along the jet axis (zch||) was measured in the range 0.4<zch||<1.0 in four ranges of the jet transverse momentum. Comparisons of results for different collision energies and jet resolution parameters are also presented. The measurements are compared to predictions from Monte Carlo event generators based on leading-order and next-to-leading-order perturbative quantum chromodynamics calculations. A generally good description of the main features of the data is obtained in spite of a few discrepancies at low pT;chjet. Measurements were also done for R=0.3 at s√ = 5.02 TeV and are shown along with their comparisons to theoretical predictions in an appendix to this paper.
The azimuthal (Δφ) correlation distributions between heavy-flavor decay electrons and associated charged particles are measured in pp and p−Pb collisions at sNN−−−√=5.02 TeV. Results are reported for electrons with transverse momentum 4<pT<16 GeV/c and pseudorapidity |η|<0.6. The associated charged particles are selected with transverse momentum 1<pT<7 GeV/c, and relative pseudorapidity separation with the leading electron |Δη|<1. The correlation measurements are performed to study and characterize the fragmentation and hadronization of heavy quarks. The correlation structures are fitted with a constant and two von Mises functions to obtain the baseline and the near- and away-side peaks, respectively. The results from p−Pb collisions are compared with those from pp collisions to study the effects of cold nuclear matter. In the measured trigger electron and associated particle kinematic regions, the two collision systems give consistent results. The Δφ distribution and the peak observables in pp and p−Pb collisions are compared with calculations from various Monte Carlo event generators.
A newly developed observable for correlations between symmetry planes, which characterize the direction of the anisotropic emission of produced particles, is measured in Pb-Pb collisions at sNN−−−√=2.76 TeV with ALICE. This so-called Gaussian Estimator allows for the first time the study of these quantities without the influence of correlations between different flow amplitudes. The centrality dependence of various correlations between two, three and four symmetry planes is presented. The ordering of magnitude between these symmetry plane correlations is discussed and the results of the Gaussian Estimator are compared with measurements of previously used estimators. The results utilizing the new estimator lead to significantly smaller correlations than reported by studies using the Scalar Product method. Furthermore, the obtained symmetry plane correlations are compared to state-of-the-art hydrodynamic model calculations for the evolution of heavy-ion collisions. While the model predictions provide a qualitative description of the data, quantitative agreement is not always observed, particularly for correlators with significant non-linear response of the medium to initial state anisotropies of the collision system. As these results provide unique and independent information, their usage in future Bayesian analysis can further constrain our knowledge on the properties of the QCD matter produced in ultrarelativistic heavy-ion collisions.
Measurements of the elliptic flow coefficient relative to the collision plane defined by the spectator neutrons v2{ΨSP} in collisions of Pb ions at center-of-mass energy per nucleon-nucleon pair sNN−−−√=2.76 TeV and Xe ions at sNN−−−√=5.44 TeV are reported. The results are presented for charged particles produced at midrapidity as a function of centrality and transverse momentum. The ratio between v2{ΨSP} and the elliptic flow coefficient relative to the participant plane v2{4}, estimated using four-particle correlations, deviates by up to 20% from unity depending on centrality. This observation differs strongly from the magnitude of the corresponding eccentricity ratios predicted by the TRENTo and the elliptic power models of initial state fluctuations that are tuned to describe the participant plane anisotropies. The differences can be interpreted as a decorrelation of the neutron spectator plane and the reaction plane because of fragmentation of the remnants from the colliding nuclei, which points to an incompleteness of current models of initial state fluctuations. A significant transverse momentum dependence of the ratio v2{ΨSP}/v2{4} is observed in all but the most central collisions, which may help to understand whether momentum anisotropies at low and intermediate transverse momentum have a common origin in initial state fluctuations. The ratios of v2{ΨSP} and v2{4} to the corresponding initial state eccentricities for Xe-Xe and Pb-Pb collisions at similar initial entropy density show a difference of (7.0±0.9)% with an additional variation of +1.8% when including RHIC data in the TRENTo parameter extraction. These observations provide new experimental constraints for viscous effects in the hydrodynamic modeling of the expanding quark-gluon plasma.
