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Im Gegensatz zu den anderen Wirbeltieren spielt sich das Leben der Fische ausschließlich im Wasser ab und bleibt den Blicken des Menschen verborgen. Systematische Arterfassungen werden erst seit jüngerer Zeit durchgeführt, aber jede Methode der Bestandserfassung liefert nur ein unvollkommenes Bild. Daher blieb es auch lange Zeit unbekannt, dass etliche Fischarten nur noch in geringen Restbeständen vorkommen, einige sogar völlig verschwunden sind. Als diese Situation bekannt wurde (Paepke 1981), erregte sie kaum Aufmerksamkeit. Erst in den 1980er Jahren begannen auch im heutigen Sachsen-Anhalt Fischkundler mit der systematischen Erfassung der Vorkommen von Fischen und Rundmäulern (Engelke 1988, Wüstemann 1989, Zuppke 1986). Nach 1990 wurden diese Bemühungen dank der Verfügbarkeit effektiverer Fanggeräte intensiviert.
Typisch für die 'Theaterfigur' ist, dass der an der Rolle ausgerichtete Entwurf Ausgangspunkt ihrer Gestaltung ist. Welchen Charakter soll sie verkörpern? Welche Bewegungen muss sie zulassen? Wie soll sie wirken? Überlegungen, wie sie auch bei der Besetzung einer Rolle mit einem menschlichen Darsteller maßgeblich sind. Bei der 'Theaterfigur' wird der Versuch unternommen, sie für die gedachten Anforderungen maßzuschneidern. Die Grenzen der Gestaltung sind dabei naturgemäß viel weiter gesteckt als diejenigen der Verwandlung, die Kostüm und Maske an einem Darsteller aus Fleisch und Blut erreichen können, ein Grund, weshalb 'Theaterfiguren' für extreme Rollen prädestiniert sind. Wichtiger als das gestalterische Moment ist allerdings die Bewegung, die Aktion."
Essential for my study is to show the nature and status of gypsy women from Transylvania, which has to be necessarily considered in the context of its own culture. The pictures of these women are mostly shown in the work of Heinrich von Wlislocki, transylvanian gypsy researcher, translator and folklorist of the 19th century. The gypsy women can occupy positions of power, such as an old wise woman,as magic woman, as a mother and as a potential wife. In these cases she is highly valued by the tribe. The above criteria for a gypsy woman to be measured, can be seen only in the context of tribal laws and customs of traditional gypsy groups.
Wie kann das 'Funktionieren' von Prophezeiungen erklärt werden. Eine begriffliche Analyse von Furcht und Angst, und von Zeit und Wissen zeigt, dass durch Prophezeiungen Angst gebunden werden kann. Mit dem Glauben einer Prophezeiung kann aus Unbestimmtheit, der jede Vorstellung fehlt, Zukunftserwartung werden, die dadurch Bestimmtheit besitzt, dass es eine gewisse Vorstellung von dem gibt, was sich ereignen wird. Auf diese Weise kann sich Angst in Furcht, Hoffnung oder frohes Erwarten verwandeln. Als Prophezeiung hat auch die Offenbarung des Johannes dieses Potenzial der Bindung. Ihr Text im Neuen Testament sagt aber nicht nur voraus, was einst geschehen soll, sondern er lässt auch dadurch, wie er die Voraussage verfasst, Bedingungen seines 'Funktionierens' erkennen. Versucht man, die Zusammenhänge dieser Bedingungen zu bestimmen, gelangt man zur Logik von Modellen und zu der Beobachtung, dass die gewaltige Wirkkraft der Offenbarung über bald 2000 Jahre der zivilisatorischen und kulturellen Entwicklung hinweg besser verständlich wird, wenn man in ihr ein Modell sieht. Es ist zu vermuten, dass die Logik des Prophezeiens, die die Offenbarung als Modell erkennen lässt, allgemeinere Gültigkeit besitzt. Sie könnte Prognostik und Prophetie für modelltheoretische Analysen zugänglich machen.
