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Knowledge about the herbaceous layer in relation to environmental factors in West African savannas is still scarce. Early life-cycle events like germination of the herbaceous species are of special interest, as these stages can play critical roles in establishing of the plants and determine population and community dynamics. We aim to assess intraspecific differences in the germinability of herbaceous savanna species with respect to environmental conditions to reveal adaptations in this early life cycle stage. The study was conducted in the Sudanian savanna of Burkina Faso in West Africa. We collected seeds of two annual herbs (Chamaecrista mimosoides, Spermacoce stachydea) along a climatic gradient from different habitats and land use types and conducted germination experiments under equal conditions in climate chambers. For both species several environmental factors showed a significant impact on the germination rates. While higher precipitation caused an increase in the germination rate only for S. stachydea, habitat conditions had a significant influence for both species. Intermediate habitats with balanced soil moisture caused an enhancement of the germination success. Moreover shrub cover had a positive effect on the germinability of C. mimosoides, whereas the germinability of S. stachydea decreased due to an increasing herbaceous cover. The study showed that certain environmental factors are able to modify the intraspecific variability of the germinability trait, which might affect the establishment of the species populations.
Ziel: Das Ziel dieser Studie war es, den Einfluss der Erfahrung von Radiologen auf die Qualität der radiologischen Diagnostik von Speicheldrüsentumoren mittels MRT- und CT-Aufnahmen zu analysieren.
Material und Methoden: Drei Radiologen mit unterschiedlicher Erfahrung (R1 > 20, R2 > 11 und R3 > 7 Jahre) diagnostizierten retrospektiv 128 Fälle (116 MRT-, 12 CT-Studien) mit Verdacht auf Speicheldrüsentumoren hinsichtlich der Dignität und Entität mit Histopathologie als Referenzstandard. Um die diagnostische Leistung zu vergleichen, wurden die Sensitivität, die Spezifität, der positive/negative Vorhersagewert und die Inter-Observer-Übereinstimmung unter Verwendung von Cohens Kappa (κ) berechnet.
Ergebnisse: In 87 Fällen waren die Tumoren gutartig und in 23 Fällen bösartig, 18 Fälle waren ohne Neoplasien (davon 15 Fälle mit sonstigen Erkrankungen and 3 Fälle ohne pathologischen Befund). Bei CT-Aufnahmen wurde bei der Dignitätsbestimmung die höchste Inter-Observer-Reliabilität zwischen R1 und R2 (κ = 0,74, p <0,001) erreicht und die niedrigste zwischen R2 und R3 (κ = 0,28, p <0,001). Bei MRT-Aufnahmen war die Sensitivität/Spezifität bei der Klassifizierung von pleomorphen Adenomen wie folgt: R1 (100 % / 100 %), R2 (76,92 % / 87,01 %), R3 (43,53 % / 67,53 %) und für CT: R1 (100 % / 100 %), R2 (100 % / 88,89 %), R3 (66,67 % / 88,89 %); für Warthin-Tumor mit MRT: R1 (100 % / 97,44 %), R2 (68,42 % / 83,33 %), R3 (50,00 % / 67,95 %) und unter Verwendung von CT: R1 (100 % / 100 %), R2 (50,00 % / 100 %), R3 (100 % / 100 %); für Plattenepithelkarzinome mittels MRT: R1 (100 % / 100 %), R2 (75,00 % / 97,12 %), R3 (75,00 % / 99,04 %) und unter Verwendung von CT: R1 (100 % / 100 %), R2 (66,67 % / 88,89 %), R3 (66,67 % / 66,67 %). Bei MRT bestand die größte Übereinstimmung zwischen R1 und R2 (κ = 0,62, p <0,001) und die niedrigste zwischen R1 und R3 (κ = 0,28, p <0,001).
Schlussfolgerung: Die diagnostische Qualität bei der Bewertung von Speicheldrüsentumoren ist von der Erfahrung des Radiologen abhängig und die Diagnostikgüte steigt mit zunehmender Berufserfahrung.
Proteostasis stressors that destabilize the cellular proteome, like heat shock, trigger transcription and translational reactions leading to the accumulation of heat shock proteins, also called molecular chaperones. During stress, induction of stress response genes is prioritized so that molecular chaperones and other stress response proteins are synthesized to cope with proteome misfolding and aggregation. In order to promote the selective translation of stress-specific genes, translation of others genes that are nonessential for cell survival has to stop. Nonessential protein-coding mRNAs accumulate in the cytosol with the associated proteins to form granular structures called stress granules (SG). These membrane-less organelles are thought to be involved in cell survival, mRNA stabilization and mRNA triage. They were proposed to form via the liquid-liquid phase separation which can be triggered by the high local concentration of RNA-binding proteins. mRNAs were long thought to simply play a scaffolding role by bringing RNA-binding proteins together and allowing their concentration and local aggregation. Recently, the active role of mRNAs in the SG assembly became apparent, too. For example, the spontaneous assembly of total yeast RNA into granules was observed, and these RNA granules showed a large overlap with SG transcriptome. Furthermore, cytosolic mRNAs can be released from polyribosomes under stress and be exposed to the cytosolic contents as free mRNAs. It has been suggested that this massive increase of free mRNA in the cytosol might overload the capacities of RNA-stabilizing proteins. The remaining free mRNA molecules would then become exposed to misfolded and aggregation-prone proteins and trigger granulation.
We investigated the role of free mRNAs in different stress conditions during the early and chronic phases of stress response and explored their involvement in SGs assembly and amlyoidogenesis. We identified and studied the interactome of a free mRNA probe incubated with heat shocked cell lysate by means of quantitative mass spectrometry. Proteomics analysis allowed us to identify 79 interactors of free mRNA. Among these interactors, we focused on the translation initiation factor eIF2α and on the RNA methyltransferase TRMT6/61A. Both interactions were verified biochemically, which confirmed that the association is enhanced in heat shocked lysate. In vitro reconstitution showed that free mRNA and TRMT6 interact directly. Ex vivo pulldowns revealed that eIF2α and TRMT6/61A interact under stress conditions and that this interaction is RNA-dependent.
TRMT6/61A is a tRNA methytransferase responsible for the methylation of the adenosine 58 at the position 1 producing m1A. However, also mRNAs have been recently found to be methylated by TRMT6/61A. Our bioinformatics analyses revealed that significantly more mRNAs enriched in SG contain the motif for methylation than SG-depleted mRNAs. We hypothesized that m1A methylation of mRNAs could constitute a tag for the mRNAs targeting to SGs. TRMT61A knock-down (KD) cell lines were generated using the CRISPR-Cas9 technique. In TRMT61A KD cells, m1A was significantly reduced on mRNAs, which correlated with an increased sensitivity of the cells to proteostasis stress. KD cells also showed defects in SG assembly. In heat shocked cells, an m1A motif-containing mRNA recovered better after returning to normal temperature than a control mRNA with mutated motif. In addition, we could isolate SGs and analyze their m1A and m6A content by mass spectrometry. While m6A content in SG mRNAs was very similar to cytosolic mRNAs, m1A was almost 8 times enriched in SGs. Thus, we could confirm experimentally the results of the bioinformatics analysis and directly support the hypothesis that m1A is a tag to direct mRNAs for sequestration. Finally, we compared amyloidogenesis in wild-type and TRMT61A KD cell lines. Cells with reduced levels of TRMT61A demonstrated an increased accumulation of transfected Aβ and an impaired aggregate clearance. Various assays led us to conclude that the lack of m1A deposition on mRNAs enhanced RNA co-aggregation with amyloids.
Based on our results, we propose a model explaining the fate of free mRNA during proteostasis stress. Upon polysome disassembly, free mRNA is released and becomes free to interact with other proteins, including the methyltransferase TRMT6/61A. TRMT6/61A methylates the freed mRNAs containing the cognate motif. The m1A tag then targets mRNAs to SGs promoting sequestration. Upon stress release, SGs disassemble, thus releasing rescued mRNAs which could now reenter translation and support cell recovery. On the other hand, non-sequestered mRNAs increasingly co-aggregate with aggregating proteins. Thus, deficiency of the N1-adenine methylation of mRNAs due to the lack of TRMT6/61A increases the amount of unpacked mRNAs. The deposition of m1A on mRNAs could then be a way to protect them during exposure to stress, to limit their co-aggregation with misfolded proteins and to allow a faster recovery upon stress release.
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.
Verbreitungsbilder von Artefakten regten die archäologische Forschung seit dem späten 19. Jahrhundert dazu an, "Kulturkreise" zu definieren und auf dieser Basis Siedlungsräume ethnischer Gruppen, deren (Fremd)bezeichnung in lateinischen und griechischen Schriftquellen überliefert ist, zu lokalisieren. Diese Herangehensweise provoziert seit nunmehr fast zwei Jahrzehnten eine heftige Diskussion über die Interpretierbarkeit materieller Quellen im Hinblick auf die Benennung, Definition und Lokalisierung antiker Ethnien und Identitäten. ...
Einem ganz anderen Sujet widmet sich der abschließende archäobiologische Beitrag "Searching for Rome’s boundaries: An archaeobiological perspective" von Sabine Deschler-Erb, die anhand des Tierknochenspektrums verschiedener Fundplätze im Dreieck zwischen Avenches, Bregenz und Chur der Frage des Einflusses naturräumlicher Faktoren im Tierknochenbestand und den daraus resultierenden Speisegewohnheiten nachgeht. ...
