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Zur Gliederung von Erophila verna s.l. mit Merkmalsprüfungen für die in Hessen vorkommenden Arten
(2003)
Die historische Entwicklung der Erophila-Systematik wird dargestellt und die unterschiedlichen Zugänge von Schulz, Winge und Filfilan & Elkington werden erörtert. Für die in Deutschland vorkommenden Arten wird ein Schlüssel erarbeitet und ihre Verbreitung in Hessen und seinen Randgebieten dargestellt.
Saxifraga sponhemica besitzt ihr einziges rechtsrheinisches Vorkommen an der Bodensteiner Ley im hessischen Teil des Lahn-Tals. Der Bestand ist durch Klettersport stark zurückgegangen und bedarf des dringenden Schutzes. Die momentan bestehende Einstufung in der Roten Liste der Farn- und Blütenpflanzen Hessen sollte von R (seltene Art) zu 1 (vom Aussterben bedroht) korrigiert werden.
Type I interferons (IFNs) signal for their diverse biological effects by binding a common receptor on target cells, composed of the two transmembrane IFNAR1 and IFNAR2 proteins. We have previously differentially enhanced the antiproliferative activity of IFN by increasing the weak binding affinity of IFN to IFNAR1. In this study, we further explored the affinity interdependencies between the two receptor subunits and the role of IFNAR1 in differential IFN activity. For this purpose, we generated a panel of mutations targeting the IFNAR2 binding site on the background of the IFNalpha2 YNS mutant, which increases the affinity to IFNAR1 by 60-fold, resulting in IFNAR2-to-IFNAR1 binding affinity ratios ranging from 1000:1 to 1:1000. Both the antiproliferative and antiviral potencies of the interferon mutants clearly correlated to the in situ binding IC(50) values, independently of the relative contributions of the individual receptors, thus relating to the integral lifetime of the complex. However, the antiproliferative potency correlated throughout the entire range of affinities, as well as with prolonged IFNAR1 receptor down-regulation, whereas the antiviral potency reached a maximum at binding affinities equivalent to that of wild-type IFNalpha2. Our data suggest that (i) the specific activity of interferon is related to the ternary complex binding affinity and not to affinity toward individual receptor components and (ii) although the antiviral pathway is strongly dependent on pSTAT1 activity, the cytostatic effect requires additional mechanisms that may involve IFNAR1 down-regulation. This differential interferon response is ultimately mediated through distinct gene expression profiling.
Symbiosis represents a widely distributed principle of mutual relationships among organisms, belonging to different systematic groups. The cell endosymbiosis is considered to be the most important event, which starts the evolution of all eukaryotic organisms. We recognize about five successful endosymbioses. Some of them resulted in obtaining mitochondria the peroxisomes, perhaps derived from different groups of bacterial ancestors. The special interest represents the origin of the chloroplasts. As it was suggested using the molecular methods, the single-celled cyanobacteria were the ancestors of chloroplasts in glaucophytes, red and green algae. All these groups are classified into kingdom Plantae. Green algae and vascular plants form a monophyletic group. Their chloroplasts are surrounded only by double membrane envelopes, no connection with endoplasmic reticulum or with the nuclear envelope were observed. Endosymbiosis with cyanobacterial chloroplast ancestor is considered to be the primary endosymbiosis. It was of an ancient origin with the age of about 2 billion years. Chloroplasts of other algal divisions were obtained via secondary, sometimes even as tertiary endosymbioses. In dinophytes and euglenophytes, the plastids are the remainder of single celled eukaryotic algae, covered with the triple envelope membranes. Two inner membranes are similar to the chloroplast envelopes in plant chloroplasts, the third outer membrane is of unknown origin. Some experts consider the third plastid membrane as a phagosome (food vacuole) membrane. No connections with the nuclear envelope were observed. In cryptophytes and chromophyte algae (Chromophyta, syn. Heterocontophyta, syn. Ochrista) and Haptophyta (syn. Prymnesiophyta) plastids are covered with four membranes, two additional membranes are derived from the rough endoplasmic reticulum, which is often connected with the outer membrane of nuclear envelope. This kind of endosymbiosis is called the secondary symbiosis, and is much younger than the primary symbioses. Taking in account the six- kingdoms system of life proposed by CAVALIER-SMITH (1998), the secondary endosymbioses are classified into two different kingdoms: Protozoa (Dinophyta, Euglenophyta) and Chromista. The primary endosymbioses form the kingdom Plantae. The classification of Chlorarachniophyta is not clear and recently they are not mentioned as a separate division. Besides Chlorarachnion reptans, some other filarplasmodium forming protozoans containing plastids (Chrysarachnion, Chrysophyceae, Myxochloris, Xanthophyceae) or without plastids (Corallomyxa, Reticulosphaera, GRELL 1991) were recognized.
The prediction of protein–ligand interactions and their corresponding binding free energy is a challenging task in structure-based drug design and related applications. Docking and scoring is broadly used to propose the binding mode and underlying interactions as well as to provide a measure for ligand affinity or differentiate between active and inactive ligands. Various studies have revealed that most docking software packages reliably predict the binding mode, although scoring remains a challenge. Here, a diverse benchmark data set of 99 matched molecular pairs (3D-MMPs) with experimentally determined X-ray structures and corresponding binding affinities is introduced. This data set was used to study the predictive power of 13 commonly used scoring functions to demonstrate the applicability of the 3D-MMP data set as a valuable tool for benchmarking scoring functions.
Resilience has been defined as the maintenance or quick recovery of mental health during and after times of adversity. How to operationalize resilience and to determine the factors and processes that lead to good long-term mental health outcomes in stressor-exposed individuals is a matter of ongoing debate and of critical importance for the advancement of the field. One of the biggest challenges for implementing an outcome-based definition of resilience in longitudinal observational study designs lies in the fact that real-life adversity is usually unpredictable and that its substantial qualitative as well as temporal variability between subjects often precludes defining circumscribed time windows of inter-individually comparable stressor exposure relative to which the maintenance or recovery of mental health can be determined. To address this pertinent issue, we propose to frequently and regularly monitor stressor exposure (E) and mental health problems (P) throughout a study's observation period [Frequent Stressor and Mental Health Monitoring (FRESHMO)-paradigm]. On this basis, a subject's deviation at any single monitoring time point from the study sample's normative E–P relationship (the regression residual) can be used to calculate that subject's current mental health reactivity to stressor exposure (“stressor reactivity,” SR). The SR score takes into account the individual extent of experienced adversity and is comparable between and within subjects. Individual SR time courses across monitoring time points reflect intra-individual temporal variability in SR, where periods of under-reactivity (negative SR score) are associated with accumulation of fewer mental health problems than is normal for the sample. If FRESHMO is accompanied by regular measurement of potential resilience factors, temporal changes in resilience factors can be used to predict SR time courses. An increase in a resilience factor measurement explaining a lagged decrease in SR can then be considered to index a process of adaptation to stressor exposure that promotes a resilient outcome (an allostatic resilience process). This design principle allows resilience research to move beyond merely determining baseline predictors of resilience outcomes, which cannot inform about how individuals successfully adjust and adapt when confronted with adversity. Hence, FRESHMO plus regular resilience factor monitoring incorporates a dynamic-systems perspective into resilience research.
Eine Studie zur fehleranalytischen Kompetenz der Studierenden in der Deutschlehrendenausbildung
(2018)
Die Fehleranalyse gilt seit langem als eine wertvolle Hilfe beim Fremdsprachenunterricht, weil sowohl Lernende als auch Lehrende dadurch wichtige Informationen über den Spracherwerbsprozess bekommen können. Auch die vorliegende Arbeit beabsichtigt mit Hilfe der Fehleranalyse zu Erkenntnissen über die fehleranalytische Kompetenz der künftigen Deutschlehrer zu gelangen. Ausgangspunkt dieser Studie war die Frage, ob es eine direkte Verbindung zwischen dem Sprachniveau und der fehleranalytischen Kompetenz der Studierenden gebe. An der Untersuchung haben 37 Studierenden der Gazi Universität teilgenommen, von denen sieben Rückkehrende aus Deutschland waren und über gute Sprachkenntnisse verfügten. Alle Probanden befanden sich im sechsten Semester und hatten sich im Rahmen der angewandten Linguistik ein semesterlang mit der Fehleranalyse befasst. Den Probanden wurden zwei Texte vorgelegt, deren Fehler sie identifizieren und anhand eines Rasters klassifizieren mussten. Es hat sich herausgestellt, dass bei der Fehleridentifizierung die Fremdsprachenkenntnisse ein entscheidender Faktor waren. Bei der Fehlerklassifizierung dagegen, schienen die Fremdsprachenkenntnisse eher eine untergeordnete Rolle zu spielen.
An der erfolgreichen Inszenierung "Verrücktes Blut" des Kreuzberger Theaters 'Ballhaus Naunynstraße' interessiert in diesem Beitrag vor allem die Bühnensprache und die Diskrepanz zwischen der Intention der Künstler und der Rezeption der Inszenierung durch das Berliner Publikum. Die Frage nach der Rolle der Ironie in der Bühnensprache des Ballhauses führt zur Antwort auf die Frage nach den Gründen für den Erfolg dieser Inszenierung.
Im Bereich des Naturschutzgebietes "Untere Seegeniederung" (Landkreis Lüchow-Dannenberg/Niedersachsen), nahe der Elbe wurde nach Überschwemmungsjahren auf Ackerflächen die Quirltänel-Sand-binsengesellschaft (Elatino alsinastri-Juncetum tenageiae Libbert 1933) mit der Niederliegenden Teichbinse (Schoenoplectus supinus) gefunden. Dieses Vorkommen wird beschrieben, Verbreitung, Gefährdung und Schutzmaßnahmen werden besprochen. Das Elatino alsinastri-Juncetum tenageiae ist eine spezialisierte Gesellschaft sehr unregelmäßig überfluteter, offener nährstoff- und kalkarmer Sandböden im stärker kontinental getönten Klimabereich. Die allesamt höchst seltenen Charakterarten und die ebenso gefährdete Artenkombination, bedürfen intensiven Schutzes. Voraussetzung für das Vorkommen ist einerseits der ungestörte Überschwemmungsrhytmus der Elbe, andererseits die Beibehaltung der Nutzung.
Reelle Bestandsgrößen und Verteilung gebäudebrütender Vogelarten sind vielfach nicht bekannt. Dauerhaft genutzte Lebensstätten dieser Arten sind jedoch nach dem Bundesnaturschutzgesetz ganzjährig geschützt. Um Anträge auf Befreiung vom Zerstörungsverbot von Niststätten für geplante Abriss- und Sanierungsarbeiten von Gebäuden zügig bearbeiten zu können, wird der Gebäudebrüterbestand in der Stadt Dessau im Auftrag der Stadt seit 2002 erfasst. Die Bearbeitung wurde zunächst innerhalb des unmittelbaren Stadtgebietes begonnen und seither im Rahmen der finanziellen Möglichkeiten auch auf die äußeren Stadtteile ausgedehnt. Als Ergebnis liegen der Stadt gebäudespezifische Angaben über Brutvögel vor.
Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as superoxide anion or hydrogen peroxide, are produced in the nociceptive system during chronic inflammatory and neuropathic pain and act as specific signaling molecules in pain processing. Among potential ROS sources in the somatosensory system are NADPH oxidases, a group of electron-transporting transmembrane enzymes whose sole function seems to be the generation of ROS. Interestingly, the expression and relevant function of the Nox family members Nox1, Nox2, and Nox4 in various cells of the nociceptive system have been demonstrated. Studies using knockout mice or specific knockdown of these isoforms indicate that Nox1, Nox2, and Nox4 specifically contribute to distinct signaling pathways in chronic inflammatory and/or neuropathic pain states. As selective Nox inhibitors are currently being developed and investigated in various physiological and pathophysiological settings, targeting Nox1, Nox2, and/or Nox4 could be a novel strategy for the treatment of chronic pain. Here, we summarize the distinct roles of Nox1, Nox2, and Nox4 in inflammatory and neuropathic processing and discuss the effectiveness of currently available Nox inhibitors in the treatment of chronic pain conditions.
