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Background: We conducted a phase I study with a granulocyte macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with solid tumors refractory to available treatments. The objectives of the study were to determine the optimal dose for further use and to assess the safety, tolerability and adverse event (AE) profile of ONCOS-102. Further, the response rate and overall survival were evaluated as well as preliminary evidence of disease control. As an exploratory endpoint, the effect of ONCOS 102 on biological correlates was examined.
Methods: The study was conducted using a classic 3 + 3 dose escalation study design involving 12 patients. Patients were repeatedly treated intratumorally with ONCOS-102 plus daily low-dose oral cyclophosphamide (CPO). Tumor response was evaluated with diagnostic positron emission tomography (PET) and computed tomography (CT). Tumor biopsies were collected at baseline and after treatment initiation for analysis of immunological correlates. Peripheral blood mononuclear cells (PBMCs) were collected at baseline and during the study to assess antigen specificity of CD8+ T cells by interferon gamma (IFNγ) enzyme linked immunospot assay (ELISPOT).
Results: No dose limiting toxicity (DLT) or maximum tolerated dose (MTD) was identified for ONCOS-102. Four out of ten (40 %) evaluable patients had disease control based on PET/CT scan at 3 months and median overall survival was 9.3 months. A short-term increase in systemic pro-inflammatory cytokines and a prominent infiltration of TILs to tumors was seen post-treatment in 11 out of 12 patients. Two patients showed marked infiltration of CD8+ T cells to tumors and concomitant systemic induction of tumor-specific CD8+ T cells. Interestingly, high expression levels of genes associated with activated TH1 cells and TH1 type immune profile were observed in the post-treatment biopsies of these two patients.
Conclusions: ONCOS-102 is safe and well tolerated at the tested doses. All three examined doses may be used in further development. There was evidence of antitumor immunity and signals of clinical efficacy. Importantly, treatment resulted in infiltration of CD8+ T cells to tumors and up-regulation of PD-L1, highlighting the potential of ONCOS-102 as an immunosensitizing agent for combinatory therapies with checkpoint inhibitors.
Trial registration: NCT01598129. Registered 19/04/2012
Um zukünftig den städtischen Verkehr – vor allem in Städten und Regionen mit Bevölkerungszuwächsen – ökologisch nachhaltiger abzuwickeln und gleichzeitig die Stadt als attraktiven Wohnort zu gestalten, wird aktuell in Forschung und Praxis eine Vielzahl unterschiedlicher Konzepte diskutiert und erprobt. Eine mögliche stadtplanerische Maßnahme in diesem Kontext ist die Entwicklung autofreier oder autoreduzierter Stadtquartiere. Im Rahmen bisheriger wissenschaftlicher Untersuchungen sind die Voraussetzungen für die Umsetzung solcher Konzepte meist eher unzureichend dokumentiert und analysiert worden. In dieser Forschungsarbeit wurde deshalb untersucht, welche Relevanz verschiedene stadt- und projektbezogene Rahmenbedingungen und Einflussfaktoren bei der Entwicklung autofreier bzw. autoreduzierter Stadtquartiere besitzen.
Wenngleich bei der Realisierung autofreier oder autoreduzierter Projekte zahlreiche Faktoren wirksam sind, können als Ergebnis der Untersuchung vor allem zwei Aspekte als entscheidend für eine erfolgreiche Umsetzung solcher Projekte betrachtet werden. Dies ist zunächst eine ausreichende Unterstützung der Projekte durch die städtische Politik und Verwaltung. Als zweiter wesentlicher Einflussfaktor kann eine Förderung autofreier und autoreduzierter Projekte durch private Initiativen und Vereine gelten.
Trotz einer fast 30-jährigen Forschungs- und Umsetzungshistorie stellen Projekte zum Aufbau integrierter Datenhaushalte (Data Warehouses) für Unternehmen immer noch eine große Herausforderung dar. Gerade in Data Warehouse-Projekten bei Finanzdienstleistern führt eine hohe semantische Komplexität häufig zu Projektverzögerungen oder zum Scheitern der Vorhaben. Dies zeigt die Arbeit anhand von explorativen Fallstudien auf und fragt nach den Gründen für diesen typischen Verlauf. Eine mögliche Ursache liegt in einer unzureichenden Kommunikation zwischen den Projektbeteiligten, was zu Missverständnissen in der Konzeption und somit zu Fehlimplementierungen führt, die – gerade wenn sie spät erkannt werden – deutliche Verzögerungen und Budgetüberschreitungen zur Folge haben. Ausgehend von diesen beobachteten Praxisproblemen sucht die vorliegende Arbeit auf der Grundlage des Design-Science-Research nach Lösungsansätzen: unter Übertragung der Erkenntnisse der Kommunikationstheorie wurden drei Artefakte entwickelt, sukzessive verbessert und validiert. Die Paper zeigen auf, dass sich durch den Einsatz formalisierter Templates, eines verbesserten Vorgehensmodells in Verbindung mit einem korrespondieren Softwaretool das Kommunikationsverhalten in den Projekten verbessern lässt und somit eine höhere Projekt-Performance erreicht wird. Hierzu wurden insgesamt sechs Projekte zum Aufbau von Data Warehouses im Finanzdienstleistungsumfeld in Fallstudien analysiert und zudem Experten-Interviews mit den Projektbeteiligten durchgeführt, die im Ergebnis die positive Wirkung der Artefakte unterstützen.
Basierend auf den Daten der Erhebung „Gesundheit in Deutschland Aktuell“ von 2010 (GEDA2010)vom Robert Koch-Institut wird in dieser Dissertation der Frage nachgegangen, wie sich
Arbeitsbedingungen auf die Gesundheit und das Gesundheitsverhalten auswirken und eine systematische Analyse für Deutschland durchgeführt. Dabei werden sowohl Aspekte der Geschlechterforschung als auch der Erforschung sozialer Ungleichheiten mitbetrachtet. Die Ergebnisse liefern unteranderem Hinweise darauf, dass Gesundheitsverhalten als Coping-Strategie in stressreichen Arbeitssituationen, die beispielsweise durch Leistungsdruck oder Schichtarbeit gekennzeichnet sind, genutzt wird.
SAFE Newsletter : 2016, Q2
(2016)
Random ordinary differential equations (RODEs) are ordinary differential equations (ODEs) which have a stochastic process in their vector field functions. RODEs have been used in a wide range of applications such as biology, medicine, population dynamics and engineering and play an important role in the theory of random dynamical systems, however, they have been long overshadowed by stochastic differential equations.
Typically, the driving stochastic process has at most Hoelder continuous sample paths and the resulting vector field is, thus, at most Hoelder continuous in time, no matter how smooth the vector function is in its original variables, so the sample paths of the solution are certainly continuously differentiable, but their derivatives are at most Hoelder continuous in time. Consequently, although the classical numerical schemes for ODEs can be applied pathwise to RODEs, they do not achieve their traditional orders.
