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The total stratospheric organic chlorine and bromine burden was derived from balloon-borne measurements in the tropics (Teresina, Brazil, 5°04´ S, 42°52´ W) in 2005. Whole air samples were collected cryogenically at altitudes between 15 and 34 km. For the first time, we report measurements of a set of 28 chlorinated and brominated substances in the tropical upper troposphere and stratosphere including ten substances with an atmospheric lifetime of less than half a year. The substances were quantified using pre-concentration techniques followed by Gas Chromatography with Mass Spectrometric detection. In the tropical tropopause layer at altitudes between 15 and 17 km we found 1.1–1.4% of the chlorine and 6–8% of the bromine to be present in the form of very short-lived organic compounds. By combining the data with tropospheric reference data and age of air observations the abundances of inorganic chlorine and bromine (Cly and Bry) were derived. At an altitude of 34 km we calculated 3062 ppt of Cly and 17.5 ppt of Bry from the decomposition of both long- and short-lived organic source gases. Furthermore we present indications for the presence of additional organic brominated substances in the tropical upper troposphere and stratosphere.
Although Walter Benjamin was never timid when it came to writing, one practice he consistently avoided was that of creating neologisms. It is therefore with all the more reluctance that I find myself compelled to resort to something similar, in order to sum up a motif that has imposed itself over the years in my reading of Benjamin. What is involved is, to be sure, not exactly a neologism, since it does not involve the creation of a new word, but rather the highlighting of a word-part, a suffix (eine Nachsilbe). In English, to be sure, this suffix, when spoken, is indistinguishable from a word: what distinguishes it from a word is not audible, but only legible: a hyphen, marking a separation that is also a joining, a 'Bindestrich' that does not bind it to anything in particular and yet that requires it to be bound to something else. The suffix in question thus sounds deceptively familiar, since it coincides, audibly, with the word "abilities". However, unlike that word, its first letter - which purely by accident happens to be the first letter of the alphabet--is preceded by a dash. When written in isolation, this gives it a somewhat bizarre appearance, to be sure, since suffixes are not usually encountered separately from the words they modify. But this bizarre appearance pales when compared to its German 'original'. If the book of essays to be published in English under the title, "Benjamin’s -abilities," is ever translated into German - "back" into German I was tempted to write, since German here is of course the language in which Benjamin wrote and in which I generally read him - then its title, were it to be entirely faithful to the English, would indeed have to involve the creation of a neologism. For translated back into German, the German title would require its readers to "read, what was never written", namely: "Benjamins -barkeiten" (written, "Bindestrich- b--kleingeschrieben").
In a letter to Scholem, dated 22 December, 1924, Benjamin famously writes of the manuscript that was to become his 'Trauerspiel' book: "[I]ndessen überrascht mich nun vor allem, daß, wenn man so will, das Geschriebene fast ganz aus Zitaten besteht" (GS I.3, 881). Much has been made of the mosaic-like citational technique to which Benjamin refers here; his "Zitatbegriff" is said, for example, to subtend the theory of a "mikrologische Verarbeitung" of "Denkbruchstücken" into "Ideen" that Benjamin develops as his theory of representation in the "Erkenntniskritische Vorrede", which in turn figures the relation between individual phenomena and their "ideas" in astral terms. Because, however, the 'Trauerspiel' book is so often understood only on this theoretical level, e.g. as either an early articulation of Benjamin’s "avant garde" and "messianic" philosophy of history (Jäger, Kany, and Pizer) or as a performance of his systems of allegory (Menninghaus) and "constructivism" (Schöttker), his "Zitierpraxis" and the actual citations that form large parts of 'Der Ursprung des deutschen Trauerspiel' have seldom been read for the purchase they provide on the vexed status of the period and concept that was the book’s direct subject, namely, the German Baroque.
The 14 known localities of Coenagrion armatum in Ukraine are listed and the 27 dragonfly species recorded are presented. An expedition devoted to revisit 10 of them in spring 2007 did not result in a confirmation at any of them. Here, all localities are described in detail and possible reasons for the absence of the species are discussed. These include habitat alterations because of anthropogenic impact, such as agricultural activity, as well as decreasing competitiveness against Mediterranean species that spread in response to altered climatic conditions. Proposed measures of conservation of C. armatum in Ukraine include a) the inclusion into the Red Data Book of Ukraine under category I (Endangered) and b) additional studies, monitoring and habitat conservation.
Twenty-eight Odonata species were recorded in the Poliskyi Nature Reserve (Zhytomyr oblast’, North Ukraine) in 2006 and 2007, 18 of which were reported for the first time from this location. This included such rare species as Somatochlora arctica (second record in the Ukraine, first record for 100 years), Leucorrhinia dubia, Leucorrhinia rubicunda and Leucorrhinia albifrons. A breeding site and a dense population of Nehalennia speciosa were found in a bog near the river. Zholobnytsya. The record of Orthetrum coerulescens is the northernmost in Ukraine.
The claim of this paper is that embedded definites can, despite the appearances, be accounted for on the uniqueness approach. Far from being a surprise, we argue that the behavior of embedded definites is actually expected once two independent facts are taken into account: the ability of noun phrases to take scope, i.e., to be interpreted in a different place from their syntactic position, and the interaction of presuppositions and scope-taking elements. Specifically, we analyze embedded definites as a case of inverse linking (Gabbay and Moravscik, 1974; May, 1977): the embedded definite takes scope over the embedding one. The presupposition of the embedded definite is weakened as a result of the independently motivated process of intermediate accommodation (Kratzer, 1989; Berman, 1991). In our case, this process transfers the presupposition of the embedding definite into the restrictor of the embedded one.
Like other scope-taking processes, inverse linking is generally taken to be subject to locality constraints: if a syntactic island, such as a finite clause boundary, intervenes in the path of a scope-taking element, then the resulting reading is unavailable or degraded (Rodman, 1976). Since our account views embedded definites as cases of inverse linking, we predict that inserting an island into an embedded definite, all else being equal, should lead to a similar degradation. We report results from an online survey with 800 participants that confirm this prediction.
The paper presents an additional argument for a specific account of semantic binding: the flat-binding analysis. The argument is based on observations concerning sloppy interpretations in verb phrase ellipsis when the binder is not the subject of the elided VP. In one such case, it is important that one of the binders belong to the domain of the other. This case can be derived from the flat-binding analysis as is shown in the paper, while it is unclear how to account for it within other analyses of semantic binding.
The purpose of this phase III clinical trial was to compare two different extracellular contrast agents, 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine, for magnetic resonance imaging (MRI) in patients with known or suspected focal renal lesions. Using a multicenter, single-blind, interindividual, randomized study design, both contrast agents were compared in a total of 471 patients regarding their diagnostic accuracy, sensitivity, and specificity to correctly classify focal lesions of the kidney. To test for noninferiority the diagnostic accuracy rates for both contrast agents were compared with CT results based on a blinded reading. The average diagnostic accuracy across the three blinded readers (‘average reader’) was 83.7% for gadobutrol and 87.3% for gadopentate dimeglumine. The increase in accuracy from precontrast to combined precontrast and postcontrast MRI was 8.0% for gadobutrol and 6.9% for gadopentate dimeglumine. Sensitivity of the average reader was 85.2% for gadobutrol and 88.7% for gadopentate dimeglumine. Specificity of the average reader was 82.1% for gadobutrol and 86.1% for gadopentate dimeglumine. In conclusion, this study documents evidence for the noninferiority of a single i.v. bolus injection of 1.0 M gadobutrol compared with 0.5 M gadopentate dimeglumine in the diagnostic assessment of renal lesions with CE-MRI.
„Great writers,“ those who constitute our canon (at any given moment, one should add warily, since aesthetic canons fluctuate considerably over time), have invariably been the focus of reception studies, partly because they provide the most fertile ground for research, but partly also because literary scholars (and in particular the aspiring doctoral candidate: I myself graduated with an influence /reception study of this kind) need some justification for their endeavors, and what better ticket into the ivory rower - or onto the book market - than the study of the most seminal and widely accepted authors? James Joyce is just such a „great author.“ And „James Joyce and German Literature,“ the subject of this essay, must inevitably result in some form of reception study. But just what form should it take? Within the limited space of one article, it would be impossible to survey in toto Joyce's influence on German literature; that is, the multiple receptions of Joyce by some four or five generations of authors writing in German.
A list of all liverworts and mosses reported from the Maltese Islands with references has been compiled from the literature, which includes 23 species of liverworts and hornworts as well as 96 taxa of mosses. The list is completed by the results of a bryological fieldtrip in March 2008. During this trip, 14 species of liverworts and 40 species of mosses were collected, of which Cephaloziella baumgartneri, Didymodon luridus, Fissidens gracilifolius, Fossombronia echinata, Funaria pulchella, Riccia cavernosa and Weissia fallax are new to Malta. This raises the number of species known from the Maltese Islands to 23 horn- and liverworts and 100 mosses.