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations. To better understand the mechanism beyond physiological signaling we used Organotypic Entorhino-Hippocampal Slice Cultures (OHSC) and investigated the temporal regulation of 2-AG in different cell subsets during excitotoxic lesion and dendritic lesion of long range projections in the enthorhinal cortex (EC), dentate gyrus (DG) and the cornu ammonis region 1 (CA1).
RESULTS: 2-AG levels were elevated 24 h after excitotoxic lesion in CA1 and DG (but not EC) and 24 h after perforant pathway transection (PPT) in the DG only. After PPT diacylglycerol lipase alpha (DAGL) protein, the synthesizing enzyme of 2-AG was decreased when Dagl mRNA expression and 2-AG levels were enhanced. In contrast to DAGL, the 2-AG hydrolyzing enzyme monoacylglycerol lipase (MAGL) showed no alterations in total protein and mRNA expression after PPT in OHSC. MAGL immunoreaction underwent a redistribution after PPT and excitotoxic lesion since MAGL IR disappeared in astrocytes of lesioned OHSC. DAGL and MAGL immunoreactions were not detectable in microglia at all investigated time points. Thus, induction of the neuroprotective endocannabinoid 2-AG might be generally accomplished by down-regulation of MAGL in astrocytes after neuronal lesions.
CONCLUSION: Increase in 2-AG levels during secondary neuronal damage reflects a general neuroprotective mechanism since it occurred independently in both different lesion models. This intrinsic up-regulation of 2-AG is synergistically controlled by DAGL and MAGL in neurons and astrocytes and thus represents a protective system for neurons that is involved in dendritic reorganisation.
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes. Endocannabinoids (eCBs) play a central role in controlling local responses and influencing neural plasticity and survival. However, little is known about the functional relevance of eCBs in long-range projection damage as observed in stroke or spinal cord injury (SCI).
Methods: In rat organotypic entorhino-hippocampal slice cultures (OHSC) as a relevant and suitable model for investigating projection fibers in the CNS we performed perforant pathway transection (PPT) and subsequently analyzed the spatial and temporal dynamics of eCB levels. This approach allows proper distinction of responses in originating neurons (entorhinal cortex), areas of deafferentiation/anterograde axonal degeneration (dentate gyrus) and putative changes in more distant but synaptically connected subfields (cornu ammonis (CA) 1 region).
Results: Using LC-MS/MS, we measured a strong increase in arachidonoylethanolamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) levels in the denervation zone (dentate gyrus) 24 hours post lesion (hpl), whereas entorhinal cortex and CA1 region exhibited little if any changes. NAPE-PLD, responsible for biosynthesis of eCBs, was increased early, whereas FAAH, a catabolizing enzyme, was up-regulated 48hpl.
Conclusion: Neuronal damage as assessed by transection of long-range projections apparently provides a strong time-dependent and area-confined signal for de novo synthesis of eCB, presumably to restrict neuronal damage. The present data underlines the importance of activation of the eCB system in CNS pathologies and identifies a novel site-specific intrinsic regulation of eCBs after long-range projection damage.
In this paper we propose a compositional semantics for lexicalized tree-adjoining grammar (LTAG). Tree-local multicomponent derivations allow separation of the semantic contribution of a lexical item into one component contributing to the predicate argument structure and a second component contributing to scope semantics. Based on this idea a syntax-semantics interface is presented where the compositional semantics depends only on the derivation structure. It is shown that the derivation structure (and indirectly the locality of derivations) allows an appropriate amount of underspecification. This is illustrated by investigating underspecified representations for quantifier scope ambiguities and related phenomena such as adjunct scope and island constraints.
Background: Knee osteoarthritis is associated with higher kinetic friction in the knee joint, hence increased acoustic emissions during motion. Decreases in compressive load and improvements in movement quality might reduce this friction and, thus, sound amplitude. We investigated if an exercise treatment acutely affects knee joint sounds during different activities of daily life.
Methods: Eighteen participants with knee osteoarthritis (aged 51.8 ± 7.3 years; 14 females) were included in this randomized crossover trial. A neuromuscular exercise intervention and a placebo laser needle acupuncture treatment were performed. Before and after both interventions, knee joint sounds were measured during three different activities of daily living (standing up/sitting down, walking, descending stairs) by means of vibroarthrography. The mean amplitude (dB) and the median power frequency (MPF, Hz) were assessed at the medial tibial plateau and the patella. Differences in knee acoustic emissions between placebo and exercise interventions were calculated by analyses of covariance.
Results: Controlled for participant's age, knee demanding activity level and osteoarthritis stage, the conditions significantly differed in their impact on the MPF (mean(± SD) pre-post-differences standing up: placebo: 9.55(± 29.15) Hz/ exercise: 13.01(± 56.06) Hz, F = 4.9, p < 0.05) and the amplitude (standing up: placebo:0.75(± 1.43) dB/ exercise: 0.51(± 4.68) dB, F = 5.0, p < 0.05; sitting down: placebo: 0.07(± 1.21) dB/ exercise: -0.16(± .36) dB, F = 4.7, p < 0.05) at the tibia. There were no differences in the MPF and amplitude during walking and descending stairs (p > 0.05). At the patella, we found significant differences in the MPF during walking (placebo 0.08(± 1.42) Hz/ exercise: 15.76(± 64.25) Hz, F = 4.8, p < .05) and in the amplitude during descending stairs (placebo: 0.02 (± 2.72) dB/ exercise: -0.73(± 2.84) dB, F = 4.9, p < 0.05). There were no differences in standing up/ sitting down for both parameters, nor in descending stairs for the MPF and walking for the amplitude (p > 0.05).
Conclusion: The MPF pre-post differences of the exercise intervention were higher compared to the MPF pre-post differences of the placebo treatment. The amplitude pre-post differences were lower in the exercise intervention. In particular, the sound amplitude might be an indicator for therapy effects in persons with knee osteoarthritis.
Trial registration: The study was retrospectively registered in the German Clinical Trials Register (DRKS00022936, date of registry: 26/08/2020).
Knee acoustic emissions provide information about joint health and loading in motion. As the reproducibility of knee acoustic emissions by vibroarthrography is yet unknown, we evaluated the intrasession and interday reliability of knee joint sounds. In 19 volunteers (25.6 ± 2.0 years, 11 female), knee joint sounds were recorded by two acoustic sensors (16,000 Hz; medial tibial plateau, patella). All participants performed four sets standing up/sitting down (five repetitions each). For measuring intrasession reliability, we used a washout phase of 30 min between the first three sets, and for interday reliability we used a washout phase of one week between sets 3 and 4. The mean amplitude (dB) and median power frequency (Hz, MPF) were analyzed for each set. Intraclass correlation coefficients (ICCs (2,1)), standard errors of measurement (SEMs), and coefficients of variability (CVs) were calculated. The intrasession ICCs ranged from 0.85 to 0.95 (tibia) and from 0.73 to 0.87 (patella). The corresponding SEMs for the amplitude were ≤1.44 dB (tibia) and ≤2.38 dB (patella); for the MPF, SEMs were ≤13.78 Hz (tibia) and ≤14.47 Hz (patella). The intrasession CVs were ≤0.06 (tibia) and ≤0.07 (patella) (p < 0.05). The interday ICCs ranged from 0.24 to 0.33 (tibia) and from 0 to 0.82 (patella) for both the MPF and amplitude. The interday SEMs were ≤4.39 dB (tibia) and ≤6.85 dB (patella) for the amplitude and ≤35.39 Hz (tibia) and ≤15.64 Hz (patella) for the MPF. The CVs were ≤0.14 (tibia) and ≤0.08 (patella). Knee joint sounds were highly repeatable within a single session but yielded inconsistent results for the interday reliability.
A glenohumeral internal rotation deficit (GIRD) of the shoulder, is associated with an increased risk of shoulder injuries in tennis athletes. The aim of the present study was to reveal the impact of 1) age, sex, specific training data (i.e. training volume, years of tennis practice, years of competitive play) and 2) upper extremity injuries on GIRD in youth competitive tennis athletes.
A cross-sectional retrospective study design was adopted. Youth tennis players (n = 27, 12.6 ± 1.80 yrs., 18 male) belonging to an elite tennis squad were included. After documenting the independent variables (anthropometric data, tennis specific data and history of injury), the players were tested for internal (IR) and external (ER) shoulder rotation range of motion (RoM, [°]). From these raw values, the GIRD parameters ER/IR ratio and side differences and TRoM side differences were calculated. Pearson’s correlation analyses were performed to find potential associations of the independent variables with the GIRD outcomes.
A significant positive linear correlation between the years of tennis training and IR side asymmetry occurred (p < .05). A significant negative linear relation between the years of tennis training and the ratio of ER to IR range of motion (RoM) in the dominant side (p < .05) was found. The analysis of covariance showed a significant influence of the history of injuries on IR RoM (p < .05).
Injury and training history but not age or training volume may impact on glenohumeral internal rotation deficit in youth tennis athletes. We showed that GIRD in the dominant side in youth tennis players is progressive with increasing years of tennis practice and independent of years of practice associated with the history of injuries. Early detection of decreased glenohumeral RoM (specifically IR), as well as injury prevention training programs, may be useful to reduce GIRD and its negative consequences.
Serum GFAP for stroke diagnosis in regions with limited access to brain imaging (BE FAST India)
(2021)
Introduction: Despite a high burden of stroke, access to rapid brain imaging is limited in many middle- and low-income countries. Previous studies have described the astroglial protein GFAP (glial fibrillary acidic protein) as a biomarker of intracerebral hemorrhage. The aim of this study was to test the diagnostic accuracy of GFAP for ruling out intracranial hemorrhage in a prospective cohort of Indian stroke patients. Patients and methods: This study was conducted in an Indian tertiary hospital (Christian Medical College, Ludhiana). Patients with symptoms suggestive of acute stroke admitted within 12 h of symptom onset were enrolled. Blood samples were collected at hospital admission. Single Molecule Array technology was used for determining serum GFAP concentrations. Results: A total number of 155 patients were included (70 intracranial hemorrhage, 75 ischemic stroke, 10 stroke mimics). GFAP serum concentrations were elevated in intracranial hemorrhage patients compared to ischemic stroke patients [median (interquartile range) 2.36 µg/L (0.61–7.16) vs. 0.18 µg/L (0.11–0.38), p < 0.001]. Stroke mimics patients had a median GFAP serum level of 0.14 µg/L (0.09–0.26). GFAP values below the cut-off of 0.33 µg/L (area under the curve 0.871) ruled out intracranial hemorrhage with a negative predictive value of 89.7%, (at a sensitivity for detecting intracranial hemorrhage of 90.0%). Discussion: The high negative predictive value of a GFAP test system allows ruling out patients with intracranial hemorrhage. Conclusion: In settings where immediate brain imaging is not available, this would enable to implement secondary prevention (e.g., aspirin) in suspected ischemic stroke patients as soon as possible.
Activation of Notch1 signaling in neural progenitor cells (NPCs) induces self-renewal and inhibits neurogenesis. Upon neuronal differentiation, NPCs overcome this inhibition, express proneural genes to induce Notch ligands, and activate Notch1 in neighboring NPCs. The molecular mechanism that coordinates Notch1 inactivation with initiation of neurogenesis remains elusive. Here, we provide evidence that Prox1, a transcription repressor and downstream target of proneural genes, counteracts Notch1 signaling via direct suppression of Notch1 gene expression. By expression studies in the developing spinal cord of chick and mouse embryo, we showed that Prox1 is limited to neuronal precursors residing between the Notch1+ NPCs and post-mitotic neurons. Physiological levels of Prox1 in this tissue are sufficient to allow binding at Notch1 promoter and they are critical for proper Notch1 transcriptional regulation in vivo. Gain-of-function studies in the chick neural tube and mouse NPCs suggest that Prox1-mediated suppression of Notch1 relieves its inhibition on neurogenesis and allows NPCs to exit the cell cycle and differentiate. Moreover, loss-of-function in the chick neural tube shows that Prox1 is necessary for suppression of Notch1 outside the ventricular zone, inhibition of active Notch signaling, down-regulation of NPC markers, and completion of neuronal differentiation program. Together these data suggest that Prox1 inhibits Notch1 gene expression to control the balance between NPC self-renewal and neuronal differentiation.
