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This paper deals with the control exerted by the mitochondrial translocator FLX1, which catalyzes the movement of the redox cofactor FAD across the mitochondrial membrane, on the efficiency of ATP production, ROS homeostasis, and lifespan of S. cerevisiae. The deletion of the FLX1 gene resulted in respiration-deficient and small-colony phenotype accompanied by a significant ATP shortage and ROS unbalance in glycerol-grown cells. Moreover, the flx1Δ strain showed H2O2 hypersensitivity and decreased lifespan. The impaired biochemical phenotype found in the flx1Δ strain might be justified by an altered expression of the flavoprotein subunit of succinate dehydrogenase, a key enzyme in bioenergetics and cell regulation. A search for possible cis-acting consensus motifs in the regulatory region upstream SDH1-ORF revealed a dozen of upstream motifs that might respond to induced metabolic changes by altering the expression of Flx1p. Among these motifs, two are present in the regulatory region of genes encoding proteins involved in flavin homeostasis. This is the first evidence that the mitochondrial flavin cofactor status is involved in controlling the lifespan of yeasts, maybe by changing the cellular succinate level. This is not the only case in which the homeostasis of redox cofactors underlies complex phenotypical behaviours, as lifespan in yeasts.
This work derived the value of α-induced production cross sections of 77Kr and 77Br at α-energies of 12 MeV and 14 MeV, the thick target yields of 77Kr and 77Br at α-energies of 11.19 MeV, 13 MeV and 15.1 MeV and the thick target yield of 80Br as well as 80mBr at an α-energy of 15.1 MeV using the activation technique...
Background: Chronic particulate matter (PM) exposure is correlated to various health effects, even at low amounts. WHO has defined PM concentration limits as daily and annual mean values which were made legally binding in the European Union. While many studies have focused on PM concentrations in special environments, little is known about the average PM- exposure for both employees and passengers in the German public transportation system.
Methods: Particulate matter (PM10, PM2.5, PM1) - concentrations were monitored for 30 minutes at 15 different areas in Frankfurt am Main with major public traffic. Maximum and mean concentrations and, as a surrogate for the inhaled dosage, the Area Under the Curve (AUC) for 15 minutes of exposure were calculated.
Results: The WHO limits for PM10 and PM2.5 were exceeded at nearly all times and areas. Highest maximum concentrations were found at underground stations, subterranean railway stations and subterranean shopping arcades with much lower values obtained at surface points. In one measurement at a surface test point smokers who neglected the non-smoking policy could be identified as a major cause for a at least temporary strong increase of PM-load as seen in high maximum values and normal averages.
Conclusions: Subterranean areas have high particulate matter contamination exceeding WHO limits. Improvement may be achieved by increased ventilation. Subterranean shops and kiosks, being workplaces with long term exposure, should be equipped with external air supply. The non- smoking policy of the "Deutsche Bahn" for public spaces should be enforced.
Background: Multimorbidity is a common phenomenon in primary care. Until now, no clinical guidelines for multimorbidity exist. For the development of these guidelines, it is necessary to know whether or not patients are aware of their diseases and to what extent they agree with their doctor. The objectives of this paper are to analyze the agreement of self-reported and general practitioner-reported chronic conditions among multimorbid patients in primary care, and to discover which patient characteristics are associated with positive agreement.
Methods: The MultiCare Cohort Study is a multicenter, prospective, observational cohort study of 3,189 multimorbid patients, ages 65 to 85. Data was collected in personal interviews with patients and GPs. The prevalence proportions for 32 diagnosis groups, kappa coefficients and proportions of specific agreement were calculated in order to examine the agreement of patient self-reported and general practitioner-reported chronic conditions. Logistic regression models were calculated to analyze which patient characteristics can be associated with positive agreement.
Results: We identified four chronic conditions with good agreement (e.g. diabetes mellitus κ = 0.80;PA = 0,87), seven with moderate agreement (e.g. cerebral ischemia/chronic stroke κ = 0.55;PA = 0.60), seventeen with fair agreement (e.g. cardiac insufficiency κ = 0.24;PA = 0.36) and four with poor agreement (e.g. gynecological problems κ = 0.05;PA = 0.10).Factors associated with positive agreement concerning different chronic diseases were sex, age, education, income, disease count, depression, EQ VAS score and nursing care dependency. For example: Women had higher odds ratios for positive agreement with their GP regarding osteoporosis (OR = 7.16). The odds ratios for positive agreement increase with increasing multimorbidity in almost all of the observed chronic conditions (OR = 1.22-2.41).
