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Radical land reform programmes generate changes in agrarian structures and capital accumulation trajectories in the countryside. This book examines how capital accumulation is being reshaped by changing financing and marketing of agricultural commodities and presents an emerging Quadi-PMMR-model agrarian structure composed of the poor, middle, middle-to-rich peasants and some rich capitalists with a growing middle scale farmer base constituting two thirds of the rural population in Zimbabwe. This evidence based assessment, 15 years after the FTLRP, sheds light on policy outcomes and impacts on communities, revealing the changing production, marketing, capital accumulation and class formation tendencies across Zimbabwe's settlement models and agro-ecological settings. The book fuses the reliance on agrarian political economy lenses and factor component analysis to reveal the dynamics of agrarian change and to explore the dialectic between production and circulation and between the centre and periphery in exceptional fashion that expands our understanding of Zimbabwe's agrarian transition.
Yves R. Simon (1903-1961), one of the greatest contemporary philosophers, gives a modern formulation for many classical philosophical concepts such as authority, the common good, and natural law. These topics have received extensive attention from scholars. Simon also discusses the nature of human virtue, moral and intellectual, but this topic has been less studied until now. The idea of virtue, and in our case virtue in political life, runs through Simon's works. Through a close study of Simon's works and the relevant secondary literature, this book explores Simon's definition of virtue in order to highlight its originality, and show how he weaves the need for it into the fabric of three facets of political life, namely, the common good, the virtue of the ruler and the ruled, and the law. These ideas are important for the ruler-ship of any country and especially of developing nations which are populated by sit-tight dictators. Philosophy can be dry and abstract, yet in this case we deal with one of its more practical manifestations.
The Ways We Stretch Toward One Another is a collection of essays on the work of Pamela Reynolds. The essays take cues from Reynolds decades-long contributions to the field of anthropology in different ways. The authors weave Reynolds groundbreaking scholarship on the anthropology of childhoodof labour, of family, of resistance, justice, war and sufferingthrough the terms of their own work, in places and contexts that may at first appear quite distant from the villages of Zimbabwe and townships of South Africa that feature in Reynolds ethnographies. The Ways We Stretch Toward One Another is about anthropologists stretching in thought and practice toward one another, between generations, toward the people encountered in the field, through worlds entered and past, and how, in turn, these worlds lean into our own. At the core of each essay is a question about how we learn, how we pass lessons on, how we assume the mantle of anthropology for understanding the contemporary worldsomething that often requires folding intellectual friendships into the tools of our practice. The Ways We Stretch Toward One Another demonstrates how a master anthropologist has come to shape the priorities of others, in terms that are both creative and aware. Contributors: Thomas Cousins, Stefanos Geroulanos, Todd Meyers, Pamela Reynolds, Fiona Ross, and Vaibhav Saria; and a Foreword by Francis B. Nyamnjoh
The book consists of novel and empirical research in broad areas of technology and curriculum in selected African countries. The central theme of the book is technology and the higher education curriculum. The book consists of case studies from selected African countries, namely, Lesotho; Namibia; Kenya; South Africa; Zimbabwe; Tanzania and Nigeria. These studies confirm that in this contemporary digital era, educational technology is playing an increasingly important role. It has become so ubiquitous and fundamental in the teaching and learning. Higher education sectors across the continent are increasingly compelled to use educational technology to keep up with needs of 21st century students who want to be afforded opportunities to be able to learn in real time, anytime, and on their own terms using opportunities for creative innovation made possible by new information and communication technologies.
This book comprises 19 creative non-fiction pieces and essays centred around the topics of language, thought, art and existence seen through the prism of practising artist in contemporary Africa. The collection continues with Zimbabwe's Tendai Mwanaka's creative non-fiction ideology of presenting non-fiction in a creative, fresh, easy reading, simple language. With most of the essays driven by personal stories, the author ably renders them accessible to a wide spectrum of readers from the scholarly to the journalistic and the general. The pieces are grouped according to the topics, with the language essays starting the book, followed by thought, existential, and art essays. In tune with the adage the personal is political, Mwanaka lets the personal drive these essays as he tries to investigate and conversationally navigate his thoughts, beliefs, feelings and experience on language, existence and art. This is an invaluable contribution to the academic establishment, social theorists, linguists, literary theorists, journalists, activists and the general readership.