This article presents new measurements of the fragmentation properties of jets in both proton-proton (pp) and heavy-ion collisions with the ALICE experiment at the Large Hadron Collider (LHC). We report distributions of the fraction zr of transverse momentum carried by subjets of radius r within jets of radius R. Charged-particle jets are reconstructed at midrapidity using the anti-kT algorithm with jet radius R=0.4, and subjets are reconstructed by reclustering the jet constituents using the anti-kT algorithm with radii r=0.1 and r=0.2. In proton-proton collisions, we measure both the inclusive and leading subjet distributions. We compare these measurements to perturbative calculations at next-to-leading logarithmic accuracy, which suggest a large impact of threshold resummation and hadronization effects on the zr distribution. In heavy-ion collisions, we measure the leading subjet distributions, which allow access to a region of harder jet fragmentation than has been probed by previous measurements of jet quenching via hadron fragmentation distributions. The zr distributions enable extraction of the parton-to-subjet fragmentation function and allow for tests of the universality of jet fragmentation functions in the quark-gluon plasma (QGP). We find indications that there is a turnover in the ratio between the distributions in Pb-Pb and pp collisions as zr→1, exposing qualitatively new possibilities to disentangle competing jet quenching mechanisms. By comparing our results to theoretical calculations based on an independent extraction of the parton-to-jet fragmentation function, we find consistency with the universality of jet fragmentation and no indication of factorization breaking in the QGP.
The production yields of non-prompt Ds+ mesons, namely Ds+ mesons from beauty-hadron decays, were measured for the first time as a function of the transverse momentum (pT) at midrapidity (|y|<0.5) in central and semi-central Pb−Pb collisions at a centre-of-mass energy per nucleon pair sNN−−−√=5.02 TeV with the ALICE experiment at the LHC. The Ds+ mesons and their charge conjugates were reconstructed from the hadronic decay channel Ds+→ϕπ+, with ϕ→K−K+, in the 4<pT<36 GeV/c and 2<pT<24 GeV/c intervals for the 0−10% and 30−50% centrality classes, respectively. The measured yields of non-prompt Ds+ mesons are compared to those of prompt Ds+ and non-prompt D0 mesons by calculating the ratios of the production yields in Pb−Pb collisions and the nuclear modification factor RAA. The ratio between the RAA of non-prompt Ds+ and prompt Ds+ mesons, and that between the RAA of non-prompt Ds+ and non-prompt D0 mesons in central Pb−Pb collisions are found to be on average higher than unity in the 4<pT<12 GeV/c interval with a statistical significance of about 1.6σ and 1.7σ, respectively. The measured RAA ratios are compared with the predictions of theoretical models of heavy-quark transport in a hydrodynamically expanding QGP that incorporate hadronisation via quark recombination.
Charmonium production in pp collisions at center-of-mass energy of s√ = 13 TeV and p-Pb collisions at center-of-mass energy per nucleon pair of sNN−−−√ = 8.16 TeV is studied as a function of charged-particle pseudorapidity density with ALICE. Ground and excited charmonium states (J/ψ, ψ(2S)) are measured from their dimuon decays in the interval of rapidity in the center-of-mass frame 2.5<ycms<4.0 for pp collisions, and 2.03<ycms<3.53 and −4.46<ycms<−2.96 for p-Pb collisions. The charged-particle pseudorapidity density is measured around midrapidity (|η|<1.0). In pp collisions, the measured charged-particle multiplicity extends to about six times the average value, while in p-Pb collisions at forward (backward) rapidity a multiplicity corresponding to about three (four) times the average is reached. The ψ(2S) yield increases with the charged-particle pseudorapidity density. The ratio of ψ(2S) over J/ψ yield does not show a significant multiplicity dependence in either colliding system, suggesting a similar behavior of J/ψ and ψ(2S) yields with respect to charged-particle pseudorapidity density. The results are also compared with model calculations.
The first experimental information on the strong interaction between Λ and Ξ− strange baryons is presented in this Letter. The correlation function of Λ−Ξ− and Λ¯¯¯¯−Ξ¯¯¯¯+ pairs produced in high-multiplicity proton-proton (pp) collisions at s√ = 13 TeV at the LHC is measured as a function of the relative momentum of the pair. The femtoscopy method is used to calculate the correlation function, which is then compared with theoretical expectations obtained using a meson exchange model, chiral effective field theory, and Lattice QCD calculations close to the physical point. Data support predictions of small scattering parameters while discarding versions with large ones, thus suggesting a weak Λ−Ξ− interaction. The limited statistical significance of the data does not yet allow one to constrain the effects of coupled channels like Σ−Ξ and N−Ω.