"Das Publikum schrie, brüllte, tobte vor Lachen, fiel von den Stühlen, japsend", überliefert Lion Feuchtwanger die Wirkung des Münchner Komikers Karl Valentin, eines der großen Dramatiker deutscher Sprache. Hermann Hesse erzählt von "brausenden Lachsalven", die Zuschauer seien "wie Besessene vom Dämon gestoßen" worden, so sehr hätten sie gelacht. Kurt Tucholsky beschreibt einen Saal voller Lachen; Rudolf Frank berichtet von "Wogen unbändigen Lachens, die das Haus überfluteten". Und Bertolt Brecht schüttelte sich, wie er sich erinnert, vor Lachen. Im Publikum saßen begeistert die Brüder Mann, Alfred Polgar, Franz Blei, Carl Zuckmayer, Samuel Beckett (der "recht traurig viel gelacht" habe) und nicht wenige der Kulturgrößen der 1920er und 1930er Jahre. Brecht, der mit Valentin auch auf dem Oktoberfest spielte und ihm einen entscheidenden Hinweis für den Verfremdungseffekt verdankte, bezeichnete ihn als eine der "eindringlichsten Figuren der Zeit". Die Literaturgeschichten hingegen schreiben Karl Valentin keine besondere Bedeutung zu - wie sie überhaupt der Komik wenig Aufmerksamkeit widmen. Die Geringschätzung einer "Unterhaltung" verweist die komische Figur von der Bühne des Bedeutsamen: Einem Publikumserfolg mißtraut der eifersüchtige Ästhet, der sonst das Wort "Volk" politisch-moralisch gern im Munde führt.
Zum Informationsangebot deutscher Aussprachewörterbücher für tschechische Germanistikstudierende
(2013)
Aussprachewörterbücher stellen für nichtmuttersprachliche Germanistikstudierende nach wie vor eine der wichtigsten Informationsquellen über die gesprochene Form der deutschen Gegenwartssprache dar. Beim Vergleich der gängigen Aussprachewörterbücher des Deutschen kann man jedoch gravierende Unterschiede feststellen, die einen Nichtmuttersprachler leicht zu desorientieren (wenn nicht gerade zu verwirren) vermögen. Im Beitrag werden die zwei gebräuchlichsten Aussprachewörterbücher der deutschen Sprache (DUDEN Das Aussprachewörterbuch und De Gruyter Deutsches Aussprachewörterbuch) im Hinblick auf das darin enthaltene Informationsangebot für tschechische Germanistikstudierende verglichen. In den Vordergrund tritt somit die Darstellung der für tschechische Deutschstudierende problematischen phonetischen Erscheinungen. Des Weiteren wird folgenden Aspekten Aufmerksamkeit geschenkt: konzeptionelle Ausgangspunkte, Umfang und Stichwörterauswahl, theoretische Beschreibung des phonetisch-phonologischen Systems des Deutschen sowie der deutschen Standardlautung, Aktualitätsbezug, Beschreibung von regionalen Varietäten, Berücksichtigung der Phonostilistik usw.
Den Menschen als vernunftbegabtes Wesen, als animal rationale, zu begreifen heißt, ihn als rechtfertigendes Wesen anzusehen. Die Vernunft ist die Fähigkeit, sich anhand rechtfertigender Gründe in der Welt zu orientieren. Denn „ratio, raison, reason bedeutet“, wie Tugendhat hervorhebt, „ebenso sehr ‚Grund‘ wie ‚Vernunft‘. Das Vermögen der Vernunft ist die Fähigkeit, für seine Meinungen und für seine Handlungen Rede und Antwort stehen zu können; lat. rationem reddere, griech. logon didonai.“ Dieses Rede-und-Antwort-Stehen ist eine soziale Praxis kulturell und historisch situierter Wesen, die einerseits frei sind, ihre Gründe zu wählen und zu prüfen, andererseits aber daran gebunden, welche Gründe ihnen zur Verfügung stehen und welche als gut oder rechtfertigend gelten. Der Raum der Gründe ist ein Raum der Rechtfertigungen, die nicht nur Einzelhandlungen, sondern auch komplexe Handlungsordnungen, also soziale Verhältnisse und politische Institutionen, legitimieren.