In 2007, a project named Adriatic Montenegro 2007 was initiated and realised under the protection of IDF. Stimulated by the suggestion of Vincent Kalkman from the European Invertebrate Survey, The Netherlands, distribution data for the Odonata of Adriatic Montenegro were collected and used to create distribution maps. These data and maps should then be used in the evaluation of conservation measures for individual odonate species as well as for the IUCN Red List of the Mediterranean countries (organized by the IUCN Centre for Mediterranean Cooperation) and the Project on an atlas of European dragonflies (a co-operation of all European countries organised by the European Invertebrate Survey, The Netherlands).
In July 2005, Rafal Bernard requested Oleg Kosterin to collect some samples of Nehalennia speciosa from West Siberia for a DNA analysis. Oleg replied that so far he had only seen one individual of this species 25 years ago, but asked in which habitats it should be sought for exactly. Rafal sent him a draft of his paper (Bernard & Wildermuth, 2005) devoted to this subject. Having read it, Oleg came to the conclusion that this habitat (shallow water with Sphagnum and Carex limosa or C. lasiocarpa) might occupy the largest area in the world just in the boggy West Siberian Plain. Personal consultation with the geobotanist Dr. Nikolai Lashchinskii confirmed this notion. Then an almost automatic supposition followed that this area may serve as the main reservoir of N. speciosa, considered a local and endangered species in Western and Central Europe. At the same time, the existing records of N. speciosa from West Siberia were remarkably scarce. It was known from the Khanty-Mansi Autonomous Region (basins of the Tura and Konda Rivers), a small number of records from North Altai and adjacent areas north of it, a record from the steppe zone of Novosibirsk Province (Karasuk), a record in the basin of the Tuba River (Krasnoyarskii Krai), and a dubious old record from Omsk (see the map in Belyshev (1973) and a review in Bernard & Wildermuth (2005)). There was no record from the boggy Irtysh-Ob’ interfluve, where we would expect the species to flourish. This could be explained by the lack of attention by odonatologists to that interesting area. In these circumstances, the project of a special expedition(-s) was put forward, aimed to check the presence, pattern of distribution, abundance and habitat preferences of N. speciosa in these areas. For a decisive expedition we chose the Vasyugan Bog, the largest bog in the world, more precisely its north-eastern margin where we could find a good base in Plotnikovo village, Bakchar District, Tomsk Province.
This paper presents a novel model of the lending process that takes into account that loan officers must spend time and effort to originate new loans. Besides generating predictions on loan officers’ compensation and its interaction with the loan review process, the model sheds light on why competition could lead to excessively low lending standards. We also show how more intense competition may fasten the adoption of credit scoring. More generally, hard-information lending techniques such as credit scoring allow to give loan officers high-powered incentives without compromising the integrity and quality of the loan approval process.
We investigate methods and tools for analyzing translations between programming languages with respect to observational semantics. The behavior of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
We investigate methods and tools for analysing translations between programming languages with respect to observational semantics. The behaviour of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
We investigate methods and tools for analysing translations between programming languages with respect to observational semantics. The behaviour of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
This paper proves several generic variants of context lemmas and thus contributes to improving the tools for observational semantics of deterministic and non-deterministic higher-order calculi that use a small-step reduction semantics. The generic (sharing) context lemmas are provided for may- as well as two variants of must-convergence, which hold in a broad class of extended process- and extended lambda calculi, if the calculi satisfy certain natural conditions. As a guide-line, the proofs of the context lemmas are valid in call-by-need calculi, in callby-value calculi if substitution is restricted to variable-by-variable and in process calculi like variants of the π-calculus. For calculi employing beta-reduction using a call-by-name or call-by-value strategy or similar reduction rules, some iu-variants of ciu-theorems are obtained from our context lemmas. Our results reestablish several context lemmas already proved in the literature, and also provide some new context lemmas as well as some new variants of the ciu-theorem. To make the results widely applicable, we use a higher-order abstract syntax that allows untyped calculi as well as certain simple typing schemes. The approach may lead to a unifying view of higher-order calculi, reduction, and observational equality.
We present a higher-order call-by-need lambda calculus enriched with constructors, case-expressions, recursive letrec-expressions, a seq-operator for sequential evaluation and a non-deterministic operator amb that is locally bottom-avoiding. We use a small-step operational semantics in form of a single-step rewriting system that defines a (nondeterministic) normal order reduction. This strategy can be made fair by adding resources for bookkeeping. As equational theory we use contextual equivalence, i.e. terms are equal if plugged into any program context their termination behaviour is the same, where we use a combination of may- as well as must-convergence, which is appropriate for non-deterministic computations. We show that we can drop the fairness condition for equational reasoning, since the valid equations w.r.t. normal order reduction are the same as for fair normal order reduction. We evolve different proof tools for proving correctness of program transformations, in particular, a context lemma for may- as well as mustconvergence is proved, which restricts the number of contexts that need to be examined for proving contextual equivalence. In combination with so-called complete sets of commuting and forking diagrams we show that all the deterministic reduction rules and also some additional transformations preserve contextual equivalence.We also prove a standardisation theorem for fair normal order reduction. The structure of the ordering <=c a is also analysed: Ω is not a least element, and <=c already implies contextual equivalence w.r.t. may-convergence.
In this study I analysed past and recent Daphnia populations from Lake Constance and Greifensee. Herefore, I first established a set of microsatellite markers applicable to European Hyalodaphnia species (chapter 1). Primers were also identified for species specific fragment lengths. 32 markers were then available to characterize the resting egg banks of Daphnia galeata and D. hyalina. Chapter 2 presents the reconstruction of the taxonomic composition in these two ecologically different lakes. This part of my work shows that the eutrophication that occurred in both lakes in the mid of the last century has strongly influenced the Daphnia populations. In both lakes Daphnia galeata established and hybridized with the indigenous D. hyalina. Interspecific hybridization resulted in introgression on the mitochondrial and nuclear level. In chapter 3 resting eggs from the sediments of the 1960s, 1970s, 1980s, 1990s and 2000s were characterized with microsatellite markers. The aim was to specify the extent of interspecific hybridization and nuclear introgression assuming that the genetic exchange between both species has an impact on their adaptation to their habitat. In life history experiments D. galeata and D. galeata x hyalina clones hatched from different time periods showed significant differential responses to food quality. Therefore, the question had to be answered how the Daphnia resting egg bank and the planktonic population are connected. In chapter 4 hatching experiments were conducted to bridge this gap of scientific knowledge in the life cycle of cyclic parthenogenetic waterfleas. Only D. galeata individuals were able to establish a clonal lineage after maturity. All observed recombinant individuals did not reproduce at all or firstly went through another sexual phase of reproduction i.e. produced resting eggs. In order to compare the findings of chapter 4 with the taxon composition of the recent planktonic population of Daphnia in Lake Constance, samples were taken over one season (between May 2005 and September 2006). During the season, the taxonomic composition of Daphnia changes severely with D. galeata being most abundant during the warm season and D. hyalina in the cold season. Moreover, some individuals were detected, that did not follow this pattern. With mitochondrial analysis those individuals were identified as mitochondrial introgressants and processed to life history experiments. Significant differences in the somatic growth rate under different temperatures (5°C, 12.5°C and 20°C) were related to the origin of the mitochondrial genome rather than the nuclear taxonomic assignment of the individual.
The findings of this study show that all organisms exposed to rapid ecological changes and their microevolutionary reaction to those.
G. A. Cohen argues that John Rawls’s focus on the basic structure of society as the exclusive subject of social justice is misguided. I argue that two understandings of the notion of basic structure seem to be present in the literature, either in implicit or in explicit terms. (1) According to the first, the basic structure is to be equated with a given set of institutions: if they endorse the right principles of justice, the basic structure of society is just; (2) According to the second, a society has a just basic structure if and only if its institutional web manages to realize the relevant principles of justice as well it can. In (2), the institutional structure is not a given: different social circumstances call for different institutional solutions in order to achieve a just basic structure overall. The first part of the paper make a case for (2), and explores some of its normative implications. The second part asks which consequences this understanding may have for the idea of a global basic structure.
Much of the recent philosophical literature about distributive justice and equality in the domestic context has been dominated by a family of theories now often called ‘luck egalitarianism’, according to which it is unfair if some people are worse off than others through no choice or fault of their own. This principle has also found its way into the literature about global justice. This paper explores some difficulties that this principle faces: it is largely insensitive to the causes of global inequality, and it is so demanding that it can only give rise to weak moral claims. I go on to argue that a) understanding justice claims as merely weak claims rests on an implausible and impractical concept of justice, and b) using the global luck egalitarian argument in practical discourse is likely to lead to misunderstanding, and to be counterproductive if the aim is to tackle global inequality. While these considerations do not suffice to make a conclusive case against the luck egalitarian principle, they should be acknowledged by global luck egalitarians – as some similar problems have indeed been by domestic luck egalitarians – and need to be addressed.
