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MiR144/451 expression is repressed by RUNX1 during megakaryopoiesis and disturbed by RUNX1/ETO
(2016)
Abstract: A network of lineage-specific transcription factors and microRNAs tightly regulates differentiation of hematopoietic stem cells along the distinct lineages. Deregulation of this regulatory network contributes to impaired lineage fidelity and leukemogenesis. We found that the hematopoietic master regulator RUNX1 controls the expression of certain microRNAs, of importance during erythroid/megakaryocytic differentiation. In particular, we show that the erythorid miR144/451 cluster is epigenetically repressed by RUNX1 during megakaryopoiesis. Furthermore, the leukemogenic RUNX1/ETO fusion protein transcriptionally represses the miR144/451 pre-microRNA. Thus RUNX1/ETO contributes to increased expression of miR451 target genes and interferes with normal gene expression during differentiation. Furthermore, we observed that inhibition of RUNX1/ETO in Kasumi1 cells and in RUNX1/ETO positive primary acute myeloid leukemia patient samples leads to up-regulation of miR144/451. RUNX1 thus emerges as a key regulator of a microRNA network, driving differentiation at the megakaryocytic/erythroid branching point. The network is disturbed by the leukemogenic RUNX1/ETO fusion product.
Author Summary: The regulatory network between transcription factors, epigenetic cofactors and microRNAs is decisive for normal hematopoiesis. The transcription factor RUNX1 is important for the establishment of a megakaryocytic gene expression program and the concomitant repression of erythroid genes during megakaryocytic differentiation. Gene regulation by RUNX1 is frequently disturbed by mutations and chromosomal translocations, such as the t(8;21) translocation, which gives rise to the leukemogenic RUNX1/ETO fusion protein. We found that RUNX1 regulates microRNAs, which are of importance at the megakaryocytic/erythroid branching point. Specifically, RUNX1 down-regulates expression of the microRNA cluster miR144/451 during megakaryocytic differentiation by changing the epigenetic histone modification pattern at the locus. We could show that miR451, one of the micorRNAs of the miR144/451 cluster, supports erythroid differentiation. We found that expression of miR451 is repressed by the RUNX1/ETO fusion protein, resulting in up regulation of miR451 target genes. Our data support the notion that RUNX1 suppresses the erythroid gene expression program including the erythroid microRNA miR451 and that the RUNX1/ETO fusion protein interferes with normal gene regulation by RUNX1.
A stochastic forward-looking model to assess the profitability and solvency of european insurers
(2016)
In this paper, we develop an analytical framework for conducting forward-looking assessments of profitability and solvency of the main euro area insurance sectors. We model the balance sheet of an insurance company encompassing both life and non-life business and we calibrate it using country level data to make it representative of the major euro area insurance markets. Then, we project this representative balance sheet forward under stochastic capital markets, stochastic mortality developments and stochastic claims. The model highlights the potential threats to insurers solvency and profitability stemming from a sustained period of low interest rates particularly in those markets which are largely exposed to reinvestment risks due to the relatively high guarantees and generous profit participation schemes. The model also proves how the resilience of insurers to adverse financial developments heavily depends on the diversification of their business mix. Finally, the model identifies potential negative spillovers between life and non-life business thorugh the redistribution of capital within groups.
Recently there has been an explosion of research on whether the equilibrium real interest rate has declined, an issue with significant implications for monetary policy. A common finding is that the rate has declined. In this paper we provide evidence that contradicts this finding. We show that the perceived decline may well be due to shifts in regulatory policy and monetary policy that have been omitted from the research. In developing the monetary policy implications, it is promising that much of the research approaches the policy problem through the framework of monetary policy rules, as uncertainty in the equilibrium real rate is not a reason to abandon rules in favor of discretion. But the results are still inconclusive and too uncertain to incorporate into policy rules in the ways that have been suggested.