Menschen sind aber auch erzählende Wesen. Der Raum der Gründe, in dem sie sich orientieren, ist kein nackter Raum einzelner Sätze oder gar Normen, sondern bevölkert von Narrativen.
Der Hochmoorlaufkäfer (Carabus menetriesi pacholei) ist eine prioritäre Anhang-Art der FFH-Richtlinie und Art mit hoher Schutzverantwortung Deutschlands. Seine Lebensräume liegen in noch weitgehend intakten Hoch-, Übergangs- und Hochlagen-Quellmooren einschließlich von Moorwäldern. In einem prognostizierten, wärmer und trockener werdenden Klima werden einige Vorkommen außerhalb der hier vorgelegten Klimahülle zu liegen kommen und daher für die Art voraussichtlich verloren gehen. Das gilt in besonderem Maße für die endemischen Vorkommen im Voralpengebiet. Andere Vorkommen werden nur zu halten sein, wenn jegliche Anstrengungen unternommen werden, einen naturnahen Wasserhaushalt wiederherzustellen. Die Klimahülle für die Nominatform reicht etwas weiter in den trockenen und auch warmen Bereich, erfordert aber ebenfalls sämtliche Bemühungen zu ihrem Erhalt. Zu den notwendigen Maßnahmen gehört unter anderem auch die konsequente Erhaltung naturnaher Moor- und Moorrandwälder. Eine Theorie zur Erklärung der disjunkten Verbreitung im Voralpengebiet basierend auf der Vereisungsgeschichte wird präsentiert, da die Klimaverhältnisse allein die Verbreitung nicht erklären können.
Im Juni 2009 fand in der slowakischen Hauptstadt Bratislava unter dem Titel "20 Jahre Freiheit: Deutschland sagt Danke!" eine Veranstaltung statt, die das Auswärtige Amt und die Deutsche Botschaft Pressburg in Zusammenarbeit mit dem Außen- und Kulturministerium der Slowakischen Republik und weiteren Partnern durchführten. Ähnliche Veranstaltungen wurden in Prag, Warschau, Danzig und Budapest organisiert, um deutsche Perspektiven auf die Ereignisse vor und nach 1989 mit den Blickwinkeln der anderen postsozialistischen Länder in einen Dialog treten zu lassen. Darüber hinaus wollten die Veranstalter das seit dem Fall des Eisernen Vorhangs gemeinsam Erreichte deutlich machen, die Menschen emotional mitnehmen und die Dankbarkeit und Weltoffenheit Deutschlands erlebbar machen. Im Rahmen des abwechslungsreichen Kultur- und Unterhaltungsprogramms las Monika Maron "aus ihrem neuen Werk Stille Zeile sechs, wie es in allen Ankündigungen der Lesung hieß. Marons Roman ist aber 1991 erschienen, also achtzehn Jahre davor. Nach der Lesung führte einer der bekannten jungen Moderatoren eines slowakischen Nachrichtensenders ein kurzes Gespräch mit der Schriftstellerin, das er mit der Frage "Frau Maron, wie fühlen Sie sich als Mensch zwanzig Jahre nach dem Fall der Mauer?" einleitete. Monika Maron versuchte vor laufenden Fernsehkameras mühsam eine Antwort auf die peinliche Frage zu finden. Sie schien sich dessen bewusst zu sein: Das Mauerfall-Jubiläum ist ein medial inszeniertes Ereignis...
Der Aufsatz präsentiert einen der historiographischen Texte aus den böhmischen Ländern, der am Ende des 16. Jahrhunderts vom Humanisten Matthaeus Meisner (1543–nach 1600) verfasst wurde. Das Manuskript über die Geschichte der Stadt Brüx (Most) in Nordwestböhmen ist zurzeit im Archiv der Prager Burg als Bestandteil der Bibliothek des Metropolitankapitels von St. Veit deponiert. Der Aufsatz behandelt die textologische Charakteristik des Manuskripts und die Aspekte, die für die Wahl der im Manuskript vorkommenden, also der lateinischen, deutschen und tschechischen, Sprachen relevant waren.
