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This paper deals with the control exerted by the mitochondrial translocator FLX1, which catalyzes the movement of the redox cofactor FAD across the mitochondrial membrane, on the efficiency of ATP production, ROS homeostasis, and lifespan of S. cerevisiae. The deletion of the FLX1 gene resulted in respiration-deficient and small-colony phenotype accompanied by a significant ATP shortage and ROS unbalance in glycerol-grown cells. Moreover, the flx1Δ strain showed H2O2 hypersensitivity and decreased lifespan. The impaired biochemical phenotype found in the flx1Δ strain might be justified by an altered expression of the flavoprotein subunit of succinate dehydrogenase, a key enzyme in bioenergetics and cell regulation. A search for possible cis-acting consensus motifs in the regulatory region upstream SDH1-ORF revealed a dozen of upstream motifs that might respond to induced metabolic changes by altering the expression of Flx1p. Among these motifs, two are present in the regulatory region of genes encoding proteins involved in flavin homeostasis. This is the first evidence that the mitochondrial flavin cofactor status is involved in controlling the lifespan of yeasts, maybe by changing the cellular succinate level. This is not the only case in which the homeostasis of redox cofactors underlies complex phenotypical behaviours, as lifespan in yeasts.
This work derived the value of α-induced production cross sections of 77Kr and 77Br at α-energies of 12 MeV and 14 MeV, the thick target yields of 77Kr and 77Br at α-energies of 11.19 MeV, 13 MeV and 15.1 MeV and the thick target yield of 80Br as well as 80mBr at an α-energy of 15.1 MeV using the activation technique...
Background: Chronic particulate matter (PM) exposure is correlated to various health effects, even at low amounts. WHO has defined PM concentration limits as daily and annual mean values which were made legally binding in the European Union. While many studies have focused on PM concentrations in special environments, little is known about the average PM- exposure for both employees and passengers in the German public transportation system.
Methods: Particulate matter (PM10, PM2.5, PM1) - concentrations were monitored for 30 minutes at 15 different areas in Frankfurt am Main with major public traffic. Maximum and mean concentrations and, as a surrogate for the inhaled dosage, the Area Under the Curve (AUC) for 15 minutes of exposure were calculated.
Results: The WHO limits for PM10 and PM2.5 were exceeded at nearly all times and areas. Highest maximum concentrations were found at underground stations, subterranean railway stations and subterranean shopping arcades with much lower values obtained at surface points. In one measurement at a surface test point smokers who neglected the non-smoking policy could be identified as a major cause for a at least temporary strong increase of PM-load as seen in high maximum values and normal averages.
Conclusions: Subterranean areas have high particulate matter contamination exceeding WHO limits. Improvement may be achieved by increased ventilation. Subterranean shops and kiosks, being workplaces with long term exposure, should be equipped with external air supply. The non- smoking policy of the "Deutsche Bahn" for public spaces should be enforced.
Background: Multimorbidity is a common phenomenon in primary care. Until now, no clinical guidelines for multimorbidity exist. For the development of these guidelines, it is necessary to know whether or not patients are aware of their diseases and to what extent they agree with their doctor. The objectives of this paper are to analyze the agreement of self-reported and general practitioner-reported chronic conditions among multimorbid patients in primary care, and to discover which patient characteristics are associated with positive agreement.
Methods: The MultiCare Cohort Study is a multicenter, prospective, observational cohort study of 3,189 multimorbid patients, ages 65 to 85. Data was collected in personal interviews with patients and GPs. The prevalence proportions for 32 diagnosis groups, kappa coefficients and proportions of specific agreement were calculated in order to examine the agreement of patient self-reported and general practitioner-reported chronic conditions. Logistic regression models were calculated to analyze which patient characteristics can be associated with positive agreement.
Results: We identified four chronic conditions with good agreement (e.g. diabetes mellitus κ = 0.80;PA = 0,87), seven with moderate agreement (e.g. cerebral ischemia/chronic stroke κ = 0.55;PA = 0.60), seventeen with fair agreement (e.g. cardiac insufficiency κ = 0.24;PA = 0.36) and four with poor agreement (e.g. gynecological problems κ = 0.05;PA = 0.10).Factors associated with positive agreement concerning different chronic diseases were sex, age, education, income, disease count, depression, EQ VAS score and nursing care dependency. For example: Women had higher odds ratios for positive agreement with their GP regarding osteoporosis (OR = 7.16). The odds ratios for positive agreement increase with increasing multimorbidity in almost all of the observed chronic conditions (OR = 1.22-2.41).
Conclusions: For multimorbidity research, the knowledge of diseases with high disagreement levels between the patients' perceived illnesses and their physicians' reports is important. The analysis shows that different patient characteristics have an impact on the agreement. Findings from this study should be included in the development of clinical guidelines for multimorbidity aiming to optimize health care. Further research is needed to identify more reasons for disagreement and their consequences in health care.
After The Tears
(2014)
Busi is pregnant with Parks' baby. Her granny is sick, there is no money for food, and her mother is still in Jozi. Her friends are supportive, but they don't understand how lonely it feels to be pregnant while they are out partying. She knows she should forget Parks, but she can't. So when he sends her an SMS telling her to meet him she goes - only to find out that he is not alone. And so Busi's life becomes more complicated than she can ever imagine.
The publication is the latest in the African Studies in Russia series of compilations and contains full articles and annotations of the most important - from the point of view of editors - works of Russian Africanists over a certain period. The authors work at the Institute for African Studies of the Russian Academy of Sciences (RAS). The present issue covers the years 2010 to 2013 and consists of two sections. The first section presents conceptual articles on Africa published in authoritative journals. The second section offers synopses of books by Russian authors on economics, cultural anthropology, social and political development, gender studies, and international relations of African countries. The main objective of the triennial series of compilations is to introduce new findings of Russian Africanists to interested foreign scholars who do not speak Russian.