Recently, Gruene and Kloeden derived the explicit averaged Euler scheme by taking the average of the noise within the vector field. In addition, new forms of higher order Taylor-like schemes for RODEs are derived systematically by Jentzen and Kloeden.
However, it is still important to build higher order numerical schemes and computationally less expensive schemes as well as numerically stable schemes and this is the motivation of this thesis. The schemes by Gruene and Kloeden and Jentzen and Kloeden are very general, so RODEs with special structure, i.e., RODEs with Ito noise and RODEs with affine structure, are focused and numerical schemes which exploit these special structures are investigated.
The developed numerical schemes are applied to several mathematical models in biology and medicine. In order to see the performance of the numerical schemes, trajectories of solutions are illustrated. In addition, the error vs. step sizes as well as the computational costs are compared among newly developed schemes and the schemes in literature.
The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70S6K1 dependent phosphorylation of Pdcd4 followed by β-TrCP1-mediated ubiquitination, and proteasomal destruction of the protein was characterized as a major mechanism contributing to the loss of Pdcd4 expression in tumors. In an attempt to identify stabilizers of Pdcd4, we used a luciferase-based high-throughput compatible cellular assay to monitor phosphorylation-dependent proteasomal degradation of Pdcd4 in response to mitogen stimulation. Following a screen of approximately 2000 compounds, we identified 1,2-bis(4-chlorophenyl)disulfide as a novel Pdcd4 stabilizer. To determine an initial structure-activity relationship, we used 3 additional compounds, synthesized according to previous reports, and 2 commercially available compounds for further testing, in which either the linker between the aryls was modified (compounds 2–4) or the chlorine residues were replaced by groups with different electronic properties (compounds 5 and 6). We observed that those compounds with alterations in the sulfide linker completely lost the Pdcd4 stabilizing potential. In contrast, modifications in the chlorine residues showed only minor effects on the Pdcd4 stabilizing activity. A reporter with a mutated phospho-degron verified the specificity of the compounds for stabilizing the Pdcd4 reporter. Interestingly, the active diaryl disulfides inhibited proliferation and viability at concentrations where they stabilized Pdcd4, suggesting that Pdcd4 stabilization might contribute to the anti-proliferative properties. Finally, computational modelling indicated that the flexibility of the disulfide linker might be necessary to exert the biological functions of the compounds, as the inactive compound appeared to be energetically more restricted.
Dang Hyang Astapaka and his cultural geography in spreading Vajrayana Buddhism in medieval Bali
(2016)
The sway of Hinduism and Buddhism in Indonesia archipelago had imprinted deep cultural heritages in various modes. The role of holy persons and kings were obvious in the spread of these religious and philosophical traditions. Dang Hyang Asatapaka, a Buddhist priest from East Java had travelled to Bali in spreading Vajrayana sect of Mahayana Buddhist in 1430. He came to Bali as the ruler of Bali invited him to officiate Homa Yajna together with his uncle Dang Hyang Nirartha, who had stayed earlier in Bali. Impressed with deep knowledge and spiritual acumen of him, the ruler Waturenggong King appointed him as a purohito (palace priest), whose jobs were to give spiritual consultation and political advisor in ruling the country. During his life times in Bali, he travelled from one place to another spreading Vajrayana sect of Buddhism. Lastly he settled in Budakeling village in East Bali where he built gerya (house) and temples for worship and meditation. From here he, his descents, and followers spread the Vajrayana to all over Bali and Lombok. He left us with Vajrayana sect of Buddhism, which was assimilated with Saivism. Dang Hyang Astapaka and his uncle Dang Hyang Nirartha were the advocators of Saiva-Buddha cult in Bali backed up by the rulers.
Understanding the shift from micro to macro-prudential thinking: a discursive network analysis
(2016)
While some economists argued for macro-prudential regulation pre-crisis, the macro-prudential approach and its emphasis on endogenously created systemic risk have only gained prominence post-crisis. Employing discourse and network analysis on samples of the most cited scholarly works on banking regulation as well as on systemic risk (60 sources each) from 1985 to 2014, we analyze the shift from micro to macro-prudential thinking in the shift to the post crisis period. Our analysis demonstrates that the predominance of formalism, particularly, partial equilibrium analysis along with the exclusion of historical and practitioners’ styles of reasoning from banking regulatory studies impeded economists from engaging seriously with the endogenous sources of systemic risk prior to the crisis. Post-crisis, these topics became important in this discourse, but the epistemological failures of banking regulatory studies pre-crisis were not sufficiently recognized. Recent attempts to conceptualize and price systemic risk as a negative externality point to the persistence of formalism and equilibrium thinking, with its attending dangers of incremental innovation due to epistemological barriers constrains theoretical progress, by excluding observed phenomena, which cannot yet be accommodated in mathematical models.
We argue two alternative routes that lead entrepreneurial start-ups to acquisition outcomes instead of liquidation. On one hand, acquisitions can come about through the control route with external financers such as venture capitalists (VCs). VCs take control through their board seats along with other contractual rights that can bring about changes in a start-up necessary to successfully attract a strategic acquirer. Consistent with this view, we show that VCs often replace the founding entrepreneur as CEO long before an acquisition exit. On the other hand, acquisitions can come about through advice and support provided to the start-up, such as that provided by an incubator or technology park. Based on a sample of 251 Crunchbase companies in the U.S. over the years 2007 to 2014, we present evidence that is strongly consistent with these propositions. Further, we show that the data indicate a tension between VC-backing of start-ups resident in technology parks insofar as such start-ups are slower to become, and less likely to be, acquired.
Intrinsic motivation for honesty is perceived as an important determinant of large and persistent variation in cheating behavior. However, little is known about its actual role due to challenges in obtaining precise measures of motivation for honesty, as well as field outcomes on cheating. We fill these gaps using a unique setting of informal milk markets in India. A novel behavioral experiment, which combines a standard die roll task with Bluetooth technology, is used to measure motivation for honesty of milkmen at both extensive and intensive margins. We then buy milk from the same milkmen and show that cheating in the field, measured by the amount of water added to milk, widens significantly with a milkman’s degree of dishonesty. Additional analyses show that conventional binary measure of motivation for honesty suffers from measurement errors, resulting in underestimation of this association.