Im vorliegenden Beitrag wird die Ebene der sprachwissenschaftlichen Verknüpfungen im Bereich der Syntax von zwei zu vergleichenden Sprachsystemen behandelt. Im Fokus der Untersuchung steht die Problematik der syntaktischen Korrelation in der deutschen und slowakischen Sprache. Behandelt werden syntaktische Korrelate sowohl im Deutschen als auch im Slowakischen, ihre Funktion in der Hypotaxe und ihre Verwendung in konkreten Nebensatztypen in beiden Sprachen...
Nicht jeder Innenraum ist ein Interieur. Das Interieur ist ein unter spezifischen historischen, gesellschaftlichen und kulturpoetischen Bedingungen entstandenes komplexes Gebilde. Es lässt sich durch die Bündelung von drei Aspekten rekonstruieren: 1. einer Kultur- und Komfortgeschichte de Wohnens; 2. einer Beschreibung des Widerspiels von Draußen und Drinnen und 3. der interieurspezifischen Bestimmung einer Raumästhetik, bestehend aus einer Poetik der Atmosphäre und der Dinge und konstituiert aus Erwartung, Erinnerung und Koketterie.
Zottelige Landschaftspfleger
(2013)
Zimbabwe: The Blame Game
(2013)
The Blame Game is a cycle of creative non-fiction pieces, pulling the readers through the politics of modern day Zimbabwe. Like in any game, there are players in this game, opposing each other. The game is told through the eyes of one of the players, thus it is subjective. It centres on truthfully trying to find who to blame for Zimbabwe's problems, and how to undo all these problems. Finding who to blame should be the beginning for the search of solutions. It encourages talking to each other, maybe about the wrongs we have done to each other, and genuinely trying to embrace and forgive each other. In trying to undo the problems in Zimbabwe, it also offers insight or solutions on a larger platform - Africa: particularly South Africa; that it might learn from other African countries that have imploded before it, how to solve its own problems.
Der vorliegende Beitrag zeigt auf, dass die zunehmende Komplexität der Aufgaben von Zentralbanken zu einer strukturellen Überforderung führen kann. Aufgrund der funktionellen Komplexität einer makroprudenziellen Prozesspolitik auf der Ziel- und Instrumentenebene sollte eher nach einer Reduktion als nach einer Ausweitung des makroprudenziellen Werkzeugkastens Ausschau gehalten werden. Weiterhin steht die sich derzeit teilweise noch vergrößernde institutionelle Komplexität der makroprudenziellen Politik ihrer funktionellen Komplexität um nichts nach. Bei entsprechenden Vorkehrungen können die bereits eingetretenen und die potenziellen Überforderungen jedoch zumindest teilweise in verkraftbare Herausforderungen überführt werden. Der Aufsatz schließt mit Empfehlungen für entsprechende Maßnahmen.
Von den unmittelbar auf Musik und Klang bezogenen Passagen im Werk Walter Benjamins besteht die längste zu einem bemerkenswert großen Teil aus Zitaten: In dem 1924/25 geschriebenen Ursprung des deutschen Trauerspiels (GS I, 203–430; hier 387–389) bringt Benjamin auf 96 Zeilen, die dem Abschnitt über die Oper folgen und sich mit Klang und Schrift befassen, 27 Zeilen mit Zitaten aus den Fragmenten aus dem Nachlasse eines jungen Physikers2 v on Johann Wilhelm Ritter. Ritter, heute weitgehend in Vergessenheit geraten, war Naturwissenschaftler und philosophierender Schriftsteller, ein spekulativer, perspektivenreicher Denker der Romantik, ein universell interessierter, zugleich aber auch schwer verständlicher Autor. Er bot Benjamin mit seinen Ideen und Assoziationen eine Fülle von Anknüpfungsmöglichkeiten, und es waren vor allem die auf Musik, Klang, Schrift und Sprache bezogenen und an ältere akustische Experimente anknüpfenden Ideen und Assoziationen Ritters, die Benjamins Aufmerksamkeit auf sich zogen.