With new integrative and indigenous approaches to literary affairs the focus of this volume is on the influence of tradition in African writing. Using the work of Chinua Achebe two scholars from outside Africa offer insight on oratorical devices in modern African fiction, two chapters follow which, by fusing traditional elements in transitional societies, illustrate the cultural awareness that touch on the exalted role of the artist in their communities. The post colonial rhetoric also continues with echoes of political commitment on modern poetry - town issues in the discourse of Africa's literary progress in the last decade. The growing concern for African youth development is at the heart of a dialogue with children's fiction writer Anezi Okoro. Two scholars of Africa orature have written on the birth songs of Cameroonian women performers and the riddle contents of youth artists from Nigerian in a manner which recognises the immediate relevance of this cherished but neglected part of African literary aesthetics.
African land rights systems
(2014)
This book, from ethical, interdisciplinary, and African perspectives, unveils the root causes of the increasing land disputes. Its significance lies upon the effort of presenting a broad overview founded upon a critical analysis of the existing land-related disputes. It is a perspective that attempts to evaluate the renewed interest in evolving theories of land rights by raising questions that can help us to understand better differences underlying land ownership systems, conflict between customary and statutory land rights systems, and the politics of land reform. Other dimensions explored in the book include the market influence on land-grabbing and challenges accompanying trends of migration, resettlement, and integration. The methodology applied in the study provides a perspective that raises questions intended to identify areas of contention, dispute, and conflict. The study, which could also be categorized as a critical assessment of the African land rights systems, is intended to be a resource for scholars, activists, and organizations working to resolve land-related disputes.
African Cultures, Memory and Space is an impeccable volume that powerfully grapples with a gamut of cultural heritage issues, challenges and problems from a vista of inter- and multi-disciplinary approach. The book, which is designed as a foundational text to the study of culture in ever-changing environments, makes an important argument that the dynamism of culture in highly globalised societies such as that of Zimbabwe can be studied from any perspective, but most importantly through careful examination of cultural elements such as memory, oral history and space, among others. While the book makes special reference to Zimbabwe, it profoundly and audaciously dissect and cut across different geographical and cultural spaces through its penetrating interrogation and scrutiny of different issues commonplace in many African contexts and even beyond. The book, written by scholars from different backgrounds and orientations, should appeal to scholars, researchers and students from various disciplines which include but not limited to Cultural Heritage Studies, Policy Studies, Social-Cultural Anthropology, Sociology, Development Studies and African Studies.
Africa's dynamic security environment is characterized by great diversity - from conventional challenges such as insurgencies, resource and identity conflicts, and post-conflict stabilization to growing threats from piracy, narcotics trafficking, violent extremism, and organized crime taking root in urban slums, among others. This precarious environment jeopardizes security at the societal, community and individual levels. In a globalized and interconnected world, millions of people worldwide are affected by some form of human insecurity. Infectious and parasitic diseases annually kill millions. Internally displaced persons number millions, including 5 million in Sudan alone. In Zambia 1 million people in a population of 11 million are reported to be HIV-positive, a situation much worse in other countries. Potable water crisis looms almost everywhere. In this book Tatah Mentan points out the need to shift the focus away from a state-centric and military-strategic emphasis on security to an interdisciplinary and people-centric approach that embraces notions like global citizenship, empowerment and participation. The primary elements of economic, food, health, environment, personal, community and political security all comprise the broader understanding of human security in an intricately interconnected world.
Advertising arbitrage
(2014)
Speculators often advertise arbitrage opportunities in order to persuade other investors and thus accelerate the correction of mispricing. We show that in order to minimize the risk and the cost of arbitrage an investor who identifies several mispriced assets optimally advertises only one of them, and overweights it in his portfolio; a risk-neutral arbitrageur invests only in this asset. The choice of the asset to be advertised depends not only on mispricing but also on its "advertisability" and accuracy of future news about it. When several arbitrageurs identify the same arbitrage opportunities, their decisions are strategic complements: they invest in the same asset and advertise it. Then, multiple equilibria may arise, some of which inefficient: arbitrageurs may correct small mispricings while failing to eliminate large ones. Finally, prices react more strongly to the ads of arbitrageurs with a successful track record, and reputation-building induces high-skill arbitrageurs to advertise more than others.
Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development.
This study presents a taxonomic update of the Tetramorium weitzeckeri species group.
Tetramorium mpala sp. nov. is described from Laikipia, Kenya, and placed in the T. weitzeckeri species complex. In addition, we also provide an illustrated identification key to the three species complexes of the T. weitzeckeri species group, and an updated illustrated identification key to the species of the T. weitzeckeri species complex.
This paper explores consequences of consumer education on prices and welfare in retail financial markets when some consumers are naive about shrouded add-on prices and firms try to exploit it. Allowing for different information and pricing strategies we show that education is unlikely to push firms to disclose prices towards all consumers, which would be socially efficient. Instead, price discrimination emerges as a new equilibrium. Further, due to a feedback on prices, education that is good for consumers who become sophisticated may be bad for consumers who stay naive and even for the group of all consumers as a whole
Immunotherapy of cancer utilizes dendritic cells (DCs) for antigen presentation and the induction of tumor-specific immune responses. However, the therapeutic induction of anti-tumor immunity is limited by tumor escape mechanisms. In this study, immortalized dendritic D2SC/1 cells were transduced with a mutated version of the p53 tumor suppressor gene, p53M234I, or p53C132F/E168G, which are overexpressed in MethA fibrosarcoma tumor cells. In addition, D2SC/1 cells were fused with MethA tumor cells to generate a vaccine that potentially expresses a large repertoire of tumor-antigens. Cellular vaccines were transplanted onto Balb/c mice and MethA tumor growth and anti-tumor immune responses were examined in vaccinated animals. D2SC/1-p53M234I and D2SC/1-p53C132F/E168G cells induced strong therapeutic and protective MethA tumor immunity upon transplantation in Balb/c mice. However, in a fraction of immunized mice MethA tumor growth resumed after an extended latency period. Analysis of these tumors indicated loss of p53 expression. Mice, pre-treated with fusion hybrids generated from D2SC/1 and MethA tumor cells, suppressed MethA tumor growth and averted adaptive immune escape. Polyclonal B-cell responses directed against various MethA tumor proteins could be detected in the sera of D2SC/1-MethA inoculated mice. Athymic nude mice and Balb/c mice depleted of CD4(+) or CD8(+) T-cells were not protected against MethA tumor cell growth after immunization with D2SC/1-MethA hybrids. Our results highlight a potential drawback of cancer immunotherapy by demonstrating that the induction of a specific anti-tumor response favors the acquisition of tumor phenotypes promoting immune evasion. In contrast, the application of DC/tumor cell fusion hybrids prevents adaptive immune escape by a T-cell dependent mechanism and provides a simple strategy for personalized anti-cancer treatment without the need of selectively priming the host immune system.