This book is a biography based on a qualitative ethnographic study of adaptation to climate by Mr Zephaniah Phiri Maseko, an award-winning smallholder farmer from Zvishavane, rural Zimbabwe. Ethnographic data provides insight and lessons of Mr Phiri Maseko and other farmers' practices for rethinking existing strategies for adaptation to climate change. The concept of adaptation is probed in relationship to the closely related concepts of vulnerability, resilience and innovation. This study also explores the concept of conviviality and argues that Mr Phiri Maseko's adaptation to climate hinges on mediating barriers between local and exogenous knowledge systems. The book argues that Mr Phiri Maseko offered tangible adaptive climate strategies through his innovations that 'marry water and soil so that it won't elope and run-off but raise a family' on his plot. His agricultural practices are anchored on the Shona concept of' hurudza'(an exceptionally productive farmer). This book explores the concept and practices of 'uhurudza,'to suggest that the latter-day 'hurudza' (commercial farmer)'as embodied by Mr Phiri Maseko offers an important set of resources for the development of climate adaptation strategies in the region. This study of smallholder farmers' adoption of innovations to climate highlights the 'complex interplay' of multiple factors that act as barriers to uptake. Such interplay of multiple stressors increases the vulnerability of smallholders. The study concludes by arguing that in as much as the skewed colonial land policy impoverished the smallholder farmers, Mr Phiri Maseko nonetheless redefined himself as a latter-day 'hurudza and thus breaks free from the poverty cycle by conjuring ingenious ways of reducing vulnerability to climate. The book does not suggest that Mr Phiri Maseko's innovations offer a silver bullet solution to the insecure rural livelihoods of smallholder farmers; nevertheless, they are a source of hope in an environment of uncertainty. His steely tenacity in the face of a multi-stressor environment is to be treasured.
Barbed Forest
(2017)
Ivory Stars is Tanzanias first ever all-girls football team, but what makes this team even more unique is that they are people with albinism. Disregarded by society, the team is determined to show the world that they wont be held back. As International Albinism Awareness Day approaches, climbing Mount Kilimanjaro would defy stereotypes and prove that they are extraordinarily capable. Join Tatu, the team leader, and the Ivory Stars on their quest to reach the summit of the highest peak in Africa. Find out whether their determination will meet the challenges ahead. How will they manoeuvre through the twists and turns that lie in wait for them? What would it mean for them if they failed?
Reading these tales from Northern Malawi readers come close to watching an original performance and the tales and the songs encapsulate the essence of Malawian culture. The authors presentation, using performance directions, allows the reader to see and hear old Nyaviyuyi as she, through word, voice, tone and gesture, mocks nosy wives, and celebrates the devotion of friendship and parental love. The author has made a further contribution to the topic by including musical notations for the songs.
Democracy and Education in Namibia and beyond debates the educationdemocracy nexus in Namibia and the southern African context. It defines and explores the meaning of democracy and related concepts. It also looks at what democracy means in the context of human rights and access to education. The ten chapters in this collection interrogate the strengths and limitations of education as an instrument of social change and question whether or not the Namibian educational objectives and practices do develop and help to sustain a democratic culture in Namibia. The authors in the collection have drawn material from their own teaching and research experience across the fields of education and social science in Namibia and beyond, and present their findings in a pedagogical framework suitable as a challenging text for tertiary students. At a time when education is in crisis, especially in South Africa where strident calls for free tertiary education and Africanisation of the curriculum are spreading like wildfire, this book gives scholarly insight into the history and social conditions that gave rise to our current predicament.