In left critiques of globalization, it is often argued that liberal-egalitarian principles are inadequate for thinking about and struggling for global justice; that they are, in fact, part of the problem. For the case of identity politics as a left alternative, the paper points at two fallacies in this notion, regarding two ‘liberal’ elements: individualism and universalism. The paper examines groupidentity claims in far right conceptions of global injustice, and shows that cultural diversity of groups does not necessitate or even favour equality and democratic participation. It then examines the left group-based claims in the global justice discourse, showing that the aspirations for equality and freedom assume the liberal notions that have been often rejected as inadequate. The paper concludes that this ambivalent position undermines the democratic and egalitarian aspirations of left critiques of the global order. The analysis is based on manifestos and publications of political parties and movements in Western Europe (France, Germany and Austria).
Rhetoric and global justice
(2008)
Activists have long recognized the importance of rhetoric and emotional appeal in building support for the global justice movement. However, many political theorists worry that the use of rhetoric may obstruct clear presentation of the issues at stake, and may result in our policies being determined by where the sympathies of the best rhetoricians lie. In this article I examine the ways in which contemporary theorists try to accommodate the need for rhetoric and emotional appeal, and I argue that their attempts are unsatisfactory because they view rhetoric as a tool or skill that can be used to manipulate people to support any position. Yet if we question the sharp separation between rhetoric and reason, then the aims of building support for a cause, identifying the causes we ought to support, and treating others with respect need no longer conflict. Re-examining the radical liberal theories of J.S. Mill, L.T. Hobhouse and J.A. Hobson, will help us to see how this separation might be questioned and rhetoric recovered as a respectful and respectable form of argument.
The origin and justification of human rights, whether anchored in biological theory, natural law theory, or interests theory, as well as their cultural specificity and actual value as international legal instruments are subject to ongoing lively debates. As theoretical and rhetorical discourses challenge and enrich current understanding of the value of human rights and their relevance to democratic governance, they have found their way into public health in recent decades and play today an increasing role in the shaping of health policies, programs and practice. Human rights define the obligations of states to their people and towards each other, create grounds for governmental accountability and inspire recognition of, and action on, factors influencing people’s attainment of the highest possible standard of health. This article highlights the evolution that has brought health and human rights together in mutually reinforcing ways. It draws from the experience gained in the global response to HIV/AIDS, summarizes key dimensions of public health and of human rights and suggests a manner in which these dimensions intersect in a framework for analysis and action.
Every day thousands of people die from poverty-related causes. Many of these deaths could be avoided if appropriate medical treatments were available to the world’s poor. Due to the current structure of the international patent regime, they are not. Since the risks and costs associated with pharmaceutical innovation are extremely high, to incentivise research, inventor firms are granted a temporary monopoly over newly invented drugs. While allowing firms to make up for the costs of research, this has the morally perverse effect of raising the prices of pharmaceuticals to a level where they become unaffordable to the world's poor. To correct this grievous flaw, the paper proposes a concrete and realistic alternative scheme which, by rewarding medical innovators in proportion to the impact of their drugs on the global disease burden, would incentivise the production and selling of crucial drugs for the world’s poor at prices accessible to them.
In this article, we illustrate the flexibility of the algebraic integration formalism introduced in M. Gubinelli (2004), Controlling Rough Paths, J. Funct. Anal. 216, 86-140, by establishing an existence and uniqueness result for delay equations driven by rough paths. We then apply our results to the case where the driving path is a fractional Brownian motion with Hurst parameter H > 1/3.
It has been established since Kanerva’s work that focus conditions phrasing – directly or indirectly – in several other Bantu languages, e.g. Chimwiini (Kisseberth 2007, Downing 2002, Kisseberth & Abasheikh 2004), Xhosa (Jokweni 1995, Zerbian 2004), Chitumbuka (Downing 2006, 2007), Zulu (Cheng & Downing 2006, Downing 2007), Bemba (Kula 2007), etc.
In this paper, I will argue that focus also conditions phrasing in Shingazidja, a Bantu language3 spoken on Grande Comore (or Ngazidja, the largest island of the Comoros).
Many works have been dedicated to the tonology of Shingazidja. The bases of the system were firstly identified by Tucker & Bryan (1970) and reanalyzed by Philippson (1988). Later, Cassimjee & Kisseberth (1989, 1992, 1993, 1998) provide a very convincing analysis of the whole system of the language, and my own research (Patin 2007a) shows a great correspondence with their results. However, little attention has been paid by these authors or others (Jouannet 1989, Rey 1990, Philippson 2005) to the phonology-pragmatics interface, especially on the relation between focus and phrasing. This paper thus proposes to explore this question. It will be claimed that focus, beside syntax, has an influence on phrasing in Shingazidja.
We present the results of an experimental study which targets prosodic correlates of subclausal quotation marks. We found that written sentences containing passages enclosed by quotation marks were read aloud in a manner that significantly differs in prosody from spoken realizations of corresponding disquoted counterparts. However, we also observed that such prosodic marking of subclausal quotation wasn't strong enough to survive subsequent back-translation into written language: there was no correlation between the presence/absence of quotation marks in the original written examples, and the presence/absence of quotation marks in corresponding back-translations from oral renditions. We investigated three different kinds of uses of quotation marks and found no systematic difference between them with respect to prosodic marking.
Rate effects on aerodynamics of intervocalic stops : evidence from real speech data and model data
(2008)
This paper is a first attempt towards a better understanding of the aerodynamic properties during speech production and their potential control. In recent years, studies on intraoral pressure in speech have been rather rare, and more studies concern the air flow development. However, the intraoral pressure is a crucial factor for analysing the production of various sounds.
In this paper, we focus on the intraoral pressure development during the production of intervocalic stops.
Two experimental methodologies are presented and confronted with each other: real speech data recorded for four German native speakers, and model data, obtained by a mechanical replica which allows reproducing the main physical mechanisms occurring during phonation. The two methods are presented and applied to a study on the influence of speech rate on aerodynamic properties.
The unfolding discussion will focus on the internal representation of turbulent sounds in the phonology of German as well as pinpoint the special status of the prime defining the quality of turbulence. It will also be argued that this prime is capable of entering into special types of licensing relations, which results in specific phonetic manifestations of forms. We shall compare the effects of two processes attested in German: consonant degemination and spirantisation with a view to revealing the role of the turbulence-defining element in the two operations. Furthermore, our attention will be focused on the workings of the Obligatory Contour Principle which, as will be shown below, exerts decisive impact on prime interplay and consequently the phonetic realization of sounds and words. We shall see that segmental identity is contingent on the languagespecific interpretation of inter-element bonds.
Aware of the importance of prime autonomy in determining the manifestation of sounds, let us start with a brief outline of the fundamental segment structure principles offered by the theory of Phonological Government.
Much work on the interaction of prosody and focus assumes that, crosslinguistically, there is a necessary correlation between the position of main sentence stress (or accent) and focus, and that an intonational pitch change on the focused element is a primary correlate of focus. In this paper, I discuss primary data from three Bantu languages – Chichewa, Durban Zulu and Chitumbuka – and show that in all three languages phonological re-phrasing, not stress, is the main prosodic correlate of focus and that lengthening, not pitch movement, is the main prosodic correlate of phrasing. This result is of interest for the typology of intonation in illustrating languages where intonation has limited use and where, notably, intonation does not highlight focused information in the way we might expect from European stress languages.
In this paper it is argued that several typologically unrelated languages share the tendency to avoid voiced sibilant affricates. This tendency is explained by appealing to the phonetic properties of the sounds, and in particular to their aerodynamic characteristics. On the basis of experimental evidence it is shown that conflicting air pressure requirements for maintaining voicing and frication are responsible for the avoidance of voiced affricates. In particular, the air pressure released from the stop phase of the affricate is too high to maintain voicing which in consequence leads to a devoicing of the frication part.
This study is an electropalatographic investigation of clusters composed of /n/ or /l/ followed by the (alveolo)palatal consonants /ʎ, ɲ/ or by dental /t/ in three Catalan dialects, i.e., Majorcan, Valencian and Eastern. Data show that articulatory blending through superposition occurs in the palatalizing environment except when C1 is highly constrained (e.g., dark /l/) or C2 is purely palatal and therefore, produced at a distant articulatory location from C1. Contrary to previous descriptions in the literature, data for /nt, lt/ reveal that blending through superposition rather than assimilation is at work. The implications of these data for theories of speech production are discussed.
The present article illustrates that the specific articulatory and aerodynamic requirements for voiced but not voiceless alveolar or dental stops can cause tongue tip retraction and tongue mid lowering and thus retroflexion of front coronals. This retroflexion is shown to have occurred diachronically in the three typologically unrelated languages Dhao (Malayo-Polynesian), Thulung (Sino-Tibetan), and Afar (East-Cushitic). In addition to the diachronic cases, we provide synchronic data for retroflexion from an articulatory study with four speakers of German, a language usually described as having alveolar stops. With these combined data we supply evidence that voiced retroflex stops (as the only retroflex segments in a language) did not necessarily emerge from implosives, as argued by Haudricourt (1950), Greenberg (1970), Bhat (1973), and Ohala (1983). Instead, we propose that the voiced front coronal plosive /d/ is generally articulated in a way that favours retroflexion, that is, with a smaller and more retracted place of articulation and a lower tongue and jaw position than /t/.