Die nachfolgende Untersuchung hat nicht nur Sabine Schos Farben-Band zum Gegenstand, sondern will Werke acht weiterer deutschsprachiger Autorinnen und Autoren auf den Gebrauch von Farbworten in den Gedichten hin analysieren. Voraussetzung für die Aufnahme in das Korpus war - bis auf Sabine Scho -, dass mindesten drei Gedichtbände vorliegen müssen, damit eine mögliche Entwicklung oder Veränderung deutlich werden kann. Beachtet werden nur Werke, die nach 2000 erschienen sind oder Autoren, deren Publikationstätigkeit erst kurz vor oder nach der Jahrtausendwende begonnen hat. Diese Kriterien erfüllen Nico Bleutge, Björn Kuhligk, Albert Ostermaier, Steffen Popp, Marion Poschmann, Monika Rinck, Jan Wagner und Ron Winkler. Ausgangspunkt bei der Lektüre ihrer Werke ist die Überlegung, dass Farben markante Adjektive sind, die den Anschein erwecken, als könne in einem schwarzweißen Druckerzeugnis bunte Sichtbarkeit hergestellt werden. Wenn es aber stimmt, dass gerade das "Sichtbare nicht zu den Stärken der Dichtung" gehört, dann können Farbworte in den - zumeist kurzen - lyrischen Texten ein besonderer Brennpunkt sein, der nicht nur eine metaphorisch-symbolische Ebene signalisiert, sondern auch Anschaulichkeit und optische Prägnanz anstreben kann. Das mit Farben ebenfalls verbundene heikle Gefühls- und Stimmungsspektrum wird in der Lyrik im 21. Jahrhundert nicht mehr unbedingt angestrebt; deswegen ist von Interesse, wie mit der emotionalen Gefahrenzone umgegangen wird. Entscheidende Fragen in diesem Zusammenhang sind: Wird Gottfried Benns Warnung vor "Wortklischees" berücksichtigt? Wie oft ist der Himmel blau, die Rose rot und der Baum grün? Werden Komposita gebildet und wenn ja, welche, und wie werden bekannte Farbbezeichnungen in unbekannte Zusammenhänge eingeordnet? Spielen synästhetische Effekte und Vergleiche eine größere Rolle? Wie wichtig ist die Stellung der Farbworte im Gedicht oder im Vers, zu Beginn, am Ende oder unauffälliger mitten im Text? Insgesamt soll über den Fokus Farbe eine allgemeinere Diagnostik gegenwartslyrischer Schreibweisen erstellt werden.
Ach, waren das Zeiten, damals! Noch immer verbinden sich nicht nur mit der deutschen Studentenbewegung im Jahre 1968 Erinnerungen und Diskussionen, die weit über die oftmals historischen Jubiläen gewidmeten Aufmerksamkeiten hinausgehen. Viel stand damals auf dem Spiel, gesellschaftliche Umbrüche, sexuelle Befreiung, die Öffnung der Universitäten, die Bewegung gegen den Vietnamkrieg. Einige dieser Aspekte möchten wir in der 8. Ausgabe der REAl betrachten.
Warum versucht sich ein zu diesem Zeitpunkt berühmter Gelehrter wie Georg Simmel, der ja 1900 "Philosophie des Geldes" publiziert, in der Dichtung? Ganz unabhängig von seinem Scheitern in diesem Fach möchte ich im Folgenden diese Frage ausweiten und in den Kontext einer umfassenderen Beobachtung stellen. Nämlich der, dass sich im Laufe der langen Jahrhundertwende Texte herausbilden, die in ihrer Form einmalig oder zumindest besonders sind und zu denen auch viele Arbeiten von Georg Simmel gehören – nicht nur die, die er als Momentbilder publiziert. In einem ersten Schritt werde ich diese neuen Texte der langen Jahrhundertwende beschreiben, um im Anschluss Überlegungen dazu anzustellen, welche Bedingungen diese Formen begünstigt haben. Abschließend wende ich mich kurz einem Vergleich von Simmel und Benjamin zu, um auf diese Weise aufzuzeigen, dass für diese Texte die Formation mehr ist als nur Grundlage für die Vermittlung von Konzepten und selbst eine konzeptuelle Funktion übernehmen soll. Daher ist es hilfreich, die jeweils formalen Strukturen und Modi genauer unter die Lupe zu nehmen. Ich werde mich Simmel also nicht aus der Perspektive der Soziologie oder Kunstphilosophie nähern, sondern aus der einer kulturwissenschaftlichen Literaturwissenschaft.
We analyze cyclical co-movement in credit, house prices, equity prices, and longterm interest rates across 17 advanced economies. Using a time-varying multi-level dynamic factor model and more than 130 years of data, we analyze the dynamics of co-movement at different levels of aggregation and compare recent developments to earlier episodes such as the early era of financial globalization from 1880 to 1913 and the Great Depression. We find that joint global dynamics across various financial quantities and prices as well as variable-specific global co-movements are important to explain fluctuations in the data. From a historical perspective, global co-movement in financial variables is not a new phenomenon, but its importance has increased for some variables since the 1980s. For equity prices, global cycles play currently a historically unprecedented role, explaining more than half of the fluctuations in the data. Global cycles in credit and housing have become much more pronounced and longer, but their importance in explaining dynamics has only increased for some economies including the US, the UK and Nordic European countries. We also include GDP in the analysis and find an increasing role for a global business cycle.
We propose a simple modification of the time series filter by Hamilton (2018) that yields reliable and economically meaningful real-time output gap estimates. The original filter relies on 8-quarter-ahead forecast errors of a simple autoregression of log real GDP. While this approach yields a cyclical component of GDP that is hardly revised with new incoming data due to the one-sided filtering approach, it does not cover typical business cycle frequencies evenly, but short business cycles are muted and medium length business cycles are amplified. Further, the estimated trend is as volatile as GDP itself and can thus hardly be interpreted as potential GDP. A simple modification that is based on the mean of 4- to 12-quarter-ahead forecast errors shares the favorable real-time properties of the Hamilton filter, but leads to a much better coverage of typical business cycle frequencies and a smooth estimated trend. Based on output growth and inflation forecasts and a comparison to revised output gap estimates from policy institutions, we find that real-time output gaps based on the modified Hamilton filter are economically much more meaningful measures of the business cycle than those based on other simple statistical trend-cycle decomposition techniques such as the HP or the Bandpass filter.
Introduction: The Retro-IDEAL (ILUVIEN Implant for chronic DiabEtic MAcuLar edema) study is a retrospective study designed to assess real-world outcomes achieved with the ILUVIEN® (0.19 mg fluocinolone acetonide (FAc)) in patients with chronic diabetic macular edema (DME) in clinical practices in Germany.
Methods: This study was conducted across 16 sites in Germany and involved 81 eyes (63 patients) with persistent or recurrent DME and a prior suboptimal response to a first-line intravitreal therapy (primarily anti-VEGF intravitreal therapies).
Results: Patients were followed-up for 30.8 ± 11.3 months (mean ± standard deviation) and had a mean age of 68.0 ± 10.4 years. Best-recorded visual acuity (BRVA) improved by +5.5 letters at month 9 (P ⩽ 0.005, n=56; from a baseline of 49 letters) and this was maintained through to month 30 (P ⩽ 0.05, n = 42). There was a concurrent improvement in central macular thickness with a reduction from 502 µm at baseline to 338 µm at year 1 (P ⩽ 0.0001, n = 43). This effect was sustained to year 3 (i.e. 318 µm; P ⩽ 0.0001, n = 29). Mean intraocular pressure (IOP) remained constant between baseline and year 3 with a peak change of 1.9 mm Hg occurring at year 1. Elevated IOP was observed in a similar percentage of patients prior to (22.2% of cases) and following (27.2%) treatment with the FAc implant. In the majority of cases, these elevations were managed effectively with IOP medications.
Conclusions: Despite substantial amounts of prior intravitreal treatments – primarily with anti–vascular endothelial growth factor (VEGF) drugs – this real-world study showed that sustained structural and functional improvements can last for up to 3 years with a single FAc implant.
Der Begriff Neue Medien nimmt in der Regel Bezug auf neue Technologien. In der Medienwissenschaft wird zwischen digitalen und analogen Medien unterschieden. Digitale Medien resultieren aus der Digitalisierung, die in der zweiten Hälfte des 20. Jahrhunderts entwickelt wurde. Digitalisierung bezeichnet den Prozess der Umwandlung von analogen (stetigen) Informationen in eine digitale (schrittweise, numerische) Form. Als digitale Medien werden meist interaktive Medien auf multimedialer und/oder elektronischer Basis bezeichnet, wie zum Beispiel Internet, CD-Roms, DVDs, MP3-Player, Digitalkameras etc. Mit der rasanten Verbreitung digitaler Technologien entwickelte sich erstmals eine komplexe Vernetzung der Geräte untereinander, die weltweit Daten- und Kommunikationsflüsse ermöglicht. Im Spannungsfeld von Technik, Kultur und Gesellschaft stellen digitale Medien weit mehr als technische Systeme dar und bilden einen untrennbaren Bestandteil einer modernen Gesellschaft. Im Laufe der Zeit wurden neue Medien und v. a. ihre tägliche Nutzung einer starken Kritik unterworfen. Wir möchten feststellen, dass wir es im wirklichen Leben sowie auch im täglichen Unterrichtsprozess für viel wichtiger halten, welche Medien, auf welche Art und Weise, zu welchem Zweck und mit welchem Ziel verwendet werden.
Musik ist ein überall präsentes Phänomen und Menschen sind täglich in ständigem Kontakt mit Musik. Beide Phänomene – Musik und Sprache – bauen auf streng festgelegten Grundlagen auf und sind fest im menschlichen Gehirn verankert. In unserer Arbeit präsentieren wir die Ergebnisse der Zusammenarbeit zwischen Linguisten, Neurologen und Musikern, nämlich eine EEG-Studie. Das Hauptziel war es, Unterschiede beim Vergleich der Gehirnreaktionen von Fremdsprachenlernenden und Nicht-Fremdsprachenlernenden auf kommende Reize zu identifizieren. Es wird erwartet, dass diese Identifizierung für den Bereich der Fremdsprachenmethodik fruchtbar sein kann. Unsere Ergebnisse bestätigten die Existenz eines sogenannten dichotomischen Modells des Gehirns (linke Hemisphäre – Sprache, rechte Hemisphäre – Musik).