Glioblastoma is the most common and most aggressive type of brain tumor in adults. In contrast to epithelial cancers, glioblastomas do not metastasize. While the major treatment challenge in epithelial cancers is not the primary tumor but metastasis, glioblastoma patients die of the primary tumor.
However, there is a common theme which underlies the malignant properties of progressed epithelial cancers and glioblastoma: invasion from the primary tumor into the surrounding tissue. In the case of epithelial cancers this is the first and necessary step to metastasis, whereas invasion leads inevitably to tumor recurrence after resection in the case of glioblastoma, causing it to be incurable.
A cellular program which has been described in detail to promote the invasive phenotype in epithelial tumors, is the epithelial-mesenchymal-transition (EMT). Differentiated neural cells are not epithelial, thus, strictly speaking, EMT does not occur in glioblastoma. However, the traits acquired in the process of EMT, especially invasiveness and stemness, are highly relevant to glioblastoma. One of the key transcription factors known to induce EMT in epithelial cancers is ZEB1, which has been described only marginally in the central nervous system so far. Here, I investigate the expression and function of ZEB1 in glioblastoma and during human fetal neural development.
ZEB1 mRNA was significantly upregulated in all histological types of glioma, including glioblastoma, when compared to normal brain. There was no correlation between ZEB1 mRNA levels and tumor grade. Immunohistochemical staining of glioma samples demonstrated that ZEB1 was highly expressed in the great majority of tumor cells. In the developing human brain, intense staining for ZEB1 could be observed in the ventricular and subventricular zone, where stem- and progenitor cells reside. ZEB1 positive cells included cells stained with stem- and progenitor markers like PAX6, GFAP and Nestin. In contrast, ZEB1 was never found in early neuronal cells as identified by TUBB3 staining.
To gain insight into ZEB1 function I generated a human fetal neural stem cell line and a glioblastoma cell line with ZEB1 knockdown, which were compared with their respective control cell lines. First, I found that ZEB1 does not regulate the micro RNA 200 family in either cell line, which has been described as an essential ZEB1 target in epithelial cancers. Second, regulated target genes were identified with a genome wide microarray. The third approach was to directly identify genomic binding sites of ZEB1 by chromatin immunoprecipitation sequencing (ChIP-seq). All three approaches showed that the ZEB1 transcriptional program is surprisingly similar in the neural stem cell line and the glioblastoma cell line. In contrast, it bears only little resemblance to the program described in epithelial cancers.
The most interesting, previously unrecognized ZEB1 target gene identified in this study is integrin b1. It was regulated after ZEB1 knockdown detected by microarray analysis, and has a ZEB1 binding site in its promoter region detected by ChIP-seq. Finally, I addressed the question whether ZEB1 influences tumor growth and invasiveness in a glioblastoma model. After intracranial xenotransplantation in mice, ZEB1 knockdown glioblastoma cells formed significantly smaller and less invasive tumors than control glioblastoma cells.
This study demonstrates that ZEB1 is widely expressed in glioma and relevant for glioblastoma growth and invasion. In contrast to what is known about ZEB1 function in epithelial cancers, ZEB1 is not associated with glioma progression, but instead seems to be an early and necessary event in tumorigenesis. Also with regard to ZEB1 target genes, ZEB1 functions differently in glioblastoma than in epithelial cancers. The two most important ZEB1 targets in epithelial cancers are E-cadherin and the miR-200 family members. Both are not relevant to ZEB1 function in glioblastoma. Interestingly, while the ZEB1 transcriptional program is different from the one described in epithelial cancers, it is highly similar in glioblastoma cells and fetal neural stem cells. This suggests that an embryonic pathway restricted to stem- and progenitor cells during development is reactivated in glioblastoma.
Previously known ZEB1 target genes were tissue specific and therefore seemed unlikely to mediate ZEB1 function in the central nervous system. However, the newly identified ZEB1 target gene integrin b1 is well known to play pivotal roles in both glioblastoma tumorigenesis and invasion as well as in neural stem cells. Additionally, integrin b1 is widely expressed and seems a likely ZEB1 target in other organs than the brain.
