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Hot hypernuclear matter is investigated in an explicit SU(3) quark model based on a mean field description of nonoverlapping baryon bags bound by the self-consistent exchange of scalar sigma, zeta and vector omega,phi mesons. The sigma, omega mean fields are assumed to couple to the u, d-quarks while the zeta ,phi mean fields are coupled to the s-quark. The coupling constants of the mean fields with the quarks are assumed to satisfy SU(6) symmetry. The calculations take into account the medium dependence of the bag parameter on the scalar fields sigma, zeta. We consider only the octet baryons N,Lambda,Sigma, Xi in hypernuclear matter. An ideal gas of the strange mesons K and K is introduced to keep zero net strangeness density. Our results for symmetric hypernuclear matter show that a phase transition takes place at a critical temperature around 180 MeV in which the scalar mean fields sigma, zeta take nonzero values at zero baryon density. Furthermore, the bag contants of the baryons decrease significantly at and above this critical temperature indicating the onset of quark deconfinement. The present results imply that the onset of quark deconfinement in SU(3) hypernuclear matter is much stronger than in SU(2) nuclear matter. PACS:21.65.+f, 24.85.+p, 12.39Ba
Irreversibility, steady state, and nonequilibrium physics in relativistic heavy ion collisions
(1999)
Heavy ion collisions at ultrarelativistic energies offer the opportunity to study the irreversibility of multiparticle processes. Together with the many-body decays of resonances, the multiparticle processes cause the system to evolve according to Prigogine s steady states rather than towards statistical equilibrium. These results are general and can be easily checked by any microscopic string-, transport-, or cascade model for heavy ion collisions. The absence of pure equilibrium states sheds light on the di culties of thermal models in describing the yields and spectra of hadrons, especially mesons, in heavy ion collisions at bombarding energies above 10 GeV/nucleon. PACS numbers: 25.75.-q, 05.70.Ln, 24.10.Lx
Homogeneous nucleation of quark gluon plasma, finite size effects and longlived metastable objects
(1998)
The general formalism of homogeneous nucleation theory is applied to study the hadronization pattern of the ultra-relativistic quark-gluon plasma (QGP) undergoing a first order phase transition. A coalescence model is proposed to describe the evolution dynamics of hadronic clusters produced in the nucle- ation process. The size distribution of the nucleated clusters is important for the description of the plasma conversion. The model is most sensitive to the initial conditions of the QGP thermalization, time evolution of the energy den- sity, and the interfacial energy of the plasma hadronic matter interface. The rapidly expanding QGP is first supercooled by about T = T Tc = 4 6%. Then it reheats again up to the critical temperature Tc. Finally it breaks up into hadronic clusters and small droplets of plasma. This fast dynamics occurs within the first 5 10 fm/c. The finite size e ects and fluctuations near the critical temperature are studied. It is shown that a drop of longitudinally expanding QGP of the transverse radius below 4.5 fm can display a long-lived metastability. However, both in the rapid and in the delayed hadronization scenario, the bulk pion yield is emitted by sources as large as 3 4.5 fm. This may be detected experimentally both by a HBT interferometry signal and by the analysis of the rapidity distributions of particles in narrow pT -intervals at small |pT | on an event-by-event basis. PACS numbers: 12.38.Mh, 24.10.Pa, 25.75.-q, 64.60.Qb
We reexamine the scenario of homogeneous nucleation of the quark-gluon plasma produced in ultra-relativistic heavy ion collisions. A generalization of the standard nucleation theory to rapidly expanding system is proposed. The nucleation rate is derived via the new scaling parameter Z. It is shown that the size distribution of hadronic clusters plays an important role in the dynamics of the phase transition. The longitudinally expanding system is supercooled to about 3 6%, then it is reheated, and the hadronization is completed within 6 10 fm/c, i.e. 5 10 times faster than it was estimated earlier, in a strongly nonequilibrium way. PACS: 12.38.Mh; 12.39.Ba; 25.75.-q; 64.60.Qb
Release of neuropeptides from dense core vesicles (DCVs) is essential for neuromodulation. Compared to the release of small neurotransmitters, much less is known about the mechanisms and proteins contributing to neuropeptide release. By optogenetics, behavioral analysis, electrophysiology, electron microscopy, and live imaging, we show that synapsin SNN-1 is required for cAMP-dependent neuropeptide release in Caenorhabditis elegans hermaphrodite cholinergic motor neurons. In synapsin mutants, behaviors induced by the photoactivated adenylyl cyclase bPAC, which we previously showed to depend on acetylcholine and neuropeptides (Steuer Costa et al., 2017), are altered like in animals with reduced cAMP. Synapsin mutants have slight alterations in synaptic vesicle (SV) distribution, however, a defect in SV mobilization was apparent after channelrhodopsin-based photostimulation. DCVs were largely affected in snn-1 mutants: DCVs were ∼30% reduced in synaptic terminals, and not released following bPAC stimulation. Imaging axonal DCV trafficking, also in genome-engineered mutants in the serine-9 protein kinase A phosphorylation site, showed that synapsin captures DCVs at synapses, making them available for release. SNN-1 co-localized with immobile, captured DCVs. In synapsin deletion mutants, DCVs were more mobile and less likely to be caught at release sites, and in non-phosphorylatable SNN-1B(S9A) mutants, DCVs traffic less and accumulate, likely by enhanced SNN-1 dependent tethering. Our work establishes synapsin as a key mediator of neuropeptide release.
Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs
(2022)
As essential components of the cellular protein synthesis machineries, tRNAs undergo a tightly controlled biogenesis process, which include the incorporation of a large number of posttranscriptional chemical modifications. Maturation defaults resulting in lack of modifications in the tRNA core may lead to the degradation of hypomodified tRNAs by the rapid tRNA decay (RTD) and nuclear surveillance pathways. Although modifications are typically introduced in tRNAs independently of each other, several modification circuits have been identified in which one or more modifications stimulate or repress the incorporation of others. We previously identified m1A58 as a late modification introduced after more initial modifications, such as Ѱ55 and T54 in yeast elongator tRNAPhe. However, previous reports suggested that m1A58 is introduced early along the tRNA modification process, with m1A58 being introduced on initial transcripts of initiator tRNAiMet, and hence preventing its degradation by the nuclear surveillance and RTD pathways. Here, aiming to reconcile this apparent inconsistency on the temporality of m1A58 incorporation, we examined the m1A58 modification pathways in yeast elongator and initiator tRNAs. For that, we first implemented a generic approach enabling the preparation of tRNAs containing specific modifications. We then used these specifically modified tRNAs to demonstrate that the incorporation of T54 in tRNAPhe is directly stimulated by Ѱ55, and that the incorporation of m1A58 is directly and individually stimulated by Ѱ55 and T54, thereby reporting on the molecular aspects controlling the Ѱ55 → T54 → m1A58 modification circuit in yeast elongator tRNAs. We also show that m1A58 is efficiently introduced on unmodified tRNAiMet, and does not depend on prior modifications. Finally, we show that the m1A58 single modification has tremendous effects on the structural properties of yeast tRNAiMet, with the tRNA elbow structure being properly assembled only when this modification is present. This rationalizes on structural grounds the degradation of hypomodified tRNAiMet lacking m1A58 by the nuclear surveillance and RTD pathways.
Layered {\alpha}-RuCl3 is a promising material to potentially realize the long-sought Kitaev quantum spin liquid with fractionalized excitations. While evidence of this exotic state has been reported under a modest in-plane magnetic field, such behavior is largely inconsistent with theoretical expectations of Kitaev phases emerging only in out-of-plane fields. These predicted field-induced states have been mostly out of reach due to the strong easy-plane anisotropy of bulk crystals, however. We use a combination of tunneling spectroscopy, magnetotransport, electron diffraction, and ab initio calculations to study the layer-dependent magnons, anisotropy, structure, and exchange coupling in atomically thin samples. Due to structural distortions, the sign of the average off-diagonal exchange changes in monolayer {\alpha}-RuCl3, leading to a reversal of magnetic anisotropy to easy-axis. Our work provides a new avenue to tune the magnetic interactions in {\alpha}-RuCl3 and allows theoretically predicted quantum spin liquid phases for out-of-plane fields to be more experimentally accessible.
Ribosomes catalyze protein synthesis by cycling through various functional states. These states have been extensively characterized in vitro, yet their distribution in actively translating human cells remains elusive. Here, we optimized a cryo-electron tomography-based approach and resolved ribosome structures inside human cells with a local resolution of up to 2.5 angstroms. These structures revealed the distribution of functional states of the elongation cycle, a Z tRNA binding site and the dynamics of ribosome expansion segments. In addition, we visualized structures of Homoharringtonine, a drug for chronic myeloid leukemia treatment, within the active site of the ribosome and found that its binding reshaped the landscape of translation. Overall, our work demonstrates that structural dynamics and drug effects can be assessed at near-atomic detail within human cells.