BACKGROUND: Transient episodes of ischemia in a remote organ or tissue (remote ischemic preconditioning, RIPC) can attenuate myocardial injury. Myocardial damage is associated with tissue remodeling and the matrix metalloproteinases 2 and 9 (MMP-2/9) are crucially involved in these events. Here we investigated the effects of RIPC on the activities of heart tissue MMP-2/9 and their correlation with serum concentrations of cardiac troponin T (cTnT), a marker for myocardial damage.
METHODS: In cardiosurgical patients with cardiopulmonary bypass (CPB) RIPC was induced by four 5 minute cycles of upper limb ischemia/reperfusion. Cardiac tissue was obtained before as well as after CPB and serum cTnT concentrations were measured. Tissue derived from control patients (N = 17) with high cTnT concentrations (≥0.32 ng/ml) and RIPC patients (N = 18) with low cTnT (≤0.32 ng/ml) was subjected to gelatin zymography to quantify MMP-2/9 activities.
RESULTS: In cardiac biopsies obtained before CPB, activities of MMP-2/9 were attenuated in the RIPC group (MMP-2: Control, 1.13 ± 0.13 a.u.; RIPC, 0.71 ± 0.12 a.u.; P < 0.05. MMP-9: Control, 1.50 ± 0.16 a.u.; RIPC, 0.87 ± 0.14 a.u.; P < 0.01), while activities of the pro-MMPs were not altered (P > 0.05). In cardiac biopsies taken after CPB activities of pro- and active MMP-2/9 were not different between the groups (P > 0.05). Spearman's rank tests showed that MMP-2/9 activities in cardiac tissue obtained before CPB were positively correlated with postoperative cTnT serum levels (MMP-2, P = 0.016; MMP-9, P = 0.015).
CONCLUSIONS: Activities of MMP-2/9 in cardiac tissue obtained before CPB are attenuated by RIPC and are positively correlated with serum concentrations of cTnT. MMPs may represent potential targets for RIPC mediated cardioprotection.
TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT00877305.
Efficient algorithms for object recognition are crucial for the newly robotics and computer vision applications that demand real-time and on-line methods. Some examples are autonomous systems, navigating robots, autonomous driving. In this work, we focus on efficient semantic segmentation, which is the problem of labeling each pixel of an image with a semantic class.
Our aim is to speed-up all of the parts of the semantic segmentation pipeline. We also aim at delivering a labeling solution on a time budget, that can be decided on-the-fly. For this purpose, we analyze all the components of the semantic segmentation pipeline, and identify the computational bottleneck of each of them. The different components of the pipeline are over-segmenting the image with local regions, extracting features and classify the local regions, and the final inference of the image labeling with semantic classes. We focus on each of these steps.
First, we introduce a new superpixel algorithm to over-segment the image. Our superpixel method runs in real-time and can deliver a solution at any time budget. Then, for feature extraction, we focus on the framework that computes descriptors and encodes them, followed by a pooling step. We see that the encoding step is the bottleneck, for computational efficiency and performance. We present a novel assignment-based encoding formulation, that allows for the design of a new, very efficient, encoding. Finally, the image labeling output is obtained modeling the dependencies with a Conditional Random Field (CRF). In semantic image segmentation, the computational cost of instantiating the potentials is much higher than MAP inference. We introduce Active MAP inference to on-the-fly select a subset of potentials to be instantiated in the energy function, leaving the rest as unknown, and to estimate the MAP labeling from such incomplete energy function.
We perform experiments on all proposed methods for the different parts of the semantic segmentation pipeline. We show that our superpixel extraction achieves higher accuracy than state-of-the-art on standard superpixel benchmark, while it runs in real-time. We test our feature encoding on standard image classification and segmentation benchmarks, and we show that our method achieves competitive results with the state-of-the-art, and requires less time and memory. Finally, results for semantic segmentation benchmark show that Active MAP inference achieves similar levels of accuracy but with major efficiency gains.
The Kenyan population is highly concentrated in urban centres, leading to increased social, economic and environmental strains, with a significant percentage of urban dwellers living in sprawling slums. Urban development is increasingly a major focus, especially in the fight against urban sustainability problems. There is little practical orientation in the academic literature for the growing gap between the rich and poor. Current literature is enormously concerned with resource use and environmental pressures, paying scant attention to the nexus between urban sustainability and empowerment of the urban poor. This book initiates debates on the segment of urban population often referred to as 'the bottom of the pyramid (BOP)', by analysing the microfinance innovation following evaluation of the impacts of access to microfinance and financial training and the implications to urban sustainability in Kenya. The main conclusion reached is that microfinance has an instrumental role to play in promoting sustainable urban development as it supports social welfare improvement and increases the livelihood of participants, business development and urban sustainability to a certain extent, thereby empowering the urban poor in contributing to poverty alleviation.
From the late middle ages to early modern times (ca. 1200-1600) the Lübeck City Council was the most important courthouse in the Baltic. About 100 cities and towns on its shores lived according to the law of Lübeck. The paper deals with the old theory that Imperial law, i.e. mainly the learned Ius commune, was generally rejected by the council on the grounds of its foreign nature. The paper rejects this view with the help of 8 case studies. There exist rather spectacular statements against Imperial Law, but a closer look reveals that they have to be seen in the light of a specific practical context. They must not be confounded with general statements in which the council had no interest. Its attitude towards Learned Law was flexible and purely pragmatic.