Etwa 800 000 Bundesbürger leiden an rheumatoider Arthritis (RA), der häufigsten chronisch-entzündlichen Erkrankung der Gelenke. Obwohl die Forschung in den vergangenen Jahren erhebliche Fortschritte gemacht hat, sind die Ursachen dieser schmerzhaften, bisher unheilbaren Krankheit noch nicht im Einzelnen geklärt. In vielerlei Richtungen diskutiert wird eine Fehlsteuerung des Immunsystems, bei der körpereigene Gewebsmatrix, wie der Gelenkknorpel, von Zellen des Immunsystems angegriffen wird. Die Forschungen der Mediziner, auch der Frankfurter Gruppe, konzentrieren sich weltweit auf die entzündungsfördernden Faktoren, spezielle Zytokine, und die Hemmstoffe dieser Zytokine. Aus diesen Ansätzen resultieren die neuartigen "Biologics": gentechnisch hergestellte monoklonale Antikörper, die natürlich vorkommenden Wirkstoffen entsprechen. Sie richten sich spezifisch gegen bestimmte vom menschlichen Organismus gebildete Zytokine.
Dichterhäuser produzieren Mythen. Dies ist bei Hofmannsthals barockem Wohnhaus in Rodaun bei Wien nicht anders. Als Vorbesitzer seines Hauses erwähnt Hofmannsthal in einem Brief an Eberhard von Bodenhausen vom 16. März 1901 beiläufig einen Fürsten Trautson: das Haus sei "zur Zeit der Kaiserin Maria Theresia von einem Fürsten Trautsohn, der ein Schwarzkünstler gewesen sein soll, für seine Geliebte gebaut worden". Das gemeinhin als 'Schlösschen Fuchs' oder 'Fuchs-Schlössel' bezeichnete Anwesen wurde von Hofmannsthal von 1901 bis zu seinem Tod 1929 bewohnt und von seiner Familie noch bis 1937 gemietet. Das Landhaus aus dem 17./18. Jahrhundert, dessen Erbauungs- oder Umgestaltungsdatum nicht belegbar ist, wird in der Forschungsliteratur zu Hofmannsthal, in Zeitungsartikeln und in der Lokalgeschichtsschreibung kaum mit Trautsohn, sondern vielmehr mit einer anderen Vorbesitzerin in Verbindung gebracht: mit einer der Kaiserin Maria Theresia nahestehenden Gräfin Fuchs.
In the absence of an active prophylactic vaccine against HIV-1, passively administered, broadly neutralizing antibodies (bnAbs) identified in some chronically infected persons were shown to prevent HIV-1 infection in animal models. However, passive administration of bnAbs may not be suited to prevent sexual HIV-1 transmission in high-risk cohorts, as a continuous high level of active bnAbs may be difficult to achieve at the primary site of sexual transmission, the human vagina with its acidic pH. Therefore, we used Lactobacillus, a natural commensal in the healthy vaginal microbiome, to express bn nanobodies (VHH) against HIV-1 that we reported previously. After demonstrating that recombinant VHHA6 expressed in E. coli was able to protect humanized mice from mucosal infection by HIV-1Bal, we expressed VHHA6 in a soluble or in a cell-wall-anchored form in Lactobacillus rhamnosus DSM14870. This strain is already clinically applied for treatment of bacterial vaginosis. Both forms of VHHA6 neutralized a set of primary epidemiologically relevant HIV-1 strains in vitro. Furthermore, VHHA6 was still active at an acidic pH. Thus, lactobacilli expressing bn VHH potentially represent an attractive vector for the passive immunization of women in cohorts at high risk of HIV-1 transmission.
Taking blood via venipuncture is part of the necessary surveillance before and after liver transplantation. The spectrum of response from children and their parents is variable, ranging from a short and limited aversion to paralyzing phobia. The aim of this retrospective, cross-sectional study was to determine the level of anxiety amongst children during venipuncture, to compare the anxiety reported by children and parents, and to identify the factors affecting the children’s and parents’ anxiety in order to develop therapeutic strategies. In total, 147 children (aged 0–17 years, 78 female) and their parents completed questionnaires. Statistical analysis was performed using qualitative and quantitative methods. Results showed that the majority of children reported anxiety and pain during venipuncture. Younger children had more anxiety (self-reported or assessed by parents). Children and parental reports of anxiety were highly correlated. However, the child’s anxiety was often reported as higher by parents than by the children themselves. The child’s general anxiety as well as the parents’ perceived stress from surgical interventions (but not the number of surgical interventions) prompted parental report of child anxiety. For children, the main stressors that correlated with anxiety and pain were factors during the blood collection itself (e.g., feeling the puncture, seeing the syringe). Parental anxiety was mainly related to circumstances before the blood collection (e.g., approaching the clinic, sitting in the waiting room). The main stressors mentioned by parents were the child’s discomfort and their inability to calm the child. Results indicate that the children’s fear of factors during the blood collection, along with the parents’ perceived stress and helplessness as well as their anticipatory anxiety are important starting points for facilitating the drawing of blood from children before and after liver transplantation, thereby supporting a better disease course in the future.
The implications of telework are discussed controversially and research on its positive and negative effects has produced contradictory results. We explore voluntariness of employee telework as a boundary condition which may underpin these contradictory findings. Under normal circumstances, individuals who do more telework should perceive fewer disadvantages. However, during the COVID-19 pandemic, employees could no longer voluntarily choose to telecommute, as many organizations were forced to introduce telework by governmental regulations. In two studies, we examine whether the voluntary nature of telework moderates the association between the amount of telework and perceptions of disadvantage. In Study 1, we collected data before and during the COVID-19 pandemic (N = 327). Results show that pre-pandemic participants (who were more likely to voluntarily choose this form of work) reported fewer disadvantages the more telework they did, but this was not the case for employees during the COVID-19 pandemic. To validate these findings, we measured employees’ voluntariness of telework in Study 2 (N = 220). Results support the importance of voluntariness: Individuals who experience a high degree of voluntariness in choosing telework perceive fewer disadvantages the more they telework. However, the amount of telework was not related to reduced perceptions of disadvantages for those who experienced low voluntariness regarding the telecommuting arrangement. Our findings help to understand when telework is related to the perception of disadvantages and they can provide organizations with starting points for practical interventions to reduce the negative effects of telework.
The implications of telework are discussed controversially and research on its positive and negative effects has produced contradictory results. We explore voluntariness of employee telework as a boundary condition which may underpin these contradictory findings. Under normal circumstances, individuals who do more telework should perceive fewer disadvantages. However, during the COVID-19 pandemic, employees could no longer voluntarily choose to telecommute, as many organizations were forced to introduce telework by governmental regulations. In two studies, we examine whether the voluntary nature of telework moderates the association between the amount of telework and perceptions of disadvantage. In Study 1, we collected data before and during the COVID-19 pandemic (N = 327). Results show that pre-pandemic participants (who were more likely to voluntarily choose this form of work) reported fewer disadvantages the more telework they did, but this was not the case for employees during the COVID-19 pandemic. To validate these findings, we measured employees’ voluntariness of telework in Study 2 (N = 220). Results support the importance of voluntariness: Individuals who experience a high degree of voluntariness in choosing telework perceive fewer disadvantages the more they telework. However, the amount of telework was not related to reduced perceptions of disadvantages for those who experienced low voluntariness regarding the telecommuting arrangement. Our findings help to understand when telework is related to the perception of disadvantages and they can provide organizations with starting points for practical interventions to reduce the negative effects of telework.
The ability to respond appropriately to employees' work-related well-being requires leaders to pay attention to their employees' well-being in the first place. We propose that leaders' stress mindset, that is, the belief that stress is enhancing versus debilitating, may bias their perception of employees' well-being. We further propose that this judgment then influences leaders' intention to engage in or refrain from health-oriented leadership behavior, to express higher performance expectations, or to promote their employees. We expect this process to be stronger if leaders strongly identify with their team, increasing their perceived similarity with their employees. In three experiments (N1 = 198, N2 = 292, N3 = 250), we tested the effect of participants' stress mindset on their intention to show certain leadership behaviors, mediated by their perception of employee well-being (emotional exhaustion, somatic symptoms, work engagement) and moderated by their team identification. Our findings largely support the association between stress mindset and the perception of well-being. The results for the proposed mediation and the moderating function of identification were mixed. Overall, the results emphasize the critical role of leaders' stress mindset and may, thus, improve health promotion in organizations by helping leaders to adequately recognize employees' well-being and respond appropriately.
Although researchers and practitioners increasingly focus on health promotion in organizations, research has been mainly fragmented and fails to integrate different organizational levels in terms of their effects on employee health. Drawing on organizational climate and social identity research, we present a cascading model of organizational health climate and demonstrate how and when leaders' perceptions of organizational health climate are linked to employee well‐being. We tested our model in two multisource studies (NStudy 1 = 65 leaders and 291 employees; NStudy 2 = 401 leader–employee dyads). Results showed that leaders' perceptions of organizational health climate were positively related to their health mindsets (i.e., their health awareness). These in turn were positively associated with their health‐promoting leadership behavior, which ultimately went along with better employee well‐being. Additionally, in Study 1, the relationship between perceived organizational health climate and leaders' health mindsets was moderated by their organizational identification. High leader identification strengthened the relationship between perceived organizational health climate and leaders' health mindsets. These findings have important implications for theory and practice as they show how the dynamics of an organizational health climate can unfold in organizations and how it is related to employee well‐being via the novel concept of health‐promoting leadership.
Although researchers and practitioners increasingly focus on health promotion in organizations, research has been mainly fragmented and fails to integrate different organizational levels in terms of their effects on employee health. Drawing on organizational climate and social identity research, we present a cascading model of organizational health climate and demonstrate how and when leaders' perceptions of organizational health climate are linked to employee well-being. We tested our model in two multisource studies (NStudy 1 = 65 leaders and 291 employees; NStudy 2 = 401 leader–employee dyads). Results showed that leaders' perceptions of organizational health climate were positively related to their health mindsets (i.e., their health awareness). These in turn were positively associated with their health-promoting leadership behavior, which ultimately went along with better employee well-being. Additionally, in Study 1, the relationship between perceived organizational health climate and leaders' health mindsets was moderated by their organizational identification. High leader identification strengthened the relationship between perceived organizational health climate and leaders' health mindsets. These findings have important implications for theory and practice as they show how the dynamics of an organizational health climate can unfold in organizations and how it is related to employee well-being via the novel concept of health-promoting leadership.
Despite the increasing interest in leaders’ health-promoting behavior, the employees’ role in the effectiveness of such behavior and the mechanisms underlying how such leadership behavior affects their well-being have largely been ignored. Drawing on implicit leadership theories, we advance the health-oriented leadership literature by examining employees’ ideals, that is, their expectations regarding such leader behavior, as a moderating factor. We propose that higher expectations increase the association between actual health-oriented leader behavior and employee-rated leader-member relationships (LMX) and health-oriented behaviors by employees, which, in turn, positively relate to their well-being (here: exhaustion and work engagement). We tested our theoretical model in three studies, using a cross-sectional design (Study 1, N = 307), a two-wave time-lagged design (Study 2, N = 144) and an experimental design (Study 3, N = 173). We found that the effect of actual health-oriented leader behavior on LMX is contingent on employees’ ideal health-oriented leader behavior. Yet, for employees’ self-care behavior, the proposed moderation was only significant in Study 1. High expectations strengthened the relationship between actual health-oriented leader behavior with LMX and self-care behavior, which, in turn, were associated with less exhaustion and more work engagement (only LMX), supporting most of our mediation hypotheses. Our results highlight the pivotal role of employees’ expectations regarding leaders’ health support and help in building practical interventions with regard to leaders’ health promotion.
Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer cell line HT-29 and human colorectal carcinoma cell line T84 were treated with or without DMF. Effects of DMF on proliferation, cell cycle progression, and apoptosis were analyzed mainly by Bromodeoxyuridine (BrdU)- and Lactatdehydrogenase (LDH)-assays, caspase activation, flowcytometry, immunofluorescence, and immunoblotting. In addition, combinational treatments with radiation and chemotherapy were performed. DMF inhibits cell proliferation in both cell lines. It was shown that DMF induces a cell cycle arrest in G0/G1 phase, which is accompanied by upregulation of p21 and downregulation of cyclin D1 and Cyclin dependent kinase (CDK)4. Furthermore, upregulation of autophagy associated proteins suggests that autophagy is involved. In addition, the activation of apoptotic markers provides evidence that apoptosis is involved. Our results show that DMF supports the action of oxaliplatin in a synergetic manner and failed synergy with radiation. We demonstrated that DMF has distinct anti-tumorigenic, cell dependent effects on colon cancer cells by arresting cell cycle in G0/G1 phase as well as activating both the autophagic and apoptotic pathways and synergizes with chemotherapy.
Background: Peritonitis is responsible for thousands of deaths annually in Germany alone. Even source control (SC) and antibiotic treatment often fail to prevent severe sepsis or septic shock, and this situation has hardly improved in the past two decades. Most experimental immunomodulatory therapeutics for sepsis have been aimed at blocking or dampening a specific pro-inflammatory immunological mediator. However, the patient collective is large and heterogeneous. There are therefore grounds for investigating the possibility of developing personalized therapies by classifying patients into groups according to biomarkers. This study aims to combine an assessment of the efficacy of treatment with a preparation of human immunoglobulins G, A, and M (IgGAM) with individual status of various biomarkers (immunoglobulin level, procalcitonin, interleukin 6, antigen D-related human leucocyte antigen (HLA-DR), transcription factor NF-κB1, adrenomedullin, and pathogen spectrum).
Methods/design: A total of 200 patients with sepsis or septic shock will receive standard-of-care treatment (SoC). Of these, 133 patients (selected by 1:2 randomization) will in addition receive infusions of IgGAM for 5 days. All patients will be followed for approximately 90 days and assessed by the multiple-organ failure (MOF) score, by the EQ QLQ 5D quality-of-life scale, and by measurement of vital signs, biomarkers (as above), and survival.
Discussion: This study is intended to provide further information on the efficacy and safety of treatment with IgGAM and to offer the possibility of correlating these with the biomarkers to be studied. Specifically, it will test (at a descriptive level) the hypothesis that patients receiving IgGAM who have higher inflammation status (IL-6) and poorer immune status (low HLA-DR, low immunoglobulin levels) have a better outcome than patients who do not receive IgGAM. It is expected to provide information that will help to close the knowledge gap concerning the association between the effect of IgGAM and the presence of various biomarkers, thus possibly opening the way to a personalized medicine.
Trial registration: EudraCT, 2016–001788-34; ClinicalTrials.gov, NCT03334006. Registered on 17 Nov 2017.
Trial sponsor: RWTH Aachen University, represented by the Center for Translational & Clinical Research Aachen (contact Dr. S. Isfort).
Es wird über ein mindestens seit dem Jahre 2009 bestehendes Vorkommen des Neophyten Persicaria nepalensis (MEISN.) H. GROSS (Polygonaceae) im Waldgebiet "Die Haard" (Haltern am See, Kreis Recklinghausen) berichtet. Die Art stammt ursprünglich aus den gemäßigten und tropischen Zonen Asiens. Vorkommen in NRW waren bereits aus dem Sauerland und der Wahner Heide bekannt. Die Art stammt aus Wildacker-Ansaaten und ist in der Haard entlang schattiger Waldwege eingebürgert.
Es wird über Vorkommen des Rauen Straußgrases Agrostis scabra WILLD. (Poaceae) in Essen und in Nordrhein-Westfalen berichtet. Die Art stammt ursprünglich aus Nordamerika und Ostasien. Sie ist im Ruhrgebiet mindestens seit 1992 eingebürgert und besiedelt offene Standorte auf Zechenbrachen und an Talsperren.
Das Laerholz an der Grenze zwischen den Bochumer Stadtteilen Querenburg und Laer ist ein strukturreicher Laubmischwald mit Eichen und Buchen hohen Alters. Es wird von der Asbecke durchflossen. Trotz des hohen Bebauungsdrucks im letzten Jahrhundert durch das aufstrebende Universitätsviertel wurde das Laerholz erhalten, sodass der ehemals zum Haus Laer gehörende Forst heute rege zur Naherholung genutzt wird. Nachdem wir das Gebiet von West nach Ost fast komplett durchlaufen hatten, erreichten wir den evangelischen Friedhof an der Schattbachstr. und die Obstwiese des BUND Bochum. Sie wird nach Methoden des
Since the discovery of the reversible intercalation of lithium-ion materials associated with promising electrochemical properties, lithium-containing materials have attracted attention in the research and development of effective cathode materials for lithium-ion batteries. Despite various studies on synthesis, and electrochemical properties of lithium-based materials, fairly little fundamental optical and thermodynamic studies are available in the literature. Here, we report on the structure, optical, magnetic, and thermodynamic properties of Li-excess disordered rocksalt, Li1.3Nb0.3Mn0.4O2 (LNMO) which was comprehensively studied using powder X-ray diffraction, transient absorption spectroscopy, magnetic susceptibility, and low-temperature heat capacity measurements. Charge carrier dynamics and electron–phonon coupling in LNMO were studied using ultra-fast laser spectroscopy. Magnetic susceptibility and specific heat data are consistent with the onset of long-range antiferromagnetic order at the Néel temperatures of 6.5 (1.5) K. The effective magnetic moment of LNMO is found to be 3.60 μB. The temperature dependence of the inverse magnetic susceptibility follows the Curie–Weiss law in the high-temperature region and shows negative values of the Weiss temperature 52 K (3), confirming the strong AFM interactions.
Three new deep-sea species of Thyasiridae (Mollusca: Bivalvia) from the northwestern Pacific Ocean
(2023)
The Thyasiridae is one of the species-richest families in the abyssal and hadal zones of the northwestern Pacific Ocean. Many thyasirid species dominate benthic communities in terms of abundance and play an important role in the functioning of deep-sea ecosystems. Most of the thyasirid species in the region are new to science and have not been described. Based on the material collected from 1954 to 2016 by seven deep-sea expeditions, three new species of Thyasiridae (Parathyasira coani sp. nov., P. pauli sp. nov., and Thyasira kharkovensis sp. nov.) are described from the abyssal and hadal zones (3210–7540 m depth) of the Sea of Okhotsk, the Bering Sea, as well as the Kuril-Kamchatka and Japan trenches. The new species are remarkable among their congeners due to the combination of the following characters: an obliquely-rhomboidal shell with a weak and shallow posterior sulcus and a large prodissoconch with sculpture of lamellated folds. Comparisons with related species are provided.
The pA system is typically regarded in heavy ion collisions as a “cold” nuclear matter environment and thought to isolate and identify initial state effects due to the presence of multiple nucleons in the incoming nucleus. Moreover, pA collisions bridge the gap between peripheral AA collisions and the pp baseline to create a more complete understanding of underlying production mechanisms and how they evolve with multiplicity. Recent measurements at both RHIC and the LHC provide an indication, however, that the “cold” nuclear matter picture may be somewhat naïve.
Recent LHC results from the 2013 p–Pb run at √sNN = 5.02 TeV will be discussed.
A handling study to assess use of the Respimat(®) Soft Mist™ inhaler in children under 5 years old
(2015)
Background: Respimat® Soft Mist™ Inhaler (SMI) is a hand-held device that generates an aerosol with a high, fine-particle fraction, enabling efficient lung deposition. The study objective was to assess inhalation success among children using Respimat SMI, and the requirement for assistance by the parent/caregiver and/or a valved holding chamber (VHC).
Methods: This open-label study enrolled patients aged <5 years with respiratory disease and history of coughing and/or recurrent wheezing. Patients inhaled from the Respimat SMI (air only; no aerosol) using a stepwise configuration: “1” (dose released by child); “2” (dose released by parent/caregiver), and “3” (Respimat SMI with VHC, facemask, and parent/caregiver help). Co-primary endpoints included the ability to perform successful inhalation as assessed by the investigators using a standardized handling questionnaire and evaluation of the reasons for success. Inhalation profile in the successful handling configuration was verified with a pneumotachograph. Patient satisfaction and preferences were investigated in a questionnaire.
Results: Of the children aged 4 to <5 years (n=27) and 3 to <4 years (n=30), 55.6% and 30.0%, respectively, achieved success without a VHC or help; with assistance, another 29.6% and 10.0%, respectively, achieved success, and the remaining children were successful with VHC. All children aged 2 to <3 years (n=20) achieved success with the Respimat SMI and VHC. Of those aged <2 years (n=22), 95.5% had successful handling of the Respimat SMI with VHC and parent/caregiver help. Inhalation flow profiles generally confirmed the outcome of the handling assessment by the investigators. Most parent/caregiver and/or child respondents were satisfied with operation, instructions for use, handling, and ease of holding the Respimat SMI with or without a VHC.
Conclusions: The Respimat SMI is suitable for children aged <5 years; however, children aged <5 years are advised to add a VHC to complement its use.
Wie verfährt man mit einem kanonisierten Text, auf den die Selbstaussagen des Autors ein schiefes Licht werfen? Wenn dies auf Werke eines Autors zutrifft, dessen Briefwechsel ebenso Teil des Kanons ist, steht der Leser vor einer besonders heiklen Aufgabe. Man fühlt sich dazu aufgerufen, den Text gegenüber jener Instanz in Schutz zu nehmen, welche innerhalb der historischen Hermeneutik das letzte Wort hat: dem von Roland Barthes als Gott identifizierten Autor.
Während Tragödien für gewöhnlich mit der Größe des Helden stehen und fallen, drückt sich Friedrich Schiller betont distanziert über den Titelhelden aus Wallenstein aus: "Er hat nichts Edles, er erscheint in keinem einzelnen LebensAkt [sic] groß, er hat wenig Würde und dergleichen." Doch Schiller schickt sogleich eine Erklärung hinterher, weshalb er das dramatische Projekt trotzdem nicht aufzugeben gedenke. Er plane "auf rein realistischem Wege einen dramatisch großen Character in ihm aufzustellen, der ein ächtes Lebensprincip in sich hat." Ohne Verklärung (wie in der Jungfrau von Orleans) oder idealistische Überformung (wie im Don Carlos) solle Wallenstein groß erscheinen, was umso schwerer fällt, weil nichts für den Protagonisten einnimmt: "Seine Unternehmung ist moralisch schlecht, und sie verunglückt physisch. Er ist im Einzelnen nie groß, und im Ganzen kommt er um seinen Zweck. Er berechnet alles auf die Wirkung, und diese mißlingt." Die Beantwortung der Frage aber, wie es Schiller angestellt hätte, die "bloße Wahrheit" des Charakters für sich sprechen zu lassen, blieb zuletzt der Literaturwissenschaft überlassen, die im Laufe der Zeit ein breites Spektrum an Antwortmöglichkeiten zur Verfügung gestellt hat. Seit den 1990er Jahren hat sich der Ansatz verfestigt, dass es sich bei solchen Selbstaussagen nicht um Geburtsschmerzen, sondern um das Eingeständnis eines scheiternden Dramatikers handle. Wenn er Goethe gegenüber erwähnt, dass es ihm "fast zu arg [sei], wie der Wallenstein mir anschwillt" und dennoch bei der großzügigen Organisation des Textes bleibt, weckt er Erinnerungen an den Zauberlehrling, der sich eine Aufgabe stellt, der er letztendlich nicht Herr werden kann.