Das Leistungsfähigkeitsprinzip als zentraler Grundsatz der Einkommensbesteuerung ist in hohem Maße konkretisierungsbedürftig und damit für Wertentscheidungen offen. Diese Offenheit wird von der traditionellen Steuerrechtswissenschaft mit Wertungen gefüllt, die aus der Perspektive der Geschlechtergerechtigkeit äußerst problematisch sind. In diesem Aufsatz werden zunächst Einnahmenseite und Ausgabenseite des Einkommens für die Bemessung der Leistungsfähigkeit betrachtet. Dabei wird aufgezeigt, dass die fehlende Berücksichtigung der Reproduktionsarbeit in Kombination mit dem Ehegattensplitting auf Seite der Einnahmen das Leistungsfähigkeitsprinzip erheblich verzerrt und die Verweigerung der vollen Absetzbarkeit von Kinderbetreuungskosten beispielsweise auf Seite der Ausgaben das traditionelle Familienmodell weiterhin begünstigt. Einem solchen Steuerrecht, das die Genderperspektive systematisch ausblendet, stehen aber Verfassungsnormen entgegen, die im Folgenden anhand der argumentativen Leitlinien skizziert werden. Daher muss das Steuerrecht weiter entwickelt und an die verfassungsrechtlichen Anforderungen an Gleichberechtigung von Mann und Frau gekoppelt werden.
Am Montag, 30. Mai 2016 von 18.00-20.00h, laden das Institut für soziale Bewegungen (ISB) und die Gemeinsame Arbeitsstelle RUB/IGM zum 3. Bochumer Disput ein. Diskutiert wird zum Thema „Handelspolitik gerecht gestalten? Die Transatlantische Handels- und Investitionspartnerschaft (TTIP) als politischer Prozess“.
CfP: "Digital -Dis-Orders"
(2016)
The 7th Annual Graduate Conference of the Cluster of Excellence „Normative Orders“ is taking place from 17 to 19 November 2016 at Goethe-University Frankfurt. The call for papers to this year’s conference theme „Digital <Dis>Orders“ (@digdis2016) is open until 30 June 2016.
Scholarship and practice
(2016)
How can I as an international lawyer, conscious that international law is deeply implicated in today’s global injustices and that the course of history will not be changed by any grand legal design, practice law responsibly? Taking as a point of departure my own desire not to seek comfort in the formulation of a critique of law, but to aspire to a responsible practice, I consult two quite different bodies of work: first, critical theory of law and second, recent scholarship on international law that argues a practice guided by ethics may enhance the legitimacy of international law. I turn then to my own practice of international economic law focusing on my occasional role as legal expert on the so-called megaregionals the EU aims to conclude with Canada and the United States. I propose that the debate on international economic law lacks an investigation into the role of law in shaping political economy; that this lack can be explained by the compartmentalization of expertise which leads to justification gaps with respect to projects such as the megaregionals. One way how lawyers can assume responsibility is to work on closing these gaps even if it means leaving the ‘inside’ of the legal discipline. Finally, I suggest that a responsible legal practice of social change might follow Roberto Unger’s call for institutional imagination. Maybe I can satisfy my wish for a transformative practice by joining forces with friends in experimenting with institutions, hoping to build an alternative political economy.
This text is an only slightly modified version of the Herbert Krüger Memorial Lecture that I held upon invitation of the Arbeitskreis Überseeische Verfassungsvergleichung on 4 July 2014 at Bucerius Law School in Hamburg. My point of departure is the observation that even though the economic exploitation of natural resources triggers a multitude of distribution conflicts, international and transnational law treat these conflicts inadequately. While the New International Economic Order had as one of its objectives distributional justice between resource exporting poor states (former colonies) and resource importing high income states (mostly former imperial powers) its demands were never fully realized. Instead a transnational economic law emerged which can be interpreted as itself establishing a distribution order -- albeit a distribution order that is not oriented towards distributional justice, but rather posits the market as the best distribution device. This distribution order has depoliticized and deterritorialized distribution conflicts between resource exporting and resource importing states and has secured – through the promotion of privatizations, protection of foreign investments and dismantling of trade barriers – access to resources for the resource importing states. At the same time it has freed importing states from responsibility for the harms that accrue from resource exploitation to the resource exporting states and their populations. I call in this text for a repoliticization of distribution conflicts at the international as well as the (trans)national level, a repoliticization that may be achieved not only through the reform of political, but also economic institutions.
This is the 27. and final article in our series Trouble on the Far-Right.