ISOE-Newsletter 04/2019
(2019)
Alltagsprodukte aus Plastik: Chemikalienmix aus schädlichen und unbekannten Substanzen +++ Kooperationen zwischen Kommunen sichern Lebensqualität im ländlichen Raum +++ IAA im gesellschaftlichen Wandel: Wenn die Verkehrswende der Leitmesse die Show stiehlt +++ „Wasserwende“ gegen Versorgungsengpässe +++ Zielgruppengerechte Ansprache für energieeffizientes und sicheres Wohnen im Alter +++ Wasser in Plastik – Plastik im Wasser. Warum es schwierig ist, die Ökobilanz von PET-Flaschen zu erstellen +++ Lehrveranstaltungen im Wintersemester 2019/20 +++ ISOE unterstützt „Globale Aktionswoche gegen die Klimakrise“ +++ Aus dem ISOE +++ Termine +++ Publikationen
ISOE-Newsletter 05/2019
(2019)
Zukunft gestalten im Anthropozän: Gestaltungsprinzipien für eine kritische Nachhaltigkeitsforschung +++ Institutsbericht 2019 des ISOE erschienen +++ 30 Jahre ISOE: Aufbruch in die Gegenwart. Die sozial-ökologische Zukunft heute gestalten +++ Das ISOE auf Instagram +++ Forschungsergebnisse aus der Schweiz zu nachhaltigem Mobilitätsverhalten +++ Klimaanpassung in den Städten: Was Infrastrukturen dazu beitragen können +++ Kipppunkte in Ökosystemen: Maßnahmen zum Erhalt der Savannen im südlichen Afrika +++ Termine +++ Publikationen
Resistance
(2019)
The term 'resistance', as it appears in the writings of Walter Benjamin, marks the attempt to think a politics that emerges out of a certain experience of history and time. This entry shows that 'Widerstand' is conceived here principally as a resistance against the course of a catastrophic history - a desire for time to cease its flow and come to a standstill.
Im Folgenden erörtert Alexander Nebrig den Zusammenhang zwischen der international anschlussfähigen Philosophie Spinozas in Auerbachs Werk einerseits und der internationalen Verbreitung ebendieses Werkes andererseits. Es geht um die ideellen Eigenschaften von Literatur, die ihren Entstehungs- und primären Vertriebsraum überschreitet und in Übersetzungen Erneuerung findet. Bislang wurden Auerbachs Erzählungen vornehmlich mit dem Pantheismus Spinozas in Verbindung gebracht. Die Spinoza-Rezeption lässt sich aber noch stärker präzisieren. Zu zeigen ist, dass die Affektenlehre der spinozistischen Ethik für Auerbachs Figurenpsychologie strukturbildend wurde (I, II). Im Anschluss an die Überprüfung dieser Hypothese wird in einem zweiten Schritt Auerbachs Spinoza-Rezeption in Verbindung mit seiner Einstellung auf internationale Kontrolle des Werkes gebracht (III, IV). Das neue grenzüberschreitende Verwertungsbewusstsein wurde von der Entstehung des übersetzungsrechtlichen Denkens ermöglicht. Auerbach verfolgte aufmerksam die urheberrechtliche Entwicklung und trat selbst als Lobbyist internationaler Urheberübereinkünfte auf, was ihn zu einem Pionier internationaler Werkherrschaft macht. Leitend ist an dieser Zusammenführung von literarischer Hermeneutik und Urheberrechtsgeschichte die bereits an anderen Fällen erörterte These, dass Vertriebs- und Vermittlungslösungen in einem wechselseitigen Verhältnis mit der Werkstruktur stehen können.
The financial crisis of 2007-08 has stressed the importance of a sound financial system. Unlike other studies weighing the pros and cons of market versus bank-based systems, this paper investigates whether the main elements of the German financial system can be regarded as complementary and consistent. This assessment refers to the idea that there is a potential for positive interaction between different elements in the system that is actually used to make it more valuable to economy and society and more robust to crises. It is shown that the old German bank-based system, where the risk of long-term lending by large private commercial banks was limited by the membership in supervisory boards and strong personal ties between all stakeholders, was a consistent system of well-adjusted complementary elements. After reunification, a hybrid system has emerged where, on the one hand, public savings banks and cooperative banks maintain their role as lenders, but on the other, large private banks have withdrawn from their former dominant role in financing and corporate governance. It is argued that this transition to stronger capital-market and, accordingly, shareholder value orientations has occurred at the expense of consistency.
In his widely acclaimed book “Das Kalte Herz” (The Cold Heart), economic historian Werner Plumpe tells the story of the history of capitalism, which in his view represents a sober form of economics which has proved itself superior and higher performing than other systems. To this day, the long tradition of capitalism criticism has not understood that in capitalism, great wealth is utilized to produce goods that are usually affordable for people with small incomes.
The volume under review is the result of a conference on historical graffiti held at the Ludwig-Maximilians-University of Munich in 2017. The aim of this book is to analyse — for the first time — graffiti from the ancient, medieval and modern periods in their historical and geographical contexts from an interdisciplinary point of view. Following this comparative approach the authors show the tremendous potential of this nascent area of research by investigating epigraphic material that has been neglected and underestimated by scholars for a long time. ...
It is a rare and wonderful thing when a book of 383 pages leaves a reader wanting to read more, much more in fact. That is certainly the case with this intriguing collection of thirteen assorted essays on the Rhine economy from 1815 to the present, organized in six broad topical sections: origins, enterprises, sectors and clusters, infrastructures, transport, and environment. ...
Partant des conditions de mise en place de l’une des dernières commissions d’historiens bilatérales en date – à savoir la commission germano-italienne en 2008 – et du constat de la nature à la fois ambigüe et excessive des attentes formulées à son encontre, cet ouvrage collectif dirigé par deux historiens du temps présent (l’Allemand Christoph Cornelißen et l’Italien Paolo Pezzino) place au cœur de la réflexion la figure de l’historien confronté à une demande d’expertise croissante dans le contexte de l’après guerre froide. Il examine les usages pratiques (voire politiques) des savoirs académiques historiques et leurs effets sur les standards de production de ces savoirs assurant la légitimité professionnelle et sociale des historiens. ...
Within the last decades, western democracies have experienced a rise of inequality, with the gap between lower and upper class citizens steadily increasing and a widespread sentiment of growing inequalities also in the political sphere. Against this background, and in the context of the current “crisis of democracy”, democratic innovations such as direct democratic instruments are discussed as a very popular means to bring citizens back in. However, research on direct democracy has produced rather inconsistent results with regard to the question of which effects referenda and initiatives have on equality. Studies in this field are often limited to single countries and certain aspects of equality. Moreover, most existing studies look at the mere availability of direct democratic instruments instead of actual bills that are put to a vote. This paper aims to take a first step to fill these gaps by giving an explorative overview of the outputs of direct democratic bills on multiple equality dimensions, analyzing all national referenda and initiatives in European democracies between 1990 and 2015. How many pro- and contra-equality bills have been put to a vote, how many of those succeeded at the ballot, and are there differences between country groups? Our findings show that a majority of direct democratic bills was not related to equality at all. Regarding the successful bills, we detect some regional differences along with the general tendency that there are more pro- than contra-equality bills. Our paper sheds new light on the question if direct democracy can serve as an appropriate means to complement representative democracy and to shape democratic institutions in the future. The potential of direct democracy in fostering or impeding equality should be an important criterion for the assessment of claims to extend decision-making by citizens.
The hillfort settlement of Monkodonja, located in the vicinity of the town Rovinj, is representative of the Bronze Age Castellieri culture in Istria. Twelve years of excavations that lasted one month each year revealed a proto-urban settlement with extensive fortification system, and a tripartite division of its interior that could well reflect the hierarchical social structure of its inhabitants. Remarkably, a change in the fortification concept during the time of the settlement’s existence could also be observed. With regard to bronze objects and ceramic finds the settlement is dated generally between the developed Early Bronze Age and the beginning of the Middle Bronze Age, or in Br A2 and Br B1 periods according to the chronology of Paul Reinecke. Moreover, about 40 radiocarbon dates from the Monkodonja settlement have also been analysed. The foundation of the settlement is dated to around 1800 cal BC. The second extensive building phase, including the rebuilding of the fortification system according to new defensive concepts, is dated approximately to 1600 cal BC, while the destruction of the settlement occurred around 1500 cal BC or in the middle of the 15th century BC at the latest.
Hofmannsthal ist seit seiner Kindheit mit der orientalischen Welt vertraut. Erst nach langjähriger Beschäftigung mit dem Orient hat Hofmannsthal eine Reise in den Orient unternommen. Hofmannsthals "Reise nach Nordafrika" im Jahre 1925 war sein erster und letzter direkter Kontakt mit dem Orient. Er reiste mit der Familie Zifferer nach Marokko, Algerien und Tunesien. Die Städte Fés und Saleh hatten ihn beeindruckt. Er schrieb einen Reisebericht über diese Reise. Der erste Teil seines Reiseberichts Fez berichtet über die Atmosphäre der Stadt und die Einwohner sowie Hofmannsthals Eindrücke und Wahrnehmungen. Er wurde am 12. April 1925 im Berliner Tageblatt publiziert. Im zweiten Teil des Berichts "Das Gespräch in Saleh" handelt es sich um ein Gespräch über das Vorhandensein der Franzosen in Marokko und Reflexionen über die französische und die deutsche Sprache und Kultur. Er wurde am 31. Mai 1925 in der Wiener Freien Presse veröffentlicht. In diesem Aufsatz wird Hofmannsthals Orientbild anhand seines Reiseberichts analysiert.
Immunosuppressive compounds affect the fungal growth and viability of defined aspergillus species
(2019)
Immunosuppressive drugs are administered to a number of patients; e.g., to allogeneic hematopoietic stem cell transplant recipients. Immunosuppressive drugs impair the immune system and thus increase the risk of invasive fungal disease, but may exhibit antifungal activity at the same time. We investigated the impact of various concentrations of three commonly used immunosuppressive compounds—cyclosporin A (CsA), methylprednisolone (mPRED), and mycophenolic acid (MPA)—on the growth and viability of five clinically important Aspergillus species. Methods included disc diffusion, optical density of mycelium, and viability assays such as XTT. MPA and CsA had a species-specific and dose-dependent inhibitory effect on the growth of all Aspergillus spp. tested, although growth inhibition by MPA was highest in A. niger, A. flavus and A. brasiliensis. Both agents exhibited species-specific hyphal damage, which was higher when the immunosuppressants were added to growing conidia than to mycelium. In contrast, mPRED increased the growth of A. niger, but had no major impact on the growth and viability of any of the other Aspergillus species tested. Our findings may help to better understand the interaction of drugs with Aspergillus species and ultimately may have an impact on individualizing immunosuppressive therapy.