We investigate the early time dynamics of heavy ion collisions studying the time evolution of the energy-momentum tensor as well as energy-momentum correlations within a uniformly thermalizing holographic QGP. From these quantities, we suggest a far-from equilibrium definition of shear viscosity, which is a crucial property of QCD matter as it significantly determines the generation of elliptic flow already at early times. During an exemplary initial heating phase of the holographic QGP the shear viscosity of entropy density ratio decreases down to 60%, followed by an overshoot to 110% of the near-equilibrium value, η/s=1/(4π). Implications for the QCD QGP are discussed. Subsequently, we consider a holographic QGP which is Bjorken-expanding. Its energy-momentum tensor components have a known hydrodynamic attractor to which all time evolutions collapse independent of the initial conditions. Based on this, we propose a definition for a far from equilibrium speed of sound, and analytically compute its hydrodynamic attractor. Subjecting this Bjorken-expanding plasma to an external magnetic field and an axial chemical potential, we study the chiral magnetic effect far from equilibrium.
Observations show that, at the beginning of their existence, neutron stars are accelerated briskly to velocities of up to a thousand kilometers per second. We argue that this remarkable effect can be explained as a manifestation of quantum anomalies on astrophysical scales. To theoretically describe the early stage in the life of neutron stars we use hydrodynamics as a systematic effective-field-theory framework. Within this framework, anomalies of the Standard Model of particle physics as underlying microscopic theory imply the presence of a particular set of transport terms, whose form is completely fixed by theoretical consistency. The resulting chiral transport effects in proto-neutron stars enhance neutrino emission along the internal magnetic field, and the recoil can explain the order of magnitude of the observed kick velocities.
Vorwort
(2004)
Die Europäische Union erlies im Jahr 1992 die Fauna-Flora-Habitat-(FFH)Richtlinie, um einen besseren, grenzübergreifenden Schutz gefährdeter Lebensraume, Tier- und Pflanzenarten als Bestandteil des europäischen Naturerbes zu gewährleisten. Um dieses Ziel zu erreichen, wurde das europaweite Netz von Besonderen Schutzgebieten NATURA 2000 für die in Anhang I und Anhang II der FFH-Richtlinie aufgeführten Lebensraumtypen und Arten ausgewiesen. Ebenfalls von gemeinschaftlicher Bedeutung sind die streng zu schützenden Arten des Anhangs IV der FFH-Richtlinie.
Die Ehle entspringt am westlichen Fläminghang und mündet nach ca. 46 km als östlicher Nebenfluss in Höhe von Lostau in die Eibe. Die Quelle befindet sich bei Schweinitz 95 m über NN in einem Erlenbruch; der Mündungsbereich liegt etwa 44 m über NN. Das durchschnittliche Gefälle des Flusses beträgt 0,11 % (oberhalb Rosian ca. 0,3 %; Rosian-Loburg ca. 0,18 %; Unterlauf ca. 0,07 %). Unterhalb von Gommern (bei Vogelsang) wird die Ehle durch den Ehlekanal in den sogenannten Elbumflutkanal umgeleitet und fließt als Umflutehle durch zahlreiche Altwässer und ausgedehnte seenartige Abschnitte der Eibe zu. Der alte Ehleverlauf zwischen Vogelsang und Heyrothsberge ist nunmehr nur noch ein ichthyofaunistisch wertloser Wiesengraben. Der häufig gebrauchte Begriff "Umflutkanal" für den Abschnitt der Umflutehle ist irreführend. Bei normaler Wasserführung wechseln breite, stehende Gewässerteile mit schmalen und fließenden, niederungsbachähnlichen Gewässerstrecken ab. Nur in extremen Hochwasserzeiten dient dieser Ehleabschnitt der Umleitung eines Teiles des Elbewassers um die Landeshauptstadt Magdeburg herum.
Fische und Rundmäuler
(1995)
Neben der Havel, ihren Altarmen und Altwässern sind auch zahlreiche Meliorationsgräben, Fließe sowie austrocknungsgefährdete kleine Standgewässer für die Fischfauna im beschriebenen Gebiet von Bedeutung. Alle Fließgewässer im Gebiet der unteren Havel sind durchgehend begradigt und weisen die bekannten Nachteile von Flurbereinigungs- und Entwässerungsmaßnahmen auf. Die Hauptvorfluter sind zur Wasserhaltung mit Schöpfwerken und Staueinrichtungen versehen, die die Passierbarkeit für Wassertiere einschränken. Die Havel selbst weist als Bundeswasserstraße durch Uferbefestigungen und Ausbauten nur wenige ichthyologisch wertvolle Strukturen auf. Allen Gewässern gemeinsam ist eine starke Anreicherung mit Pflanzennährstoffen und damit ein hoher Trophiegrad.
Die Biologische Versuchsanstalt in Wien organisierte während der Monate Dezember 1903 und Jänner 1904 eine Reise durch Aegypten und den englisch-ägyptischen Sudan, und zwar zu dem Zwecke, lebendes Untersuchungsmaterial aus der Pflanzen- und Tierwelt jener Länder mit nach Europa zu bringen.
Insbesondere galt es. solche Arten kleinerer Lebewesen aufzufinden, welche sich in irgend einer Beziehung zu Versuchen auf dem Gebiete der experimentellen Morphologie (der Lehre yon den die Formbildung der Organismen verursachenden und beeinflussenden Faktoren) eignen. In dem Bestreben, das gesammelte Material lebend heimzubringen, bestand das Neue dieser Expedition im Vergleiche zu anderen wissenschaftlichen Sammelreisen, welche ihr Hauptaugenmerk auf konserviertes Material zu richten pflegen.
Sollten nun die Transporte und später die Versuche an den mitgebrachten Pflanzen und Tieren gelingen, so stellte sich als erstes Erfordernis die Wahl solcher Pflanzen und Tiere heraus welche bei Veränderungen der äusseren Lebensbedingungen über eine gewisse Widerstandskraft verfügen und daher vor allem auch.die Gefangenhaltung gut ertragen.
Die Teilnehmer der Reise waren: LEOPOLD RITTER v. PORTHEIM als Botaniker, Dr. HANS PRZIBRAM und der Verfasser vorliegender Reiseschilderung als Zoologen, sowie Dr. GUlDO BUNZEL als Jagdfreund und Amateurphotograph.
Use of drug-eluting balloon coronary intervention prior to living donor kidney transplantation
(2014)
Background: Kidney transplantation is the gold standard of therapy in patients with terminal renal insufficiency. Living donor transplantation is a well-established option in this field. Enlarging the donor's pool implicates the acceptance of an increased rate of comorbidities. Among them, coronary artery disease is a growing problem. An increasing number of patients, undergoing living donation, receive antiplatelet therapies due to coronary disease.
Case presentation: Here we report about the perioperative treatment with a drug-eluting balloon in a patient with major cardiac risk factors who underwent kidney transplantation.
Conclusion: At the current time no recommendation can be given for the routine use of drug-eluting balloons.
The human immunodeficiency virus type 1 (HIV-1) coreceptor use and viral evolution were analyzed in blood samples from an HIV-1 infected patient undergoing allogeneic stem cell transplantation (SCT). Coreceptor use was predicted in silico from sequence data obtained from the third variable loop region of the viral envelope gene with two software tools. Viral diversity and evolution was evaluated on the same samples by Bayesian inference and maximum likelihood methods. In addition, phenotypic analysis was done by comparison of viral growth in peripheral blood mononuclear cells and in a CCR5 (R5)-deficient T-cell line which was controlled by a reporter assay confirming viral tropism. In silico coreceptor predictions did not match experimental determinations that showed a consistent R5 tropism. Anti-HIV directed antibodies could be detected before and after the SCT. These preexisting antibodies did not prevent viral rebound after the interruption of antiretroviral therapy during the SCT. Eventually, transplantation and readministration of anti-retroviral drugs lead to sustained increase in CD4 counts and decreased viral load to undetectable levels. Unexpectedly, viral diversity decreased after successful SCT. Our data evidence that only R5-tropic virus was found in the patient before and after transplantation. Therefore, blocking CCR5 receptor during stem cell transplantation might have had beneficial effects and this might apply to more patients undergoing allogeneic stem cell transplantation. Furthermore, we revealed a scenario of HIV-1 dynamic different from the commonly described ones. Analysis of viral evolution shows the decrease of viral diversity even during episodes with bursts in viral load.
Im August 2006 brach die BTD erstmals in Mitteleuropa aus. Zunächst traten Fälle in Holland und Belgien auf, schnell folgten Deutschland und Frankreich, und schließlich auch Luxemburg. Betroffen waren vorwiegend Kühe und Schafe, vereinzelt Ziegen und Wildwiederkäuer. Überraschenderweise erkrankten neben Schafen auch zahlreiche Kühe schwer, und einige verendeten sogar. Als infektiöses Agens konnte der BTV-Serotyp 8 identifiziert werden, der niemals zuvor in Europa aufgetreten war. Bis zum Jahresende konnte sich die BTD insbesondere im Dreiländereck von Holland, Belgien und Deutschland weiter ausbreiten. Nach dem Animal Disease Notification System der EU waren Ende 2006 in den betroffenen fünf Ländern BTD-Ausbrüche in 2047 Viehwirtschaftsbetrieben bestätigt worden: Holland 456, Belgien 695, Deutschland 885, Frankreich 6 und Luxemburg 5 Obwohl die Hoffnung bestand, dass die Ceratopogoniden mit dem Einbruch des Winters verschwinden und keine Virustransmission mehr stattfinden würden, wurden neue Ausbrüche auch nachfolgend verzeichnet (75 weitere bis 1. Februar 2007, davon allein 67 in Deutschland; ProMED-Mail 2007), wobei bisher nicht klar ist, ob es sich tatsächlich um Neuinfektionen oder um verspätet diagnostizierte Infektionen aus 2006 handelt. Die Aktivitätsdichte der Gnitzen nahm gegen Ende 2006 mit sinkenden Temperaturen zwar ab, war jedoch zumindest bis zum 21. Dezember niemals gleich Null (Mehlhorn & al. 2007). Mit fortschreitender Dauer der Epizootie wurde auch eine geografische Ausbreitung nach Osten beobachtet. Anfang Februar 2007 waren fast alle deutschen Bundesländer von den BTD-Schutz- und Überwachungszonen betroffen (Abb. 1), in denen besondere Vorschriften für den Transport und Handel mit Wiederkäuern gelten (EU 2005).
Background A procedure for including activity against enveloped viruses in the post-contamination treatment of hands has been recommended, but so far no European standard is available to implement it. In 2004, the German Robert Koch-Institute (RKI) and the German Association for the Control of Virus Disease (DVV) suggested that vaccinia virus and bovine viral diarrhea virus (BVDV) should be used as test viruses in a quantitative suspension test to determine the activity of a disinfectant against all enveloped viruses. Methods We have studied the activities of three commonly-used alcohol-based hand rubs (hand rub A, based on 45% propan-2-ol, 30% propan-1-ol and 0.2% mecetronium etilsulfate; hand rub B, based on 80% ethanol; hand rub C, based on 95% ethanol) against vaccinia virus and BVDV, and in addition against four other clinically relevant enveloped viruses: herpes simplex virus (HSV) types 1 and 2, and human and avian influenza A virus. The hand rubs were challenged with different organic loads at exposure time of 15, 30 and 60 s. According to the guidelines of both BGA/RKI and DVV, and EN 14476:2005, the reduction of infectivity of each test virus was measured on appropriate cell lines using a quantitative suspension test. Results All three alcohol-based hand rubs reduced the infectivity of vaccinia virus and BVDV by >= 4 log10-steps within 15 s, irrespective of the type of organic load. Similar reductions of infectivity were seen against the other four enveloped viruses within 15 s in the presence of different types of organic load. Conclusions Commonly used alcohol-based hand rubs with a total alcohol concentration >= 75% can be assumed to be active against clinically relevant enveloped viruses if they effectively reduce the infectivities of vaccinia virus and BVDV in a quantitative suspension test.