Taken together, I demonstrate that ZEB1 is a new regulator of glioblastoma growth and invasion. The transcriptional program of ZEB1 differs from the one in epithelial cancers but is strikingly similar to the one in neural stem cells. The newly identified ZEB1 target gene integrin b1 is likely to mediate crucial ZEB1 functios. Thus, this study identifies ZEB1 as a yet unrecognized player in glioblastoma and neural development. Furthermore, it sets the stage for more research which will help to deepen our understanding of ZEB1 function in the central nervous system and beyond.
Alman ekonomisinin yükselen konjonktürü ile 60'lı yıllarda birçok Türk vatandaşı imzalanan ikili anlaşmalar sonrasında işçi olarak Almanya’ya göç etmiştir. "Misafir işçi" göçünün başlamasıyla bir "göçmen işçi" edebiyatının çıkması da rastlantı değildir. Göçmen işçi edebiyatı (Gastarbeiterliteratur) teriminin kullanılmamasının nedeni negatif bir anlam taşımasıdır. Bunun yerine daha naif ve yanlış anlamlara neden olmayacak bir terim olan göçmen edebiyatı (Migrantenliteratur) tercih edilmiştir.
Göçmen edebiyatının günümüzde Almanya'da çok önemli bir yer tuttuğunun da altını çizmek gerekir. Göçmen edebiyatı yeni eserler verdikçe araştırmalara da yenisi eklenmektedir. Yazarlar ise konu itibariyle her iki kültürün bakış açısıyla yazar ve sentez oluştururlar. Kültürel aktarıma yazdığı ve çevirdiği eserleriyle katkıda bulunan Türk kökenli göçmen yazarlarından biri de Yüksel Pazarkaya'dır.
Mediha adlı eserinde sadece Yunan tragedyasının ana karakterinin maruz kaldığı haksızlığı tekrar canlandırmamış aynı zamanda Almanya'da yaşayan Türklerin ailevi sorunlarına da değinmiştir.
Elections provide a tremendous opportunity for national transformation and the pursuit of democratic practice. They can be a moment of national renewal. However, in most of Africa elections are often characterized by violent conflict as politicians seek to capture or maintain power through ethnic mobilization, propaganda and misrepresentation. Considering opportunities offered by information technology especially mobile phones and the discovery of extensive natural resources, Africa has an opportunity to significantly change the lives of ordinary citizens. But this transformation requires that youth are fully 'present' in the political, economic, social and cultural arenas. They will need to marshal their energies and stay focused on the things that are important for the continent of Africa. In the case of Kenya, youth should not wait to be invited to take up political leadership. Instead, they will need to invite themselves to the table and take advantage of the opportunity provided in Constitution and demand accountability and transparency in the conduct of national affairs. This book is part of ongoing work at Twaweza Communications in the pursuit of democracy, peace and justice. Themes covered include youth and leadership; elections and peace; youth as peace makers; family and global values among other topics.
Background: A number of scientific papers on yellow fever have been published but no broad scientometric analysis on the published research of yellow fever has been reported. The aim of the article based study was to provide an in-depth evaluation of the yellow fever field using large-scale data analysis and employment of bibliometric indicators of production and quantity.
Methods: Data were retrieved from the Web of Science database (WoS) and analyzed as part of the NewQis platform. Then data were extracted from each file, transferred to databases and visualized as diagrams. Partially by means of density-equalizing mapping makes the findings clear and emphasizes the output of the analysis.
Results: In the study period from 1900 to 2012 a total of 5,053 yellow fever-associated items were published by 79 countries. The United States (USA) having the highest publication rate at 42% (n = 751) followed by far from Brazil (n = 203), France (n = 149) and the United Kingdom (n = 113). The most productive journals are the "Public Health Reports", the "American Journal of Tropical Medicine and Hygiene" and the "Journal of Virology". The gender analysis showed an overall steady increase of female authorship from 1950 to 2011. Brazil is the only country of the five most productive countries with a higher proportion of female scientists.