Suppression of light nuclei production in collisions of small systems at the Large Hadron Collider
(2019)
We show that the recently observed suppression of the yield ratio of deuteron to proton and of helium-3 to proton in p+p collisions compared to those in p+Pb or Pb+Pb collisions by the ALICE Collaboration at the Large Hadron Collider (LHC) can be explained if light nuclei are produced from the coalescence of nucleons at the kinetic freeze-out of these collisions. This suppression is attributed to the non-negligible sizes of deuteron and helium-3 compared to the size of the nucleon emission source in collisions of small systems, which reduces the overlap of their internal wave functions with those of nucleons. The same model is also used to study the production of triton and hypertriton in heavy-ion collisions at the LHC. Compared to helium-3 in events of low charged particle multiplicity, the triton is less suppressed due to its smaller size and the hypertriton is even more suppressed as a result of its much larger size.
The term structure of interest rates is crucial for the transmission of monetary policy to financial markets and the macroeconomy. Disentangling the impact of monetary policy on the components of interest rates, expected short rates and term premia, is essential to understanding this channel. To accomplish this, we provide a quantitative structural model with endogenous, time-varying term premia that are consistent with empirical findings. News about future policy, in contrast to unexpected policy shocks, has quantitatively significant effects on term premia along the entire term structure. This provides a plausible explanation for partly contradictory estimates in the empirical literature.
We study how the mass and magnetic moment of the quarks are dynamically generated in nonequilibrium quark matter. We derive the equal-time transport and constraint equations for the quark Wigner function in a magnetized quark model and solve them in the semi-classical expansion. The quark mass and magnetic moment are self-consistently coupled to the Wigner function and controlled by the kinetic equations. While the quark mass is dynamically generated at the classical level, the quark magnetic moment is a pure quantum effect, induced by the quark spin interaction with the external magnetic field.
In the course of the crisis, the European System of Central Banks (ESCB) has acted several times to support the EU Member States and banking systems in financial distress by purchasing debt instruments: Covered Bonds Programmes (CBP), Securities Market Programmes (SMP), Long Term Refinancing Operations (LTRO), and Targeted Long Term Refinancing Operations (TLTRO), followed by the Outright Monetary Transactions (OMT) and then the Extended Asset Purchase Programmes (EAPP) – colloquially labelled as Quantitative Easing (QE).
Initially, the support measures of the ESCB might have to be judged as monetary policy but the selectivity of OMT and – even more – SMP in conjunction with the transfer of risks to the ESCB speak against it.
Ceritinib-induced regression of an insulin-like growth factor-driven neuroepithelial brain tumor
(2019)
The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood–brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IGF pathway using ceritinib, an off-target inhibitor of the IGF1 receptor (IGF1R) and insulin receptor (INSR), in a pediatric patient with an unclassified brain tumor and a notch receptor 1 (NOTCH1) germline mutation. Pathway analysis of the tumor revealed activation of the sonic hedgehog (SHH), the wingless and integrated-1 (WNT), the IGF, and the Notch pathway. The proliferation of the patient tumor cells (225ZL) was inhibited by arsenic trioxide (ATO), which is an inhibitor of the SHH pathway, by linsitinib, which is an inhibitor of IGF1R and INSR, and by ceritinib. 225ZL expressed INSR but not IGF1R at the protein level, and ceritinib blocked the phosphorylation of INSR. Our first personalized treatment included ATO, but because of side effects, we switched to ceritinib. After 46 days, we achieved a concentration of 1.70 µM of ceritinib in the plasma, and after 58 days, MRI confirmed that there was a response to the treatment. Ceritinib accumulated in the tumor at a concentration of 2.72 µM. Our data suggest ceritinib as a promising drug for the treatment of IGF-driven brain tumors.
Der betongraue Bunker ist von Zwangsarbeitern der Nationalsozialisten im Zweiten Weltkrieg errichtet worden. Geplant war er als Luftschutzbunker für die Mitarbeiter und Kunden der Reichsbahn, damit sie sich im Ernstfall vom nah gelegenen Bahnhof, dem heutigen Bahnhof Friedrichstrasse, vor dem Bombenhagel retten konnten; bis zu 2.500 Menschen finden darin Platz. Nach dem Ende des Zweiten Weltkrieges wurde der Bunker sehr unterschiedlich genutzt: Zuerst diente er als Kriegsgefängnis der Roten Armee, danach als Lager für Textilien und anschließend für Südfrüchte, was ihm den Namen „Bananenbunker“ einbrachte. Nach dem Mauerfall ging das Gebäude in den Besitz des Bundes über und die Kultur Berlins zog ein: Erst in Form eines Techno-Clubs, in welchem auch Theaterstücke aufgeführt wurden, bis der Bund das Gebäude vorerst schloss. Der Werbeagentur-Inhaber Christian Boros erwarb zusammen mit seiner Frau Karen Boros den Bunker schließlich und baute ihn fünf Jahre lang um: Seit 2008 werden die Kunstwerke aus Boros’ privater Kunstsammlung präsentiert. ...
The combination of high-throughput sequencing and in vivo crosslinking approaches leads to the progressive uncovering of the complex interdependence between cellular transcriptome and proteome. Yet, the molecular determinants governing interactions in protein-RNA networks are not well understood. Here we investigated the relationship between the structure of an RNA and its ability to interact with proteins. Analysing in silico, in vitro and in vivo experiments, we find that the amount of double-stranded regions in an RNA correlates with the number of protein contacts. This relationship —which we call structure-driven protein interactivity— allows classification of RNA types, plays a role in gene regulation and could have implications for the formation of phase-separated ribonucleoprotein assemblies. We validate our hypothesis by showing that a highly structured RNA can rearrange the composition of a protein aggregate. We report that the tendency of proteins to phase-separate is reduced by interactions with specific RNAs.
Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease and tumors with PAX3-FOXO1 fusion genes that encode a potent transcription factor that drives tumourigenesis through transcriptional reprogramming. Polo-Like Kinase-1 (PLK1) is a serine/threonine kinase that phosphorylates a wide range of target substrates and alters their activity. PLK1 functions as a pleiotropic master regulator of mitosis and regulates DNA replication after stress. Taken together with high levels of expression that correlate with poor outcomes in many cancers, including rhabdomyosarcomas, it is an attractive therapeutic target. This is supported in rhabdomyosarcoma models by characterization of molecular and phenotypic effects of reducing and inhibiting PLK1, including changes to the PAX3-FOXO1 fusion protein. However, as tumor re-growth has been observed, combination strategies are required. Here we review preclinical evidence and consider biological rationale for PLK1 inhibition in combination with drugs that promote apoptosis, interfere with activity of PAX3-FOXO1 and are synergistic with microtubule-destabilizing drugs such as vincristine. The preclinical effects of low doses of the PLK1 inhibitor volasertib in combination with vincristine, which is widely used in rhabdomyosarcoma treatment, show particular promise in light of recent clinical data in the pediatric setting that support achievable volasertib doses predicted to be effective. Further development of novel therapeutic strategies including PLK1 inhibition may ultimately benefit young patients with rhabdomyosarcoma and other cancers.
Since Inhibitor of Apoptosis (IAP) proteins have been implicated in cellular adaptation to endoplasmic reticulum (ER) stress, we investigated the regulation of ER stress-induced apoptosis by small-molecule second mitochondria-derived activator of caspase (Smac) mimetics that antagonize IAP proteins. Here, we discover that Smac mimetic suppresses tunicamycin (TM)-induced apoptosis via resolution of the unfolded protein response (UPR) and ER stress. Smac mimetics such as BV6 selectively inhibit apoptosis triggered by pharmacological or genetic inhibition of protein N-glycosylation using TM or knockdown of DPAGT1, the enzyme that catalyzes the first step of protein N-glycosylation. In contrast, BV6 does not rescue cell death induced by other typical ER stressors (i.e., thapsigargin (TG), dithiothreitol, brefeldin A, bortezomib, or 2-deoxyglucose). The protection from TM-triggered apoptosis is found for structurally different Smac mimetics and for genetic knockdown of cellular IAP (cIAP) proteins in several cancer types, underlining the broader relevance. Interestingly, lectin microarray profiling reveals that BV6 counteracts TM-imposed inhibition of protein glycosylation. BV6 consistently abolishes TM-stimulated accumulation of ER stress markers such as glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) and reduces protein kinase RNA-like ER kinase (PERK) phosphorylation and X box-binding protein 1 (XBP1) splicing upon TM treatment. BV6-stimulated activation of nuclear factor-κB (NF-κB) contributes to the resolution of ER stress, since NF-κB inhibition by overexpression of dominant-negative IκBα superrepressor counteracts the suppression of TM-stimulated transcriptional activation of CHOP and GRP78 by BV6. Thus, our study is the first to show that Smac mimetic protects from TM-triggered apoptosis by resolving the UPR and ER stress. This provides new insights into the regulation of cellular stress responses by Smac mimetics.
Telecommunications Law and Practice in Nigeria -Perspectives on Consumer Protection is intended primarily to provide an indigenous source of information on the theoretical and legal framework of the regulation of telecommunications in Nigeria with respect to how such legal framework assists in addressing the consumers problems in the field of telecommunications. The book covers the evolution of telecommunications the world over and its variant in Nigeria, a variety of issues including the early controlling organs, regulatory regimes, the deregulation era, interconnectivity and privacy law, telecommunications and intellectual property, international trade and drafting of international trade contracts, encryption technology and privacy in telecommunications. The book should be an invaluable companion on the Nigerian telecommunications law and practice with perspectives on consumer protection.