In this paper, we examine how the institutional design affects the outcome of bank bailout decisions. In the German savings bank sector, distress events can be resolved by local politicians or a state-level association. We show that decisions by local politicians with close links to the bank are distorted by personal considerations: While distress events per se are not related to the electoral cycle, the probability of local politicians injecting taxpayers’ money into a bank in distress is 30 percent lower in the year directly preceding an election. Using the electoral cycle as an instrument, we show that banks that are bailed out by local politicians experience less restructuring and perform considerably worse than banks that are supported by the savings bank association. Our findings illustrate that larger distance between banks and decision makers reduces distortions in the decision making process, which has implications for the design of bank regulation and supervision.
We employ a unique dataset on members of an elite service club in Germany to investigate how elite networks affect the allocation of resources. Specifically, we investigate credit allocation decisions of banks to firms inside the network. Using a quasi-experimental research design, we document misallocation of bank credit inside the network, with state-owned banks engaging most actively in crony lending. The aggregate cost of credit misallocation amounts to 0.13 percent of annual GDP. Our findings, thus, resonate with existing theories of elite networks as rent extractive coalitions that stifle economic prosperity.
The term 'financialization' describes the phenomenon that commodity contracts are traded for purely financial reasons and not for motives rooted in the real economy. Recently, financialization has been made responsible for causing adverse welfare effects especially for low-income and low-wealth agents, who have to spend a large share of their income for commodity consumption and cannot participate in financial markets. In this paper we study the effect of financial speculation on commodity prices in a heterogeneous agent production economy with an agricultural and an industrial producer, a financial speculator, and a commodity consumer. While access to financial markets is always beneficial for the participating agents, since it allows them to reduce their consumption volatility, it has a decisive effect with respect to overall welfare effects who can trade with whom (but not so much what types of instruments can be traded).
The eurozone remains in a deep, largely macro-economic crisis. A robust global economy and falling oil prices have supported Europe’s economy for some time, but by now it is clear that the eurozone will only be able to pull itself out of this crisis by means of more decisive action. One response, the recent easing of monetary policy by the European Central Bank (ECB), has, for the most part, been sharply and one-sidedly criticised in Germany. Monetary policy inaction seems to be the preferred option of many in Germany.
The authors discuss the following question: What would happen if the ECB failed to respond to the excessively low inflation and the weak economy? And what economic policy would be suitable under the current circumstances, if not monetary policy?
Euro area shadow banking activities in a low-interest-rate environment: a flow-of-funds perspective
(2016)
Very low policy rates as well as the substantial redesign of rules and supervisory institutions have changed background conditions for the Euro Area’s financial intermediary sector substantially. Both policy initiatives have been targeted at improving societal welfare. And their potential side effects (or costs) have been discussed intensively, in academic as well as policy circles. Very low policy rates (and correspondingly low market rates) are likely to whet investors’ risk taking incentives. Concurrently, the tightened regulatory framework, in particular for banks, increases the comparative attractiveness of the less regulated, so-called shadow banking sector. Employing flow-of-funds data for the Euro Area’s non-bank banking sector we take stock of recent developments in this part of the financial sector. In addition, we examine to which extent low interest rates have had an impact on investment behavior. Our results reveal a declining role of banks (and, simultaneously, an increase in non-bank banking). Overall intermediation activity, hence, has remained roughly at the same level. Moreover, our findings also suggest that non-bank banks have tended to take positions in riskier assets (particularly in equities). In line with this observation, balance-sheet based risk measures indicate a rise in sector-specific risks in the non-bank banking sector (when narrowly defined).
Non-bank (-balance sheet) based financial intermediation has become considerably more important over the last couple of decades. For the U.S., this trend has been discussed ever since the mid-1990s. As a consequence, traditional monetary transmission mechanisms, mainly operating through bank balance sheets, have apparently become less relevant. This in particular applies to the bank lending channel. Concurrently, recent theoretical and empirical work uncovered a "risk-taking channel" of monetary policy. This mechanism is not confined to traditional banks but has been found to operate also across the spectrum of financial intermediaries and intermediation devices, including securitization and collateralized lending/borrowing. In addition, recent empirical evidence suggests that the increasing importance of shadow-banking activities might have given rise to a so-called "waterbed effect". This is a mediating mechanisms, dampening or counteracting typically to be expected reactions to monetary policy impulses. Employing flow-of-funds data, we can document also for the Euro Area that a trend towards non-bank (not necessarily more 'market'-based) intermediation has occurred. This is, however, a fairly recent development, substantially weaker than in the U.S. Nonetheless, analyzing the response of Euro Area bank and nonbank financial intermediaries to monetary policy impulses, we find some notable behavioral differences between mainly deposit-funded and more 'market'-based financial intermediaries. We also detect, inter alia, the existence of a (still) fairly weak, but potentially policyrelevant, "waterbed" effect.
French far right activism experienced tremendous changes in recent years. Besides traditional far right party politics, new patterns of street-based mobilization attract especially action-oriented youths. This trend is epitomized by the growing popularity of the Bloc Identitaire (official name; shortened to “Identitaires”). Its ideology rests on the idea that there exists a struggle between different political families in order to become the legitimate representative of the people, and that the extreme right is winning this struggle. Behind the scenes, the recurring idea of the Bloc Identitaires is to occupy a cultural and “meta-political” territory that was once the monopoly of the left. Their aim is that they are gradually associated with the only possible alternative to change the world. They try to frame a maximum of popular needs and present themselves as substitutes for when the economy and the state will be bankrupt. So you can eat the food of the Identitaires, drink their beer (the “Desouchière”), buy their clothes, listen to their music or read their books and thus participate in financing the movement...
Nachkriegsländer gehören zu den schwierigsten politischen Arenen. Die Herausforderungen bestehen nicht nur darin, diese Länder dabei zu unterstützen Kriege zu beenden und neue Gewaltausbrüche zu verhindern, sondern vielmehr zu einem friedlichen Zusammenleben zurückzukehren. In diesem Zusammenhang ist in den letzten Jahren das Interesse vieler Wissenschaftler als auch vieler internationaler Akteure gestiegen, das mögliche Potential des nachhaltigen Managements natürlicher Ressourcen zu nutzen um Friedensprozesse zu unterstützen. Die Hoffnung liegt dabei darin, dass eine gute Regierungsführung („Good Governance“) und insbesondere die nachhaltige Entwicklung und Nutzung von Ressourcen wie Wasser, Wald oder landwirtschaftlichen Flächen, Kooperation zwischen Konfliktparteien ermöglichen und dabei zum Neustart der internen Beziehungen beitragen. Die wachsende Bedeutung des Zusammenspiels zwischen der Entwicklung von Frieden und Umweltschutz sowie der nachhaltigen Nutzung von Ressourcen wurde erst kürzlich durch die Ziele nachhaltiger Entwicklung der Vereinten Nationen bestätigt....
This is the 20. article in our series Trouble on the-Far-Right.