Acceleration of Biomedical Image Processing and Reconstruction with FPGAs
Increasing chip sizes and better programming tools have made it possible to increase the boundaries of application acceleration with reconfigurable computer chips. In this thesis the potential of acceleration with Field Programmable Gate Arrays (FPGAs) is examined for applications that perform biomedical image processing and reconstruction. The dataflow paradigm was used to port the analysis of image data for localization microscopy and for 3D electron tomography from an imperative description towards the FPGA for the first time.
After the primitives of image processing on FPGAs are presented, a general workflow is given for analyzing imperative source code and converting it to a hardware pipeline where every node processes image data in parallel. The theoretical foundation is then used to accelerate both example applications. For localization microscopy, an acceleration of 185 compared to an Intel i5 450 CPU was achieved, and electron tomography could be sped up by a factor of 5 over an Nvidia Tesla C1060 graphics card while maintaining full accuracy in both cases.
In this article, the author shows that progress of info-communications is a key factor of society changes, as it radically changes the key aspects of human life. Studying the time of progress and comparing it with the most important anthropic characteristic - length of human life, he comes to the conclusion that our generation has witnessed the tipping point in the rate of development of human civilization. This showing up in the fact that the present stage of the scientific and technological advance lead to the transformation, perhaps on the same scale, what were the appearance of written language and publishing, but these multiple fundamental changes in the life of society occur within the life of a single generation. In these circumstances, the task of forecasting, in its traditional setting, is becoming increasingly inaccurate. According to the author, the only possibility is to venture outside the framework of formal logic and technocratic approaches and try to find answers to these questions by generating new meanings of the realities surrounding us and in this context philosophy has a special role.
Acacia pendula, Weeping Myall, (family Fabaceae) is the most legislatively protected plant species in the New South Wales Hunter Valley. Under the NSW Threatened Species Conservation Act 1995 it is listed as an Endangered Population (in the Hunter Valley) and as a component of two Endangered Ecological Communities (one in the Hunter, one elsewhere in NSW); it is also listed as a Critically Endangered Ecological Community (in the Hunter Valley) on the Commonwealth Environment Protection and Biodiversity Conservation Act 1999 and listed as threatened in three other eastern Australian States.
To ascertain the likely original distribution of stands of Acacia pendula in the Hunter Valley, this paper examines the writings of early Australian explorers, herbarium and database records, and the species habitat attributes across NSW. None of the journals examined, including those of botanist/explorer Allan Cunningham (who originally collected Acacia pendula from the Lachlan River in 1817), Thomas Mitchell or Ludwig Leichhardt, make note of the species for the Hunter Valley. Several explorers do, however, record Acacia pendula regularly (>100 times) across other parts of NSW, Queensland, and South Australia.
Historical herbarium and database records show a paucity of records from the Hunter prior to the year 2000, after which a 37-fold increase in observations since 1951 is apparent. For the first 128 years of botanical exploration (1823 to 1951), there are no validated collections or records of Acacia pendula from the Hunter Valley. The single exception is a specimen collected by Cunningham from 1825 (lodged at Kew, UK), purported to be from ‘Hunters River’, but which is morphologically different to other collections of Acacia pendula from that time. There is some uncertainty over the origins of this specimen.
Analysis of habitats supporting Acacia pendula in NSW outside of the Hunter show them to differ significantly in geological age, soil type, rainfall and elevation from those in the Hunter.
Collectively, these findings provide a strong circumstantial case that Acacia pendula was absent from the Hunter at the time of European settlement; this has important implications for the conservation and management of Hunter stands. Rather than being a threatened species in the Hunter Valley, it is postulated that Acacia pendula has been intentionally and/or accidentally introduced to the region, and may now be imposing a new and emerging threat to the endangered grassy woodlands and forests there. There is now an urgent need for genetic studies to clarify the origins of the current Hunter Valley stands, and to define the taxonomic limits of Acacia pendula and its close relatives.
Acacia
(2014)
Acacia is a strong and independent woman whose heart and heritage like rooted in Africa, while her reality in contemporary America finds itself in a very different time and place. In living her life, she must breach the distance between her current space and the ties that bind her. Straddling two sometimes opposing worlds of medicine and dance, Dr Acacia Graeme must find the balance between feeding her mind through work and study, and nourishing her soul and spirit through dance. And what happened when the music stops? Because it does, often. How will she get through the silence of her every day? This is the story of a flawed heroine whose intentions are pure, her truth perhaps less so. Torn between the enduring innocence of her first love and the life-long search that is her longing for one true love, she is compelled to come to terms with her own free nature and independent spirit and, in so doing, turn tragedy to triumph.
The ab-initio molecular dynamics framework has been the cornerstone of computational solid state physics in the last few decades. Although it is already a mature field it is still rapidly developing to accommodate the growth in solid state research as well as to efficiently utilize the increase in computing power. Starting from the first principles, the ab-initio molecular dynamics provides essential information about structural and electronic properties of matter under various external conditions. In this thesis we use the ab-initio molecular dynamics to study the behavior of BaFe2As2 and CaFe2As2 under the application of external pressure. BaFe2As2 and CaFe2As2 belong to the family of iron based superconductors which are a novel and promising superconducting materials. The application of pressure is one of two key methods by which electronic and structural properties of iron based superconductors can be modified, the other one being doping (or chemical pressure). In particular, it has been noted that pressure conditions have an important effect, but their exact role is not fully understood. To better understand the effect of different pressure conditions we have performed a series of ab-initio simulations of pressure application. In order to apply the pressure with arbitrary stress tensor we have developed a method based on the Fast Inertial Relaxation Engine, whereby the unit cell and the atomic positions are evolved according to the metadynamical equations of motion. We have found that the application of hydrostatic and c axis uniaxial pressure induces a phase transition from the magnetically ordered orthorhombic phase to the non-magnetic collapsed tetragonal phase in both BaFe2As2 and CaFe2As2. In the case of BaFe2As2, an intermediate tetragonal non-magnetic tetragonal phase is observed in addition. Application of the uniaxial pressure parallel to the c axis reduces the critical pressure of the phase transition by an order of magnitude, in agreement with the experimental findings. The in-plane pressure application did not result in transition to the non-magnetic tetragonal phase and instead, rotation of the magnetic order direction could be observed. This is discussed in the context of Ginzburg-Landau theory. We have also found that the magnetostructural phase transition is accompanied by a change in the Fermi surface topology, whereby the hole cylinders centered around the Gamma point disappear, restricting the possible Cooper pair scattering channels in the tetragonal phase. Our calculations also permit us to estimate the bulk moduli and the orthorhombic elastic constants of BaFe2As2 and CaFe2As2.