Trouble on the far right has become troubling for Europe. Not only do right-wing motivated attacks occur regularly against Roma camps, ethnic minorities, LGBTQI people and Jewish institutions. At the same time, a xenophobic discourse on refugees has gained momentum in politics and society and further blurred the lines between far right agitation and mainstream politics. In order to classify these events adequately, far right activism should not just be regarded as a security issue that can be eliminated by force, but as a threat that threatens the foundations of open, democratic and pluralist societies. Hence, we should be aware that far right politics are neither a new nor an isolated phenomenon but often bank on existing cultures of (gender, competitive, nativist) domination in capitalist societies.1
Certain developments have recently accelerated a radicalization of the political mainstream in terms of rhetoric, demands and policy outcomes and transformed the institutional landscape. The Slovakian parliamentary elections and the fateful presidential elections in Austria are central events during our 10-week blog series that prove the inherent dynamic. The right-wing government in Poland that has started removing fundamental rights and facilitated the spread of nationalist values is another example.
Contrary to the one-sided academic focus on elections, far right influence on European societies should be measured on three further levels: Massive street mobilizations epitomized by Pegida in Germany (and beyond) and the Italian Stop Invasione rallies, clandestine organizing such as the British far right militants and prospering relations between state authorities and far right movements, for example in Turkey, testify a growing diversification of far right activism. These scenarios demand methodologically and theoretically innovative perspectives. Our blog series Trouble on the Far Right has provided them with an international forum.
This is the 26. article in our series Trouble on the Far-Right.
In Poland, the long lasting culture war1 over gender roles and religion has been easily framed by the far right into Samuel Huntington’s concept of the “clash of civilizations”. A well-known juxtaposition used in right-wing propaganda: ‘civilization of life’ vs. ‘civilization of death’ in reference to anti-abortion and pro-choice movements respectively is now used to refer to Christians and Muslims. The role of Polish women and the right to abortion remain in the center of the conflict of modernity.
In Europe, the far right heats up the moral panic caused by fear of terrorism, pointing to Muslims as a threat to ‘European’ liberties, especially women’s and LGBT rights. The assaults on women celebrating New Year’s Eve on the streets of Cologne, serve Pegida and many nationalist organizations in Europe as a proof of Arab’s attitude to ‘Western’ expressions of femininity. This argument in the anti-immigration discourse of the far right is well-grounded in nationalists’ ideal of a strong man defending ‘his’ woman. Although, the task might be understood literally, in the context of the assaults in Cologne, protecting wives, mothers, sisters and daughters of the nation has a broader symbolic meaning. Scholars interested in relationship between gender and nation, state that in nationalists discourse women symbolize the nation and are bearers of values.2 In islamophobic discourse female citizens of Europe signify Europeans’ equality and freedom...
Dies ist der 25. Artikel in unserer Blogreihe Trouble on the Far-Right.
Ein Mädchen auf einem Fahrrad. Weiße Bluse, schwarzer langer Rock, weiße Socken, schwarze Schuhe. Sie fährt durch eine idyllische, friedlich wirkende, sommerliche Landschaft. Unter dem Foto steht: „Revolt against the modern world – justnationalistgirls“.
Eine Demonstration. Einzig bengalische Feuer erleuchten die Dunkelheit. Schemenhaft erkennt man eine Frau, die auf eine gefährlich anmutende Menge zugeht. Sie wirkt stark. Unter dem Foto steht: „The night’s still young – justnationalistgirls“.
Dass rechte Bewegungen Facebook zur Mobilisierung nutzen, ist bekannt. Auch die extrem rechte Facebookseite justnationalistgirls, die knapp 9000 Nutzer*innen liken, transportiert extrem rechte Inhalte, jedoch ungleich subtiler verpackt, als es auf so manch dezidiert neonazistischer Facebookseite der Fall ist. Justnationalistgirls und ähnliche Seiten reproduzieren auf den ersten Blick, scheinbar harmlos, eine idealisierte Vorstellung von Mädchen und jungen Frauen, die ihr heimisches Idyll beschützen möchten. Die im April 2014 gegründete Seite hat sich vor allem in Frankreich, Deutschland, Österreich, Polen und den USA eine Anhänger*innenschaft erarbeitet. Die generelle Botschaft ist nicht offensichtlich erkennbar. Mit Sicherheit gesagt werden kann jedoch, dass justnationalistgirls mindestens zwei, scheinbar widersprüchliche Weiblichkeitsbilder verbreitet, welche in den meisten rechten Gruppen oder Bewegungen Anklang finden: Zum einen die traditionelle Rolle der Frau als Mutter der Nation, zum anderen die der Kämpferin neben dem Mann im „nationalen Befreiungskampf“.