Just a few days ago during a parliamentary session, a Kurdish deputy was violently attacked and injured by members of the governing Justice and Development Party (AKP). As if to support Charles Tilly’s statement that ‘political violence occurs when actors have few opportunities, yet enough resources to mobilize for violence’1, many groups in Turkey are currently involved in a battle against Kurdish, Alevi or left Turkish citizens. The Turkish President Recep Tayyip Erdoğan in a political stalemate, uses military and police, but also the Nationalist Movement Party’s (MHP) youth organization Grey Wolves as well as Islamist militias like Esedullah Timleri (Arabic for: Lions of Allah) have increasingly resorted to violence as tool of action.
Political violence has been a central characteristic of the Turkish far right, which largely resembles street-based mobilization in Western Europe. Despite the common ultra-nationalist ideology, the Gülen Movement (GM) stands out. AKP’s former “soft-power instrument” now appears to be the only reasonable and non-violent player among all of these self-named animal groups. Since the power struggle escalated between Erdoğan and Fethullah Gülen in 2013, the GM has been seen as a victim of Erdoğan’s repressive measures, instead of making itself conspicuous by using violence. How can we explain this exception?
This is the 22. article in our series Trouble on the Far-Right.
Changing political and economic situations generate new types of political protagonists – the far right is no exception here. Whether its structures and organizational forms endure, whether they diffuse (trans)nationally, whether their models prove successful, depends on various factors. A model that is currently about to serve as a flagship for the far right in Europe is the neo-fascist movement / party CasaPound. So why is this organizational model within the far right in Italy and Europe so successful?
My contribution is intended to shed light on the hybridity of CasaPound and the resulting force for the renewal of fascism. To carry out my argument, I will first describe the evolution of CasaPound from a movement to a party. Then I will discuss strategies and practices in terms of organizational and ideological hybridization, to finally outline the European dimension of the self-proclaimed „fascists of the third millennium“...
Children’s interpretations of sentences containing focus particles do not seem adult-like until school age. This study investigates how German 4-year-old children comprehend sentences with the focus particle ‘nur’ (only) by using different tasks and controlling for the impact of general cognitive abilities on performance measures. Two sentence types with ‘only’ in either pre-subject or pre-object position were presented. Eye gaze data and verbal responses were collected via the visual world paradigm combined with a sentence-picture verification task. While the eye tracking data revealed an adult-like pattern of focus particle processing, the sentence-picture verification replicated previous findings of poor comprehension, especially for ‘only’ in pre-subject position. A second study focused on the impact of general cognitive abilities on the outcomes of the verification task. Working memory was related to children’s performance in both sentence types whereas inhibitory control was selectively related to the number of errors for sentences with ‘only’ in pre-subject position. These results suggest that children at the age of 4 years have the linguistic competence to correctly interpret sentences with focus particles, which–depending on specific task demands–may be masked by immature general cognitive abilities.
Abstract:
Snakebite is an important medical emergency in rural Nepal. Correct identification of the biting species is crucial for clinicians to choose appropriate treatment and anticipate complications. This is particularly important for neurotoxic envenoming which, depending on the snake species involved, may not respond to available antivenoms. Adequate species identification tools are lacking. This study used a combination of morphological and molecular approaches (PCR-aided DNA sequencing from swabs of bite sites) to determine the contribution of venomous and non-venomous species to the snakebite burden in southern Nepal. Out of 749 patients admitted with a history of snakebite to one of three study centres, the biting species could be identified in 194 (25.9%). Out of these, 87 had been bitten by a venomous snake, most commonly the Indian spectacled cobra (Naja naja; n = 42) and the common krait (Bungarus caeruleus; n = 22). When both morphological identification and PCR/sequencing results were available, a 100% agreement was noted. The probability of a positive PCR result was significantly lower among patients who had used inadequate “first aid” measures (e.g. tourniquets or local application of remedies). This study is the first to report the use of forensic genetics methods for snake species identification in a prospective clinical study. If high diagnostic accuracy is confirmed in larger cohorts, this method will be a very useful reference diagnostic tool for epidemiological investigations and clinical studies.
Author Summary:
Snakebite is an important medical problem in sub-tropical and tropical regions, including Nepal where tens of thousands of people are bitten every year. Snakebite can result in life-threatening envenoming, and correct identification of the biting species is crucial for care providers to choose appropriate treatment and anticipate complications. This paper explores a number of methods, including molecular techniques, to assist care providers in identifying the species responsible for bites in rural Nepal. Out of 749 patients with a history of snakebite, the biting species could be identified in 194 (25.9%). Out of these, 87 had been bitten by a venomous snake, most commonly cobras (n = 42) and kraits (n = 22). This study is the first to report the use of molecular techniques for snake species identification. The diagnostic accuracy of this method appears high but needs to be confirmed in larger studies.
Eine möglichst realistische Abschätzung von Strahlenschäden ist von entscheidender Bedeutung im Strahlenschutz und für die Strahlentherapie. Die primären Strahlenschäden an der DNS werden heute mit Monte-Carlo-Codes berechnet. Diese Codes benötigen möglichst genaue Fragmentierungsquerschnitte verschiedenster biomolekularer Systeme als Eingangsparameter. Im Rahmen der vorliegenden Arbeit wurde ein Experiment aufgebaut, welches die Bestimmung der Fragmentierungsquerschnitte von Biomolekülen ermöglicht. Die einzelnen Baugruppen des Aufbaus wurden vor dem Beginn des Experimentes bezüglich ihrer Eigenschaften, die die Genauigkeit der Messergebnisse beeinflussen können, charakterisiert. Die Resultate dieser Experimente werden als Eingangsdaten für die Berechnung von primären strahleninduzierten Schäden in der DNS mit Hilfe von Monte-Carlo-Codes eingesetzt.
Eine besondere Herausforderung stellte die Präparation eines Überschallgasstrahls für biomolekulare Substanzen dar. Für die Präparation müssen die Targetsubstanzen zunächst in die Gasphase überführt werden. Im Falle von Biomolekülen ist diese Überführung auf Grund ihrer niedrigen Dampfdrücke bei Raumtemperatur und chemischen Reaktivität mit technischen Problemen verbunden. Die Probleme wurden mittels einer speziellen Konstruktion der Präparationseinrichtung, welche eine direkte Einleitung der Probensubstanzen in die vom Trägergas durchströmte Mischkammer ermöglicht, gelöst. Für die Genauigkeit der gemessenen Fragmentierungsquerschnitte spielen mehrere Faktoren eine Rolle. Neben dem Bewegungsprofil des Überschallgasstrahls, den kinetischen Energien der Fragmentionen und den ionenoptischen Eigenschaften des Flugzeitspektrometers beeinflusst die geometrische Beschaffenheit der Detektionszone maßgeblich die Genauigkeit des Experimentes. Die Position und Ausdehnung des sichtbaren Volumens sind nicht nur durch den Überlappungsbereich zwischen dem Elektronen- und dem Überschallgasstrahl bestimmt, sondern hängen auch von der kinetischen Energie der Fragmente ab. Für dessen Ermittlung wurden daher auch die Trajektorien der Fragmente simuliert. Bei den Experimenten an der PTB-Apparatur ist die frei wählbare Zeitdifferenz zwischen dem Auslösen eines Elektronenpulses und dem Absaugen der Fragmentionen ein wichtiger Messparameter. Ihr Einfluss auf die Messergebnisse wurde ebenfalls neben der Nachweiswahrscheinlichkeit des verwendeten Ionendetektors untersucht. Die Kalibrierung der Flugzeitspektren, d. h. die Umwandlung der Flugzeitspektren in Massenspektren erfolgte anhand der bekannten Flugzeitspektren von Edelgasen und Wasserstoff.