Highlighting the problematiques of working with a narrow version of greenhouse effects or global warming, this book posits the theory of necroclimatism that encompasses broader versions of greenhouse effects and global warming. Conceiving cultures, societies, moral sensibilities, epistemologies, polities, economies, legal systems and religions of the formerly colonised peoples as greenhoused and entrapped in the heat of global apartheid and neo-colonialism, the book refuses to be confined to the pufferies of physical conceptualisations of greenhousing and global warming. Underlining the supposed disposability and dispensability of colonised peoples, the notion of necroclimatism explicates ways in which some people suffer various forms of death, which have increasingly become a feature of global apartheid and neo-colonialism that are cast in spectral sacrificial logics. Deemed to constitute disposable bodies, disposable cultures, disposable polities, disposable societies, disposable epistemologies, disposable religions, disposable laws and disposable economies, the sacrificed are, in the age of climate catastrophism, once again reminded that they have duties to die, to become extinct in order to save the global spaceship that is sinking due to climate change and global warming. This book therefore argues that in a sacrificial world (dis)order, binaries between humans and animals, good and evil, moral and immoral, the dead and the living necessarily vanish in the nefarious logic of what marks the era of climate catastrophism and the attendant necroclimatism. The book further argues that a sacrificial world (dis)order is necessarily a posthumanist and postanthropocentric world (dis)order, which should be never granted space in African worlds and even beyond. The book thus, raises fundamental questions for African anticipatory regimes, and for this reason it is handy for scholars in political science, sociology, social anthropology, development studies, environmental studies, agricultural studies, legal studies, food science, geography, religious studies and decolonial fields of studies.
As the world today faces messy problems, what in some circles has been called global weirding, the term resilience has taken centre stage. This is crunch time - as we grapple with the negative effects of both climate change and urbanisation. Some commentators have compared the huge problems we face today to Oom Schalk's proverbial leopard waiting for us in the withaak's shade. Do we endlessly count Oom Schalk's proverbial leopard's spots? This is the question posed by a stellar cast of academics, researchers, and experts whose contributions in this text is a rallying cry for action to build resilience to the challenging impact of urbanisation and climate change. To that end, this volume gives hope about the potential for human agency. Our challenge however, is to re-examine our values, to change our conservation conversation and return to a more wise and holistic understanding of ourselves and our place in the Universe. Perhaps, then only can the obituaries on our demise stay locked in the drawer.
At the heart of 21st century discourses are questions of whose lives may matter more than others. While the debates themselves are not new, the #hashtags they are linked to and the media through which concerns around moralities of living together are expressed allow for debates to reach large numbers of people in accelerated, individualised and accessible ways. The new media have been powerful in (re)igniting debates and (re)activating demands for social change. Yet, the focus of ubiquitous #hashtags on binary positions may render it easy to neglect their nuances and facets. In recognition of grey-zones, contradictions and ambiguities, this ethnography focuses on a suburb of Cape Town, Observatory, and its recently revived Neighbourhood Watch as an urban renewal project and attempt to decrease notions of vulnerability to crime and violence. In Observatory considered to be liberal and bohemian by its inhabitants the framing of topics within the Neighbourhood Watch group often take on an abstract, intellectualised form. Nevertheless, the group with its rather clashing ideals is grounded in and fuelled by recycled crime stories as well as snapshots of suspected criminals that continue to reappear via various social media channels. Individual experiences, stories and inner conflicts of local Neighbourhood Watch members are at the centre of this exploratory engagement with how fear becomes embodied, everyday practice and the ways in which desires for relationality and spatial exclusivity become entangled in a place where every life matters only in principle.
Fundamental Theories of Ethnic Conflict : Explaining the Root Causes of Ethnic and Racial Hate
(2019)
This book develops and expands on theories that aim at explaining the root causes of ethnic and racial conflicts. The aim is to shift focus from research, policies and strategies based on tackling the effects of ethnic and racial conflicts, which have so far been ineffective as evidenced by the increase in ethnic conflicts, to more fundamental ideas, models and strategies. Contents extend across many disciplines including evolution, biology, religion, communication, mythology and even introspective perspectives. Drawn from around the world, contributors to the book are respected and experienced award winning authors, scholars and thinkers with deep understanding of their special fields of contribution. The book was inspired by the conditions in Kenya, where ethnic violence flared up with terrifying consequences following a disputed election in 2008. Although the conflict was resolved by the intervention of the international community, Kenyans - like many other Africans - continue to live in fear of ethnic conflicts breaking out with more disastrous consequences. The book will be useful to policy makers, NGOs and others involved in promoting peace. It will also be useful in guiding research and as a text book in universities and colleges.
De novo fatty acid biosynthesis in humans is accomplished by a multidomain protein, the Type I fatty acid synthase (FAS). Although ubiquitously expressed in all tissues, fatty acid synthesis is not essential in normal healthy cells due to sufficient supply with fatty acids by the diet. However, FAS is overexpressed in cancer cells and correlates with tumor malignancy, which makes FAS an attractive selective therapeutic target in tumorigenesis. Herein, we present a crystal structure of the condensing part of murine FAS, highly homologous to human FAS, with octanoyl moieties covalently bound to the transferase (MAT—malonyl‐/acetyltransferase) and the condensation (KS—β‐ketoacyl synthase) domain. The MAT domain binds the octanoyl moiety in a novel (unique) conformation, which reflects the pronounced conformational dynamics of the substrate‐binding site responsible for the MAT substrate promiscuity. In contrast, the KS binding pocket just subtly adapts to the octanoyl moiety upon substrate binding. Besides the rigid domain structure, we found a positive cooperative effect in the substrate binding of the KS domain by a comprehensive enzyme kinetic study. These structural and mechanistic findings contribute significantly to our understanding of the mode of action of FAS and may guide future rational inhibitor designs.
Adults with autism spectrum disorder (ASD) are frequently prescribed selective serotonin reuptake inhibitors (SSRIs). However, there is limited evidence to support this practice. Therefore, it is crucial to understand the impact of SSRIs on brain function abnormalities in ASD. It has been suggested that some core symptoms in ASD are underpinned by deficits in executive functioning (EF). Hence, we investigated the role of the SSRI citalopram on EF networks in 19 right-handed adult males with ASD and 19 controls who did not differ in gender, age, IQ or handedness. We performed pharmacological functional magnetic resonance imaging to compare brain activity during two EF tasks (of response inhibition and sustained attention) after an acute dose of 20 mg citalopram or placebo using a randomised, double-blind, crossover design. Under placebo condition, individuals with ASD had abnormal brain activation in response inhibition regions, including inferior frontal, precentral and postcentral cortices and cerebellum. During sustained attention, individuals with ASD had abnormal brain activation in middle temporal cortex and (pre)cuneus. After citalopram administration, abnormal brain activation in inferior frontal cortex was ‘normalised’ and most of the other brain functional differences were ‘abolished’. Also, within ASD, the degree of responsivity in inferior frontal and postcentral cortices to SSRI challenge was related to plasma serotonin levels. These findings suggest that citalopram can ‘normalise’ atypical brain activation during EF in ASD. Future trials should investigate whether this shift in the biology of ASD is maintained after prolonged citalopram treatment, and if peripheral measures of serotonin predict treatment response.
Background: Disease progression and delayed neurological complications are common after aneurysmal subarachnoid hemorrhage (aSAH). We explored the potential of quantitative blood-brain barrier (BBB) imaging to predict disease progression and neurological outcome.
Methods: Data were collected as part of the Co-Operative Studies of Brain Injury Depolarizations (COSBID). We analyzed retrospectively, blinded and semi-automatically magnetic resonance images from 124 aSAH patients scanned at 4 time points (24–48 h, 6–8 days, 12–15 days and 6–12 months) after the initial hemorrhage. Volume of brain with apparent pathology and/or BBB dysfunction (BBBD), subarachnoid space and lateral ventricles were measured. Neurological status on admission was assessed using the World Federation of Neurosurgical Societies and Rosen-Macdonald scores. Outcome at ≥6 months was assessed using the extended Glasgow outcome scale and disease course (progressive or non-progressive based on imaging-detected loss of normal brain tissue in consecutive scans). Logistic regression was used to define biomarkers that best predict outcomes. Receiver operating characteristic analysis was performed to assess accuracy of outcome prediction models.
Findings: In the present cohort, 63% of patients had progressive and 37% non-progressive disease course. Progressive course was associated with worse outcome at ≥6 months (sensitivity of 98% and specificity of 97%). Brain volume with BBBD was significantly larger in patients with progressive course already 24–48 h after admission (2.23 (1.23–3.17) folds, median with 95%CI), and persisted at all time points. The highest probability of a BBB-disrupted voxel to become pathological was found at a distance of ≤1 cm from the brain with apparent pathology (0·284 (0·122–0·594), p < 0·001, median with 95%CI). A multivariate logistic regression model revealed power for BBBD in combination with RMS at 24-48 h in predicting outcome (ROC area under the curve = 0·829, p < 0·001).
Interpretation: We suggest that early identification of BBBD may serve as a key predictive biomarker for neurological outcome in aSAH.
Fund: Dr. Dreier was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) (DFG DR 323/5-1 and DFG DR 323/10–1), the Bundesministerium für Bildung und Forschung (BMBF) Center for Stroke Research Berlin 01 EO 0801 and FP7 no 602150 CENTER-TBI.
Dr. Friedman was supported by grants from Israel Science Foundation and Canada Institute for Health Research (CIHR). Dr. Friedman was supported by grants from European Union's Seventh Framework Program (FP7/2007–2013; grant #602102).
Prescribing practice of pregabalin/gabapentin in pain therapy : an evaluation of German claim data
(2019)
Objectives: To analyse the prevalence and incidence of pregabalin and gabapentin (P/G) prescriptions, typical therapeutic uses of P/G with special attention to pain-related diagnoses and discontinuation rates.
Design: Secondary data analysis.
Setting: Primary and secondary care in Germany.
Participants: Four million patients in the years 2009–2015 (anonymous health insurance data).
Intervention: None.
Primary and secondary outcome measures: P/G prescribing rates, P/G prescribing rates associated with pain therapy, analysis of pain-related diagnoses leading to new P/G prescriptions and the discontinuation rate of P/G.
Results: In 2015, 1.6% of insured persons received P/G prescriptions. Among the patients with pain first treated with P/G, as few as 25.7% were diagnosed with a typical neuropathic pain disorder. The remaining 74.3% had either not received a diagnosis of neuropathic pain or showed a neuropathic component that was pathophysiologically conceivable but did not support the prescription of P/G. High discontinuation rates were observed (85%). Among the patients who had discontinued the drug, 61.1% did not receive follow-up prescriptions within 2 years.