The maximum recoverable strain of most crystalline solids is less than 1% because plastic deformation or fracture usually occurs at a small strain. In this work, we show that a SrNi2P2 micropillar exhibits pseudoelasticity with a large maximum recoverable strain of ~14% under uniaxial compression via unique reversible structural transformation, double lattice collapse-expansion that is repeatable under cyclic loading. Its high yield strength (~3.8±0.5 GPa) and large maximum recoverable strain bring out the ultrahigh modulus of resilience (~146±19MJ/m3) a few orders of magnitude higher than that of most engineering materials. The double lattice collapse-expansion mechanism shows stress-strain behaviors similar with that of conventional shape memory alloys, such as hysteresis and thermo-mechanical actuation, even though the structural changes involved are completely different. Our work suggests that the discovery of a new class of high performance ThCr2Si2-structured materials will open new research opportunities in the field of pseudoelasticity
Liebesbriefe von Kindern, Jugendlichen und Erwachsenen : eine Textsorte im lebenszeitlichen Wandel
(2003)
Das Alter als soziolinguistische und – mit Bezug auf die Historizität des sozialen Alltags – als sozialhistorische Grösse ist in seiner Wirkung auf die Gestaltung des Liebesbriefs wenig offensichtlich. Unbestritten dürfte aber wohl sein, dass nicht alterslose Menschen einander Liebesbriefe schreiben. Und – Alter prägt, wie dies die hier vorliegende empirische Analyse zeigen wird, die Textsorte Liebesbrief vielleicht stärker als gemeinhin angenommen. Bereits die Briefstellerliteratur der Jahrhundertwende zeigt deutlich eine Altersspezifik der Sprache des Liebesbriefs. ...
Der Liebesbrief des 20. Jahrhunderts ist Ausdruck einer konkreten lebensweltlichen und historisch zu verortenden Praxis der Liebeskommunikation. Liebesbriefe sind Brautbriefe, Liebesbekenntnisse, Berichte aus dem Alltag, Soldatenbriefe, Vereinbarungen von Treffen, E-Mail-Korrespondenzen, Flirtbriefe und Zettelchen – es gibt eine reiche Palette an Funktionen und Typen. Im Hinblick auf eine Geschichte des Liebesbriefs im 20. Jahrhunderts zeigte sich, dass im Liebesbrief neben der Liebeserklärung auch „Beziehungsarbeit“ und besonders aber die Konstruktion von Intimität eine zentrale Rolle spielt. Die Kritik an der Sprache der Liebe und des Liebesbriefs (des 19. Jahrhunderts) kann bereits in den 1920er Jahren beobachtet werden. Zu einem Codewechsel kommt es in Briefen der 1960er Jahre. Die Schriftlichkeit des Liebesbriefs entfernt sich allmählich von einer ausschließlichen Schreibschriftlichkeit. Der Liebesbrief wird mehr und mehr zu einem Sprache-Bild-Text. Die neuen Medien der Liebesschriftlichkeit zeigen eine Mediatisierung auch im Bereich des Liebesdiskurses: neben neuen Liebesbrieftypen, wie dem Flirtbrief, bilden sich neue Liebesbeziehungstypen heraus. Darüber hinaus fungieren die neuen Medien immer schon selbstreflexiv als Metakommunikatoren der Modernität.
Klugheit wird gemeinhin als das Gegenteil von Torheit aufgefasst. Auf diese Weise erfährt sie eine sprachlich vorstrukturierte positive Bewertung und erhält einen ausgezeichneten gesellschaftlichen Status. "Positiv" bedeutet eine Verknüpfung mit spezifischen je gesellschaftlich richtigen Wertmassstäben, die aber in unterschiedlichen Milieus und Regionen durchaus verschieden ausfallen. Diese bilden den impliziten Subtext für die alltägliche Zuschreibung von "Klugheit". Klugheit fokussiert das Verhalten der Menschen, die Handlungen, die Performanz. Klugheit wird denjenigen Personen zugeschrieben, die "das Richtige" tun, und nachdem sie das Richtige getan haben, etabliert sich erst das Kriterium für die Richtigkeit dieser Beurteilung: der Ausgang der Geschichte. Klugheit wird zwar im vornhinein behauptet, stellt sich aber erst im Nachhinein heraus: denn sie misst sich nicht an der vorgeführten Handlung selbst, sondern am Ausgang der "Geschichte". Eine Bauerntochter handelt dann klug, wenn ihre Handlungen zu einem – im Sinne des Erzählers – guten Ende führen, zu einem Happy-End sozusagen. ...