Conclusions: The present data shows an increase in research productivity over the entire study period, in particular an increase of female scientists. Brazil shows a majority of female authors, a fact that is confirmed by other studies.
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence. In brain CSC, the PI3-K/AKT and the RAS/mitogen activated protein kinase (MAPK) pathways are found to be activated. In consequence, the human transcription factor YB-1, knowing to be responsible for the emergence of drug resistance and driving adenoviral replication, is phosphorylated and activated. With this knowledge, YB-1 was established in the past as a biomarker for disease progression and prognosis. This study determines the expression of YB-1 in glioblastoma (GBM) specimen in vivo and in brain CSC lines. In addition, the capacity of Ad-Delo3-RGD, an YB-1 dependent oncolytic adenovirus, to eradicate CSC was evaluated both in vitro and in vivo.
Methods: YB-1 expression was investigated by immunoblot and immuno-histochemistry. In vitro, viral replication as well as the capacity of Ad-Delo3-RGD to replicate in and, in consequence, to kill CSC was determined by real-time PCR and clonogenic dilution assays. In vivo, Ad-Delo3-RGD-mediated tumor growth inhibition was evaluated in an orthotopic mouse GBM model. Safety and specificity of Ad-Delo3-RGD were investigated in immortalized human astrocytes and by siRNA-mediated downregulation of YB-1.
Results: YB-1 is highly expressed in brain CSC lines and in GBM specimen. Efficient viral replication in and virus-mediated lysis of CSC was observed in vitro. Experiments addressing safety aspects of Ad-Delo3-RGD showed that (i) virus production in human astrocytes was significantly reduced compared to wild type adenovirus (Ad-WT) and (ii) knockdown of YB-1 significantly reduced virus replication. Mice harboring othotopic GBM developed from a temozolomide (TMZ)-resistant GBM derived CSC line which was intratumorally injected with Ad-Delo3-RGD survived significantly longer than mice receiving PBS-injections or TMZ treatment.
Conclusion: The results of this study supported YB-1 based virotherapy as an attractive therapeutic strategy for GBM treatment which will be exploited further in multimodal treatment concepts.
Writing Lives
(2013)
Writing Lives, a collection of short stories, featuring Lawrence Hoba, Tendai Huchu, Tendai Machingaidze, Nevanji Madanhire, Daniel Mandishona, Christopher Mlalazi, Blessing Musariri, Chiedza Musengezi, Sekai Nzenza, Fungisayi Sasa and Emmanuel Sigauke. Writing Lives is the seventh of Weaver's anthologies of short stories following Writing Still, Writing Now, Laughing Now, Women Writing Zimbabwe, Mazambuko and Writing Free. As with the other anthologies, this vibrant collection reflects the lives and experiences of Zimbabweans as filtered through the lens of each author's perceptions. Writing Lives gives us stories that will make us laugh and bring tears to our eyes as it provides a focus on the past, the present and even the future.
Dieser Beitrag beschäftigt sich mit verschiedenen Ansätzen der Konstruktion von Grundwortschatzbeständen für den Bereich Deutsch als Fremdsprache. Am Beispiel des kommunikativ-pragmatisch erstellten Wortschatzes, der in Profile Deutsch erfasst ist, und zwei frequenzorientierten Listen, der DeReWo Wortliste und der Herder/BYU Häufigkeitsliste, werden anhand einer empirischen Gegenüberstellung Stärken und Schwächen der verschiedenen Ansätze herausgestellt. Resümierend werden in diesem Beitrag Desiderate sowie mögliche Lösungsansätze zur validen und empirisch abgesicherten Grundwortschatzbestimmung zur Diskussion gestellt.