Dendrite morphology, a neuron's anatomical fingerprint, is a neuroscientist's asset in unveiling organizational principles in the brain. However, the genetic program encoding the morphological identity of a single dendrite remains a mystery. In order to obtain a formal understanding of dendritic branching, we studied distributions of morphological parameters in a group of four individually identifiable neurons of the fly visual system. We found that parameters relating to the branching topology were similar throughout all cells. Only parameters relating to the area covered by the dendrite were cell type specific. With these areas, artificial dendrites were grown based on optimization principles minimizing the amount of wiring and maximizing synaptic democracy. Although the same branching rule was used for all cells, this yielded dendritic structures virtually indistinguishable from their real counterparts. From these principles we derived a fully-automated model-based neuron reconstruction procedure validating the artificial branching rule. In conclusion, we suggest that the genetic program implementing neuronal branching could be constant in all cells whereas the one responsible for the dendrite spanning field should be cell specific.
Between 1993 and 2005 I investigated the introduced plant species on the Newcastle foreshores at Stockton and Macquaries Pier (lat 32º 56’ S, long 151º 47’ E). At North Stockton in a rehabilitated area, cleared of *Chrysanthemoides monilifera subsp. rotundata, and planted with *Ammophila arenaria interspersed with native shrubs, mainly Acacia longifolia subsp. sophorae and Leptospermum laevigatum, is a rich flora of introduced species of which *Panicum racemosum and *Cyperus conglomeratus have gradually become dominant in the groundcover. Notwithstanding continuing maintenance, *Chrysanthemoides monilifera subsp. rotundata has re-established among the native shrubs, and together with Acacia longifolia subsp. sophorae, is important in sand stabilisation along the seaward edge of the dune terrace. The foredune of Little Park Beach, just inside the Northern Breakwater, is dominated by Spinifex sericeus and backed by Acacia longifolia subsp. sophorae-*Chrysanthemoides monilifera subsp. rotundata shrubbery. In places the shrubbery has given way to introduced species such as *Oenothera drummondii, *Tetragonia decumbens and especially *Heterotheca grandiflora. At Macquaries Pier *Chrysanthemoides monilifera subsp. rotundata forms an almost continuous fringe between the rocks that protect the pier against heavy southerlies. However, its presence on adjacent Nobbys Beach is localised and the general aspect of this beach is no different from any other along the coast as it is dominated by Spinifex sericeus. Many foreign plant species occur around the sandy foreshores at Port Hunter. Since the first coal exports in the 1850s the Newcastle wharves and ballast-ground at Stockton became points of entry for foreign species, either directly, or via stopovers at other Australian ports. Some of these, *Panicum racemosum, *Tetragonia decumbens, *Ursinia speciosa, *Hebenstretia dentata and until recently, *Heterotheca grandiflora, remained restricted to the Newcastle region, while others, e.g. *Chrysanthemum monilifera subsp. rotundata, *Hydrocotyle bonariensis, *Gladiolus gueinzii and *Oenothera drummondii, spread further afield, but only colonised their preferred coastal habitat. Many more species spread far and wide, their port of introduction no longer recognisable. Other species were introduced as garden plants, escaped and became naturalised. However, for most foreign, generally widespread, species their mode of entry can no longer be determined. 99 species were recorded in the six areas regularly visited, about 25% native to Australia, and 75% about evenly divided between species from Africa, Asia and Europe. More detailed information on 15 of the more notable introduced species is provided in an appendix. On the dune terrace vegetation of North Stockton, only about 20% of the 50 species are native to Australia, the only one of any prominence being Acacia longifolia subsp. sophorae. Nevertheless, on first impression this ‘multinational’ assemblage looks quite normal, and when one compares the ecological functioning of the 1930s vegetation with that of the present vegetation, it appears that, due to presence of more graminoids, and the fact that *Panicum racemosum produces a denser sward than Spinifex sericeus, the present vegetation is more effective in sand-catching and dune stabilisation than the vegetation in the 1930s would have been. However in view of the increasing influence of climate change, e.g. a rise in sea level and more extreme weather events, there is no indication that the present terrace, notwithstanding the increased density of the rhizomatous species and a sprawling shrubby vegetation along the crest, will endure such attacks any better than in the 1990s.
The vegetation of montane lagoons of the New England Tablelands Bioregion, New South Wales is examined using flexible UPGMA analysis of frequency scores on all vascular plant taxa, charophytes and one liverworts. Seven communities are described: 1. Hydrocotyle tripartita – Isotoma fluviatilis – Ranunculus inundatus – Lilaeopsis polyantha herbfield; 2. Eleocharis sphacelata – Potamogeton tricarinatus sedgeland; 3. Eleocharis sphacelata – Utricularia australis – Isolepis fluitans, herbfield; 4. Utricularia australis – Nitella sonderi herbfield; 5. Eleocharis sphacelata – Utricularia australis – Ricciocarpus natans sedgeland; 6. Carex gaudichaudiana – Holcus lanatus – Stellaria angustifolia sedgeland; 7. Cyperus sphaeroides – Eleocharis gracilis – Schoenus apogon – Carex gaudichaudiana sedgeland. 58 lagoons were located and identified, only 28% of which are considered to be intact and in good condition. Two threatened species (Aldovandra vesiculosa and Arthaxon hispidus) and three RoTAP-listed taxa were encountered during the survey.
The vegetation of Gibraltar Range National Park and adjoining parts of eastern Washpool National Park, 65 km east of Glen Innes (29° 31’S 152° 18’E) on the eastern escarpment of New South Wales is described. In total 124, 20m x 50m full vascular plant floristic sites were recorded and information from an additional 53 sites was collated. Thirteen vegetation assemblages are defined based on flexible UPGMA analysis of cover-abundance scores of all vascular plant taxa. Many of the vegetation communities are typical of what is found along the north eastern escarpment of NSW. Three communities are considered to be rare and two vulnerable. A total of 878 vascular plant taxa from 138 families were recorded, of which only 21 (2%) were of introduced origin and 81 (9%) were found to be of conservation significance. Pattern diversity, species density, species accumulation and average geographic range size, along with general measures of richness and diversity, were analysed for all communities. Each of the communities described varied considerably in the diversity attributes measured. Communities with a high number of shrubs had greater constancy between sites compared to those that contained a high number of closed forest species. The community from rock outcrops had the largest average geographical range size.
Tropical lowland plant communities in north-eastern Queensland remain under pressure from continuing clearing, fragmentation, exotic species invasion, inappropriate fire regimes, and altered hydrological patterns. Comparatively little scientific research has been conducted on the highly diverse and ecologically significant range of remnant vegetation types. Additionally, most plant communities remain very poorly represented in the existing conservation reserve system. Melaleuca viridiflora Sol. ex Gaertn. open woodlands were selected for investigation based on their relatively simple structure, compared to other lowland communities, and the large extent to which they have been affected by past clearing patterns. A detailed analysis of community structure and composition was conducted at 24 sites throughout the wet-tropics coastal region between Townsville and Cooktown. Surprisingly, a high diversity of structural and floristic types was recorded, with a total of 127 species documented across the 24 sites. Classification analyses of species composition data produced seven or eight main groups of sites (dependent on the statistical technique used), essentially related to a gradient of latitude and rainfall. These floristic groups were not well explained by either species richness, past fire frequencies or soil types. Structural classification analyses based upon DBH data identified six or seven main groups, the singularly most striking of which were sites with annual fire histories. Ordinations based on both the DBH and species composition data produced groupings that supported those detected by the classification techniques. On closer examination of sites with similar fire histories, soil moisture and soil type were both found to have significant effects on community structure and composition. Many of the woodland types recorded are not adequately included (some not at all) in the existing conservation reserve system.
A study was conducted on the Liverpool Plains (30o 43’–31o 44’S; 149o 40’–150o 41’E), North Western Slopes of NSW, to determine the original boundaries of the naturally-treeless grasslands, to determine reasons for the lack of woody vegetation on these areas, and to assess the status of Austrostipa aristiglumis (Plains Grass), a species that is today commonly dominant on the few remaining remnant grassland areas and is commonly assumed to characterise the original grassland community. The original tree line boundaries were reconstructed using NSW Lands Department survey portion plans and other historical records. The lack of woody vegetation was attributed primarily to a combination of fine-textured soil, climate and topography restricting the availability of water below the grass root zone, with waterlogging and deep soil cracking possibly playing minor roles. Published and anecdotal evidence and landholder experience indicate that the Austrostipa aristiglumis dominated remnants are probably a relatively recent anthropogenic feature, a consequence of post-settlement management practices. The pre-settlement grasslands appear to have been composed of a wide range of grasses, possibly dominated by species such as Themeda avenacea (Native Oatgrass) and Eulalia aurea (Silky Browntop), with a range of forbs occupying the interstitial spaces. Management implications are discussed.