Conclusion: The results show that P/G is widely prescribed in cases of chronic pain irrespective of neuropathic pain diagnoses. The high discontinuation rate indicates a lack of therapeutic benefits and/or the occurrence of adverse effects.
Administrative Law: Cases and Materials is an important and comprehensive contribution to the legal literature on Namibian law. It will contribute to the development of Namibias jurisprudence. Experienced author and judge of the Namibian High Court, Dr Collins Parker discusses key principles of administrative law applicable to Namibia under the common law as developed and broadened by article 18 of the Namibian Constitution. To support propositions of law discussed in the text, he presents carefully selected extracts of judgments delivered in important cases. The book offers a rich source of judicial pronouncements as precedent that are not readily available to many students and teachers of law. The selected cases are from the superior courts in Namibia, South Africa, England, and Canada, all common law countries. There are also footnote references to cases from other common law countries like India, Zambia and Zimbabwe. Practitioners of law at the Bar or on the Bench, law researchers and other professionals in public authorities, including parastatals, private companies and other ord this book useful in the performance of their professional tasks.
Education in Tanzania in the Era of Globalisation Challenges and Opportunities is a product of papers presented at a National Education Conference held in Dodoma, Tanzania in November 2016 and organised by the Aga Khan University-Institute for Educational Development, East Africa (AKU-IED-EA). At present, Tanzania's development direction is guided by Vision 2025, which aims to achieve a high quality livelihood for its people be attainment of Vision 2025 will depend largely on rapid socio-economic development based on several social and economic pillars including, most importantly, education. Clearly, for Tanzania, the scope and quality of education remains the single most important prerequisite to the attainment of Vision 2025 and the 17 Sustainable Development Goals (SDGs). The individual chapters in this publication, and their collective thrust, discuss the challenges in the education system in good faith and in the spirit of cooperation and collaboration guided by the belief that it is not the responsibility of the Government alone to see how these can be addressed. AKU IED EA has identd this as the responsibility of all well-meaning corporate bodies and citizens, and initiated thst conference of its type as its contribution to thore conference, as well as the publication, has to be seen as a model of good practice for universities in terms of sharing knowledge, experience, and practice with other stakeholders who are not in the academy, and more so, with politicians as well as government policy planners. The various authors of Education in Tanzania in the Era of Globalisation Challenges and Opportunities discuss issues within the context of the Tanzanian political economy against thects of globalization and seek to initiate a new kind of debate that is long overdue; a debate aimed at charting out appropriate strategies whose objective is to improve the quality of education in Tanzania so that it becomes a useful vehicle in enhancing processes of social change, transformation and development.
To be or not to be is an analysis of linguistic, cultural, political, economic and social factors, which explain the intricate root causes of conflicts which have ravished Sudan. It stands in stark contrast to the dominant simplification and distortions which have come to typify presentations of the region. Central to the book is an unapologetic explanation of Arabization; which often is portrayed as individual choices of religious loyalty, but, in fact, masks an intentional power-system which viciously corrupts Afrikan identities. By highlighting the detrimental complexities of manipulation, geopolitics, identity confusion and cultural imperialism, Hashim has not only written an authoritative book about Sudan, but also presented a comprehensive case study that all of Afrika must learn from. Rarely are we presented with such a vigourous inside-view to an area of Afrika which once was held in the highest civilizational esteem, but has been reduced to an ideological field of Arab-led terror, massacres and disintegration.
South Sudan: Elites, Ethnicity, Endless Wars and the Stunted State is likely to achieve its objective of stimulating debate about the future of South Sudan as a viable polity. The hope is that readers, through the debate generated by this book, will rediscover the commonality that marked the struggle for freedom, justice, and fraternity, and abandon ethnic ideologies as a means of constructing a modern state in South Sudan. South Sudan: Elites, Ethnicity, Endless Wars and the Stunted State is a must-read for South Sudanese intellectuals who want to reshape the socioeconomic and political development trajectory.
Durch natürliche Selektion werden Funktionen, die dem Überleben und dem Fortpflanzungserfolg eines Organismus dienen, optimiert. Da die Struktur eines Organs dessen Funktion und umgekehrt die Funktion eines Organs dessen Struktur bestimmt, kann durch das Studium der Morphologie die Funktionsweise von Organen verstanden werden. Trotz des umfangreichen Wissens über die Struktur von Nervensystemen sowohl auf mikro- als auch auf makroskopischer Ebene, ist es weiterhin unklar, wie Bewusstsein und ein kohärentes Abbild der Umwelt im Gehirn erzeugt werden. Der Grund hierfür ist vor allem die gewaltige Komplexität neuronaler Netzwerke, die unmöglich geistig erfasst werden können. Eine Möglichkeit, das Gehirn ohne das detaillierte Wissen über all seine Bestandteile zu verstehen, bietet das Studium von Optimierungsprinzipien und deren Anwendung in theoretischen Modellen. So wie eingangs erwähnt die Funktion von Organen durch natürliche Selektion optimiert wird, sollte auch die Funktion neuronaler Netzwerke optimiert werden und neuronale Netzwerke sollten entsprechend solcher Optimierungsprinzipien aufgebaut sein. Ein wichtiges Prinzip, das essenziell für die Effizienz neuronaler Netzwerke ist, ist die Minimierung der Verbindungslänge zwischen Neuronen. Basierend auf diesem Prinzip wurde im Rahmen dieser Dissertation eine algorithmische Methode etabliert, die es ermöglicht Vorhersagen der relativen Position von Neuronen anhand ihrer Verbindungen zu treffen. Diese neuronale Platzierungsmethode beruht darauf, dass Neuronen mit ähnlicher Verbindungsnachbarschaft näher zueinander platziert werden als zu Neuronen mit weniger ähnlichen Verbindungsnachbarn, wodurch die durchschnittliche Verbindungslänge minimiert wird. Nach der Etablierung dieser Methode, wurde diese benutzt um Modelle zu erstellen, die es ermöglichen die Entstehung neuronaler Karten und kortikaler Faltungen im Zusammenhang mit der Konnektivität und der Anzahl der Neuronen zu untersuchen.
Neuronale Karten sind geordnete Muster auf der Oberfläche des Kortex, die durch die präferierte Aktivität einzelner Neuronen in Antwort auf Stimuli einer Modalität beobachtet werden können. Im visuellen Kortex existieren sogar mehrere Karten, je nachdem welche Qualität visueller Stimuli man betrachtet. Abhängig von der Präferenz für einen Sehwinkel, ein stimuliertes Auge oder der Orientierung eines Balken-Stimulus, können retinotopische Karten, Karten mit streifenartigen Mustern oder Karten mit sogenannten „Pinwheel“-Strukturen beobachtet werden. Pinwheels sind periodische Strukturen, die sichtbar werden indem man die Orientierungspräferenz von Neuronen für die spezifische Orientierung eines Balken-Stimulus mit der entsprechenden Farbe des Farbkreises visualisiert. Da diese Strukturen eine Ähnlichkeit mit bunten Windrädern haben, werde sie als Pinwheels bezeichnet. Die in dieser Dissertation erstellten Modelle sagen vorher, dass die Entstehung strukturierter neuronaler Karten im Allgemeinen von der Anzahl der Neuronen abhängt. In der Tat könnte diese Abhängigkeit auch für neuronale Karten im Kortex gelten. Während strukturierte Karten im visuellen Kortex in verschiedenen Säugerordnungen wie Primaten, Karnivoren und Huftieren existieren, sind sie in kleinen Nagern mit weniger Neuronen nicht vorhanden, trotz ähnlicher Verbindungsspezifizität. Folglich müssen Unterschiede in der Struktur neuronaler Karten im Kortex nicht zwangsläufig mit einer unterschiedlichen Funktionsweise zusammenhängen, sondern könnten auch durch allgemeine Optimierungsprinzipien beim Aufbau neuronaler Netzwerke bedingt werden. Eine weitere Gemeinsamkeit zwischen verschiedenen Säugetierordnungen ist, dass die relative Dichte der Pinwheels ziemlich genau bei der Zahl Pi liegt. Entsprechend der Ergebnisse dieser Dissertation könnte dies dadurch erklärt werden, dass für neuronale Karten ähnlicher Struktur die Anzahl der Neuronen pro Pinwheel relativ konstant ist. Unterschiede in der räumlichen Dichte der Pinwheels könnten dann einfach durch Unterschiede in der Dichte der Neuronen erklärt werden.
Neben den Modellen für neuronale Karten wurde im Rahmen dieser Dissertation auch ein Modell kortikaler Faltungen mit derselben neuronalen Platzierungsmethode erstellt. Die Existenz kortikaler Faltungen wird gemeinhin damit erklärt, dass der Kortex ohne Faltungen wegen seiner verhältnismäßig großen Oberfläche nicht in den Schädel gepackt werden könnte. Allerdings haben Experimente gezeigt, dass die Faltungen nicht durch eine Restriktion des wachsenden Kortex an der Schädeloberfläche entstehen, da auch mit mehr Platz für die Expansion des Kortex die gleichen Faltungsmuster exprimiert werden. Interessanterweise entstehen die kortikalen Faltungen erst, wenn die Proliferation der Neuronen während der Entwicklung größtenteils abgeschlossen ist und die Neuronen anfangen ihre Verbindungen auszubilden. Um kortikale Faltungen basierend auf der Konnektivität zwischen Neuronen im Modell vorherzusagen, genügt es das allgemeine Muster einer starken lokalen, aber schwachen globalen Konnektivität zwischen Neuronen nachzubilden. Abhängig von Variationen dieser Konnektivität, der Anzahl der kortikalen Kolumnen und der Neuronenanzahl innerhalb dieser Kolumnen, können im Modell viele Eigenschaften kortikaler Faltungsmuster in Säugetieren vorhergesagt werden. Ähnlich wie in Säugetieren ist der Faltungsgrad der vom Modell vorhergesagt wird von dem Verhältnis zwischen Parametern, die die Größe und Dicke des Kortex beschreiben, abhängig. Dementsprechend werden mehr und mehr Faltungen mit steigender Anzahl der Kolumnen, aber gleicher Anzahl von Neuronen pro Kolumne vorhergesagt. Wie in Säugetieren entstehen dabei auch die größeren primären Faltungen zuerst bevor es innerhalb der größeren Faltungen zu kleineren Faltungen höherer Ordnung kommt. Neben der Abhängigkeit des Faltungsgrads von der Größe des Kortex können Variationen in der Konnektivität erklären, wie es einerseits zu stereotypischen Faltungsmustern kommen kann, aber andererseits auch warum der Faltungsgrad zwischen verschiedenen Säugerordnungen unterschiedlich mit der Größe des Kortex skaliert. Letztlich könnten pathologische Veränderungen der Konnektivität zu den entsprechenden Änderungen im Faltungsmuster führen.