Nach der Charakterisierung der Einflussfaktoren und Kalibrierung der Flugzeitspektren wurden die energieabhängigen Fragmentierungsquerschnitte für Elektronenstoß von mehreren organischen Molekülen, darunter die von Modellmolekülen für die DNS-Bausteine gemessen. Die Flugzeitspektren von THF wurden mit der PTB-Apparatur für einige kinetische Energien der Elektronen in Abhängigkeit von der Zeitdifferenz zwischen dem Auslösen des Elektronenpulses und dem Starten der Analyse durchgeführt. Messungen von Pyrimidin wurden sowohl an der PTB-Apparatur als auch mit COLTRIMS durchgeführt. Die mit COLTRIMS gewonnenen Ergebnisse liefern wichtige Zusatzinformationen über die Fragmentierungsprozesse. COLTRIMS ermöglicht die Messung der zeitlichen Korrelationen zwischen den auftretenden Fragmentionen und damit tiefere Einblicke in die bei der Entstehung der Fragmente beteiligten Reaktionskanäle. Der Vorteil der PTB-Apparatur besteht darin, dass die relativen Auftrittswahrscheinlichkeiten aller Fragmentionen genauer bestimmt werden können.
Purpose: To evaluate the efficacy of the virtual reality training simulator Eyesi to prepare surgeons for performing pars plana vitrectomies and its potential to predict the surgeons’ performance.
Methods: In a preparation phase, four participating vitreoretinal surgeons performed repeated simulator training with predefined tasks. If a surgeon was assigned to perform a vitrectomy for the management of complex retinal detachment after a surgical break of at least 60 hours it was randomly decided whether a warmup training on the simulator was required (n = 9) or not (n = 12). Performance at the simulator was measured using the built-in scoring metrics. The surgical performance was determined by two blinded observers who analyzed the video-recorded interventions. One of them repeated the analysis to check for intra-observer consistency. The surgical performance of the interventions with and without simulator training was compared. In addition, for the surgeries with simulator training, the simulator performance was compared to the performance in the operating room.
Results: Comparing each surgeon’s performance with and without warmup trainingshowed a significant effect of warmup training onto the final outcome in the operating room. For the surgeries that were preceeded by the warmup procedure, the performance at the simulator was compared with the operating room performance. We found that there is a significant relation. The governing factor of low scores in the simulator were iatrogenic retinal holes, bleedings and lens damage. Surgeons who caused minor damage in the simulation also performed well in the operating room.
Conclusions: Despite the large variation of conditions, the effect of a warmup training as well as a relation between the performance at the simulator and in the operating room was found with statistical significance. Simulator training is able to serve as a warmup to increase the average performance.
Cryptochromes, blue-light absorbing proteins involved in the circadian clock, have been proposed to be the receptor molecules of the avian magnetic compass. In birds, several cryptochromes occur: Cryptochrome 2, Cryptochrome 4 and two splice products of Cryptochrome 1, Cry1a and Cry1b. With an antibody not distinguishing between the two splice products, Cryptochrome 1 had been detected in the retinal ganglion cells of garden warblers during migration. A recent study located Cry1a in the outer segments of UV/V-cones in the retina of domestic chickens and European robins, another migratory species. Here we report the presence of cryptochrome 1b (eCry1b) in retinal ganglion cells and displaced ganglion cells of European Robins, Erithacus rubecula. Immuno histochemistry at the light microscopic and electron microscopic level showed eCry1b in the cell plasma, free in the cytosol as well as bound to membranes. This is supported by immuno blotting. However, this applies only to robins in the migratory state. After the end of the migratory phase, the amount of eCry1b was markedly reduced and hardly detectable. In robins, the amount of eCry1b in the retinal ganglion cells varies with season: it appears to be strongly expressed only during the migratory period when the birds show nocturnal migratory restlessness. Since the avian magnetic compass does not seem to be restricted to the migratory phase, this seasonal variation makes a role of eCry1b in magnetoreception rather unlikely. Rather, it could be involved in physiological processes controlling migratory restlessness and thus enabling birds to perform their nocturnal flights.
Background and Objectives: Tick-borne encephalitis (TBE) still represents a considerable medical and health economic problem in Europe and entails a potential threat to travellers. The aim of this study was to characterise the conditions of severe TBE by precisely recording its clinical variants, the related neuroimaging features, and the variant-specific long-term outcome and by identifying predictors for severe courses.
Methods: A cohort of 111 TBE patients (median age 51, range 17–75 years; 42% females) was analysed prospectively. Data were acquired from the department of neurology, University Hospital Heidelberg, and the infectious diseases registry of the Robert-Koch institute Berlin. Neurological status was ascertained by protocol at admission and discharge and the degree of disability was scored using the modified RANKIN Scale (mRS; clinical score addressing neurological disability, range from 0, healthy to 6, dead) at admission and at follow-up. Follow-up examination was conducted by means of a telephone interview. To identify independent predictors for severe TBE and functional outcome, modelled logistic regression was performed. MRI changes were correlated with infection variants. To assess alpha-motor neuron injury patterns, we used high resolution magnetic resonance neurography (hrMRN). Analyses were performed at the Department of Neurology, University Hospital, University of Heidelberg from April 2004 through September 2014
Results: Acute course: 3.6% of patients died during the acute infection. All patients with a lethal course suffered from meningoencephaloradiculitis (MER, 14.4% of the cohort), which is associated with a significantly higher risk of requiring intensive care (p = 0.004) and mechanical ventilation (p<0.001) than menigoencephalitis (ME, 27.9% of the cohort). At admission, both MER and ME groups were severely affected, with the MER group having a statistically higher mRS score (median of 5 in the MER groups versus 4 in the ME group; p<0.001). Long-term outcome: outcome for MER was considerably worse (median mRS = 4) than for ME (mRS = 1, p<0.0001) and meningitis (mRS = 0, 57.7% of the cohort). Risk factors: advanced age (p<0.001) and male gender (p = 0.043) are independent risk factors for a severe infection course. Furthermore, we identified pre-existing diabetes mellitus (p = 0.024) as an independent risk factor for MER. In MER, alpha-motor neuron injury accounts for the poor prognosis confirmed by hrMRN.