Dry rainforests are those communities that have floristic and structural affinities to mesic rainforests and occur in parts of eastern and northern Australia where rainfall is comparatively low and often highly seasonal. The dry rainforests of the western slopes of New South Wales are poorly-understood compared to other dry rainforests in Australia, due to a lack of regional scale studies. This paper attempts to redress this by deriving a broad floristic and structural typology for this vegetation type. Phytogeographical analysis followed full floristic surveys conducted on 400 m2 plots located within dry rainforest across the western slopes of NSW. Cluster analysis and ordination of 208 plots identified six floristic groups. Unlike in some other regional studies of dry rainforest these groups were readily assigned to Webb structural types, based on leaf size classes, leaf retention classes and canopy height. Five community types were described using both floristic and structural data: 1) Ficus rubiginosa–Notelaea microcarpa notophyll vine thicket, 2) Ficus rubiginosa–Alectryon subcinereus–Notelaea microcarpa notophyll vine forest, 3) Elaeodendron australe–Notelaea microcarpa–Geijera parviflora notophyll vine thicket, 4) Notelaea microcarpa– Geijera parviflora–Ehretia membranifolia semi-evergreen vine thicket, and 5) Cadellia pentastylis low microphyll vine forest. Floristic groupings were consistent with those described by previous quantitative studies which examined smaller portions of this study area. There was also general agreement between the present analytical study and a previous intuitive classification of dry rainforest vegetation throughout the study area, but little concurrence with a continental scale floristic classification of rainforest.
Macrozamia johnsonii D. Jones & K. Hill is a locally endemic cycad (family Zamiaceae) with a restricted occurrence in north-eastern New South Wales and currently listed as Endangered. Based on recent field surveys, its mean population size is estimated as approximately 3.5 million mature plants, with the lower bound of the 95% confidence interval at 1.9 million mature plants. Thirty percent of the population occurs in a formal reserve. Macrozamia johnsonii occurs in grassy eucalypt forest, shrubby wet sclerophyll forest and in rainforest. It occurs most frequently on steeply sloping sites with high moisture index. There are no immediate significant threats to the species although timber harvesting is judged to be a potential longer term threat to part of the population. The conservation status of Macrozamia johnsonii is assessed using IUCN criteria and thresholds, using population size and extent data from this study and a plausible range of values based on available circumstantial evidence for parameters for which quantitative estimates are not available. Based on this assessment, we regard the conservation status of Macrozamia johnsonii to be in the category of Least Concern, and that its current listing as an Endangered species under the NSW Threatened Species Conservation Act (1995) needs to be revised.
Rare or threatened vascular plant species of Wollemi National Park, central eastern New South Wales
(2008)
Wollemi National Park (c. 32o 20’– 33o 30’S, 150o– 151oE), approximately 100 km north-west of Sydney, conserves over 500 000 ha of the Triassic sandstone environments of the Central Coast and Tablelands of New South Wales, and occupies approximately 25% of the Sydney Basin biogeographical region. 94 taxa of conservation significance have been recorded and Wollemi is recognised as an important reservoir of rare and uncommon plant taxa, conserving more than 20% of all listed threatened species for the Central Coast, Central Tablelands and Central Western Slopes botanical divisions. For a land area occupying only 0.05% of these divisions, Wollemi is of paramount importance in regional conservation. Surveys within Wollemi National Park over the last decade have recorded several new populations of significant vascular plant species, including some sizeable range extensions. This paper summarises the current status of all rare or threatened taxa, describes habitat and associated species for many of these and proposes IUCN (2001) codes for all, as well as suggesting revisions to current conservation risk codes for some species. For Wollemi National Park 37 species are currently listed as Endangered (15 species) or Vulnerable (22 species) under the New South Wales Threatened Species Conservation Act 1995. An additional 50 species are currently listed as nationally rare under the Briggs and Leigh (1996) classification, or have been suggested as such by various workers. Seven species are awaiting further taxonomic investigation, including Eucalyptus sp. ‘Howes Swamp Creek’ (Doherty 26), known from a single location within the park, and Pultenaea sp. (Olinda) from Dunns Swamp – both these species remain undescribed, but are listed as endangered species. After applying IUCN criteria to the 94 taxa, 2 are considered Critically Endangered; 11 are considered Endangered; 23 are considered Vulnerable; 3 are considered Near Threatened; 19 are considered Data Deficient; and 36 are considered of Least Concern. It is likely that additional highly restricted plant taxa await discovery in remote locations.
This third paper in the NSW Vegetation Classification and Assessment series covers the NSW South-western Slopes Bioregion of 8.192 million hectares being 10% of NSW. A total of 135 plant communities, comprising 97 new communities and 38 previously described communities, are classified. Their protected area and threat status is assessed. A full description of the 135 plant communities is provided in a 400 page report, generated from the NSWVCA database, on the CD accompanying this paper. Eucalyptus-dominated grassy or shrubby woodlands and open forests are the main types of vegetation in the bioregion. The CD also contains a read-only version of Version 2 of the NSWVCA database that includes updated information on the plant communities previously published in Version 1 of the NSWVCA covering the NSW Western Plains. Six new communities are added to the Western Plains. The vegetation classification and assessment is based on published and unpublished vegetation surveys and map unit descriptions that are listed in the NSWVCA Bibliography on the CD, expert advice and extensive field checking. Over 80% of the native vegetation in the NSW South-western Slopes Bioregion has been cleared making it the most cleared and fragmented of the 18 IBRA Bioregions in NSW. Exotic plant species dominate the ground cover outside conservation reserves, state forests, roadsides and travelling stock reserves. As of September 2008 about 1.9% of the Bioregion was in 105 protected areas and 28 of the 135 plant communities were assessed to be adequately protected in reserves. Using NSWVCA Threat Criteria, 18 plant communities were assessed as being Critically Endangered, 33 Endangered, 29 Vulnerable, 25 Near Threatened and 30 Least Concern. Current threats include over-grazing, especially during drought, exotic species dominance of the ground cover, impacts of fragmentation on species persistence and genetic diversity and impacts of lower rainfall due to climate change. To address these threats, linking and enlarging vegetation remnants through revegetation (including regenerating native ground cover) is required. Some progress is being made through re-vegetation schemes driven by the NSW 2003 Natural Resource reforms, however, more incentive funding for landholders would accelerate the re-vegetation program.
The floristic composition and environmental relations of wetland vegetation in the Wallis Lake catchment (32˚ 09’S; 152˚ 20’E), area 1292 km2, on the lower North Coast of NSW are described. The catchment supports wetlands listed as Endangered Ecological Communities (NSW Threatened Species Conservation Act 1995) and plant species of high conservation value. A methodology of air photo interpretation, site-based sampling (114 quadrats) and landscape differentiation was developed. A total of 393 vascular plant taxa were recorded (including 10% exotics). Wetland vegetation formations and subformations including mangrove forest, swamp sclerophyll forest, wet heathland, chenopod shrubland, tussock grassland, sedgeland and rushland are described using numerical classification. 31 plant species of national or regional conservation significance are identified. Four Endangered Ecological Communities are discussed – Coastal Saltmarsh, Swamp Oak Floodplain Forest, Swamp Sclerophyll Forest on Coastal Floodplains, and Freshwater Wetlands on Coastal Floodplains. A key recommendation is the completion of reliable wetland vegetation and soil landscape mapping for all land tenures in the catchment – to assess wetland condition and conservation significance, and representation in formal conservation reserves, thereby directing future priorities for the protection of wetland biodiversity on both public and private lands. The methodology developed can be applied to the survey and conservation of wetland biodiversity in other parts of coastal NSW.
Guidelines and core attributes for site-based vegetation surveying and mapping developed for the Northern Territory, are relevant to botanical research, forestry typing, rangeland monitoring and reporting on the extent and condition of native and non-native vegetated landscapes. These initiatives are consistent with national vegetation guidelines and the National Vegetation Information System (NVIS) framework. This paper provides a synopsis of vegetation site data collection, classification and mapping in the Northern Territory, and discusses the benefits of consistency between the guidelines, core attributes and the NVIS framework; both of which has an emphasis on the NVIS hierarchical classification system for describing structural and floristic attributes of vegetation. The long-term aim of the NVIS framework is that national attributes are adopted at regional levels to enable comparability of vegetation information within survey and jurisdictional boundaries in the Northern Territory and across Australia. The guidelines and core attributes are incorporated in current and future vegetation survey and mapping programs in the Northern Territory.
Fire is an integral component of many ecosystems worldwide. Many plant species require fire-related cues, primarily heat and smoke, to trigger germination. Despite the importance of this process, the responses of many Australian species to these cues are unknown. Without this knowledge fire management strategies may be developed that are inappropriate for individual species and vegetation communities. In this study we examined the responses of a dry sclerophyll forest seed bank to heat and smoke germination cues. Analysis was possible for 48 taxa within the soil seedbank with 34 of these showing a response to one or both of the germination cues. 10 species responded to the heat treatment, 11 species responded to the smoke treatment and 13 species responded to both the heat and smoke treatments. Germination cues acted independently for all species considered. Results in this study were consistent with published reports for most species, although some differences were seen at the species and genus level. The study highlights the importance of fire-related cues in enhancing germination of a large proportion of the species occurring in dry sclerophyll forests.