Insgesamt wurde in dieser Arbeit gezeigt, dass mittels einfacher Prinzipien, die die Verbindung zwischen Neuronen und deren relative Position zueinander beschreiben, komplexe neuroanatomische Strukturen vorhergesagt werden können. Da mit derselben Methode zur neuronalen Platzierung sowohl neuronale Karten als auch kortikalen Faltungen, also sehr unterschiedliche Strukturen vorhergesagt werden konnten, stellt sich die Frage, ob diese Strukturen durch einen gemeinsamen biologischen Mechanismus entstehen. Neuronale Zugkräfte sind ein möglicher Mechanismus, der die Entstehung kortikaler Faltungen erklären könnte. Auch wenn es eher unwahrscheinlich ist, dass die Entstehung neuronaler Karten von Zugkräften zwischen Neuronen abhängt, kann es nicht vollständig ausgeschlossen werden. Ob solche Kräfte an der Selbstorganisation neuronaler Netzwerke beteiligt sein könnten, ist eine interessante Fragestellung für zukünftige empirische Studien.
In Justice and Reconciliation in World Politics Catherine Lu endorses the idea that those who contribute to the reproduction of structural injustice have responsibilities to address that injustice (Lu, 2017). However, in the book, Lu does not explore the grounds and justification for recognising such a responsibility. In order to address this deficit, this paper proposes that those likely to contribute to the reproduction of structural injustice, in the future, have precautionary duties, in the present, that require them to take action aimed at preventing their future contribution. It is proposed that these ‘collectivization duties’ (Collins, 2013) require them to act responsively with a view to forming a collective that can end the structural injustice in question. This account recommends a collective-action solution alongside recognising that each socially connected agent is obliged to act. However, it does not entail that amorphous groups bear responsibilities and is appropriate in its attribution of blame, thus avoiding both Nussbaum’s (2011) critique of perpetually forward-looking accounts and the ‘agency objection’ (Wringe, 2010).
This article analyzes and criticizes the temporal orientation of Catherine Lu’s theory of colonial redress in Justice and Reconciliation in World Politics. Lu argues that colonial historic injustice can, with few exceptions, justify special reparative measures only if these past injustices still contribute to structural injustice in contemporary social relations. Focusing on Indigenous peoples, I argue that the structural injustice approach can and should incorporate further backward looking elements. First, I examine how Lu’s account has backward-looking elements not present in other structural injustice accounts. Second, I suggest how the structural injustice approach could include additional backward-looking features. I presuppose here, with Lu, that all agents connected to an unjust social structure have a forwardlooking political responsibility to reform this structure, regardless of their relation (or lack thereof) to victims or perpetrators of historic injustice. However, I suggest that agents with connections to historic injustice can occupy a social position that makes them differently situated than other agents within that same structure, leading to differences in how these agents should discharge their forward-looking responsibility and differentiated liability for failure to do so. Third, I argue that Lu obscures the importance of rectifying material dispossession. Reparations, pace Lu, can be justified beyond a minimum threshold of disadvantage. Theorists of settler colonialism and Indigenous scholars show how the dispossession of Indigenous land can be seen as a structure that has not yet ended. I conclude by arguing that rectification can be a precondition for genuine reconciliation.
Structural alienation: Lu's structural approach to reconciliation from within a relational framework
(2019)
In Justice and Reconciliation in World Politics Catherine Lu argues that structural reconciliation, rather than interactional reconciliation, ought to be the primary normative goal for political reconciliation efforts. I suggest that we might have good reason to want to retain relational approaches – such as that of Linda Radzik – as the primary focus of reconciliatory efforts, but that Lu’s approach is invaluable for identifying the parties who ought to bear responsibility for those efforts in cases of structural injustice. First, I outline Lu’s analysis of reconciliation, where she argues for the normative priority of structural approaches within the global political sphere, and propose that it will be useful to identify whether or not a relational account could instead identify underlying structural injustices. Second, I examine one particular relational account of reconciliation (based on Radzik’s account of atonement) and argue that this type of account brings to light underlying structural injustices of the kind Lu is concerned with. Finally, I identify an issue for relational accounts in identifying relevant responsible parties for reconciliation before returning to Lu’s structural account to address this gap.
Why do we need to communicate science? Is science, with its highly specialised language and its arcane methods, too distant to be understood by the public? Is it really possible for citizens to participate meaningfully in scientific research projects and debate? Should scientists be mandated to engage with the public to facilitate better understanding of science? How can they best communicate their special knowledge to be intelligible? These and a plethora of related questions are being raised by researchers and politicians alike as they have become convinced that science and society need to draw nearer to one another. Once the persuasion took hold that science should open up to the public and these questions were raised, it became clear that coming up with satisfactory answers would be a complex challenge. The inaccessibility of scientific language and methods, due to ever increasing specialisation, is at the base of its very success. Thus, translating specialised knowledge to become understandable, interesting and relevant to various publics creates particular perils. This is exacerbated by the ongoing disruption of the public discourse through the digitisation of communication platforms. For example, the availability of medical knowledge on the internet and the immense opportunities to inform oneself about health risks via social media are undermined by the manipulable nature of this technology that does not allow its users to distinguish between credible content and misinformation. In countries around the world, scientists, policy-makers and the public have high hopes for science communication: that it may elevate its populations educationally, that it may raise the level of sound decision-making for people in their daily lives, and that it may contribute to innovation and economic well-being. This collection of current reflections gives an insight into the issues that have to be addressed by research to reach these noble goals, for South Africa and by South Africans in particular.
Over the past fifteen years, Weaver Press has published seven anthologies of some one hundred short stories giving voice to new and established Zimbabwean writers. In Windows into Zimbabwe Franziska Kramer and Jürgen Kramer have selected from these anthologies twenty-three stories, which they consider the best or most representative of a particular period in the Zimbabwean narrative since 1980. They present the stories within sections which frame certain themes such as Independence, Gukurahundi, Land, Gender Relations, Money Matters, Social Relations, Exile and Resilience. For the general reader, Windows into Zimbabwe contains some wonderful stories rich in insight, perception, nuance and humour. Writers such as Charles Mungoshi, Petina Gappah, NoViolet Bulawayo, Valerie Tagwira and Shimmer Chinodya are included as well as relative newcomers with new perceptions and fresh voices. The compilers have also provided an introductory overview casting light on the relationship between fiction and society; and for teachers(in schools, colleges and universities) each story is accompanied by explanatory notes, questions and study tasks to further the reader's understanding. Windows into Zimbabwe will positively deepen your appreciation of the country and its people.
African visionaries
(2019)
In over forty portraits, African writers present extraordinary people from their continent: portraits of the women and men whom they admire, people who have changed and enriched life in Africa. The portraits include inventor, founders of universities, resistance fighters, musicians, environmental activists or writers. African Visionaries is a multi-faceted book, seen through African eyes, on the most impactful people of Africa. Some of the writers contributing to the collection are: Helon Habila, Virginia Phiri, Ellen Banda-Aaku, Véronique Tadjo, Tendai Huchu, Solomon Tsehaye, Patrice Nganang and Sami Tchak.
In this remarkable volume covering diverse subjects, in a span of three decades, Kenneth R. Ross articulates his views on the meaning and practice of Christian mission and challenges the binary view of mission that prevailed before the 1950s. He further reflects on Scotland's experiences in the world-wide Christian mission and demonstrates the centrality of Africa in any discourse on Christianity. This volume is invaluable in its argument for a rethinking of Christian mission especially in relation to the West, which is now a new frontier for Christian mission. The book will be immensely beneficial to students of missiology and general readers who are interested in the subject of Christian Mission.
This paper discusses two possible difficulties with Catherine Lu’s powerful analysis of the moral response to our shared history of colonial evil; both of these difficulties stem from the rightful place of shame in that moral response. The first difficulty focuses on efficacy: existing states may be better motivated by shame at the past than by a shared duty to bring about a just future. The second focuses on equity: it is, at the very least, possible that shame over past misdeeds ought to be brought into the conversation about present duties, in a manner more robust than Lu’s analysis allows.
The green building evolution
(2019)
The Green Building Evolution illuminates global examples and makes use of case studies mainly from South Africa. This book is in five parts: Part I is a single introductory chapter centred on the evolution of the green building movement; Part II addresses the green building terrain; Part III presents selected case studies; Part IV focuses on chapters that address pushing the boundaries in the green building space; while Part V presents emerging trends and policy perspectives. Further details are contained in the main body of the book. It is our sincere hope that readers will experience the book as an informative and ground-breaking adventure. Written by 14 authors from different academic disciplines and areas of specialisation, the book comes as the sixth in a series that addresses global and national concerns on climate change, sustainable development and the green economy transition agenda. The book series is conceptualised and coordinated by the Exxaro Chair in Business and Climate Change, led by Prof. Godwell Nhamo and hosted by the Institute for Corporate Citizenship (ICC) at the University of South Africa (UNISA). The books are published by the Human Sciences Research Council (HSRC) through the Africa Institute of South Africa.
Phenomenology of decolonizing the university : essays in the contemporary thoughts of afrikology
(2019)
The epistemic Eurocentric boarders, expand towards the global south, they dehumanise and obliterate existing forms of thinking through colonialism and coloniality. In doing so, the global south has lost the sense of being self, Africans have become non-thinking objects. This has led to a series of ceaseless conflicts, poor leadership, and developmental crisis and provides fertile ground for Eurocentric superiority. This book Phenomenology of Decolonizing the University: Essays in the Contemporary Thoughts of Afrikology is a diagnosis of the problems of the mind in the global south and provides solutions in the decolonisatiom of the mind such as humanising the university, the rewriting of African stories and facilitates an epistemic rebellion.