Die folgenden Einschätzung sowie daraus resultierende Handlungsempfehlungen formuliere ich aus meiner Erfahrung in der politischen Bildungsarbeit. Justnationalistgirls ist ein Türöffner zu extrem rechtem Gedankengut. Selbstredend ist der Einstieg in die organisierte und gegebenenfalls militante, extrem rechte Szene weitaus vielschichtiger und nicht nur auf das Besuchen einer bestimmten Internetseite zurückführbar. Inhalte, wie sie auf justnationalistgirls veröffentlicht werden, stellen allerdings ein niedrigschwelliges Einstiegsangebot dar, dem eine demokratische, politische Bildung dringend etwas entgegensetzen muss. In erster Linie gehört dazu die Förderung der Fähigkeit zum Hinterfragen und Dekonstruieren extrem rechter Ideen und Parolen. Betrachtet man das Publikum, welches die Inhalte von justnationalistgirls teilt, liest oder mit „gefällt mir“-markiert, fällt auf, dass es sich vor allem um Jugendliche und junge Erwachsene handelt. „Besonders Jugendliche auf der Suche nach Orientierung sind dafür empfänglich, wenn es erstmal unverfänglich aussieht.“, sagt Simone Rafael von der Amadeu-Antonio-Stiftung.
Im Folgenden soll der Frage nachgegangen werden, welche Weiblichkeitsbilder durch justnationalistgirls transportiert und anhand dieser Handlungsempfehlungen formuliert werden, an denen sich eine Form von politischer Bildung als Rechtsextremismusprävention orientieren kann. Justnationalistgirls soll hier als ein Beispiel für viele Formen versteckter rechter oder rassistischer Inhalte in sozialen Medien gesehen werden, welche vor allem von Akteur*innen politischer Bildung mehr Aufmerksamkeit erhalten sollten.
Dies ist der 24. Artikel in unserer Blogreihe Trouble on the Far-Right.
Dass deutsche Neonazis ins europäische Ausland fahren um dort an „Gedenkmärschen“ teilzunehmen, stellt grundsätzlich keinen Widerspruch dar.1 Die extreme Rechte oder der Neonazismus war und ist kein rein nationales Phänomen. Schon im 20. Jahrhundert existierten diverse Bündnisse unter den faschistischen Bewegungen in Europa und auch heute haben sich in verschiedenen europäischen Ländern extrem rechte Bewegungen und Organisationen etabliert, die sich grenzüberschreitend vernetzen, kooperieren und eine (gemeinsame) Straßenpolitik betreiben.
In der Begründung einer länderübergreifenden Zusammenarbeit rekurriert die extreme Rechte auf verschiedene Europakonzeptionen und -vorstellungen. Innerhalb des deutschen Neonazismus existiert eine starke Bezugnahme auf eine Europa-Idee, die auf völkisch-rassistische Ordnungsvorstellungen des Nationalsozialismus zurückgreift. Einen wichtigen Anknüpfungspunkt stellt die Heroisierung der SS bzw. der Divisionen dar, in denen „Waffenbrüder“ aus verschiedenen europäischen Ländern gekämpft haben. Die Orientierung an einem vermeintlichen Kampf für eine „weiße Rasse“ und ein „freies Europa der Völker“ dient der extremen Rechten auch heute als gemeinsame Basis für transnationale Kooperationen. Neben dieser allgemeinen europäischen Ausrichtung der extremen Rechten, existieren weitere konkrete Beweggründe und Faktoren, die dazu führen, dass deutsche Neonazis im europäischen Ausland an Demonstrationen teilnehmen. Ausschlaggebend können persönliche oder organisatorische Kontakte und Freundschaften zwischen extrem rechten Gruppen und Einzelpersonen sein. Dies ist besonders in Grenzgebieten der Fall, und daher finden oft durch die räumliche Nähe transnationale Kooperationen statt. Darüber hinaus kann auch die Hoffnung, sich an Ausschreitungen und Übergriffen beteiligen zu können, ein Grund für deutsche Neonazis sein, sich auf Reisen zu begeben....