Conclusion and Relevance: These data provide critical information for neurologists and other health professionals to use in evaluating TBEV patients who live in or travel to endemic areas. This information can be used to classify clinical presentation and estimate infection-associated complications and individual prognosis. Furthermore, the risk for severe, disabling infections in older patients should prompt general practitioners to recommend and encourage vaccination to those patients living in or travelling to endemic areas.
Institutsbericht 2015 des ISOE ist erschienen +++ Arzneimittelrückstände im Wasserkreislauf: Empfehlungen aus dem Forschungsprojekt Sauber+ +++ Mobiles Baden-Württemberg – Neues Forschungsprojekt zu nachhaltiger Mobilität +++ ISOE-Lecture: Transdisziplinäre Forschung in einem neuen Erdzeitalter? Die Debatte um das Anthropozän +++ ISOE-Forscherinnen beim Future Earth Summit in Berlin +++ Aus dem ISOE: Nachhaltigkeitsstrategie Hessen: ISOE unterschreibt Zielvereinbarung für nachhaltige Beschaffung +++ Termine +++ Publikationen
„Keine Gesellschaft ohne Natur“ – Beiträge zur Entwicklung der Sozialen Ökologie erschienen +++ ISOE beim Symposium deutscher Mobilitäts- und Verkehrsforscher in Berlin +++ Arzneimittelrückstände im Wasserkreislauf: Technische Lösungen stoßen an ihre Grenzen +++ Stakeholder im Forschungsprozess – für den naturnahen Umbau der Nidda +++ Neuer Stromspiegel für Deutschland: Ergebnisse aus Forschungsprojekt von ISOE und Öko-Institut +++ Best Paper Award der Zeitschrift GAIA: ISOE-Beitrag unter den drei Erstplatzierten +++ Aus dem ISOE: Girls'Day 2016: Zukunftstag für Mädchen am ISOE +++ Termine +++ Publikationen
Franz von Assisi is seen as a champion of charity in favour of the poor ones. However that is not true. Poverty has not to be eliminated but praised as the most essential quality of human existence.
Hygroscopicity of nanoparticles produced from homogeneous
nucleation in the CLOUD experiments
(2016)
Sulfuric acid, amines and oxidized organics have been found to be important compounds in the nucleation and initial growth of atmospheric particles. Because of the challenges involved in determining the chemical composition of objects with very small mass, however, the properties of the freshly nucleated particles and the detailed pathways of their formation processes are still not clear. In this study, we focus on a challenging size range, i.e., particles that have grown to diameters of 10 and 15 nm following nucleation, and measure their water uptake. Water uptake is useful information for indirectly obtaining chemical composition of aerosol particles. We use a nanometer-hygroscopicity tandem differential mobility analyzer (nano-HTDMA) at subsaturated conditions (ca. 90 % relative humidity at 293 K) to measure the hygroscopicity of particles during the seventh Cosmics Leaving OUtdoor Droplets (CLOUD7) campaign performed at CERN in 2012. In CLOUD7, the hygroscopicity of nucleated nanoparticles was measured in the presence of sulfuric acid, sulfuric acid–dimethylamine, and sulfuric acid–organics derived from α-pinene oxidation. The hygroscopicity parameter κ decreased with increasing particle size, indicating decreasing acidity of particles. No clear effect of the sulfuric acid concentration on the hygroscopicity of 10 nm particles produced from sulfuric acid and dimethylamine was observed, whereas the hygroscopicity of 15 nm particles sharply decreased with decreasing sulfuric acid concentrations. In particular, when the concentration of sulfuric acid was 5.1 × 106 molecules cm−3 in the gas phase, and the dimethylamine mixing ratio was 11.8 ppt, the measured κ of 15 nm particles was 0.31 ± 0.01: close to the value reported for dimethylaminium sulfate (DMAS) (κDMAS ∼ 0.28). Furthermore, the difference in κ between sulfuric acid and sulfuric acid–imethylamine experiments increased with increasing particle size. The κ values of particles in the presence of sulfuric acid and organics were much smaller than those of particles in the presence of sulfuric acid and dimethylamine. This suggests that the organics produced from α-pinene ozonolysis play a significant role in particle growth even at 10 nm sizes.
Der Beitrag untersucht das in jüngerer Zeit verstärkt diskutierte Phänomen einer – tatsächlichen oder vermeintlichen – „anglo-amerikanischen Rechts-hegemonie“. Es geht dabei um die Frage, ob die Rechtsordnungen Deutschlands und der Europäischen Union unter eine Vormachtstellung des amerikanischen Rechtsdenkens und amerikanischer Regelungsmuster geraten sind oder eine solche vielleicht sogar selbst aktiv befördert haben. In dem Beitrag wird diese Diskussion aus zivilrechtlicher Perspektive aufgegriffen. Nach einer Konkretisierung des Topos der Rechtshegemonie werden dabei zunächst einige Grundcharakteristika des amerikanischen Rechtssystems und des deutschen Rechtssystems gegenübergestellt und zusammengefasst, in welchen Bereichen das deutsche und das europäische Recht in den vergangenen Jahrzehnten durch amerikanische Denk- und Regelungsmuster überformt worden sind. Im Anschluss erfolgt eine Bewertung der zuvor skizzierten Entwicklung, wobei die Unterscheidung zwischen einem intrinsisch orientierten und einem funktional orientierten Verständnis von Rechtskultur als ein Kernproblem der jüngeren rechtsvergleichenden Diskussion im Zentrum steht. Im Ergebnis wird eine tendenziell skeptische Perspektive gegenüber dem suggestiven Bild eines Wettbewerbs der Rechtsordnungen eingenommen und die in jüngerer Zeit häufig geäußerte These der globalfunktionalen Überlegenheit eines wettbewerbsorientierten Rechtsmodells in Zweifel gezogen.
This is the 18. article in our series Trouble on the Far-Right.
When it comes to change in social environments, a parable of philosopher Charles Handy gets pulled out quickly. If you drop a frog in boiling water, it jumps out immediately; but placed in cold water slowly warming up, it acclimates itself and falls to sleep, unaware of being boiled alive. The parable reminds us of the perceptional relativity of change: Within communities creeping developments cause habituation, abrupt breaks an arousing shock. In terms of social movements this truism becomes apparent in a double way: On the one hand, erupting crises may destabilize social orders and create the necessary space for dissident actors to gain momentum – while they would fail to mobilize outside the scenario of an anxious community gasping for a new guarantor of order. On the other hand, the rise of a dissident actor with unconventional performances may work as a shock triggering withdrawal reflexes in the broader society – while dissidents with relative habitual sentiments can find resonance in communities disappointed by the ruling order.