This book outlines the contribution of the Missionary Sisters of the Immaculate Conception (MIC Sisters) towards girl child education in Malawi with particular focus on the establishment, growth and development of Marymount Girls' Secondary School in Mzuzu., from 1963 to 2010. The appraisal by former students of Marymount, reveals the courage of the pioneering Sisters towards the empowerment of fellow women in places where they were sent to evangelize in spite of numerous challenges that they encountered in the process. The history of Marymount shows that education of the girl child provides a viable means to development and improvement of life at family, nation and world level.
Handwell Yotamu Hara (*1942) was an ordinary boy from a village in Mzimba in Malawi. Though his parents were illiterate he was inspired through education and faith to become a primary school teacher and also earned a PhD from Pretoria University and later became a lecturer at Zomba Theological College and ?nally at Mzuzu University. This small autobiography is just one offered as part of the ongoing commitment by Mzuni Press to encourage Malawians to read meaningful books on a range of subjects reflecting their countrys society and culture.
This paper addresses the phenomenon of climate-induced displacement. I argue that there is scope for an account of asylum as compensation owed to those displaced by the impacts of climate change which needs only to appeal to minimal normative commitments about the requirements of global justice. I demonstrate the possibility of such an approach through an examination of the work of David Miller. Miller is taken as an exemplar of a broadly ‘international libertarian’ approach to global justice, and his work is a useful vehicle for this project because he has an established view about both responsibility for climate change and about the state’s right to exclude would-be immigrants. In the course of the argument, I set out the relevant aspects of Miller’s views, reconstruct an account of responsibility for the harms faced by climate migrants which is consistent with Miller’s views, and demonstrate why such an account yields an obligation to provide asylum as a form of compensation to ‘climate migrants.’
VJD Newsletter (1-3-2019)
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VJD Newsletter (1-2-2019)
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VJD Newsletter (1-1-2019)
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IFLS-Journal. Nr. 24, 2019
(2019)
Rezension zu Literary Activism. Perspectives. Ed. Amit Chaudhuri. New Delhi: Oxford University Press, 2017. 369 pp.
Das Oberverwaltungsgericht für Nordrhein-Westfalen hat am 19. März eine für die rechtsstaatliche Prägung deutscher Außenpolitik sehr bedeutsame Entscheidung getroffen. Demnach muss sich die Bundesrepublik in Zukunft vergewissern, ob durch den Einsatz von US-Drohnen, die über deutsches Gebiet gesteuert werden, Völkerrecht verletzt wird. Ist dies der Fall, muss sie Maßnahmen treffen, damit eine solche Rechtsverletzung unterbleibt. Ein einfaches Wegducken der Bundesrepublik ist damit nicht mehr möglich. ...
Anaerobic ammonium oxidation (anammox) is a major process in the biogeochemical nitrogen cycle in which nitrite and ammonium are converted to dinitrogen gas and water through the highly reactive intermediate hydrazine. So far, it is unknown how anammox organisms convert the toxic hydrazine into nitrogen and harvest the extremely low potential electrons (−750 mV) released in this process. We report the crystal structure and cryo electron microscopy structures of the responsible enzyme, hydrazine dehydrogenase, which is a 1.7 MDa multiprotein complex containing an extended electron transfer network of 192 heme groups spanning the entire complex. This unique molecular arrangement suggests a way in which the protein stores and releases the electrons obtained from hydrazine conversion, the final step in the globally important anammox process.
Literature about Mesitiinae Kieffer, 1914 has not been treated extensively from a taxonomic viewpoint in comparison with other subfamilies in Bethylidae Latreille, 1802. Our research on species of Metrionotus Móczár, 1970, Clytrovorus Nagy, 1972 and Sulcomesitius Móczár, 1970 revealed a new hypopygium shape pattern, namely a 'star-shaped' hypopygium, which is characteristic of a new genus, Astromesitius gen. nov., with two new species Astromesitius thionyi gen. et sp. nov. and Astromesitius olavoi gen. et sp. nov. The descriptions of both new species are based on male specimens collected in Thailand and the United Arab Emirates. Astromesitius quatei (Móczár, 1977) gen. et comb. nov. is designated as type species for the new genus, which is erected for a total of seven species. The main diagnostic characteristics are the head longer than wide; a clypeus with a median lobe quadrate; an antenna with distinct long setae, with pedicel caliciform, and with flagellomeres long and caliciform; pronotum and anteromesoscutum with longitudinal sulcus indistinct or absent; metapectal-propodeal complex with posterior projection hardly distinct or absent; hypopygium star-shaped; genitalia with aedeagus slender and fusiform.
Background: The number of Mesenchymal Stem/Stromal Cells (MSCs) in the human bone marrow (BM) is small compared to other cell types. BM aspirate concentration (BMAC) may be used to increase numbers of MSCs, but the composition of MSC subpopulations and growth factors after processing are unknown. The purpose of this study was to assess the enrichment of stem/progenitor cells and growth factors in BM aspirate by two different commercial concentration devices versus standard BM aspiration.
Methods: 120 mL of BM was aspirated from the iliac crest of 10 male donors. Each sample was processed simultaneously by either Emcyte GenesisCS® (Emcyte) or Harvest SmartPReP2 BMAC (Harvest) devices and compared to untreated BM aspirate. Samples were analyzed with multicolor flow cytometry for cellular viability and expression of stem/progenitor cells markers. Stem/progenitor cell content was verified by quantification of colony forming unit-fibroblasts (CFU-F). Platelet, red blood cell and total nucleated cell (TNC) content were determined using an automated hematology analyzer. Growth factors contents were analyzed with protein quantification assays. Statistical analyses were performed by ANOVA analysis of variance followed by Tukey’s multiple comparison test or Wilcoxon matched-pairs signed rank test with p < 0.05 for significance.
Results: Cell viability after processing was approximately 90% in all groups. Compared to control, both devices significantly enriched TNCs and platelets, as well as the CD45−CD73+ and CD45−CD73+CD90+ cell populations. Further, Harvest significantly concentrated CD45−CD10+, CD45−CD29+, CD45−CD90+, CD45−CD105+, CD45−CD119+ cells, and CD45dimCD90+CD271+ MSCs, whereas Emcyte significantly enriched CD45dimCD44+CD271+ MSCs. BM concentration also increased the numbers of CFU-F, platelet-derived growth factor, vascular endothelial growth factor, macrophage colony-stimulating factor, interleukin-1b, VCAM-1 and total protein. Neither system concentrated red blood cells, hematopoietic stem cells or bone morphogenetic proteins.
Conclusion: This data could contribute to the development of BMAC quality control assays as both BMAC systems concentrated platelets, growth factors and non-hematopoietic stem cell subpopulations with distinct phenotypes without loss of cell viability when compared to unprocessed BM.
During the past 15 years there have been dramatic changes in the medical landscape, particularly in oncology and regenerative medicine. Cell therapies have played a substantial part in this progress. Cellular immunotherapies can use immune cells, such as T cells or natural killer cells that, after functional modification ex vivo, exert powerful anti-cancer effects when given to the patient. Innovative technologies, such as re-programming terminally differentiated cells into pluripotent stem cells or into other cell types and applying specific enzymes to more precisely edit the human genome, are paving the way towards more potent cell and gene therapies.
Mesenchymal stromal cells are promising cellular immunotherapeutics, which also have potential for use in tissue engineering strategies and other regenerative medicine applications. However, substantial gaps in our knowledge of their biology and therapeutic efficacy present major challenges to their sustainable implementation in the clinical routine.
In this article, progress in the field of cell therapeutics during the past 15 years will be briefly discussed, with a focus on mesenchymal stromal cells, highlighting the impact of this field on patient care.
Gram‐negative bacteria are intrinsically resistant against cytotoxic substances by means of their outer membrane and a network of multidrug efflux systems, acting in synergy. Efflux pumps from various superfamilies with broad substrate preferences sequester and pump drugs across the inner membrane to supply the highly polyspecific and powerful tripartite resistance–nodulation–cell division (RND) efflux pumps with compounds to be extruded across the outer membrane barrier. In Escherichia coli, the tripartite efflux system AcrAB–TolC is the archetype RND multiple drug efflux pump complex. The homotrimeric inner membrane component acriflavine resistance B (AcrB) is the drug specificity and energy transduction center for the drug/proton antiport process. Drugs are bound and expelled via a cycle of mainly three consecutive states in every protomer, constituting a flexible alternating access channel system. This review recapitulates the molecular basis of drug and inhibitor binding, including mechanistic insights into drug efflux by AcrB. It also summarizes 17 years of mutational analysis of the gene acrB, reporting the effect of every substitution on the ability of E. coli to confer resistance toward antibiotics (http://goethe.link/AcrBsubstitutions). We emphasize the functional robustness of AcrB toward single‐site substitutions and highlight regions that are more sensitive to perturbation.
Mit dem "Prager Erbe" bezeichnete Weiskopf eine interkulturelle Kompetenz, die er vor allem auf historische und kulturgeschichtliche Ereignisse der tschechischen, jüdischen und schließlich auch deutschen Nationalitäten in den böhmischen Ländern bezieht. Die Kompetenz, die er hier für das Werk Kischs herstellte, lässt sich für Weiskopfs eigenes Schaffen herausarbeiten. Es wird davon ausgegangen, dass er in seinem Leben und Werk als Mittler tschechischer Kultur wirkte, wobei sich dieser Beitrag auf die Exilzeit Weiskopfs konzentriert. Nach einer kurzen Darstellung der Flucht und Ankunft in dem Exilort New York steht zunächst Weiskopfs journalistisches Schaffen im Mittelpunkt des Beitrages. Dieses wird unter dem Aspekt der Darstellung von Eigenem und Fremden, also dem amerikanischen Exilland und der Prager Herkunft, untersucht. Die weiteren Teile des Beitrags konzentrieren sich auf die Korrespondenzen mit Heinrich Mann und Egon Erwin Kisch. Mann erbittet Weiskopfs Meinung zu seinem Werk Lidice und abschließend wird in der Korrespondenz zwischen Weiskopf und Kisch die Diskussion über die Heimkehr in die alte Prager Heimat nach Beendigung des Weltkrieges dargestellt.