Introduced perennial grasses are capable of altering the habitat of native species, causing reductions in population size and vigour, and potentially affecting life-history processes such as survival, pollination and seedling recruitment. We examined the utility of herbicide treatment on two exotic grasses, Pennisetum clandestinum (Kikuyu) and Stenotaphrum secundatum (Buffalo grass) to restore the habitat of Calystegia affinis, a critically endangered species endemic to Lord Howe and Norfolk Islands. Using two herbicides, Asset (designed to affect only grasses) and Glyphosate (a general herbicide), we compared effectiveness in reducing grass cover on a population of Calystegia affinis. We protected Calystegia plants from the herbicides by ensuring their leaves were covered by plastic bags during herbicide application. Both herbicides were similarly effective in reducing grass cover after four weeks and had no noticeable adverse affect on Calystegia (suggesting the plastic bag protection was effective). After 26 weeks, Glyphosate was more effective in maintaining a reduced grass cover. Plots treated with either herbicide had a greater relative increase in abundance of Calystegia stems compared to untreated controls. The Glyphosate treatment resulted in the greatest relative increase in stem abundance, but this was not significantly greater than in the Asset treatment. We consider that spraying with Glyphosate treatment, with follow-up monitoring and spot-spraying, will assist the recovery of the Calystegia affinis population. Ultimately, the maintenance of a weed-free zone at the forest edge will provide suitable habitat for additional recruitment of this and other native species.
The Peak Range (22˚ 28’ S; 147˚ 53’ E) is an archipelago of rocky peaks set in grassy basalt rolling-plains, east of Clermont in central Queensland. This report describes the flora and vegetation based on surveys of 26 peaks. The survey recorded all plant species encountered on traverses of distinct habitat zones, which included the ‘matrix’ adjacent to each peak. The method involved effort comparable to a general flora survey but provided sufficient information to also describe floristic association among peaks, broad habitat types, and contrast vegetation on the peaks with the surrounding landscape matrix. The flora of the Peak Range includes at least 507 native vascular plant species, representing 84 plant families. Exotic species are relatively few, with 36 species recorded, but can be quite prominent in some situations. The most abundant exotic plants are the grass Melinis repens and the forb Bidens bipinnata. Plant distribution patterns among peaks suggest three primary groups related to position within the range and geology. The Peak Range makes a substantial contribution to the botanical diversity of its region and harbours several endemic plants among a flora clearly distinct from that of the surrounding terrain. The distinctiveness of the range’s flora is due to two habitat components: dry rainforest patches reliant upon fire protection afforded by cliffs and scree, and; rocky summits and hillsides supporting xeric shrublands. Plants endemic to the Peak Range are mainly associated with the latter of these habitats.
Species area curves from 37 sites spanning the diversity of native vegetation in Queensland were examined. For the majority of sites investigated a 500 m2 plot captured about 80–90% of the vascular plant species present at the time of sampling. Floristic data collected for grassland, heathland, acacia shrublands and most eucalypt woodlands using a 500 m2 plot is appropriate for floristic analysis and adequately represent the vascular plants present at the site at the time. Using a larger plot would only slightly increase the species capture at a site but it would generally be more efficient to increase the number of sites sampled to more adequately capture the diversity across the extent of the vegetation type. However for many Queensland rainforest communities, a much larger sample size is required to capture the full species richness of a site.
Digital document and interpretation : re-thinking "text" and scholarship in electronic settings
(2008)
The contribution starts from outlining the evolution of the scholarly production flow from the print based paradigm to the digital age and in this context it explores the opposition of digital versus analog representation modes. It then develops on the triple paradigm shift caused by genuine digital publishing and its specific consequences for the social sciences and humanities (SSH) which in turn results in re-constituting basic scholarly notions such as 'text' and 'document'. The paper concludes with discussing the specific value that could be added in systematically using digital text resources as a basis for scholarly work and also states some of the necessary conditions for such a 'digital turn' to be successful in the SSH.
The seasonality of transport and mixing of air into the lowermost stratosphere (LMS) is studied using distributions of mean age of air and a~mass balance approach, based on in-situ observations of SF6 and CO2 during the SPURT (Spurenstofftransport in der Tropopausenregion, trace gas transport in the tropopause region) aircraft campaigns. Combining the information of the mean age of air and the water vapour distributions we demonstrate that the tropospheric air transported into the LMS above the extratropical tropopause layer (ExTL) originates predominantly from the tropical tropopause layer (TTL). The concept of our mass balance is based on simultaneous measurements of the two passive tracers and the assumption that transport into the LMS can be described by age spectra which are superposition of two different modes. Based on this concept we conclude that the stratospheric influence on LMS composition is strongest in April with tropospheric fractions (α1) below 20% and that the strongest tropospheric signatures are found in October with (α1 greater than 80%. Beyond the fractions, our mass balance concept allows to calculate the associated transit times for transport of tropospheric air from the tropics into the LMS. The shortest transit times (<0.3 years) are derived for the summer, continuously increasing up to 0.8 years by the end of spring. These findings suggest that strong quasi-horizontal mixing across the weak subtropical jet from summer to mid of autumn and the considerably shorter residual transport time-scales within the lower branch of the Brewer-Dobson circulation in summer than in winter dominates the tropospheric influence in the LMS until the beginning of next year's summer.
his study aims at a detailed characterization of an ultra-fine aerosol particle counting system for operation on board the Russian high altitude research aircraft M-55 "Geophysica" (maximum ceiling of 21 km). The COndensation PArticle counting Systems (COPAS) consists of an aerosol inlet and two dual-channel continuous flow Condensation Particle Counters (CPCs).
The aerosol inlet, adapted for COPAS measurements on board the M-55 "Geophysica", is described concerning aspiration, transmission, and transport losses. The counting efficiencies of the CPCs using the chlorofluorocarbon FC-43 as the working fluid are studied experimentally at two pressure conditions, 300 hPa and 70 hPa. Three COPAS channels are operated with different temperature differences between the saturator and the condenser block yielding smallest detectable particle sizes (dp50 – as 50% detection "cut off" diameters) of 6 nm, 11 nm, and 15 nm, respectively, at ambient pressure of 70 hPa. The fourth COPAS channel is operated with an aerosol heating line (250°C) for a determination of the non-volatile number of particles. The heating line is experimentally proven to volatilize pure H2SO4-H2O particles for a particle diameter (dp) range of 11 nm<dp<200 nm.
Additionally this study includes investigation to exclude auto-nucleation of the working fluid inside the CPCs. An instrumental inter-comparison (cross-correlation) has been performed for several measurement flights and mission flights in the Arctic and the Tropics are discussed. Finally, COPAS measurements are used for an aircraft plume crossing analysis.
The ambient and laboratory molecular and ion clusters were investigated. Here we present data on the ambient concentrations of both charged and uncharged molecular clusters as well as the performance of a pulse height condensation particle counter (PH-CPC) and an expansion condensation particle counter (E-CPC). The ambient molecular cluster concentrations were measured using both instruments, and they were deployed in conjunction with ion spectrometers and other aerosol instruments in Hyytiälä, Finland at the SMEAR II station during 1 March to 30 June 2007. The observed cluster concentrations varied and were from ca. 1000 to 100 000 cm−3. Both instruments showed similar concentrations. The average size of detected clusters was approximately 1.8 nm. As the atmospheric measurements at sub 2-nm particles and molecular clusters are a challenging task, and we were most likely unable to detect the smallest clusters, the reported concentrations are our best estimates for minimum cluster concentrations in boreal forest environment.
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet activation. In this study we show that two platelet glycoprotein receptors that signal via an immunoreceptor tyrosine-based activation motif (ITAM) or an ITAM-like domain, namely the collagen receptor complex glycoprotein VI (GPVI)-FcR γ-chain and the C-type lectin-like receptor 2 (CLEC-2), respectively, support constitutive (i.e. agonist-independent) signaling in a cell line model using a nuclear factor of activated T-cells (NFAT) transcriptional reporter assay that can detect low level activation of phospholipase Cγ (PLCγ). Constitutive and agonist signaling by both receptors is dependent on Src and Syk family kinases, and is inhibited by G6b-B, a platelet immunoglobulin receptor that has two immunoreceptor tyrosine-based inhibitory motifs in its cytosolic tail. Mutation of the conserved tyrosines in the two immunoreceptor tyrosine-based inhibitory motifs prevents the inhibitory action of G6b-B. Interestingly, the inhibitory activity of G6b-B is independent of the Src homology 2 (SH2)-domain containing tyrosine phosphatases, SHP1 and SHP2, and the inositol 5′-phosphatase, SHIP. Constitutive signaling via Src and Syk tyrosine kinases is observed in platelets and is associated with tyrosine phosphorylation of GPVI-FcR γ-chain and CLEC-2. We speculate that inhibition of constitutive signaling through Src and Syk tyrosine kinases by G6b-B may help to prevent unwanted platelet activation.