Fast unbemerkt und wider alle Erwartung ist der Laie ausgerechnet unter den Bedingungen einer modernen, hoch differenzierten, aber inzwischen weitgehend entbürgerlichten Massengesellschaft zum Experten seiner selbst ernannt worden. Konsumenten, Studienfachwähler, Spiritualitätsbegeisterte und andere von ihrer Eigenkompetenz überzeugte Meinungsinhaber bekennen sich inzwischen selbstbewusst zu den Dogmen der Selbstautorisierung, Selbstbestimmung, Selbstermächtigung, Selbstherrlichkeit, Selbsterkenntnis und Selbstverliebtheit, obwohl oder gerade weil sie jedem philosophischen System abhold sind, alle Ideen für weitgehend überflüssigen Ballast und die bürgerliche Gesellschaft längst nicht mehr für eine diskutierende Klasse halten. Das spätestens seit der Reformation geltende Zeugnis vom "Priestertum aller Gläubigen": ist es im Untergang der bürgerlichen Gesellschaft endlich zur selbstverständlichen Wahrheit geworden? Das Fragezeichen ist der Ausgangspunkt der nachfolgenden Überlegungen.
wo different single particle mass spectrometers were operated in parallel at the Swiss High Alpine Research Station Jungfraujoch (JFJ, 3580 m a.s.l.) during the Cloud and Aerosol Characterization Experiment (CLACE 6) in February and March 2007. During mixed phase cloud events ice crystals from 5 μm up to 20 μm were separated from large ice aggregates, non-activated, interstitial aerosol particles and supercooled droplets using an Ice-Counterflow Virtual Impactor (Ice-CVI). During one cloud period supercooled droplets were additionally sampled and analyzed by changing the Ice-CVI setup. The small ice particles and droplets were evaporated by injection into dry air inside the Ice-CVI. The resulting ice and droplet residues (IR and DR) were analyzed for size and composition by two single particle mass spectrometers: a custom-built Single Particle Laser-Ablation Time-of-Flight Mass Spectrometer (SPLAT) and a commercial Aerosol Time of Flight Mass Spectrometer (ATOFMS, TSI Model 3800). During CLACE 6 the SPLAT instrument characterized 355 individual ice residues that produced a mass spectrum for at least one polarity and the ATOFMS measured 152 particles. The mass spectra were binned in classes, based on the combination of dominating substances, such as mineral dust, sulfate, potassium and elemental carbon or organic material. The derived chemical information from the ice residues is compared to the JFJ ambient aerosol that was sampled while the measurement station was out of clouds (several thousand particles analyzed by SPLAT and ATOFMS) and to the composition of the residues of supercooled cloud droplets (SPLAT: 162 cloud droplet residues analyzed, ATOFMS: 1094). The measurements showed that mineral dust particles were strongly enhanced in the ice particle residues. 57% of the SPLAT spectra from ice residues were dominated by signatures from mineral compounds, and 78% of the ATOFMS spectra. Sulfate and nitrate containing particles were strongly depleted in the ice residues. Sulfate was found to dominate the droplet residues (~90% of the particles). The results from the two different single particle mass spectrometers were generally in agreement. Differences in the results originate from several causes, such as the different wavelength of the desorption and ionisation lasers and different size-dependent particle detection efficiencies.
Two different single particle mass spectrometers were operated in parallel at the Swiss High Alpine Research Station Jungfraujoch (JFJ, 3580 m a.s.l.) during the Cloud and Aerosol Characterization Experiment (CLACE 6) in February and March 2007. During mixed phase cloud events ice crystals from 5–20 micro m were separated from larger ice aggregates, non-activated, interstitial aerosol particles and supercooled droplets using an Ice-Counterflow Virtual Impactor (Ice-CVI). During one cloud period supercooled droplets were additionally sampled and analyzed by changing the Ice-CVI setup. The small ice particles and droplets were evaporated by injection into dry air inside the Ice-CVI. The resulting ice and droplet residues (IR and DR) were analyzed for size and composition by the two single particle mass spectrometers: a custom-built Single Particle Laser-Ablation Time-of-Flight Mass Spectrometer (SPLAT) and a commercial Aerosol Time-of-Flight Mass Spectrometer (ATOFMS, TSI Model 3800). During CLACE 6 the SPLAT instrument characterized 355 individual IR that produced a mass spectrum for at least one polarity and the ATOFMS measured 152 IR. The mass spectra were binned in classes, based on the combination of dominating substances, such as mineral dust, sulfate, potassium and elemental carbon or organic material. The derived chemical information from the ice residues is compared to the JFJ ambient aerosol that was sampled while the measurement station was out of clouds (several thousand particles analyzed by SPLAT and ATOFMS) and to the composition of the residues of supercooled cloud droplets (SPLAT: 162 cloud droplet residues analyzed, ATOFMS: 1094). The measurements showed that mineral dust was strongly enhanced in the ice particle residues. Close to all of the SPLAT spectra from ice residues did contain signatures from mineral compounds, albeit connected with varying amounts of soluble compounds. Similarly, close to all of the ATOFMS IR spectra show a mineral or metallic component. Pure sulfate and nitrate containing particles were depleted in the ice residues. Sulfate and nitrate was found to dominate the droplet residues (~90% of the particles). The results from the two different single particle mass spectrometers were generally in agreement. Differences in the results originate from several causes, such as the different wavelength of the desorption and ionisation lasers and different size-dependent particle detection efficiencies.
In the face of the worldwide COVIV-19 pandemic, refugees represent a particularly vulnerable group with respect to access to health care and information regarding preventive behavior. In an online survey the Perceived Vulnerability to Disease Scale, self-reported changes in preventive and risk behaviors, knowledge about COVID-19, and psychopathological symptoms (PHQ-4) were assessed. The convenience sample consisted of n = 76 refugees (n = 45 Arabic speaking, n = 31 Farsi speaking refugees) and n = 76 German controls matched with respect to age and sex. Refugees reported a significantly larger fear of infection, significantly less knowledge about COVID-19, and a higher frequency of maladaptive behavior, as compared to the control group. This study shows that refugees are more vulnerable to fear of infection and maladaptive behaviors than controls. Culturally adapted, easily accessible education about COVID-19 may be beneficial in improving knowledge and preventive behaviors related to COVID-19.
Culturally adapted cognitive behavioral therapy (CA-CBT) is a well-evaluated, transdiagnostic group intervention for refugees that uses psychoeducation, meditation, and stretching exercises. In the current study, we added problem-solving training to CA-CBT and evaluated this treatment (i.e., CA-CBT+) in a randomized controlled pilot trial with a sample of Farsi-speaking refugees. Participants (N = 24) were male refugees diagnosed with DSM-5 PTSD, major depressive disorder, and anxiety disorders who were randomly assigned to either a treatment or waitlist control (WLC) condition. Treatment components were adapted both to the specific cultural background and the current social problems of asylum seekers. Assessments were performed pretreatment, 12-weeks posttreatment, and 1-year follow-up. The primary treatment outcome was the General Health Questionnaire (GHQ-28); secondary outcome measures included the Posttraumatic Stress Disorder Checklist, Patient Health Questionnaire, Somatic Symptom Scale, World Health Organization Quality of Life, and Emotion Regulation Scale. Eleven of 12 participants were randomized to CA-CBT+ completed treatment. Based on intent-to-treat data, large between-group effect sizes were seen at posttreatment in the GHQ-28, d = 3.0, and for most secondary outcome measures. Improvements for individuals in the treatment group decreased at 1-year follow-up, but effect sizes demonstrated continued large improvements on all measures as compared to pretreatment levels. In summary, CA-CBT+ led to large improvements in general psychopathological distress and quality of life, which were maintained in the long term. In addition, the dropout rate was very low, with delivery in group format. Thus, problem-solving training appears to be a promising addition to CA-CBT.
Background: Within the last decades, there has been increasing research on the occurrence of chemicals of emerging concern (CECs) in aquatic ecosystems due to their potential adverse effects on freshwater organisms and risk to human health. However, information on CECs in freshwater environments in sub-Saharan countries is very limited. Here, we investigated the occurrence of CECs in snails and sediments collected from 48 sites within the Lake Victoria South Basin, Kenya, which have been previously investigated for water contamination. Samples were analyzed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) with a target list of 429 compounds.
Results: In total, 30 compounds have been detected in snails and 78 in sediment samples, compared to 79 previously identified compounds in water. By extending the monitoring of CECs to snails and sediments, we found 68 compounds that were not previously detected in water. These compounds include the anti-cancer drug anastrozole, detected for the first time in the Kenyan environment. Individual compound concentrations were detected up to 480 ng/g wet weight (N-ethyl-o-toluenesulfonamide) in snails and 110 ng/g organic carbon (pirimiphos-methyl) in sediments. Higher contaminant concentrations were found in agricultural sites than in areas not impacted by anthropogenic activities. Crustaceans were the organisms at greatest toxic risk from sediment contamination [toxic unit (TU) up to 0.99] with diazinon and pirimiphos-methyl driving this risk. Acute and chronic risks to algae were driven by diuron (TU up to 0.24), whereas fish were found to be at low-to-no acute risk (TU up to 0.007).
Conclusions: The compound classes present at the highest frequencies in all matrices were pesticides and biocides. This study shows substantial contamination of surface water in rural western Kenya. By filling data gaps on contamination of sediments and aquatic biota, our study reveals that CECs pose a substantial risk to environmental health in Kenya demanding for monitoring and mitigation.
Den 'Gray Room' des künstlerischen Kollektivs Archizoom als Metapher für eine kuratorische Situation avant la lettre nach Bismarck aufgreifend, verbindet Nicole Kandioler diesen mit dem Konzept des "Sensoriums" nach Jacques Rancière, mit dem Letzterer das Setting des Aufeinandertreffens von Kunst und Politik beschreibt. Der als Sensorium gedachte Gray Room entfaltet in der Gegenüberstellung und Konfrontation dreier künstlerischer Positionen (Alfons Mucha, Kara Walker und Kateřina Šedá) konkrete Politiken des Medialen, die sich an post-imperialen, post-kolonialen und post-sozialistischen Motiven abarbeiten.
In der dritten Ausgabe des Periodicals möchten wir nach den Schnittstellen zwischen dem Bereich der Medienkomparatistik und dem Feld des Kuratorischen fragen, wobei wir die Verschiebung des 'Kuratierens' als inszenierende Praxis zum 'Kuratorischen' als Grundbedingung "des Öffentlich-Werdens von Kunst" sowie der Diskursivierung von medienwissenschaftlichem Wissen (über Kunst) zum Ausgangspunkt unserer Überlegungen nehmen.
During January/February 2013, at the High Alpine Research Station Jungfraujoch a measurement campaign was carried out, which was centered on atmospheric ice-nucleating particles (INP) and ice particle residuals (IPR). Three different techniques for separation of INP and IPR from the non-ice-active particles are compared. The Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI) sample ice particles from mixed phase clouds and allow for the analysis of the residuals. The combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Counterflow Virtual Impactor (IN-PCVI) provides ice-activating conditions to aerosol particles and extracts the activated INP for analysis.Collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine size, chemical composition and mixing state. All INP/IPR-separating techniques had considerable abundances (median 20 – 70 %) of instrumental contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH+IN-PCVI: steel particles). Also, potential sampling artifacts (e.g., pure soluble material) occurred with a median abundance of < 20 %. While these could be explained as IPR by ice break-up, for INP their IN-ability pathway is less clear. After removal of the contamination artifacts, silicates and Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types separated by all three techniques. Soot was a minor contributor. Lead was detected in less than 10 % of the particles, of which the majority were internal mixtures with other particle types. Sea-salt and sulfates were identified by all three methods as INP/IPR. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 μm, while the Ice-CVI also separated many submicron IPR. As strictly parallel sampling could not be performed, a part of the discrepancies between the different techniques may result from variations in meteorological conditions and subsequent INP/IPR composition. The observed differences in the particle group abundances as well as in the mixing state of INP/IPR express the need for further studies to better understand the influence of the separating techniques on the INP/IPR chemical
composition.