Does this perspective offer a potential to explain the rise of far right movements in Europe? Let’s examine it by the example of Germany where, in the last two years, far right actors have experienced a remarkable gain in political acceptance – on the streets, in the booths and in the talk shows. In this case, it could be argued that their success in protest and electoral mobilizations as well as their disproportionate high presence in the media rests on communication politics that effect a normalization of far right positions previously disreputed in public discourse. Through this creeping habituation by society, they are able to gain momentum in situations of crisis, producing themselves successfully as a legitimate agent of the “anxious citizens” disappointed by the government. To test this little argument, a finger exercise in frame analysis seems to be proper, a tool common in social movement studies to explain why certain ideas in certain contexts are potent to mobilize audiences – and are not in others.
Dies ist der 17. Artikel in unserer Blogreihe Trouble on the Far-Right.
Um eines gleich deutlich zu machen: Über rechtsradikale Tendenzen in der Ukraine zu schreiben ist ein Drahtseilakt. Schließlich ist die Debatte in einen größeren Kontext eingebettet: Seit den Ereignissen auf dem Maidan 2014 und dem anschließenden Regime-Change erheben pro-russische Medien die sachlich schwer begründbare Beschuldigung, dass der Westen den Charakter der „faschistischen Junta in Kiew“ verkenne. Auf der anderen Seite bagatellisieren einige Publikationen die real existierenden rechten Umtriebe in der Ukraine beträchtlich. So handelt man sich schnell den Vorwurf ein, wahlweise „die faschistischen Ukrainer“ zu protegieren oder sich „den imperialistischen Russen“ anzubiedern. An dieser Stelle bleibt die notwendige Aufgabe Meinungen von Fakten zu trennen.
Die bedeutendste Kraft der parlamentarischen Rechten in der Ukraine ist die „Freiheitspartei“ Swoboda. Ihre Beteiligung an der Übergangsregierung nach den Maidan-Protesten galt einigen Beobachtern als Beweis für einen Rechtsruck in der Ukraine. Mittlerweile verfügt diese Partei nicht einmal mehr über eine parlamentarische Fraktion. Wie ist es dazu gekommen? Welche Dynamiken stehen dahinter? Ist letztendlich alles in trockenen Tüchern und die Gefahr von rechts gebannt?
Dies ist der 16. Artikel in unserer Blogreihe Trouble on the Far-Right.
„Wir sind zwar hinter Gittern, aber unsere Ideen sind an der Macht“, erklärte der Führer der Grauen Wölfe, Alparslan Türkeş nach dem Militärputsch vom 12. September 1980 in der Türkei. Damals hatten die Generäle als Zeichen ihrer angeblichen Neutralität neben Zehntausenden inhaftierten Linken auch einige hundert Anhänger der faschistischen Grauen Wölfe anklagen lassen. Entsprechend könnten sich heute seine Nachfolger rühmen: „Wir sind zwar nicht an der Regierung, aber unsere Ideen sind an der Macht.“ Denn die Herrschaft der seit 2002 alleine regierenden und gemeinhin als islamisch-konservativ charakterisierten Partei für Gerechtigkeit und Aufschwung (Adalet ve Kalkınma Partisi – AKP) von Staatspräsident Recep Tayyip Erdoğan und Ministerpräsident Ahmet Davutoğlu stützt sich zunehmend auf die Ideologie, die Methoden und selbst das Personal der Grauen Wölfe. Umgekehrt ist die offiziell in der Opposition stehende parlamentarische Vertretung der Grauen Wölfe, die Partei der Nationalistischen Bewegung (Milliyetçi Hareket Partisi – MHP) eine Kriegsallianz mit der AKP-Regierung gegen die kurdische Befreiungsbewegung eingegangen...
This is the 15. article in our series Trouble on the Far-Right.
Germany’s political culture currently faces a shift to the right as anti-immigrant violence and attacks on refugee camps are on the brink of becoming a daily routine. The populist party Alternative für Deutschland (Alternative for Germany) did achieve successes in every recent federal state election. Through their success politics gained a new political quality. Anti-immigrant groups such as PEGIDA in Dresden regularly mobilize hundreds and sometimes thousands of people. The increased number of refugees that came to Germany in 2015 is instrumentalized to fuel racism and to spread nationalist sentiments...
This is the 14. article in our series Trouble on the Far-Right.
country’s domestically weak far right has managed to send its representatives to the European Parliament (EP). Prior to 2014, these MEPs remained largely isolated, retaining a non-affiliated status. Initially, Volen Siderov’s far right party Attack, the first of its kind in post-communist Bulgaria, won three seats in the legislative body in 2007. Formed in 2005, Attack quickly gained electoral support, conveying a strong xenophobic and anti-minority rhetoric combined with emphasis on Orthodox Christian values and opposition to globalization. No other Bulgarian party has previously sought to attract voters using such a strategy. Attack participated in the short-lived Identity, Tradition, Sovereignty group in the EP. Further efforts for constructing a lasting political grouping on the far right with the participation of Bulgarian parties remained futile, making their influence on debate-shaping and decision-making hardly possible. Winning a seat less in 2009, Attack remained outside of any recognized EP political group...
This is the 13. article in our series Trouble on the Far-Right.
The environment for populist radical right (PRR) parties in Europe is favourable. Both the refugee crisis as well as the recent terrorist attacks in Paris and Brussels have ostensibly fuelled further xenophobic and anti-Islam sentiments among European publics, on the basis of which PRR parties have been shown to build their support. Recent elections in Europe have indeed seen good results for parties with an outspoken xenophobic message, the victories in March 2016 for the Alternative for Germany (AfD) in the German regional elections and two far right parties (SNS and L’SNS) in the Slovak national elections being cases in point. Opinion polls in countries such as France and the Netherlands look equally promising for PRR parties. Even though not all European countries have witnessed the successful mobilisation of the PRR, it is fair to conclude that this party family is going strong. It would be too quick to conclude, however, that PRR parties only thrive on the recent salience of the immigration issue.
This is the twelth article in our series Trouble on the Far-Right.