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of immunoregulation. IL-18BP is strongly up-regulated by IFN-γ, thereby establishing a negative feedback mechanism detectable in cell culture and in vivo. Here we sought to investigate in D.L. Dexter (DLD) colon carcinoma cells molecular mechanisms of IL-18BP induction under the influence of IFN-γ. Mutational analysis revealed that a proximal γ-activated sequence (GAS) at the IL-18BP promoter is of pivotal importance for expression by IFN-γ-activated cells. Use of siRNA underscored the essential role of the signal transducer and activator of transcription (STAT)-1 in this process. Indeed, electrophoretic mobility shift assay and chromatin immunoprecipitation analysis proved STAT1 binding to this particular GAS site. Maximal expression of IL-18BP was dependent on de novo protein synthesis but unaffected by silencing of interferon regulatory factor-1. Altogether, data presented herein indicate that direct action of STAT1 on the IL-18BP promoter at the proximal GAS element is key to IL-18BP expression by IFN-γ-stimulated DLD-1 colon carcinoma cells.
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical renal cell carcinoma (RCC) models. Caki-1, KTC-26 or A498 cells were treated with various concentrations of VPA during in vitro cell proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays and to evaluate cell cycle manipulation. In vivo tumour growth was conducted in subcutaneous xenograft mouse models. The anti-tumoural potential of VPA combined with low-dosed interferon-α (IFN-α) was also investigated. VPA significantly and dose-dependently up-regulated histones H3 and H4 acetylation and caused growth arrest in RCC cells. VPA altered cell cycle regulating proteins, in particular CDK2, cyclin B, cyclin D3, p21 and Rb. In vivo, VPA significantly inhibited the growth of Caki-1 in subcutaneous xenografts, accompanied by a strong accumulation of p21 and bax in tissue specimens of VPA-treated animals. VPA–IFN-α combination markedly enhanced the effects of VPA monotherapy on RCC proliferation in vitro, but did not further enhance the anti-tumoural potential of VPA in vivo. VPA was found to have profound effects on RCC cell growth, lending support to the initiation of clinical testing of VPA for treating advanced RCC.
The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in neocorti-cal areas. Then, they expand hierarchically into further brain regions. The distribution of Aβ plaques throughout the entire brain, thereby correlates with the clinical status of the patients. Imaging techniques for Aβ make use of the hierarchical distribution of Aβ to distinguish AD patients from non-AD patients. However, pathology seen in AD patients represents a late stage of a pathological process starting 10–30 years earlier in cognitively normal individuals. In addition to the fibrillar amyloid of senile plaques, oligomeric and monomeric Aβ is found in the brain. Recent studies revealed that oligomeric Aβ is presumably the most toxic Aβ-aggregate, which interacts with glutamatergic synapses. In doing so, dendrites are presumed to be the primary target for Aβ-toxicity. In addition, vascular Aβ-deposits can lead to capillary occlusion and blood flow disturbances presumably contributing to the alteration of neurons in addition to the direct neurotoxic effects of Aβ. All these findings point to an important role of Aβ and its aggregates in the neurodegenerative process of AD. Since there is already significant neuron loss in AD patients, treatment strategies aimed at reducing the amyloid load will presumably not cure the symptoms of dementia but they may stop disease progression. Therefore, it seems to be necessary to protect the brain from Aβ-toxicity already in stages of the disease with minor neuron loss before the onset of cognitive symptoms.
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist. Recently it was also shown that FTY720 can reduce prostaglandin synthesis through the direct inhibition of the cytosolic phospholipase A2 (cPLA2). Since prostaglandins are important mediators of nociception, we studied the effects of FTY720 in different models of nociception. We found that intraperitoneal administration of FTY720 reduced dose-dependently the nociceptive behaviour of rats in the formalin assay. Although the antinociceptive doses of FTY720 were too low to alter the lymphocyte count, prostanoid concentrations in the plasma were dramatically reduced. Surprisingly, intrathecally administered FTY720 reduced the nociceptive behaviour in the formalin assay without altering spinal prostaglandin synthesis, indicating that additional antinociceptive mechanisms beside the inhibition of prostaglandin synthesis are involved. Accordingly, FTY720 reduced also the nociceptive behaviour in the spared nerve injury model for neuropathic pain which does not depend on prostaglandin synthesis. In this model the antinociceptive effect of FTY720 was similar to gabapentin, a commonly used drug to treat neuropathic pain. Taken together we show for the first time that FTY720 possesses antinociceptive properties and that FTY720 reduces nociceptive behaviour during neuropathic pain.
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions. In osteoarthritis (OA), ADAM15 is up-regulated in the chondrocytes already at early stages of cartilage degeneration where it seems to exert homeostatic effects likely associated with its ability to enhance integrin-mediated chondrocyte adhesion to the surrounding collagen matrix. The aim of our present study was, therefore, to characterize functional domains of ADAM15 involved in collagen II (CII) interaction and to analyse associated outside-in signalling events. Accordingly, ADAM15 and respective deletion mutants were stably transfected into the chondrocyte cell line T/C28a4. Transfected cells were adhered to CII and phosphoproteins analysed by Western blotting. Co-immunoprecipitation served to identify protein binding to ADAM15. Our results elucidate the prodomain as critical for the capacity of ADAM15 to enhance CII adhesion, thereby identifying for the first time a cell-adhesive role of a metalloproteinase prodomain. Moreover, the cytoplasmic tail of ADAM15 confers a modulatory effect on the autophosphorylation site Y397 of the focal adhesion kinase (FAK) during chondrocyte–collagen interaction. In conclusion, the newly uncovered impact of ADAM15 on signalling events that arise from chondrocyte interactions with its collagen matrix might contribute to the elucidation of the mechanism underlying its proposed chondroprotective role in degenerative cartilage disease.
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma
(2008)
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti-neoplastic effects in vitro may not be reached in tumour patients. In this study, we tested in vitro and in vivo effects of two VPA-derivatives (ACS2, ACS33) on pre-clinical prostate cancer models. PC3 and DU-145 prostate tumour cell lines were treated with various concentrations of ACS2 or ACS33 to perform in vitro cell proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and to evaluate tumour cell adhesion to endothelial cell monolayers. Analysis of acetylated histones H3 and H4 protein expression was performed by western blotting. In vivo tumour growth was conducted in subcutaneous xenograft mouse models. Tumour sections were assessed by immunohistochemistry for histone H3 acetylation and proliferation. ACS2 and ACS33 significantly up-regulated histone H3 and H4 acetylation in prostate cancer cell lines. In micromolar concentrations both compounds exerted growth arrest in PC3 and DU-145 cells and prevented tumour cell attachment to endothelium. In vivo, ACS33 inhibited the growth of PC3 in subcutaneous xenografts. Immunohistochemistry and western blotting confirmed increased histone H3 acetylation and reduced proliferation. ACS2 and ACS33 represent novel VPA derivatives with superior anti-tumoural activities, compared to the mother compound. This investigation lends support to the clinical testing of ACS2 or ACS33 for the treatment of prostate cancer.
This paper investigates the value of observed river discharge data for global-scale hydrological modeling of a number of flow characteristics that are e.g. required for assessing water resources, flood risk and habitat alteration of aquatic ecosystems. An improved version of the WaterGAP Global Hydrology Model (WGHM) was tuned against measured discharge using either the 724-station dataset (V1) against which former model versions were tuned or an extended dataset (V2) of 1235 stations. WGHM is tuned by adjusting one model parameter (γ) that affects runoff generation from land areas in order to fit simulated and observed long-term average discharge at tuning stations. In basins where γ does not suffice to tune the model, two correction factors are applied successively: the areal correction factor corrects local runoff in a basin and the station correction factor adjusts discharge directly the gauge. Using station correction is unfavorable, as it makes discharge discontinuous at the gauge and inconsistent with runoff in the upstream basin. The study results are as follows. (1) Comparing V2 to V1, the global land area covered by tuning basins increases by 5% and the area where the model can be tuned by only adjusting γ increases by 8%. However, the area where a station correction factor (and not only an areal correction factor) has to be applied more than doubles. (2) The value of additional discharge information for representing the spatial distribution of long-term average discharge (and thus renewable water resources) with WGHM is high, particularly for river basins outside of the V1 tuning area and in regions where the refined dataset provides a significant subdivision of formerly extended tuning basins (average V2 basin size less than half the V1 basin size). If the additional discharge information were not used for tuning, simulated long-term average discharge would differ from the observed one by a factor of, on average, 1.8 in the formerly untuned basins and 1.3 in the subdivided basins. The benefits tend to be higher in semi-arid and snow-dominated regions where the model is less reliable than in humid areas and refined tuning compensates for uncertainties with regard to climate input data and for specific processes of the water cycle that cannot be represented yet by WGHM. Regarding other flow characteristics like low flow, inter-annual variability and seasonality, the deviation between simulated and observed values also decreases significantly, which, however, is mainly due to the better representation of average discharge but not of variability. (3) The choice of the optimal sub-basin size for tuning depends on the modeling purpose. While basins over 60 000 km2 are performing best, improvements in V2 model performance are strongest in small basins between 9000 and 20 000 km2, which is primarily related to a low level of V1 performance. Increasing the density of tuning stations provides a better spatial representation of discharge, but it also decreases model consistency, as almost half of the basins below 20 000 km2 require station correction.