The Tijanya brotherhood founded by Cheikh Ahmed TIJANI in the second half of the XVIIIth century achieved a spectacular breakthrough in West Africa by the middle of the XIXth century. It was adopted and championed by the main figures of the resistance to the French colonial penetration : Cheikh Umar al-Futi TALL and Ahmadou Mahdiyu BA who were introduced to it respectively by Mohamed el-Ghali in Medina and Mohamed el-Hafez, and Id-on-Ali in Mederdra, Mauritania. Mamadou Lamine Dramé from the Gajaaga and Samba Diadana Ac also were figures of the anticolonial resistance who embraced Tijanya. Ahmadou Cheikhou, Cheikh Umar TALL's successor and eldest son, too was a tijane anticolonial hero whom Archinard's men killed in 1891, after his empire had gone through a long period of turmoil.
Motivated by recent experimental suggestions of charge-order-driven ferroelectricity in organic charge-transfer salts, such as κ-(BEDT-TTF)2Cu[N(CN)2]Cl, we investigate magnetic and charge-ordered phases that emerge in an extended two-orbital Hubbard model on the anisotropic triangular lattice at 3/4 filling. This model takes into account the presence of two organic BEDT-TTF molecules, which form a dimer on each site of the lattice, and includes short-range intramolecular and intermolecular interactions and hoppings. By using variational wave functions and quantum Monte Carlo techniques, we find two polar states with charge disproportionation inside the dimer, hinting to ferroelectricity. These charge-ordered insulating phases are stabilized in the strongly correlated limit and their actual charge pattern is determined by the relative strength of intradimer to interdimer couplings. Our results suggest that ferroelectricity is not driven by magnetism, since these polar phases can be stabilized also without antiferromagnetic order and provide a possible microscopic explanation of the experimental observations. In addition, a conventional dimer-Mott state (with uniform density and antiferromagnetic order) and a nonpolar charge-ordered state (with charge-rich and charge-poor dimers forming a checkerboard pattern) can be stabilized in the strong-coupling regime. Finally, when electron–electron interactions are weak, metallic states appear, with either uniform charge distribution or a peculiar 12-site periodicity that generates honeycomb-like charge order.
Au Tchad, à cause de ses retombées financières une attention particulière est prêtée aux arbres à karité (Vitella- ria paradoxa C.F.Gaertn.). Cependant, cette culture est menacée par les plantes vasculaires parasites de la famille des Lo- ranthaceae. La présente étude a été effectuée dans 3 sites dans la région du Mandoul pour évaluer l’ampleur des attaques de Loranthaceae (gui africain) sur des arbres en fonction des classes de circonférence du tronc à 1,5 cm du sol. Elle a consisté à dénombrer sur une de surface, les arbres à karité infestés et les touffes de parasites rencontrées sur ces arbres, afin de dé- terminer leur taux et leur intensité d’infestation. Les résultats obtenus montrent que Tapinanthus dodoneifolus (DC) Danser a été trouvée comme la seule espèce de Loranthaceae qui parasite les arbres karité étudiés dans la zone d’étude. Le taux moyen d’infestation estimé à 73% augmente avec l’âge des arbres karité. La moyenne d’intensité de l’infestation/arbre (2,75 touffes à Békôh, 2,27 à Yomi and 2,04 à Bébopen) montre que Tapinanthus dodoneifolus constitue une réelle menace pour les peu- plements de karité dans la zone d’étude. Il reste à rechercher le seuil d’infestation qui provoque une réduction significative de la fructification. Pour l’instant, bien que pénible à cause de la hauteur des arbres adultes, la lutte mécanique contre les Ta- pinanthus par la coupe systématique des branches infestées est urgente dans les parcs à karité dans cette zone d’étude.
A 24-year-old patient from Cameroon presented to our hospital because of a foreign structure in her left eye. To our knowledge, for the first time, fluorescent microscopy revealed motile microfilariae, and the diagnosis of loiasis was established. Despite substantial microfilaremia, eosinophilia only unmasked after the initiation of antiparasitic therapy.
Background: In the past, protease inhibitors (PIs) and the reverse transcriptase inhibitor abacavir were identified increasing the risk for thromboembolic complications and cardiovascular events (CVE) of HIV infected patients taking a combination antiretroviral therapy (cART). Results of the previous HIV-PLA I-study lead to the assumption that platelet activation could play a substantial role in increasing CVE risks.
Methods: The open label, monocentric HIV-PLA II-study investigated HIV-1-infected, therapy-naïve adults (n=45) starting with cART, consisting either of boosted PI (atazanavir, n= 6, darunavir, n=11), NNRTI (efavirenz, n=14) or integrase inhibitor (raltegravir, n=14), each plus tenofovir/emtricitabine co-medication. Main exclusion criteria were tobacco smoking, the intake of NSAIDs or abacavir or past CVE. Platelet adhesive molecule p-selectin (CD62P) and FITC anti-human Integrin α-IIb/Integrin β-3 (CD41/CD61) antibody (PAC-1) binding, monocyte CD11b/monocyte-associated CD41 expression and the endogenous thrombin potential (ETP) were assessed ex vivo-in vitro at baseline, weeks 4, 12 and 24. Therapy regimens were blinded to the investigators for laboratory and statistical analyses.
Results: CD11b and ETP showed no significant changes or differences between all study groups. In contrast, the mean + SD mean fluorescence units (MFI) of CD62P and PAC-1 increased significantly in patients taking PI, indicating an enhanced potential for thrombocyte activation and aggregation.
Conclusion: CD62P expression, detecting the ɑ-platelet degranulation of pro-inflammatory and pro-thrombotic factors and adhesive proteins, and PAC-1 expression, representing a marker for conformation changes of the GIIb/IIIa receptor, increased significantly in patients taking HIV protease inhibitors. The findings of this study revealed a yet unknown pathway of platelet activation, possibly contributing to the increased risk for CVE under HIV protease inhibitor containing cART.
Clinical Trial Registration No.: DRKS00000288.
This paper reflects on legal pluralism. How did medieval societies incorporate both unwritten customs and written law at the same time? How did they constitute the process of finding justice? What is the essense of legal pluralism, and will it help us understand the situation of Taiwan’s indigenous population?
We aim to solve these problems by taking a closer look at medieval Saxony: for around 400 years, both laws given by the authorities and traditional customs in Saxony worked fine in parallel. The latter were put into writing by the legal practitioner Eike von Repgow around 1230 for reasons unknown. We refer to his collection of laws and customs of the Saxons as the Sachsenspiegel ("Mirror of Saxons").
While Saxons certainly differed from Taiwan’s indigenous population for many reasons, such as the supposedly weaker egalitarianism among the Saxons than among at least some indigenous groups, the two show some remarkable similarities nonetheless. Just like the Taiwanese Gaya, the Sachsenspiegel’s spiritual origin raises the claim to validity. Furthermore, comparing the handling of a person’s sale of inherited property, the legal situations in the Sachsenspiegel and Taiwan’s unwritten customs resemble each other. The heir can transfer only property he acquired personally. Furthermore, the author discusses the different character of courts and procedure under oral law in contrast to written modern law.
Finally, the paper concludes with some remarks about a learned commentary on the Sachsenspiegel written around 1325, combined with an outlook on the possible future of Taiwanese customs.
Ob eine Suche nach Rechtsbegriffen des Mittelalters förderlich sei, erscheine – so Harald Siems – zweifelhaft. Theoretische Reflexionen über Recht habe man im Frühen Mittelalter kaum angestellt. Jedenfalls nicht in der Intensität, dass sie sich zum Begriff verdichtet hätten. Die Frage nach dem Rechtsbegriff sei auch deshalb fehl am Platze, weil im Frühmittelalter so etwas zur Lösung von Rechtsfragen nichts hätte beitragen können. Warum sollte jemand auf die Idee kommen, "quasi auf Vorrat" Rechtsbegriffe zu entwickeln? Schon wenn es um konkrete Rechtsfragen wie beispielsweise die Behandlung von Diebstahl oder Raub geht, fehle es "noch lange an Begriff und System". Diese knappe Feststellung bringt Siems’ Ausführungen für einen kurzen Moment in die Nähe von Überlegungen, die Pilch anstellt und die auf dieser Tagung zu verfolgen sind. Aber wirklich nur für einen Augenblick blitzt das auf: Siems sagt, Rechtsbegriffe seien eine schwierige, abstrakte Kategorie, für die heute die Vertreter der Rechtstheorie und der Rechtsphilosophie zuständig seien. ...
The effect of a single site mutation of Arg-54 to methionine in Paracoccus denitrificans cytochrome c oxidase was studied using a combination of optical spectroscopy, electrochemical and rapid kinetics techniques, and time-resolved measurements of electrical membrane potential. The mutation resulted in a blue-shift of the heme a alpha-band by 15 nm and partial occupation of the low-spin heme site by heme O. Additionally, there was a marked decrease in the midpoint potential of the low-spin heme, resulting in slow reduction of this heme species. A stopped-flow investigation of the reaction with ferrocytochrome c yielded a kinetic difference spectrum resembling that of heme a(3). This observation, and the absence of transient absorbance changes at the corresponding wavelength of the low-spin heme, suggests that, in the mutant enzyme, electron transfer from Cu(A) to the binuclear center may not occur via heme a but that instead direct electron transfer to the high-spin heme is the dominating process. This was supported by charge translocation measurements where Deltapsi generation was completely inhibited in the presence of KCN. Our results thus provide an example for how the interplay between protein and cofactors can modulate the functional properties of the enzyme complex.
Background and Purpose: Activation of hepatic thyroid hormone receptor β (THR-β) is associated with systemic lipid lowering, increased bile acid synthesis, and fat oxidation. In patients with non-alcoholic steatohepatitis (NASH), treatment with THR-β agonists decreased hepatic steatosis and circulating lipids, and induced resolution of NASH. We chose resmetirom (MGL-3196), a liver-directed, selective THR-β agonist, as a prototype to investigate the effects of THR-β activation in mice with diet-induced obesity (DIO) and biopsy-confirmed advanced NASH with fibrosis.
Experimental Approach: C57Bl/6J mice were fed a diet high in fat, fructose, and cholesterol for 34 weeks, and only biopsy-confirmed DIO-NASH mice with fibrosis were included. Resmetirom was administered at a daily dose of 3 mg·kg−1 p.o., for 8 weeks. Systemic and hepatic metabolic parameters, histological non-alcoholic fatty liver disease (NAFLD) activity and fibrosis scores, and liver RNA expression profiles were determined to assess the effect of THR-β activation.
Key Results: Treatment with resmetirom did not influence body weight but led to significant reduction in liver weight, hepatic steatosis, plasma alanine aminotransferase activity, liver and plasma cholesterol, and blood glucose. These metabolic effects translated into significant improvement in NAFLD activity score. Moreover, a lower content of α-smooth muscle actin and down-regulation of genes involved in fibrogenesis indicated a decrease in hepatic fibrosis.
Conclusion and Implications: Our model robustly reflected clinical observations of body weight-independent improvements in systemic and hepatic metabolism including anti-steatotic activity.
Do sentido interno
(2009)
Religion und Gesellschaft
(2016)
Abstract
Indoor air pollution with harmful particulate matter (PM) is mainly caused by cigarette smoke. Super-Slim-Size-Cigarettes (SSL) are considered a less harmful alternative to King-Size-Cigarettes (KSC) due to longer filters and relatively low contents. We ask if “Combined Mainstream and Sidestream Smoke” (CMSS)-associated PM levels of SSL are lower than of KSC and thus are potentially less harmful. PM concentrations in CMSS (PM10, PM2.5, and PM1) are measured from four cigarette types of the brand Vogue, using an “automatic-environmental-tobacco-smoke-emitter” (AETSE) and laser aerosol spectrometry: SSL-BLEUE, -MENTHE, -LILAS and KSC-La Cigarette and -3R4F reference. This analysis shows that SSL MENTHE emitted the highest amount of PM, and KSC-La Cigarette the lowest. 3R4F reference emitted PM in the middle range, exceeding SSL BLEUE and falling slightly below SSL LILAS. It emerged that PM1 constituted the biggest proportion of PM emission. The outcome shows significant type-specific differences for emitted PM concentrations. Our results indicate that SSL are potentially more harmful for passive smokers than the respective KSC. However, this study cannot give precise statements about the general influence of the size of a cigarette on PM. Alarming is that PM1 is responsible for the biggest proportion of PM pollution, since smaller particles cause more harmful effects.