It is common knowledge that plants have been the world-wide most important source of medicines and that they still play this role in developing countries. However, up to now, complete lists of medicinal and aromatic plants (MAP) exist for comparatively few countries. A review of all lists know to the authors reveals the following results: A total of 20.7 % of the plant species analyzed by either publications or own research are or were used as MAP. However, regarding single countries, the differences are considerably high. Absolutely leading the list are China (36.2 %), Burkina Faso (35.2 %) and the Korean Republic (34.5 %). Also ahead of other countries or regions are the North of Benin (32.8 %) and the entire Pakistan (30.3 %). Still above average rank Great Britain (26.7 %) and Nepal (23.3 %), while the figures for Bul¬garia (21.0 %), Germany (20.2 %) and France (19.4 %) almost represent the average. Jordan (17.3 %), Vietnam (17.1 %), Sri Lanka (16.6 %), India (16.1 %) and Thailand (15.5 %) rank slightly beneath. Clearly below the average are the percentages of MAP for Hungary (12.2 %) and the USA (11.8 %). The average numbers of MAP in the Philippines (9.5 %) and Malaysia (7.7 %) fall far behind. Calculated on a worldwide scale, every fifth plant can be regarded as MAP. This number matches that from Bulgaria, France and Germany. In northern Benin, Burkina Faso, Korea, China and Pakistan, however, every third plant is or was used as MAP, whereas in Hungary and the USA only every eighth plant can be regarded as MAP. This number drops even further for the Philippines ore Malaysia where only every tenth or thirteenth plant can be attributed to medicinal or aromatic use. These differences might be due to various factors. A geographical component of the results is obvious: in most cases geographically close countries show similar percentages. A correlation between the total number of species and the fraction of those used as MAP cannot be confirmed. The countries with percentage of MAP > 30 % in common show that they belong either entirely (Burkina Faso, Benin) or at least in their rural areas to the poorest countries of the world so that it is (was) impossible for the majority of the people to buy "modern" MAP. In those countries the number of traditional healers outnumbers largely the number of modern doctors. Therefore, the tradition of folk medicine was maintained until today. Additionally, China, Korea and partially Pakistan have a very old and well documented tradition of folk medicine. Due to this documentation even in areas where today "modern MAP" are used, the knowledge was not lost. In neighboring countries or regions, which differ with respect to a more arid or a more humid climate, for the arid country (region) more MAPs are reported than for the humid one. The potential reasons for this phenomenon are discussed in the paper. For many countries the percentage given for MAP in literature is too low. But even these low values represent a striking argument for the importance of a world-wide conservation of biodiversity.
Unique publication on the worldwide distribution of industrial robots based on company reports: about 40 country reports 2007 - 2012; by application areas; by industrial branches; by types of robots; and by other technical and economic variables. Data on production, exports and imports; Trends in robot densities, i.e. number of robots; per 10,000 persons employed in relevant sectors; Forecast 2013 - 2016; Special Features: Case Studies on Profitability of Robot Investments
Background: Only few studies deal with the workload of physical therapists and the health consequences, although this occupational group is quite important for the health care system in many industrialized countries (e.g. ca. 136 000 people are currently employed as physical therapists in Germany). Therefore, the current state of knowledge of work-related diseases and disorders of physical therapists is insufficient. The aim of the "Physical Therapist Cohort" (PTC) study is to analyze the association between work-related exposures and diseases among physical therapists in Germany. This article describes the protocol of the baseline assessment of the PTC study.
Methods/Design: A cross-sectional study will be conducted as baseline assessment and will include a representative random sample of approximately 300 physical therapists employed in Germany (exposure group), and a population-based comparison group (n = 300). The comparison group will comprise a sample of working aged (18–65 years) inhabitants of a German city. Variables of interest will be assessed using a questionnaire manual including questions regarding musculoskeletal, dermal, and infectious diseases and disorders as well as psychosocial exposures, diseases and disorders. In addition to subjective measures, a clinical examination will be used to objectify the questionnaire-based results (n = 50).
Discussion: The study, which includes extensive data collection, provides a unique opportunity to study the prospective association of work-related exposures and associated complaints of physical therapists. Baseline results will give first clues with regard to whether and how prevalent main exposures of physiotherapeutic work and typical work areas of physical therapists are associated with the development of work-related diseases. Thereby, this baseline assessment provides the basis for further investigations to examine causal relationships in accordance with a longitudinal design.