Conclusions: For multimorbidity research, the knowledge of diseases with high disagreement levels between the patients' perceived illnesses and their physicians' reports is important. The analysis shows that different patient characteristics have an impact on the agreement. Findings from this study should be included in the development of clinical guidelines for multimorbidity aiming to optimize health care. Further research is needed to identify more reasons for disagreement and their consequences in health care.
After The Tears
(2014)
Busi is pregnant with Parks' baby. Her granny is sick, there is no money for food, and her mother is still in Jozi. Her friends are supportive, but they don't understand how lonely it feels to be pregnant while they are out partying. She knows she should forget Parks, but she can't. So when he sends her an SMS telling her to meet him she goes - only to find out that he is not alone. And so Busi's life becomes more complicated than she can ever imagine.
The publication is the latest in the African Studies in Russia series of compilations and contains full articles and annotations of the most important - from the point of view of editors - works of Russian Africanists over a certain period. The authors work at the Institute for African Studies of the Russian Academy of Sciences (RAS). The present issue covers the years 2010 to 2013 and consists of two sections. The first section presents conceptual articles on Africa published in authoritative journals. The second section offers synopses of books by Russian authors on economics, cultural anthropology, social and political development, gender studies, and international relations of African countries. The main objective of the triennial series of compilations is to introduce new findings of Russian Africanists to interested foreign scholars who do not speak Russian.
With new integrative and indigenous approaches to literary affairs the focus of this volume is on the influence of tradition in African writing. Using the work of Chinua Achebe two scholars from outside Africa offer insight on oratorical devices in modern African fiction, two chapters follow which, by fusing traditional elements in transitional societies, illustrate the cultural awareness that touch on the exalted role of the artist in their communities. The post colonial rhetoric also continues with echoes of political commitment on modern poetry - town issues in the discourse of Africa's literary progress in the last decade. The growing concern for African youth development is at the heart of a dialogue with children's fiction writer Anezi Okoro. Two scholars of Africa orature have written on the birth songs of Cameroonian women performers and the riddle contents of youth artists from Nigerian in a manner which recognises the immediate relevance of this cherished but neglected part of African literary aesthetics.
African land rights systems
(2014)
This book, from ethical, interdisciplinary, and African perspectives, unveils the root causes of the increasing land disputes. Its significance lies upon the effort of presenting a broad overview founded upon a critical analysis of the existing land-related disputes. It is a perspective that attempts to evaluate the renewed interest in evolving theories of land rights by raising questions that can help us to understand better differences underlying land ownership systems, conflict between customary and statutory land rights systems, and the politics of land reform. Other dimensions explored in the book include the market influence on land-grabbing and challenges accompanying trends of migration, resettlement, and integration. The methodology applied in the study provides a perspective that raises questions intended to identify areas of contention, dispute, and conflict. The study, which could also be categorized as a critical assessment of the African land rights systems, is intended to be a resource for scholars, activists, and organizations working to resolve land-related disputes.
African Cultures, Memory and Space is an impeccable volume that powerfully grapples with a gamut of cultural heritage issues, challenges and problems from a vista of inter- and multi-disciplinary approach. The book, which is designed as a foundational text to the study of culture in ever-changing environments, makes an important argument that the dynamism of culture in highly globalised societies such as that of Zimbabwe can be studied from any perspective, but most importantly through careful examination of cultural elements such as memory, oral history and space, among others. While the book makes special reference to Zimbabwe, it profoundly and audaciously dissect and cut across different geographical and cultural spaces through its penetrating interrogation and scrutiny of different issues commonplace in many African contexts and even beyond. The book, written by scholars from different backgrounds and orientations, should appeal to scholars, researchers and students from various disciplines which include but not limited to Cultural Heritage Studies, Policy Studies, Social-Cultural Anthropology, Sociology, Development Studies and African Studies.
Africa's dynamic security environment is characterized by great diversity - from conventional challenges such as insurgencies, resource and identity conflicts, and post-conflict stabilization to growing threats from piracy, narcotics trafficking, violent extremism, and organized crime taking root in urban slums, among others. This precarious environment jeopardizes security at the societal, community and individual levels. In a globalized and interconnected world, millions of people worldwide are affected by some form of human insecurity. Infectious and parasitic diseases annually kill millions. Internally displaced persons number millions, including 5 million in Sudan alone. In Zambia 1 million people in a population of 11 million are reported to be HIV-positive, a situation much worse in other countries. Potable water crisis looms almost everywhere. In this book Tatah Mentan points out the need to shift the focus away from a state-centric and military-strategic emphasis on security to an interdisciplinary and people-centric approach that embraces notions like global citizenship, empowerment and participation. The primary elements of economic, food, health, environment, personal, community and political security all comprise the broader understanding of human security in an intricately interconnected world.