The genus Sibogasyrinx has to date included only four species of rare deep-water Conoidea, each known from few specimens. In shell characters it strongly resembles three distantly-related genera, two of which, Comitas and Leucosyrinx, belong to a different family, the Pseudomelatomidae. A molecular phylogenetic analysis of a large amount of material of Conoidea has revealed the existence of much additional undescribed diversity within Sibogasyrinx from the central Indo-Pacific and temperate Northern Pacific. Based on partial sequences of the mitochondrial cox1 gene and morphological characters of 54 specimens, 10 species hypotheses are proposed, of which six are described as new species: S. subula sp. nov., S. lolae sp. nov., S. maximei sp. nov., S. clausura sp. nov., S. pagodiformis sp. nov. and S. elbakyanae Kantor, Puillandre & Bouchet sp. nov. One of the previously described species was absent in our material. Most of the new species are very similar and are compared to Leucosyrinx spp. Species of Sibogasyrinx are unique among Conoidea on account of the high intrageneric variability in radular morphology. Three distinct radula types are found within Sibogasyrinx, two of which are confined to highly supported subclades.
The status of five genera recognized within subfamily Buccininae (Buccinidae) is critically re-assessed based on the molecular phylogenetic analysis of the cox-1, 16S, and 28S gene fragments. Our results suggest restoring Volutharpa P. Fischer, 1856 from synonymy of Buccinum and we also consider Plicibuccinum Golikov & Gulbin, 1977 as valid genus. New molecular data provide further support for the synonimization of Bathybuccinum Golikov & Sirenko, 1988 with Buccinum Linnaeus, 1758. Furthermore, our data demonstrate that Thysanobuccinum Golikov #38; Gulbin in Golikov, 1980 and Ovulatibuccinum Golikov & Sirenko, 1988 as currently construed are nested within Buccinum and their subgeneric rank is not confirmed. Therefore, we synonymize these genera with Buccinum. In the absence of molecular data the monotypic genus Corneobuccinum Golikov & Gulbin, 1977 is provisionally considered valid. Two new species, Buccinum hasegawai sp. nov. and B. bizikovi sp. nov. are described from the Kurile Islands; these species were previously erroneously identified as Bathybuccinum bombycinum (Dall, 1907) and Ovulatibuccinum ovulum (Dall, 1907), respectively. New replacement names are proposed for the secondary junior homonym Buccinum perlatum (Fraussen & Chino, 2009) and the primary junior homonyms Buccinum coronatum Golikov, 1980 and Buccinum costatum Golikov 1980.
Die kulturhistorische Forschung hat Gertrud Kantorowicz (1876-1945) - anders als ihren Cousin, den berühmten Mediävisten Ernst Kantorowicz - nur gelegentlich beachtet. Dabei hat die Simmel-Vertraute, promovierte Kunsthistorikerin und wohl einzige Dichterin des George-Kreises ein nicht unbeträchtliches Werk hinterlassen, darunter etwa eine bislang nicht gewürdigte Reihe von Michelangelo-Nachdichtungen und die bedeutende Übersetzung von Bergsons "L'évolution créatrice".
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Objective. Traumatic injury or severe surgery leads to a profound immune response with a diminished functionality of monocytes and subsequently their IL-1β release. IL-1β plays an important role in host immunity and protection against infections. Its biological activation via IL-1β-precursor processing requires the transcription of inflammasome components and their activation. Deregulated activity of NOD-like receptor inflammasomes (NLR) like NLRP3 that leads to the maturation of IL-1β has been described in various diseases. While the role of other inflammasomes has been studied in monocytes, nothing is known about NLRP3 inflammasome after a traumatic injury. Here, the role of the NLRP3 inflammasome in impaired monocyte functionality after a traumatic injury was analyzed.
Measurements and Main Results. Ex vivo-in vitro stimulation of isolated CD14+ monocytes with lipopolysaccharide (LPS) showed a significantly higher IL-1β secretion in healthy volunteers (HV) compared to trauma patients (TP) after admission. Reduced IL-1β secretion was paralleled by significantly lowered gene expression of NLRP3 in monocytes from TP compared to those of HV. Transfection of monocytes with NLRP3-encoding plasmid recovered the functionality of monocytes from TP regarding the IL-1β secretion.
Conclusions. This study demonstrates that CD14+ monocytes from TP are significantly diminished in their function and that the presence of NLRP3 components is necessary in recovering the ability of monocytes to produce active IL-1β. This recovery of the NLRP3 inflammasome in monocytes may imply a new target for treatment and therapy of immune suppression after severe injury.
Die Flechte Cladonia stygia (Fr.) Ruoss wurde anlässlich einer Bestandsaufnahme der Rentierflechten 2009 erstmals aus Hessen gemeldet. Da die Unterscheidung von der ähnlichen C. rangiferina (L.) F. H. Wigg. anhand morphologischer Merkmale oft unsicher ist, wurden molekulargenetische Daten zur Identifizierung der hessischen Belege der Art herangezogen. Phylogenetische Stammbäume auf der Grundlage von sechs mitochondrialen und nuklearen Genloci untermauern die Abgrenzung beider Arten. Nur zwei von sieben gemeldeten hessischen Vorkommen gehören nach diesen Ergebnissen zu C. stygia, die übrigen zu C. rangiferina. Eine gezielte Suche nach C. stygia und eine durch molekulargenetische Daten untermauerte Bestimmung der Belege erscheint notwendig, um den Status der Art in Hessen zuverlässig beurteilen zu können.
Anlass für diese molekular-genetische Studie war der Verdacht, dass die seit 1986 bekannten und seitdem stark expandierten Populationen des Zwerg- Sonnenröschens (Fumana procumbens) im Naturschutzgebiet "Scheid bei Volkmarsen" in Nordhessen angesalbt wurden. Die Art war zuvor aus Nordhessen nicht gemeldet; lediglich in Südhessen waren isolierte Vorkommen auf kalkreichen Sanddünen bekannt. Eine Split-Netzwerk-Analyse basierend auf AFLP-Profilen von 69 Individuen an acht Lokalitäten konnte aufdecken, dass sich die südhessischen und französischen Populationen im Netzwerk jeweils klar als eigene Gruppen abgrenzen, während sich die nordhessischen Individuen mit den thüringischen, sachsen-anhaltinischen und gotländischen Aufsammlungen mischen. Die Frage nach der Ansalbung der Bestände lässt sich durch die Studie nicht beantworten. Wurde angesalbt, dann stammte das Ausgangsmaterial höchstwahrscheinlich aus den östlich sich anschließenden Populationen.
Za svojega kratkoga boravka u Petrogradu 1912. I. Milcetic; opisao je bogatu Bercicevu zbirku glagoljickih rukopisa i tiskanih knjiga iz Ruske nacionalne knjižnice, ali nije stigao podrobno prouciti svaki sastavni dio Berciceve grade. U Milceticevu opisu kodeksa br. 1 (Klimantovicev zbornik, 1514.) spominje se prolog Muke, ali se ne upozorava da se u nastavku toga prologa nalazi ulomak iz srednjovjekovnoga prikazanja sa scenom Judine izdaje Isusa. Ta je scena u srednjem vijeku ponajviše uznemiravala puk jer se tada od svega najviše mrzila laž, izdaja i prijetvornost. U radu se opisuju i prvi put objavljuju ulomci nepoznate redakcije Muke Isuhrstove iz petrogradske Berciceve zbirke (sign. Bc 1), koji predstavljaju za sada najstariji zapisani prolog i scenu hrvatskoga srednjovjekovnoga prikazanja pasionske tematike. Stihovi ulomaka usporeduju se s mladom ciklickom Mukom Spasitelja našega iz glagoljickoga Zbornika prikazanja (1556.), s kojom se u korpusu hrvatskoga srednjovjekovnoga pjesništva ti ulomci najviše podudaraju.
Reconstructions of the vegetation of Europe during the Last Glacial Maximum (LGM) are an enigma. Pollen-based analyses have suggested that Europe was largely covered by steppe and tundra, and forests persisted only in small refugia. Climate-vegetation model simulations on the other hand have consistently suggested that broad areas of Europe would have been suitable for forest, even in the depths of the last glaciation. Here we reconcile models with data by demonstrating that the highly mobile groups of hunter-gatherers that inhabited Europe at the LGM could have substantially reduced forest cover through the ignition of wildfires. Similar to hunter-gatherers of the more recent past, Upper Paleolithic humans were masters of the use of fire, and preferred inhabiting semi-open landscapes to facilitate foraging, hunting and travel. Incorporating human agency into a dynamic vegetation-fire model and simulating forest cover shows that even small increases in wildfire frequency over natural background levels resulted in large changes in the forested area of Europe, in part because trees were already stressed by low atmospheric CO2 concentrations and the cold, dry, and highly variable climate. Our results suggest that the impact of humans on the glacial landscape of Europe may be one of the earliest large-scale anthropogenic modifications of the earth system.
Im nordwestlichen Westfalen und der Grafschaft Bentheim wurde eine Bestandserhebung von Hypericum elodes durchgeführt. Mit Vorkommen an etwa 50 Gewässern dürfte diese Art innerhalb der Bundesrepublik Deutschland in der untersuchten Region ihren Verbreitungsschwerpunkt besitzen. Aspekte der Bestandsschwankungen und Gefährdung werden diskutiert.
In den Jahren 1986 bis 1990 wurde Ranunculus ololeucos (Reinweißer Hahnenfuß) im nordwestlichen Westfalen und südöstlichen Niedersachsen an 17 Gewässern beobachtet. Einen Verbreitungsschwerpunkt bildet der Naturraum "Gildehauser Venn". Ursache für viele Neu- und Wiederfunde dürfte der für Ranunculus ololeucos günstige Witterungsverlauf der letzten Jahre mit mehreren trockenen Sommerhalbjahren gewesen sein. Noch stärker als durch Eutrophierung erscheint die Art wie auch andere Littorelletea-Arten durch die zunehmende Versauerung der nährstoffarmen Stillgewässer gefährdet.
Vom Pillenfarn sind im Untersuchungsgebiet 22 aktuelle Fundorte bekannt; einen Verbreitungsschwerpunkt besitzt er im westfälisch-niedersächsischen Grenzgebiet, im Bereich des Gildehauser Venns und der Brechte. Der Pillenfarn besiedelt heute fast ausschließlich neu angelegte, meist nährstoffärmere, schwach saure bis neutrale, aber auch schwach basische Gewässer. Vorkommen an natürlichen Heideweihern (Witte Venn, Gildehauser Venn) sind heute erloschen. Wichtigste Ursache hierfür dürfte die Gewässerversauerung der letzten Jahrzehnte sein. Wasseranalysen ergaben bei einigen Faktoren recht uneinheitliche Werte. Insbesondere fielen bei einzelnen (z. T. belasteten) Gewässern erhöhte Stickstoff- und Calciumwerte auf. Unter optimalen Bedingungen bildet der Pillenfarn in dichten Rasen wachsend die Pillenfarn-Gesellschaft (Pilularietum globuliferae). Die Ausbildung von kennartenarmen und kennartenreichen Beständen dürfte vor allem auf die floristische Ausstattung des Standortes und seiner näheren Umgebung bei Anlage der Gewässer zurückzuführen sein. Die aus der Abb. 3 ersichtliche Vegetationszonierung kann als typisch für viele nährstoffärmere Pioniergewässer der nordwestdeutschen Sandgebiete angesehen werden.