This is the 23. article in our series Trouble on the Far-Right.
ccording to several observers new waves of refugees’ arrivals could increase the popularity of far right organizations.1 In these interpretations electoral and political support should be promoted by societal resonance of ethnocentric discourses. Recent data from the Eurobarometer illustrates that in EU-member states migration from non-EU countries is now considered to be the most important concern that the Union is facing. This is a sudden shift with respect to the results of the 2013 Eurobarometer where – in the middle of the euro crisis – EU citizens seemed to be more concerned about the economy and unemployment. I propose to place the magnifying glass on the arguments developed by these organizations by focusing on the least researched members of the far right family: nonparty organizations. After introducing CasaPound Italia (CPI) it will be discussed what fuels its anti-migrant’s discourse by highlighting continuities and changes with respect to classic nativist far right rhetoric. Digging into the arguments is crucial to getting a better assessment of their potential appeal especially in a favorable context...
Dies ist eine gekürzte Version eines Beitrags, der in der Zeitschrift Internationale Politik – IP, Ausgabe Mai/Juni 2016, erschienen ist.
Während in den zehn Jahren des Afghanistan-Krieges von 1979 bis 1989 geschätzte 20 000 „foreign fighters“ zu den Mudschahedin und Al-Kaida ins Kriegsgebiet zogen, sind es im vom so genannten „Islamischen Staat“ (IS) gehaltenen Territorium nach drei Jahren bereits etwa 30 000. Zwischen 6000 und 7000 kommen aus Ländern der EU; erstmals folgen auch Frauen in signifikanter Zahl dem Ruf einer islamistischen Terrororganisation. Warum also zieht der IS so viel mehr Anhänger an, als es Al-Kaida je getan hat? Wieso machen sich Tausende junger Muslime, die in Europa geboren wurden, auf den Weg in ein angebliches Kalifat und reales Kriegsgebiet? Und welche Rolle spielen die Narrative und Angebote des IS dabei?...
Crypticerya brasiliensis (Hempel) and Crypticerya genistae (Hempel) (Hemiptera: Monophlebidae:
Iceryini) are herein reported for the fi rst time in Colombia. The above two species and Crypticerya multicicatrices Kondo and Unruh and Crypticerya zeteki (Cockerell) are briefl y diagnosed based on the adult females. The presence of C. zeteki in Colombia is confi rmed and a key to the adult females of species of the tribe Iceryini reported in Colombia is provided.
Cedar Point Biological Station (CPBS) is located in the mixed grass prairie of the central Great Plains, at the transition between the subregions known as the “tall grass” and “short grass” prairies. Adding to the habitat diversity, there are wetlands and riparian habitats associated with the North Platte River and the edge of the Sandhills region of north central Nebraska. This concurrence of habitats supports a diverse small mammal community. The purpose of this paper is to assemble all published information on ectoparasites associated with small mammals (Insectivora, Rodentia) of southwestern Nebraska, and to report the results of an intensive survey carried out by students of the Parasitology fi eld course during two summers at CPBS. In 2012 and 2013, 27 species of mammal-associated arthropods were collected, including fi ve species of sucking lice (Anoplura), a chewing louse (Ischnocera), six species of fl eas (Siphonaptera), thirteen species of mesostigmatic mites (Laelapidae, Macronyssidae, Macrochelidae), and two species of metastigmatic ticks (Ixodidae). These specimens were brushed from the pelage of 11 species of small mammals that were captured in a variety of habitats around CPBS. The arthropod
list includes 17 new records for the State of Nebraska. This collection is housed in the Harold W. Manter Laboratory of Parasitology (HWML), University of Nebraska State Museum, at the University of Nebraska-Lincoln, and serves as a taxonomic base for our continued efforts to establish a long-term catalog of parasites associated with small mammals in southwestern Nebraska.
Two new species of the mexicanus group of Vaejovis C.L. Koch are described from the Madrean pine-oak forests of the Sierra Madre Occidental in the state of Durango, Mexico. These species, Vaejovis sierrae sp. nov. and Vaejovis mcwesti sp. nov., are distinguished from each other and the only other species of the mexicanus group known from this mountain range, Vaejovis montanus Graham and Bryson, by morphometrics, carinal development of the pedipalps, granulation of the metasoma, and body size. A key to the species of the mexicanus group from
the Sierra Madre Occidental is provided.