To study the electronic structure in systems with broken translational symmetry, such as doped iron based superconductors, it is necessary to develop a method to unfold the complicated bandstructures arising from the supercell calculations. In this thesis we present the unfolding method based on group theoretical techniques. We achieve the unfolding by employing induced irreducible representations of space groups. The unique feature of our method is that it treats the point group operations on an equal footing with the translations. This permits us to unfold the bandstructures beyond the limit of translation symmetry and also formulate the tight-binding models of reduced dimensionality if certain conditions are met. Inclusion of point group operations in the unfolding formalism allows us to reach important conclusions about the two versus one iron picture in iron based superconductors.
And finally, we present the results of ab-initio structure prediction in the cases of giant volume collapse in MnS2 and alkaline doped picene. In the case of MnS2, a previously unobserved high pressure arsenopyrite structure of MnS2 is predicted and stability regions for the two competing metastable phases under pressure are determined. In the case of alkaline doped picene, crystal structures with different levels of doping were predicted and used to study the role of electronic correlations.
A Torrent of Terror
(2014)
Rome Aboh's poetry unmistakably enwraps the condition of the politically and socially cannibalised segment of his society; and the beauty of the verse radiates from his facility with language as the stylist and linguist. The section 'patriotism' with such poems as 'hour of truth' aptly brings out the socially obligatory role of the poets whose mission goes beyond versifying and sharing their personal fantasies and urges. Similarly the poem 'letter to the mp' echoes the agonies of the common masses who feel deceived by the ruling elite in their so-called democratic nations.
Characterized by small body size, apically rounded/lobed anterior gonopod telopodites, long slender posterior gonopod telopodites, and torsion in the cyphopod receptacles, Floridobolus fl oydi, n. sp., is described from the southern sector of the Brooksville Ridge in northwestern peninsular Florida. It inhabits sandy “Big Scrub” environments like F. penneri Causey, 1957, and F. orini Shelley, 2014, and is documented from the sector’s center and northern periphery, in Hernando and Citrus Counties, respectively, with a sight record from the eastern periphery. Its discovery supports the thesis that each sand ridge in peninsular Florida may harbor a unique species of this endemic genus.
A revision of the genus Asterostegus Mortensen, 1933 (Echinodermata: Ophiuroidea: Euryalidae) is based on seven specimens, including the holotype of Asterostegus maini McKnight, 2003. A new species, Asterostegus sabineae sp. nov., is described from off Reunion Island and two other species, A. tuberculatus Mortensen, 1933 and A. maini, are redescribed. A tabular key to the three species of the genus Asterostegus is provided. Some terminology of the taxonomy of euryalid ophiuroids is revised.
Based on a meta-analysis, Redick and Lindsey (2013) found that complex span and n-back tasks show an average correlation of r = 0.20, and concluded that "complex span and n-back tasks cannot be used interchangeably as working memory measures in research applications" (p. 1102). Here, we comment on this conclusion from a psychometric perspective. In addition to construct variance, performance on a test contains measurement error, task-specific variance, and paradigm-specific variance. Hence, low correlations among dissimilar indicators do not provide strong evidence for the existence, or absence, of a construct common to both indicators. One way to arrive at such evidence is to fit hierarchical latent factors that model task-specific, paradigm-specific, and construct variance. We report analyses for 101 younger and 103 older adults who worked on nine different working memory tasks. The data are consistent with a hierarchical model of working memory, according to which both complex span and n-back tasks are valid indicators of working memory. The working memory factor predicts 71% of the variance in a factor of reasoning among younger adults (83% for among older adults). When the working memory factor was restricted to any possible triplet of working memory tasks, the correlation between working memory and reasoning was inversely related to the average magnitude of the correlations among the indicators, indicating that more highly intercorrelated indicators may provide poorer coverage of the construct space. We stress the need to go beyond specific tasks and paradigms when studying higher-order cognitive constructs, such as working memory.
A summary of the milliped faunas of Pakistan, Bangladesh, and Kashmir (Arthropoda: Diplopoda)
(2014)
Three female callipodidan samples from northern Pakistan are assigned to Bollmania kohalana (Attems, 1936) (Caspiopetalidae), the only ordinal representative documented from the country; a new record of Kaschmiriosoma loebli Jeekel, 2003 (Polydesmida: Paradoxosomatidae), is also provided. Localities are summarized for the 14 Pakistani, 6 Kashmirian, and 5 Bangladeshi diplopods. The last include one unidentifi able female of Zephronia Gray, 1832 (Sphaerotheriida: Zephroniidae), and two adventive species, Trachyjulus calvus (Pocock, 1893) (Spirostreptida: Cambalopsidae) and Asiomorpha coarctata (Saussure, 1860) (Polydesmida: Paradoxosomatidae); all constitute new country records. Two obscurely documented Bangladeshi diplopods are Gonoplectus cautus (Attems, 1936) (Spirostreptida: Harpagophoridae), and Trichopeltis watsoni Pocock, 1895 (Polydesmida: Cryptodesmidae). The Pakistani polydesmidan, Quasidesmus puschtun Golovatch, 1991, is transferred from Pyrgodesmidae to Cryptodesmidae.