Während der Brief in Zeiten von persönlichen Krisen und Konflikten mancherlei Unannehmlichkeiten aus dem Kommunikationsweg räumt, stellt der Kontext Krieg für das Briefeschreiben in vielerlei Hinsicht eine Herausforderung dar. Der Privatbrief (Epistula familiaris) ist in der ersten Hälfte des 20. Jahrhunderts in Westeuropa – das heisst auch zur Zeit des 2. Weltkriegs – das wichtigste Medium informeller Distanzkommunikation, welche im Allgemeinen durch Inoffizialität und Spontaneität, durch Individualität und Vertraulichkeit gekennzeichnet ist. In der Regel ist der Privatbrief im juristischen Sinne nicht verfügbar. Ein Kennzeichen ist somit auch seine Nichtreproduzierbarkeit. Neben der thematischen Offenheit macht sich meist eine stärkere stilistische Freiheit bemerkbar. Zeichen von Flüchtigkeit oder Sorgfalt sind ausser den Formalia des Datums, der Anrede, des Textkörpers und der Unterschrift, über das geschriebene Wort hinaus nonverbale Informationen wie die Lesbarkeit der Schrift, die Wahl des Papiers, Schreibwerkzeug sowie die Länge eines Briefes (vgl. Ermert 1979, Nickisch 1991, Beyer/ Täubrich 1996, Zott 2003). Der Privatbrief wird zwar im graphischen Medium der Schrift realisiert, steht aber stilistisch der konzeptionellen "Mündlichkeit" näher. (Koch/ Oesterreicher 1994, 587) Der private Briefwechsel wird spontan aufgenommen und kann in der Regel ohne Zwang abgebrochen werden (vgl. Zott 2003). ...
Die Ressource "Wissen" rückte in den letzten Jahrzehnten als Quelle wissenschaftlicher Innovation immer stärker ins Zentrum des Interesses. Diese Fokussierung mündete in eine Selbstreflexion der Wissenschaft und der wissenschaftlichen Disziplinen: Thematisiert werden vor allem die Art und Weise, wie Wissen gewonnen wird, sowie die damit zusammenhängende Frage nach der Konstruktion von Wissenschaftlichkeit, womit das Bewusstsein gleichzeitig auf die mehr und mehr sich auflösende Abgrenzung zwischen den Disziplinen beziehungsweise zwischen den drei hauptsächlichen Wissenschaftskulturen, von Natur-, Geistes- und Kultur- sowie Sozialwissenschaften gelenkt wird. Innerhalb und außerhalb der Universitäten bildeten und bilden sich nicht immer klar verortbare "trading zones" (Gallison 1997), in denen neue Formen und Techniken der Wissensproduktion und Wissensvermittlung geprüft, geübt und teilweise auch institutionalisiert werden. ...
We compute bremsstrahlung arising from the acceleration of individual charged baryons and mesons during the time evolution of high-energy Au+Au collisions at the Relativistic Heavy Ion Collider using a microscopic transport model. We elucidate the connection between bremsstrahlung and charge stop- ping by colliding artificial pure proton on pure neutron nuclei. From the inten- sity of low energy bremsstrahlung, the time scale and the degree of stopping could be accurately extracted without measuring any hadronic observables. PACS: 25.75.-q, 13.85.Qk
The snake pipefish, Entelurus aequoreus (Linnaeus, 1758), is a slender, up to 60 cm long, northern Atlantic fish that dwells in open seagrass habitats and has recently expanded its distribution range. The snake pipefish is part of the family Syngnathidae (seahorses and pipefish) that has undergone several characteristic morphological changes, such as loss of pelvic fins and elongated snout. Here, we present a highly contiguous, near chromosome-scale genome of the snake pipefish assembled as part of a university master’s course. The final assembly has a length of 1.6 Gbp in 7,391 scaffolds, a scaffold and contig N50 of 62.3 Mbp and 45.0 Mbp and L50 of 12 and 14, respectively. The largest 28 scaffolds (>21 Mbp) span 89.7% of the assembly length. A BUSCO completeness score of 94.1% and a mapping rate above 98% suggest a high assembly completeness. Repetitive elements cover 74.93% of the genome, one of the highest proportions so far identified in vertebrate genomes. Demographic modeling using the PSMC framework indicates a peak in effective population size (50 – 100 kya) during the last interglacial period and suggests that the species might largely benefit from warmer water conditions, as seen today. Our updated snake pipefish assembly forms an important foundation for further analysis of the morphological and molecular changes unique to the family Syngnathidae.