Two-particle transverse momentum differential correlators, recently measured in Pb--Pb collisions at energies available at the CERN Large Hadron Collider (LHC), provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb-Pb collisions. The longitudinal long-range correlations and the large azimuthal anisotropy measured at low transverse momenta in small collision systems, namely pp and p-Pb, at LHC energies resemble manifestations of collective behaviour. This suggests that locally equilibrated matter may be produced in these small collision systems, similar to what is observed in Pb-Pb collisions. In this work, the same two-particle transverse momentum differential correlators are exploited in pp and p-Pb collisions at √s=7 TeV and sNN−−−√=5.02 TeV, respectively, to seek evidence for viscous effects. Specifically, the strength and shape of the correlators are studied as a function of the produced particle multiplicity to identify evidence for longitudinal broadening that might reveal the presence of viscous effects in these smaller systems. The measured correlators and their evolution from pp and p--Pb to Pb--Pb collisions are additionally compared to predictions from Monte Carlo event generators, and the potential presence of viscous effects is discussed.
Jet-like correlations with respect to K0S and Λ (Λ‾) in pp and Pb–Pb collisions at √sNN = 5.02 TeV
(2022)
Two-particle correlations with K0S, Λ/Λ¯, and charged hadrons as trigger particles in the transverse momentum range 8<pT,trig<16 GeV/c, and associated charged particles within 1<pT,assoc<8 GeV/c, are studied at mid-rapidity in pp and central Pb-Pb collisions at a centre-of-mass energy per nucleon-nucleon collision sNN−−−√=5.02 TeV with the ALICE detector at the LHC. After subtracting the contributions of the flow background, the per-trigger yields are extracted on both the near and away sides, and the ratio in Pb-Pb collisions with respect to pp collisions (IAA) is computed. The per-trigger yield in Pb-Pb collisions on the away side is strongly suppressed to the level of IAA≈0.6 for pT,assoc>3 GeV/c as expected from strong in-medium energy loss, while an enhancement develops at low pT,assoc on both the near and away sides, reaching IAA≈1.8 and 2.7 respectively. These findings are in good agreement with previous ALICE measurements from two-particle correlations triggered by neutral pions (π0-h) and charged hadrons (h-h) in Pb-Pb collisions at sNN−−−√=2.76 TeV. Moreover, the correlations with K0S mesons and Λ/Λ¯ baryons as trigger particles are compared to those of inclusive charged hadrons. The results are compared with the predictions of Monte Carlo models.
The measurement of the production of deuterons, tritons and 3He and their antiparticles in Pb-Pb collisions at sNN−−−√=5.02 TeV is presented in this article. The measurements are carried out at midrapidity (|y|< 0.5) as a function of collision centrality using the ALICE detector. The pT-integrated yields, the coalescence parameters and the ratios to protons and antiprotons are reported and compared with nucleosynthesis models. The comparison of these results in different collision systems at different centre-of-mass collision energies reveals a suppression of nucleus production in small systems. In the Statistical Hadronisation Model framework, this can be explained by a small correlation volume where the baryon number is conserved, as already shown in previous fluctuation analyses. However, a different size of the correlation volume is required to describe the proton yields in the same data sets. The coalescence model can describe this suppression by the fact that the wave functions of the nuclei are large and the fireball size starts to become comparable and even much smaller than the actual nucleus at low multiplicities.
The pseudorapidity density of charged particles with minimum transverse momentum (pT) thresholds of 0.15, 0.5, 1, and 2 GeV/c was measured in pp collisions at centre-of-mass energies of √s = 5.02 and 13 TeV with the ALICE detector. The study is carried out for inelastic collisions with at least one primary charged particle having a pseudorapidity (η) within ±0.8 and pT larger than the corresponding threshold. The measurements were also performed for inelastic and non-single-diffractive events as well as for inelastic events with at least one charged particle having |η| < 1 in pp collisions at √s = 5.02 TeV for the first time at the LHC. The measurements are compared to the PYTHIA 6, PYTHIA 8, and EPOS-LHC models. In general, the models describe the pseudorapidity dependence of particle production well, however, discrepancies are observed for event classes including diffractive events and for the highest transverse momentum threshold (pT > 2 GeV/c), highlighting the importance of such measurements for tuning event generators. The new measurements agree within uncertainties with results from the ATLAS and CMS experiments.