CD4+CD25+ regulatory T cells (Tregs) represent a specialized subpopulation of T cells, which are essential for maintaining peripheral tolerance and preventing autoimmunity. The immunomodulatory effects of Tregs depend on their activation status. Here we show that, in contrast to conventional anti-CD4 monoclonal antibodies (mAbs), the humanized CD4-specific monoclonal antibody tregalizumab (BT-061) is able to selectively activate the suppressive properties of Tregs in vitro. BT-061 activates Tregs by binding to CD4 and activation of signaling downstream pathways. The specific functionality of BT-061 may be explained by the recognition of a unique, conformational epitope on domain 2 of the CD4 molecule that is not recognized by other anti-CD4 mAbs. We found that, due to this special epitope binding, BT-061 induces a unique phosphorylation of T-cell receptor complex-associated signaling molecules. This is sufficient to activate the function of Tregs without activating effector T cells. Furthermore, BT-061 does not induce the release of pro-inflammatory cytokines. These results demonstrate that BT-061 stimulation via the CD4 receptor is able to induce T-cell receptor-independent activation of Tregs. Selective activation of Tregs via CD4 is a promising approach for the treatment of autoimmune diseases where insufficient Treg activity has been described. Clinical investigation of this new approach is currently ongoing.
A second Yalta
(2014)
We explore the parameter space of the two-flavor thermal quark–meson model and its Polyakov loop-extended version under the influence of a constant external magnetic field B. We investigate the behavior of the pseudo critical temperature for chiral symmetry breaking taking into account the likely dependence of two parameters on the magnetic field: the Yukawa quark–meson coupling and the parameter T0 of the Polyakov loop potential. Under the constraints that magnetic catalysis is realized at zero temperature and the chiral transition at B=0 is a crossover, we find that the quark–meson model leads to thermal magnetic catalysis for the whole allowed parameter space, in contrast to the present picture stemming from lattice QCD.
Twenty six species of the genus Purenleon Stange (Neuroptera: Myrmeleontidae: Nemoleontini) are recognized from the New World, of which ten are described as new species: P. oaxacae, P. fernandezi, P. tibialis, P. adamsi, P. andinus, P. apache, P. aztecus, P. cavei, P. farri and P. toltecus. Neotypes are designated for Psammoleon banksi Esben-Petersen 1933 and for Formicaleo inaequalis Navás 1913. The larvae of sixteen species have been reared and are described with data on their biologies. The genus is subdivided into three species groups based mostly on leg structure. The inscriptus group consists of fi ve species, the tibialis group consists of two species and the rest of the species are in the bistictus group. Keys to the species based both on adults and larvae are provided and descriptions given.
A revision of the genus Acentroptera Guérin-Méneville, 1844 (Coleoptera: Chrysomelidae: Cassidinae)
(2014)
The species of the genus Acentroptera Guérin-Méneville, 1844 are revised. Thirteen species are treated as valid and are illustrated. A neotype is designated for A. tessellata Baly. Acentroptera maculata Pic from Brazil and A. rubronotata Pic from Brazil are treated as incertae sedis. Acentroptera bita n. sp. and A. lineata n. sp. both from Panama are described as new. A key to the 13 treated species is presented. Five species appear to be associated with bromeliads (Bromeliaceae).
The fauna of the small carrion beetles and round fungus beetles (Leiodidae) of the oceanic islands of the West Indies is reviewed with 11 genera and 81 species recorded. Keys to adults of all genera and species, descriptions, and figures are provided to aid in identification. All species are endemic to the islands of the West Indies. Most species are endemic to a single island, but some species in the Lesser Antilles occur on more than one island. It is certain that more species remain to be discovered, especially on larger and less explored islands. Two new genera are described: Parvocyrtusa (type species Parvocyrtusa hispaniolensis), and Pseudolionothus (type species Pseudolionothus insularis). The genus Pseudoagathidium Angelini is reported from the New World for the first time with one species. The higher taxa and 61 new species and their island distributions are as follows: Cholevinae, Eucatopini, Eucatops Portevin (first West Indian record): E. annulus, Hispaniola. Ptomaphagini, Proptomaphaginus Szymczakowski (four species, no new taxa), Greater Antilles and Bahamas (new genus record). Anemadini, Dissochaetus Reitter (five species, one new species): D. santalucia, St. Lucia. Leiodinae, Agathidiini, Agathidium Panzer (first West Indian record): A. minutum, Hispaniola. Pseudoagathidium Angelini (first New World record): P. ignotum, St. Vincent. Leiodini, Isoplastus Horn (first West Indian record): I. hispaniolensis, Hispaniola. Zeadolopus Broun (five known species, 28 new species): Z. acinaces, Hispaniola; Z. angulatus, St. Vincent; Z. antiguensis, Antigua, Saba, Montserrat; Z. atratus, Cuba; Z. bahamensis, Bahamas Islands (Andros Island); Z. caborojo, Hispaniola; Z. carinatus, Jamaica; Z caymanensis, Cayman Islands (Grand Cayman); Z. cubensis, Cuba; Z. dominica, Dominica; Z. exiguus, Hispaniola; Z. flavidus, Cuba; Z. hatomayor, Hispaniola; Z. hispaniolensis, Hispaniola; Z. iviei, Hispaniola; Z. jarabacoa, Hispaniola; Z. lavega, Hispaniola; Z. longipes, Hispaniola; Z. lucidus, Cuba; Z. miniusculus, Hispaniola; Z. nanus, Hispaniola; Z. nesiotes, St. Lucia and Martinique; Z. oviedoensis, Hispaniola; Z. parvantilliensis, Montserrat, Guadeloupe, Dominica, Martinique, St. Lucia, St. Vincent, Grenada; Z. paulus, Hispaniola; Z. pedernales, Hispaniola; Z. pusillus, Cuba. Parvocyrtusa (new genus, one new species): P. hispaniolensis, Hispaniola. Pseudolionothus (new genus, two new species): P. andersoni, Cuba; P. insularis, Hispaniola. Scotocryptini, Aglyptinus Cockerell (five known species, 19 new species): A. angulatus, Hispaniola; A. bahamensis, Bahamas Islands (Andros Island); A. biserriatus, Cuba; A. capitaneus, Cuba; A. dominica, Dominica; A. fortipunctatus, Cuba; A. grandis, Hispaniola; A. grenadensis, Grenada; A. hemipterus, Jamaica; A. hispaniolensis, Hispaniola; A. longipalpus, Hispaniola; A. luciae, St. Lucia; A. maculatus, Jamaica; A. martiniquensis, Martinique; A. minutus, Cuba; A. parvoculus, Jamaica; A. parvus, St. Lucia; A. sinuatus, Cuba; A. vincentii, St. Vincent. Creagrophorus Matthews (one known species, seven new species): C. bicolor, Martinique; C. cubensis, Cuba; C. dominica, Dominica; C. hispaniolensis, Hispaniola; C. microdentatus, Hispaniola; C. santalucia, St. Lucia; C. unidentatus, St. Vincent and Grenada.