In 2008 and 2009, a group of Hungarian right-wing extremists committed a series of attacks on random members of the Roma community. Six people were killed, including a five-year-old, and another five were injured. The trial of the four suspects lasted two-and-a-half years, and the verdict was passed in August 2013. Director Eszter Hajdú filmed the trial and condensed it to create an oppressive Kammerspielfilm starring the cold-blooded suspects, an irritable judge and the victims’ families. Without any commentary, Hajdú recorded the drawn-out and sometimes chaotic trial from the cramped courtroom’s public gallery. A small static camera shows the judge’s point of view, while close-ups highlight the emotions of the people touched by the crime. Sometimes we see the protagonists outside the courtroom, for example during the reconstruction at the crime scene. At the start of the trial, the victims and next of kin assume there will be justice, and they have faith that the Hungarian authorities will protect them. But will the extremists be found guilty? The widespread anti-Roma sentiment in Hungarian society, and the bungling (intentional or otherwise) on the part of the police give them reason to fear they will not...
From an early understanding of organisational theorist (Bartlett & Ghosal, 1989; 1990), the function of global teams in transnational organisations has been conceptualised as the transformation of different embedded cultural practices for the development of a global strategy, products and services. Simultaneously, in the field, from the beginning of the 1990ies to the edge of the new millennium neo-liberal political developments enforced a free flow of capital on a global level (cf. Turner, 2006). In line with the development of respective connectivity via the internet the form of globally distributed team work was spread (Maznevski & Chudoba, 2000). In a study by Biggs (2000), published just after the millennial change, it was shown that 60% of tasks in multinational companies are accomplished by virtual teams. More recent data (Society for Human Resource Management, 2012) showed that the prevalence of such teams stayed more or less constant in the last 10 years. According to the survey 66% of companies are working with distributed global teams.
Globally distributed teams were already described by Bartlett and Ghosal (1989) in their functions of articulation and translation of differing market practices for the integration of requirements and needs on a global level. From a European perspective the importance to further develop innovation capabilities in order to compete in the global market is stressed today (Imp3rove, 2012). In a globalised economy not only the big multinational companies are involved in globally distributed research and development activities (R&D). On the level SMEs, for example, in Switzerland the involvement in global development processes is increasing (Gassmann, 2009). From my own experiences in working with Swiss SMEs, the macro-economic processes in regard to the strong Swiss Franc may accelerate such processes. Thus, the form of globally distributed teams, and their functional task in global development processes, can be viewed as highly relevant, in a globalised economy.
The crucial question for companies at the moment is, if teams can be enabled for innovative project work, which enables the integration of diverging perspectives in a globally distributed setting? Or, if such teams have to be collocated for more innovative, interdependent task work? Requirements for integrating embedded knowledge from different regionally defined clusters into global innovations at least, seems to indicate for the relevance of interdependent globally distributed team work (cf. Li, Eden, Hitt, Ireland, & Garrett, 2012). Bilateral practices of partnering, for example in the Swiss pharmaceutical sector, lead to the integration of selected subsidiaries in the R&D process of the company (Festel et al., 2010). Thus, the form of dispersion for project teams becomes more critical for effective global R&D practices (Boyer O’Leary & Cummings, 2007). So called partially distributed teams integrating balanced subgroups between two sites, hence, become an important subject of inquiry with practical relevance.
The context of partially distributed team work represents by virtue a context involving multiple perspectives influenced by the involvement of actors stemming from different cultural contexts (Dekker, Rutte, & Van den Berg, 2008). It thereby provides the synergetic potential for integrating different perspectives in the resolution of complex problems on a global level (Janssens & Brett, 2006). Simultaneously, cultural diversity engenders challenges for collaboration. Challenges, like different understandings and interpretations regarding tasks, the structuring of communication (Maznevski & Chudoba, 2000) and unexpected events occurring in the collaboration between the actors (Dekker et al., 2008; Oertel & Antoni, 2014) were identified in respective empirical studies.
Opportunities and challenges of partially distributed global teams can be compared with the problematic of face-to-face (f2f) teams with a moderate amount of diversity. Studies have shown (see Thatcher & Patel, 2011 for a meta-analysis) that when the distribution of diversity characteristics is aligned to potentially form culture specific subgroups, so-called diversity faultlines (Lau & Murnighan, 1998), negative subgroup dynamics are reinforced.
To achieve the above mentioned synergetic potentials it seems important to effectively cope with such negative dynamics and allow for a balanced participation in partially distributed teams (Janssens & Brett, 2006). In the research on faultline teams, especially the structuring of task-related interdependences across respective subgroups has been identified as an important impediment for the mentioned subgroup dynamics. Task interdependences, which cross functional roles across respective group faultlines (Bettencourt, Molix, Talley, & Eubanks, 2007; Marcus-Newhall, Miller, Holtz, & Brewer, 1993), are able to unlock the inherent potentials of globally distributed teams on more complex tasks that require the integration of different perspectives. From a work group diversity perspective (van Knippenberg & Schippers, 2007), partially distributed global teams represent a research object for studying the interaction between social categorisation processes involved in the above mentioned subgroup dynamics, and processes of task-related information processing required for innovative team outputs. The exploration of effects of task structures on the interaction between categorisation processes and task-related information processing (van Knippenberg et al., 2004), will be in the main explorative research focus of this thesis. The research thesis represents a heuristic explorative inquiry (Kleining & Witt, 2001) of respective dynamics and structural as well as process-related enablers.
The thesis starts with the theoretical part, in which the historical development of the understanding of teams as open, complex and temporally dynamic systems (Arrow et al., 2005, 2000), will be outlined. A sound definition of partially distributed global teams, including the respective contextual characteristics will be delineated. In a sensitizing framework (Blumer, 1954) which guided the explorative research process, the central boundary condition of task interdependence (Wageman, 2001) and respective episodic theories for explaining global task-related dynamics in teams (Marks et al., 2001), the dynamics of social categorisation (Gaertner, Dovidio, Anastasio, Bachman, & Rust, 1993; Gaertner & Dovidio, 2000), as well as the interaction between social categorisation processes and task-related information processing will be integrated (van Knippenberg et al., 2004). According to the framework, empirical studies on effects of task interdependence on interactions between task-related information processing and social categorisation processes will be addressed (van Knippenberg et al., 2004).
The empirical part of the contribution will be split in two parts. In the first heuristic exploratory study eleven partially distributed global teams are followed up during the time of relevant innovation projects. The approach allowed the study of task interdependence, productive interactions with social categorisation processes and there effects on team innovation. In the second empirical step, the developed hypotheses, were tested in an experimental simulation (Arrow et al., 2005, 2000) in undergraduate courses.
As a conclusion of the two exploratory studies, an episodic team process model will be outlined. The model specifies interdependence dynamics, which allows for team innovation. Furthermore, on a process level, the episodic categorisation-elaboration model (van Knippenberg et al., 2004) proposes three critical team performance episodes. Dynamics in the interplay between task-related information processing and social categorisation processes allow for the development of hypothesis for further research projects. Finally the implications for theory and the practical relevance of the heuristic model will be discussed.