Long-term average groundwater recharge, which is equivalent to renewable groundwater resources, is the major limiting factor for the sustainable use of groundwater. Compared to surface water resources, groundwater resources are more protected from pollution, and their use is less restricted by seasonal and inter-annual flow variations. To support water management in a globalized world, it is necessary to estimate groundwater recharge at the global scale. Here, we present a best estimate of global-scale long-term average diffuse groundwater recharge (i.e. renewable groundwater resources) that has been calculated by the most recent version of the WaterGAP Global Hydrology Model WGHM (spatial resolution of 0.5° by 0.5°, daily time steps). The estimate was obtained using two state-of-the-art global data sets of gridded observed precipitation that we corrected for measurement errors, which also allowed to quantify the uncertainty due to these equally uncertain data sets. The standard WGHM groundwater recharge algorithm was modified for semi-arid and arid regions, based on independent estimates of diffuse groundwater recharge, which lead to an unbiased estimation of groundwater recharge in these regions. WGHM was tuned against observed long-term average river discharge at 1235 gauging stations by adjusting, individually for each basin, the partitioning of precipitation into evapotranspiration and total runoff. We estimate that global groundwater recharge was 12 666 km3/yr for the climate normal 1961–1990, i.e. 32% of total renewable water resources. In semi-arid and arid regions, mountainous regions, permafrost regions and in the Asian Monsoon region, groundwater recharge accounts for a lower fraction of total runoff, which makes these regions particularly vulnerable to seasonal and inter-annual precipitation variability and water pollution. Average per-capita renewable groundwater resources of countries vary between 8 m3/(capita yr) for Egypt to more than 1 million m3/(capita yr) for the Falkland Islands, the global average in the year 2000 being 2091 m3/(capita yr). Regarding the uncertainty of estimated groundwater resources due to the two precipitation data sets, deviation from the mean is 1.1% for the global value, and less than 1% for 50 out of the 165 countries considered, between 1 and 5% for 62, between 5 and 20% for 43 and between 20 and 80% for 10 countries. Deviations at the grid scale can be much larger, ranging between 0 and 186 mm/yr.
We report progress in our exploration of the finite-temperature phase structure of two-flavour lattice
QCD with twisted-mass Wilson fermions and a tree-level Symanzik-improved gauge action
for a temporal lattice size Nt = 8. Extending our investigations to a wider region of parameter
space we gain a global view of the rich phase structure. We identify the finite temperature transition/
crossover for a non-vanishing twisted-mass parameter in the neighbourhood of the zerotemperature
critical line at sufficiently high b . Our findings are consistent with Creutz’s conjecture
of a conical shape of the finite temperature transition surface. Comparing with NLO lattice
cPT we achieve an improved understanding of this shape.
We perform a detailed study of the adjoint static potential in the pseudoparticle approach, which is a model for SU(2) Yang-Mills theory. We find agreement with the Casimir scaling hypothesis and there is clear evidence for string breaking. At the same time the potential in the fundamental representation is linear for large separations. Our results are in qualitative agreement with results from lattice computations.
We present the status of runs performed in the twisted mass formalism with Nf =2+1+1 flavours of dynamical fermions: a degenerate light doublet and a mass split heavy doublet. The procedure for tuning to maximal twist will be described as well as the current status of the runs using both thin and stout links. Preliminary results for a few observables obtained on ensembles at maximal twist will be given. Finally, a reweighting procedure to tune to maximal twist will be described.
We investigate the implications of the r-modes instability on the composition of a compact star rotating at a sub-millisecond period. In particular, the only viable astrophysical scenario for such an object, wich might present inside the Low Mass X-ray Binary associated with the x-ray transient XTE J1739-285, is that it has a strangeness content. Since previous analysis indicate that hyperonic stars or stars containing a kaon condensate are unlikely because of the mass-shedding constraint, the only remaining possibility is that such an object is either a strange quark star or a hybrid quark-hadron star.
The possible role of a first order QCD phase transition at nonvanishing quark chemical potential and temperature for cold neutron stars and for supernovae is delineated. For cold neutron stars, we use the NJL model with nonvanishing color superconducting pairing gaps, which describes the phase transition to the 2SC and the CFL quark matter phases at high baryon densities. We demonstrate that these two phase transitions can both be present in the core of neutron stars and that they lead to the appearance of a third family of solution for compact stars. In particular, a core of CFL quark matter can be present in stable compact star configurations when slightly adjusting the vacuum pressure to the onset of the chiral phase transition from the hadronic model to the NJL model. We show that a strong first order phase transition can have strong impact on the dynamics of core collapse supernovae. If the QCD phase transition sets in shortly after the first bounce, a second outgoing shock wave can be generated which leads to an explosion. The presence of the QCD phase transition can be read off from the neutrino and antineutrino signal of the supernova.
Introduction: Despite the fact that people older than 65 years of age have the highest incidence of developing breast cancer, these patients are excluded from clinical trials in most cases. Furthermore, most physicians tend towards therapy regimens without the use of dose-dense, highly active taxane-based treatments because of a lack of data regarding toxicities of these compounds in older patients.
Methods: Pooled side-effect data were analyzed from four prospective, randomized clinical trials in which patients of different age groups (< 60 years, between 60 and 64 years, and > 64 years) with primary breast cancer received taxane-based chemotherapy.
Results: Dose delays, dose reductions, hospitalization, and therapy discontinuation increased with age. Hematologic toxicities and some nonhematologic toxicities were generally more common in older patients. Leucopenia increased from 55.3% in patients aged < 60 years to 65.5% in patients aged > 64 years (P < 0.001), and neutropenia increased from 46.9% to 57.4% (P < 0.001). There was no difference, however, in clinically more relevant febrile neutropenia between the different age groups. Thrombopenia shows a similar age-dependent increase, whereas there is no difference between the age groups concerning anemia. Hot flushes and elevated liver enzymes decreased with increasing age.
Conclusions: The present pooled analysis of a substantial cohort of older primary breast cancer patients demonstrates that taxane-containing (neo)adjuvant chemotherapy is feasible in older patients and that toxicity can be reduced by sequential therapy regimens.
* The Professionalization of General Practice
* 42nd Congress of the DEGAM German Society of General Practice and Family Medicine
* Online Registration for students now possible
* Opera tickets for participants in the PRoMPT study
* MultiCare: Multimorbidity patterns in General Practice
* Berlin Health Prize 2008: Words are not enough
Background: There are several ways to conduct a job task analysis in medical work environments including pencil-paper observations, interviews and questionnaires. However these methods implicate bias problems such as high inter-individual deviations and risks of misjudgement. Computer-based observation helps to reduce these problems. The aim of this paper is to give an overview of the development process of a computer-based job task analysis instrument for real-time observations to quantify the job tasks performed by physicians working in different medical settings. In addition reliability and validity data of this instrument will be demonstrated.
Methods: This instrument was developed in consequential steps. First, lists comprising tasks performed by physicians in different care settings were classified. Afterwards content validity of task lists was proved. After establishing the final task categories, computer software was programmed and implemented in a mobile personal computer. At least inter-observer reliability was evaluated. Two trained observers recorded simultaneously tasks of the same physician.
Results: Content validity of the task lists was confirmed by observations and experienced specialists of each medical area. Development process of the job task analysis instrument was completed successfully. Simultaneous records showed adequate interrater reliability.
Conclusion: Initial results of this analysis supported the validity and reliability of this developed method for assessing physicians' working routines as well as organizational context factors. Based on results using this method, possible improvements for health professionals' work organisation can be identified.
Since 2002, a workshop entitled “Asthma in animal models” has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in collaboration with the collaborative research centre “Sonderforschungsbereich” 587, “Immune reactions of the lung in infection and allergy” (Hannover Medical School). The aim of these meetings is an intense scientific exchange between researchers and clinicians coming from academic or industrial background. Over the years the topics within the extensive field of asthma and COPD have ranged from methodological aspects to the influence of infections and environmental factors up to perspectives in the development of new therapeutic strategies.
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic asthma. Leukotriene receptor antagonists are recommended as add-on therapy for this disease. The cys-leukotriene-1 receptor antagonist montelukast has been used in clinical asthma therapy during the last years. Besides its inhibitory action on bronchoconstriction, only little is known about its effects on airway secretions. Therefore, the aim of this study was to evaluate the effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity.
Methods: The effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity in the rat were assessed by quantification of secreted 35SO4 labelled mucus macromolecules using the modified Ussing chamber technique.
Results: Platelet activating factor potently stimulated airway secretion, which was completely inhibited by the platelet activating factor receptor antagonist WEB 2086 and montelukast. In contrast, montelukast had no effect on tachykinin induced tracheal secretory activity.
Conclusion: Cys-leukotriene-1 receptor antagonism by montelukast reverses the secretagogue properties of platelet activating factor to the same degree as the specific platelet activating factor antagonist WEB 2086 but has no influence on treacheal secretion elicited by tachykinins. These results suggest a role of montelukast in the signal transduction pathway of platelet activating factor induced secretory activity of the airways and may further explain the beneficial properties of cys-leukotriene-1 receptor antagonists.
Metaphorization and selected translation techniques : the case study of "National Geographic"
(2008)