The Afrotropical Rhyssinae are reviewed. A total of 12 species are reported from the region, including five new species: Epirhyssa brianfisheri sp. nov., E. gavinbroadi sp. nov., E. shaka sp. nov., E. villemantae sp. nov. and E. tombeaodiba sp. nov. The generic status of E. brianfisheri sp. nov. is discussed since this species could also be considered to be an extra-limital Triancyra species, emphasizing the putative paraphyletic status of Epirhyssa. Epirhyssa ghesquierei Seyrig, 1937, E. overlaeti Seyrig, 1937 and E. uelensis Benoit, 1951 are newly reported from Cameroon. We provide illustrated diagnoses and identification notes. Finally, we discuss the apparent scarcity of African rhyssines compared to other regions.
Eleven Neotropical species of Laemophloeus Dejean with antennal clubs composed of three antennomeres are reviewed, diagnosed, and illustrated. Six of the species are described as new: L. capitesculptus Thomas, n. sp., L. corporeflavus Thomas, n. sp., L. dozieri Thomas, n. sp., L. insulatestudinorum Thomas, n. sp., L. planaclavatus Thomas, n. sp., and L. taurus Thomas, n. sp. Four new synonymies are proposed: L. catharinensis Kessel (=L. incisus Sharp), new synonym; L. similans Kessel (=L. incisus Sharp), new synonym; L. distinguendus Sharp (=L. megacephalus Grouvelle), new synonym, and L. chevrolati Grouvelle (=L. lecontei Grouvelle), new synonym. A key to the species is provided.
Orientation: Publishing methodologically sound, empirically based studies in reputable accredited scientific journals are essential in order to advance knowledge and evidence-based practice in the field of industrial and organisational psychology.
Research purpose: The purpose of the research was to conduct a broad content analysis of the articles published in the South African Journal of Industrial Psychology (SAJIP) between 2004 and 2013. The study aimed to provide a descriptive overview of the most frequent content themes,published authors and institutions, research approaches, strategies, designs and analysis techniques, software packages and sample sizes in industrial and organisational (I-O) psychology utilised in the publications.
Motivation for study: The periodic analyses of published content in scholarly journals provide an index of the extent to which the publications reflect the scope of practice in a given discipline and broaden insight into the direction and relevance of research published in a journal.
Research design, approach and method: A broad systematic content analysis was conducted of 342 documented articles published in the SAJIP between 2004 and 2013. Descriptive data(frequencies and percentages) were used to report the findings.
Main findings: The publishing pattern of the SAJIP appeared to correspond with its focus and scope. Manuscripts utilising mostly cross-sectional quantitative correlational research designs with large samples (n > 201) were published in the SAJIP. The University of Johannesburg and Professor Sebastiaan (Ian) Rothmann were the largest contributors to publications between 2004 and 2013. Organisational psychology and psychometrics were the most prominent domains in I-O psychology research. Data were predominantly processed utilising SPSS.
Practical implications: The insights derived from the findings can be employed to plan future research initiatives in the field of I-O psychology.
Contribution/value-add: The findings provide valuable insight into the current status of the foci of I-O psychology research as published in the SAJIP between 2004 and 2013 and the contribution made by the SAJIP to advancing knowledge and evidence-based practice in I-O psychology.
This paper analyzes how on-the-job search (OJS) by an agent impacts the moral hazard problem in a repeated principal-agent relationship. OJS is found to constitute a source of agency costs because efficient search incentives require that the agent receives all gains from trade. Further, the optimal incentive contract with OJS matches the design of empirically observed compensation contracts more accurately than models that ignore OJS. In particular, the optimal contract entails excessive performance pay plus efficiency wages. Efficiency wages reduce the opportunity costs of work effort and hence serve as a complement to bonuses. Thus, the model offers a novel explanation for the use of efficiency wages. When allowing for renegotiation, the model generates wage and turnover dynamics that are consistent with empirical evidence. I argue that the model contributes to explaining the concomitant rise in the use of performance pay and in competition for high-skill workers during the last three decades.
The ground beetle genus Cymindis is the most species rich amongst genera in the carabid subtribe Cymindidina (tribe Lebiini). Four subgenera are often recognized, i.e. Cymindis (sensu stricto) Latreille, Afrotarus Jeannel, Taridius Chaudoir and Pinacodera Schaum. Cymindis (sensu stricto) has a predominately Holarctic distribution (Hunting 2013) and includes Cymindis alutacea Wollaston, C. dohrnii Wollaston and C. anchomenoides Wollaston (the last one sometimes placed in Tarulus Bedel, either ranked as a genus or a subgenus), all three endemic to the Cape Verde Islands (Geisthardt 1988, 1996).
A checklist and classification of the species of Elateridae reported from mainland Ecuador are given. Anchastus boulardi Chassain, Cardiorhinus apicalis Golbach, Physorhinus marginatus Candèze, and P. sexnotatus Steinheil are reported from Ecuador for the first time. The recorded elaterid fauna of Ecuador is now represented by 140 species, 38 genera, and 9 subfamilies, which are low taxon richness numbers when compared to those of neighboring countries.