Descriptions and illustrations of the fi fth instar and prepupal larval stages of Stethon pectorosus LeConte, 1866 (Coleoptera: Eucnemidae: Eucneminae: Mesogenini) are provided. These are the fi rst larval descriptions for the genus Stethon LeConte within the subfamily Eucneminae in the Nearctic region. Biological information is provided and comparison with larval morphology of other Eucnemidae is briefl y discussed.
Nuevo género y especie de Rutelini (Coleoptera: Scarabaeidae: Rutelinae) de los Andes peruanos
(2016)
Peruquime nov. gen., is established for P. arequipensis nov. sp., a peculiar Scarabaeidae species discovered at high altitude in the Andes Mountains of southern Peru. The new genus and species is externally similar to some representatives of the subfamily Melolonthinae; however, important morphological characters place it within Rutelinae. Diagnostic characters, observations on the habitat, natural history and distribution of the new species are given. A distribution map, adult photographs and illustrations of some diagnostic features are included.
Fourteen new species of faronine pselaphines in the genus Sonoma Casey are described: S. agitator (California); S. cardiac (Oregon); S. carltoni (Oregon); S. cataloochee (North Carolina); S. caterinoi (California); S. chandleri (California); S. cobra (California); S. colberti (California); S. maryae (Oregon); S. quellazaire (Oregon); S. rossellinae (California); S. stewarti (California); S. twaini (California); and S. virgo (California, Oregon). Thirteen are from western North America and one from the eastern U.S. These species bring the total diversity of the genus to 57 species—40 from western North America and 17 from the eastern U.S. A key to, and updated distributions for, all western species are provided.
Notes on some species of Myzomorphus Sallé, 1850 (Coleoptera, Cerambycidae, Prioninae, Anacolini)
(2016)
Notes on the type of Myzomorphus quadripunctatus (Gray, 1831) are provided, and a lectotype is designated for the species. The holotype male of M. poultoni Lameere, 1912, along with a second male, are fi gured for the fi rst time, and compared with M. gounellei Lameere, 1912. Notes on Myzomorphus amabilis (Tippmann, 1960) and a key to known males of Myzomorphus are also provided.
A new Iranian, probably pholeophilous species of the scarabaeine genus Onthophagus Latreille, 1802, O. roessneri n. sp., is described, illustrated, and its placement in the semicornis group within the subgenus Palaeonthophagus Zunino, 1979 is discussed. A key to the species of the group is presented.
Pyroghatsiana, a new genus of pyrochroine Pyrochroidae is described from the Southern Ghats of the Indian continental southern tip. The only known specimen is a female, Pyroghatsiana madurensis (Pic), new combination, originally placed in Dendroides Latreille, and subsequently transferred to Pseudodendroides Blair. Several striking differences including the dorsal interocular width between the compound eyes, shape and length of the third antennal segment, and shape of the pronotum preclude placement of Pyroghatsiana in either Dendroides, Pseudodendroides, or any other existing pyrochroine genus.
We provide the current holdings of Meropeidae in the Florida State Collection of Arthropods (FSCA). To date, FSCA holds a well-curated collection of extant meropeids representing 17 U.S. states and Western Australia (n = 316 Merope tuber Newman, fi ve Austromerope poultoni Killington). Merope tuber records from Vermont, Texas, and South Carolina are published here for the fi rst time. A total of 298 pinned M. tuber and four pinned
A. poultoni; six M. tuber specimens preserved in 95% ethanol; and 12 M. tuber and one A. poultoni sputter-coated with gold-palladium for SEM are available for researchers interested in studying this unique family of insects.
Carulaspis juniperi (Bouché) is newly documented as occurring in the Korean fauna of armored scales (Hemiptera: Diaspididae). The characters of this genus and species are redescribed based on specimens collected in Korea. In addition, four species of aphelinids (Hymenoptera: Aphelinidae) associated with C. juniperi were collected in Korea during the survey. Of these, Aphytis japonicus DeBach and Azim and Encarsia explorata (Silvestri) are recorded for the fi rst time from C. juniperi.
Scale insects (Hemiptera: Coccoidea) of avocado, Persea americana Mill. (Lauraceae) were collected in the State of Valle del Cauca, Colombia. The study was conducted for one year, during October 2008–October 2009.