All giraffe (Giraffa) were previously assigned to a single species (G. Camelopardalis) and nine subspecies. However, multi-locus analyses of all subspecies have shown that there are four genetically distinct clades and suggest four giraffe species. This conclusion might not be fully accepted due to limited data and lack of explicit gene flow analyses. Here we present an extended study based on 21 independent nuclear loci from 137 individuals. Explicit gene flow analyses identify less than one migrant per generation, including between the closely related northern and reticulated giraffe. Thus, gene flow analyses and population genetics of the extended dataset confirm four genetically distinct giraffe clades and support four independent giraffe species. The new findings call for a revision of the IUCN classification of giraffe taxonomy. Three of the four species are threatened with extinction, mostly occurring in politically unstable regions, and as such, require the highest conservation support possible.
Background: Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, Major Depressive Disorder (MDD), patients only marginally differ from healthy individuals on the group-level. Whether Precision Psychiatry can solve this discrepancy and provide specific, reliable biomarkers remains unclear as current Machine Learning (ML) studies suffer from shortcomings pertaining to methods and data, which lead to substantial over-as well as underestimation of true model accuracy.
Methods: Addressing these issues, we quantify classification accuracy on a single-subject level in N=1,801 patients with MDD and healthy controls employing an extensive multivariate approach across a comprehensive range of neuroimaging modalities in a well-curated cohort, including structural and functional Magnetic Resonance Imaging, Diffusion Tensor Imaging as well as a polygenic risk score for depression.
Findings Training and testing a total of 2.4 million ML models, we find accuracies for diagnostic classification between 48.1% and 62.0%. Multimodal data integration of all neuroimaging modalities does not improve model performance. Similarly, training ML models on individuals stratified based on age, sex, or remission status does not lead to better classification. Even under simulated conditions of perfect reliability, performance does not substantially improve. Importantly, model error analysis identifies symptom severity as one potential target for MDD subgroup identification.
Interpretation: Although multivariate neuroimaging markers increase predictive power compared to univariate analyses, single-subject classification – even under conditions of extensive, best-practice Machine Learning optimization in a large, harmonized sample of patients diagnosed using state-of-the-art clinical assessments – does not reach clinically relevant performance. Based on this evidence, we sketch a course of action for Precision Psychiatry and future MDD biomarker research.
Background Vasoplegic syndrome is frequently observed during cardiac surgery and resembles a complication of high mortality and morbidity. There is a clinical need for therapy and prevention of vasoplegic syndrome during complex cardiac surgical procedures. Therefore, we investigated different strategies in a porcine model of vasoplegia.
Methods We evaluated new medical therapies and prophylaxis to avoid vasoplegic syndrome in a porcine model. After induction of anesthesia, cardiopulmonary bypass was established through median sternotomy and central cannulation. Prolonged aortic cross-clamping (120 min) simulated a complex surgical procedure. The influence of sevoflurane-guided anesthesia (sevoflurane group) and the administration of glibenclamide (glibenclamide group) were compared to a control group, which received standard anesthesia using propofol. Online hemodynamic assessment was performed using PiCCO® measurements. In addition, blood and tissue samples were taken to evaluate hemodynamic effects and the degree of inflammatory response.
Results Glibenclamide was able to break through early vasoplegic syndrome by raising the blood pressure and systemic vascular resistance as well as less need of norepinephrine doses. Sevoflurane reduced the occurrence of the vasoplegic syndrome in the mean of stable blood pressure and less need of norepinephrine doses.
Conclusion Glibenclamide could serve as a potent drug to reduce effects of vasoplegic syndrome. Sevoflurane anesthesia during cardiopulmonary bypass shows less occurrence of vasoplegic syndrome and therefore could be used to prevent it in high-risk patients.
Clinical Perspective; what is new?
* to our knowledge, this is the first randomized in vivo study evaluating the hemodynamic effects of glibenclamide after the onset of vasoplegic syndrome
* furthermore according to literature research, there is no study showing the effect of sevoflurane-guided anesthesia on the occurrence of a vasoplegic syndrome
Clinical Perspective; clinical implications?
to achieve better outcomes after complex cardiac surgery there is a need for optimized drug therapy and prevention of the vasoplegic syndrome
In this work, the phase diagram of the 2+1-dimensional Gross-Neveu model is investigated with baryon chemical potential as well as chiral chemical potential in the mean-field approximation. We study the theory using two lattice discretizations, which are both based on naive fermions. An inhomogeneous chiral phase is observed only for one of the two discretizations. Our results suggest that this phase disappears in the continuum limit.