Ribosome biogenesis in yeast requires 75 small nucleolar RNAs (snoRNAs) and a myriad of cofactors for processing, modification, and folding of the ribosomal RNAs (rRNAs). For the 19 RNA helicases implicated in ribosome synthesis, their sites of action and molecular functions have largely remained unknown. Here, we have used UV cross-linking and analysis of cDNA (CRAC) to reveal the pre-rRNA binding sites of the RNA helicase Rok1, which is involved in early small subunit biogenesis. Several contact sites were identified in the 18S rRNA sequence, which interestingly all cluster in the “foot” region of the small ribosomal subunit. These include a major binding site in the eukaryotic expansion segment ES6, where Rok1 is required for release of the snR30 snoRNA. Rok1 directly contacts snR30 and other snoRNAs required for pre-rRNA processing. Using cross-linking, ligation and sequencing of hybrids (CLASH) we identified several novel pre-rRNA base-pairing sites for the snoRNAs snR30, snR10, U3, and U14, which cluster in the expansion segments of the 18S rRNA. Our data suggest that these snoRNAs bridge interactions between the expansion segments, thereby forming an extensive interaction network that likely promotes pre-rRNA maturation and folding in early pre-ribosomal complexes and establishes long-range rRNA interactions during ribosome synthesis.
Background: According to current taxonomy only three out of 27 Sinohimalayan leaf warbler species (Phylloscopidae) are considered genetically uniform across their entire breeding range along the Southeastern margin of the Qinghai-Tibetan Plateau, the Buff-barred Warbler (Phylloscopus pulcher) being one of them. Because marked differentiation among Himalayan and Chinese populations has been recently demonstrated for a number of Phylloscopus species (or sister species) we investigated the intraspecific variation of a mitochondrial gene, songs and morphology of P. pulcher in a phylogeographic approach.
Methods: We sequenced a fragment of the mitochondrial cytochrome b, reconstructed haplotype networks and analyzed DNA polymorphism among Himalayan and Chinese populations. We measured time and frequency parameters of two distinct song types and analyzed among population-differentiation in a principal component analysis and a discriminant analysis. We also compared measurements of body size dimensions taken from museum specimens.
Results: The mitochondrial haplotype network (cytb) was divided into two distinct clusters corresponding to geographic origin of samples. Pairwise genetic distances among Himalayan and Chinese mtDNA lineages account for 1.3% which coincides with Pleistocene lineage separation at roughly 650,000 years ago. Genetic diversity is slightly higher in the Chinese part of the species’ range with respect to haplotype and nucleotide diversity while the less diversified Himalayan population lineage shows signs of recent range expansion. The vocal repertoire of P. pulcher comprises two distinct verse types that are combined with short interspersed click notes to long continuous song displays. Trill verse types showed significant differences among regions in almost all measured frequency and time parameters: Chinese males displayed more rapid and more broad-banded trills at a lower pitch. In contrast, warbling verse types showed a distinctively different structure among regions: Himalayan songs consisted of repeated syllables while Chinese songs comprised repetitions of single, long and strongly modulated elements. Subtle morphological differences among specimens from the two study regions could only be confirmed for plumage coloration but not for metric characters.
Conclusions: Based on the genetic and bioacoustic distinctiveness of Chinese Buff-barred Warbler populations, we recommend that the name Phylloscopus pulcher vegetus Bangs, 1913 should be re-validated for this taxon.
A child of a Jewish family fleeing Nazi-Germany and settling in apartheid South Africa in the 1930s, Ruth Weiss? journalistic career starts in Johannesburg of the 1950s. In 1968 banned from her home country, and then also from Rhodesia for her critical investigative journalism, she starts reporting from Lusaka, London and Cologne on virtually all issues which affect the newly independent African countries. Peasants and national leaders in southern Africa ? Ruth Weiss met them all, travelling through Africa at a time when it was neither usual for a woman to do so, nor to report for economic media as she did. Her writing gained her the friendship of diverse and interesting people. In this book she offers us glimpses into some of her many long-nurtured friendships, with Kenneth Kaunda or Nadine Gordimer and many others. Her life-long quest for tolerance and understanding of different cultures shines through the many personalized stories which her astute eye and pen reveals in this book. As she put it, one never sheds the cultural vest donned at birth, but this should never stop one learning about and accepting other cultures.
A versatile synthetic procedure is described to prepare the benzimidazole-fused 1,2,4-thiadiazoles 2a–c via a methanesulfonyl chloride initiated multistep cyclization involving the intramolecular reaction of an in-situ generated carbodiimide with a thiourea unit. The structure of the intricate heterocycle 2a was confirmed by single-crystal X-ray analysis and its mechanism of formation supported by DFT computations.
Riley (1979)'s reactive equilibrium concept addresses problems of equilibrium existence in competitive markets with adverse selection. The game-theoretic interpretation of the reactive equilibrium concept in Engers and Fernandez (1987) yields the Rothschild-Stiglitz (1976)/Riley (1979) allocation as an equilibrium allocation, however multiplicity of equilibrium emerges. In this note we imbed the reactive equilibrium's logic in a dynamic market context with active consumers. We show that the Riley/Rothschild-Stiglitz contracts constitute the unique equilibrium allocation in any pure strategy subgame perfect Nash equilibrium.
In spring and summer 2008, the Odonata fauna of the Khabr National Park (Iran) was studied for the first time. Here, we present records of the representatives of family Libellulidae only. A total of twelve libellulid Odonata were found. Most of them are common species in Iran and other parts of Kerman province. Scarce Iranian species are Trithemis arteriosa and Zygonyx torridus.
In the present paper, we concentrate on (selected) Bantu and Nilotic bare-passive strategies and lay out the basis for a typology of transitive passive constructions in these languages. We argue that bare-passives constitute an optimal strategy to change prominence relations between arguments, in languages that strongly hold to the default mapping between the highest thematic role available and the grammatical subject (i.e. Spec,TP). The Nilotic and Bantu languages discussed here differ in their way of satisfying this default mapping. In particular, impersonal bare-passives satisfy it by resorting to an agentive place-holder (an indefinite subject marker) and realizing the logical agent as a lower thematic/semantic role (e.g. instrument or locative). Left-dislocation and so called 'subjectobject' reversal bare-passives realize the default matching between agent and subject in a more straightforward way, but locate the patient in a higher argument position within the inflectional domain (Spec,TopP). As argued in Hamlaoui and Makasso (2013) and Hamlaoui (2013), and in line with Noonan (1977), the present languages display a clauseinternal split between subjecthood (being the grammatical subject in Spec,TP) and topicality (being the subject of the predication, in an inflectional-domain internal Spec,TopP).