As a result of this study, 34 scale insect species in seven families (Coccidae, Diaspididae, Kerriidae, Margarodidae,
Monophlebidae, Pseudococcidae and Putoidae) were collected. Together with previous records, the number of scale insects collected on avocado in Colombia increased to 44 species and to 137 species worldwide. Species commonly collected on avocado in Colombia include Hemiberlesia cyanophylli (Signoret), Pseudoparlatoria parlatorioides (Comstock) (Diaspididae), Ceroplastes rubens Maskell, Coccus hesperidum L., Protopulvinaria pyriformis (Cockerell), Pulvinaria psidii Maskell, Saissetia neglecta De Lotto (Coccidae) and Ferrisia williamsi Kaydan and Gullan (Pseudococcidae). Twenty-two scale insect species are new records on avocado for Colombia of which nine species are new records worldwide, namely, Lindingaspis rossi (Maskell), Pseudischnaspis bowreyi (Cockerell) (Diaspididae), Pulvinaria psidii Maskell, Saissetia neglecta De Lotto (Coccidae), Ferrisia kondoi Kaydan and Gullan, Pseudococcus jackbeardsleyi Gimpel and Miller, Ps. landoi (Balachowsky) (Pseudococcidae), Eurhizococcus colombianus Jakubski (Margarodidae) and Austrotachardiella colombiana Kondo and Gullan (Kerriidae).
The name Melolontha hypocrita Mannerheim, 1829 has been long unused, even though it is the type species of Hyporhiza Dejean, 1833. I examined the only known specimen from the type series and here designate it as the lectotype. Examination of this lectotype reveals that this species is best placed in the genus Rhinaspis Perty, 1830. Consequently, the genus Hyporhiza Dejean, 1833 is confi rmed as a junior synonym of Rhinaspis. Further, the replacement name Rhinaspis fuhrmanni is proposed for Rhinaspis hypocrita (Blanchard, 1850), a new secondary homonym of Rhinaspis hypocrita (Mannerheim, 1829). A homonymy problem was also discovered and corrected for the genus Plectris LePeletier and Serville, 1828. The replacement name Plectris schoolmeestersi is proposed for Plectris paraguayensis Moser, 1924, which is a secondary junior homonym of Plectris paraguayensis (Moser, 1921).
Epimelitta postimelina Giesbert, 1996 and Odontocera apicula Bates, 1885 are transferred to the new genus Odontomelitta. Epimelitta postimelina, with closed procoxal cavities, cannot remain in Epimelittta Bates, 1870, a genus characterized by open procoxal cavities. The short elytra and tegmen (with caliper-shaped lateral lobes) of the aedeagus of both species excludes them from the genus Odontocera Audinet-Serville, 1833, with long elytra and tegmen (with strap-shaped lateral lobes). Both species are illustrated, and host plant and host flower records provided for O. apicula.
The island arc of the Lesser Antilles lies at the eastern margin of the Caribbean Sea in the Western Hemisphere, and stretches from the eastern end of the islands of the Greater Antilles (at the Virgin Islands), south to a position near the continental islands of Trinidad and Tobago at the north eastern corner of South America. The islands are a part of the West Indian Islands biodiversity “hotspot” and have been available for terrestrial colonization for about the past 15 million years. This is a status report on present knowledge of the beetle faunas of these islands, which is composed of 90 families, 1210 genera, and 2612 recognized species. Many additional species are not yet identified, or are unnamed, or remain to be discovered. Reported for the first time from the Lesser Antilles are four families, 49 genera, 105 species, and 1253 new island records. The largest families are Curculionidae (588 species), Staphylinidae (389 species), Chrysomelidae (181 species), Tenebrionidae (142 species), Cerambycidae (138 species), Scarabaeidae (127 species), and Carabidae (126 species). There are differing patterns of species distributions: 154 species are probably introduced by human activities; 985 are endemic species (limited to a single island); 465 are species endemic to more than one island of the Lesser Antilles; 212 are species limited to just islands of the West Indies; and 800 are native (naturally occurring) species which also have part of their distributional range in North, Central, or South America. Most of the widely distributed beetle fauna has probably come from South America by over-water dispersal. There is no compelling evidence for a vicariance origin of any part of the beetle fauna. Earlier colonists have had more time to form endemic genera (18) and endemic species. The more widely distributed species probably represent distributions achieved in and since the Pleistocene.
Abstract: Neural networks, despite their highly interconnected nature, exhibit distinctly localized and gated activation. Modularity, a distinctive feature of neural networks, has been recently proposed as an important parameter determining the manner by which networks support activity propagation. Here we use an engineered biological model, consisting of engineered rat cortical neurons, to study the role of modular topology in gating the activity between cell populations. We show that pairs of connected modules support conditional propagation (transmitting stronger bursts with higher probability), long delays and propagation asymmetry. Moreover, large modular networks manifest diverse patterns of both local and global activation. Blocking inhibition decreased activity diversity and replaced it with highly consistent transmission patterns. By independently controlling modularity and disinhibition, experimentally and in a model, we pose that modular topology is an important parameter affecting activation localization and is instrumental for population-level gating by disinhibition.
Author Summary: The capacity to transmit information between connected parts of a neuronal network is fundamental to its function. The organization of network connections (the topology of the network) is therefore expected to play an important role in determining network transmission. Since modular topology characterizes many brain circuits on multiple scales, investigating the role of modularity in activity gating is clearly desirable. By engineering such modular networks in vitro, we were able to perform such an investigation. Under these experimental conditions, we can independently control the degree of modularity, as well as inhibition in the network. We show that a combination of these two properties is highly beneficial from a communication perspective. Namely, it equips connected modules and large modular networks with the capacity to gate and temporally coordinate activity between the different parts of the network.
Background: Dental biomechanics based on finite element (FE) analysis is attracting enormous interest in dentistry, biology, anthropology and palaeontology. Nonetheless, several shortcomings in FE modeling exist, mainly due to unrealistic loading conditions. In this contribution we used kinematics information recorded in a virtual environment derived from occlusal contact detection between high resolution models of an upper and lower human first molar pair (M1 and M1, respectively) to run a non-linear dynamic FE crash colliding test.
Methodology: MicroCT image data of a modern human skull were segmented to reconstruct digital models of the antagonistic right M1 and M1 and the dental supporting structures. We used the Occlusal Fingerprint Analyser software to reconstruct the individual occlusal pathway trajectory during the power stroke of the chewing cycle, which was applied in a FE simulation to guide the M1 3D-path for the crash colliding test.
Results: FE analysis results showed that the stress pattern changes considerably during the power stroke, demonstrating that knowledge about chewing kinematics in conjunction with a morphologically detailed FE model is crucial for understanding tooth form and function under physiological conditions.
Conclusions/Significance: Results from such advanced dynamic approaches will be applicable to evaluate and avoid mechanical failure in prosthodontics/endodontic treatments, and to test material behavior for modern tooth restoration in dentistry. This approach will also allow us to improve our knowledge in chewing-related biomechanics for functional diagnosis and therapy, and it will help paleoanthropologists to illuminate dental adaptive processes and morphological modifications in human evolution.
Aims: To investigate real-world clinical and patient-related variables associated with initiating GLP-1 receptor agonist (GLP-1RA) treatment relative to initiation of other glucose-lowering therapies in type 2 diabetes (T2D) patients of primary care in Germany.
Methods: Data for 938 T2D patients who started therapy with a GLP-1RA within 823 practices of primary care throughout Germany were retrospectively analyzed (Disease Analyser: 01/2011–03/2014). 5,197 T2D patients who initiated other non-GLP-1RA antidiabetic therapies were selected as controls. Multivariate logistic regression analyses were applied to identify factors associated with GLP-1RA initiation in primary care.
Results: Mean age (SD) of GLP-1RA users was 57.8 (11.8) years (males: 55.5%) and the average BMI was 36.1 (6.7) kg/m2. 22.8% were in diabetologist care and 12.0% had private health insurance. In multivariate regression, choice of GLP-1RA therapy instead of a different glucose-lowering drug class was associated with obesity (odds ratio: 1.68; 95% CI: 1.34–2.10), private health insurance (2.42; 1.89–3.09), younger age (0.94; 0.93–0.95 per year), male sex (0.85; 0.73–0.99), diabetologist care (2.11; 1.73–2.57), and geographic practice location (East vs. West-Germany; 1.25; 1.05–1.49). Among co-medication, angiotensin II antagonists (increased) and non-steroidal antirheumatic agents (decreased) were related to GLP-1RA prescriptions (both p<0.001).
Conclusions: Consistent with German guidelines, GLP-1RA is mainly prescribed preferentially in T2D patients who are obese. GLP-1RA drugs were more frequently used than other options in privately health insured patients and in patients seeing a diabetologist.