Otuzo twOvaherero
(2017)
Otuzo twOvaherero provides valuable information on Ovaherero patriclans and records folklore and praise poems in Otjiherero. Previously, these did not exist in written form. The book attempts to preserve these oral traditions before they disappear. It aims to restore pride to the Ovaherero, particularly in patrilineages that were displaced by the Ovaherero-German war of 1904-1907. Otuzo twOvaherero is structured around the Ovaherero patrilineal descent system (otuzo) which is the basis of the Ovaherero religion Oupwee. The surnames and homesteads that belong to the same patrilineage are grouped together under each patriclan to help the reader to easily trace the homesteads that belong to one patriclan (and thus have a common ancestry). The distinct features of each patriclan are specified in terms of totems, taboos, patriclans which collaborate, and praise poems of homesteads. All the patriclans and praise poems in this book were collected from Ovaherero communities living in Namibia. The author uses the term Ovaherero to include the various groups which speak the common language Otjiherero and which include the Ovahimba, Ovaherero, Ovatjimba and Ovambanderu. This book has the potential to promote unity within the Ovaherero community by showing how families are connected in lineages which trace back centuries.
The Lie of the Land
(2017)
The Lie of the Land is a novel set against the background of the German colonial wars in Namibia in the early 1900s. The central character is an academic in linguistics who occasionally acts as a British agent. He is a cynical, private individual who sees himself as a neutral observer but is eventually forced to take sides when he witnesses the atrocities of the Herero and Nama genocide and, above all, meets a young Nama woman who enchants him. The novel explores the shifting nature of the oppressor and the oppressed. Despite the unfolding tragic events, the story is lightened by surprising bursts of humour, and is ultimately a love story.
A New History of Tanzania
(2017)
Tanzania, the land and the people have been subject of a great deal of historical research, but there remains no readily accessible and concise history of the country. The aim of this volume is to fill that void. A New History of Tanzania takes its name from a lecture series introduced at the University of Dar es Salaam by Professor Isaria Kimambo in 2002. Prior to that, a book titled, A History of Tanzania, had been published in 1969 by East African Publishing House in Nairobi for the Tanzania Historical Association. That book is currently out of print and this is not a reprint. In this book, Prof. Kimambo has been joined by two other colleagues; Prof. Gregory H. Maddox of Texas Southern University, Houston (USA) and Salvatory S. Nyanto, a Tanzanian, Lecturer at the University of Dar es Salaam, and a Ph.D. candidate at the University of Iowa (USA); together they have produced an outline history of Tanzania that covers all important aspects from antiquity to the present that is different from and richer than its predecessor. Sources from the fields of archaeology, anthropology, biology, genetics and oral tradition have been used to produce this excellent book.
Although there have been a number of studies on Black resistance, very few of these have focused exclusively on such a wide range of resistance campaigns and strategies within a single volume. One of the central arguments of this study is that from as early as the sixteenth century, when Europeans attempted to systematically exploit Africans, Black people have engaged in a variety of organised and sustained resistance campaigns to assert their independence and identity. This book examines some of the different strategies employed by Black people in Africa and the Diaspora in response to European domination and exploitation. Drawing upon research from scholars based at the University of Cape Coast in Ghana and the University of the West Indies, Jamaica, this collection of original essays, covers the academic disciplines of African and Caribbean history, literature, politics and psychology. Despite these different approaches, the consistent theme throughout, centres on the strategies employed by Black people to resist European domination and oppression, by fighting for their freedom at every possible opportunity, whether they were in Africa, Britain or the Caribbean.
'It is my duty to take the message of revolt to other[s]. is is the only way to liberate the victims of suffering and slavery,' Nazmi Durrani quotes W.L. Sohan in this book. Resistance to imperialism in pre-independence Kenya by progressive South Asian Kenyans propelled the Kenyan liberation struggle to new heights. They were active in almost every field, from publishing progressive newspapers to supplying arms and material to Mau Mau. Liberating Minds consists of biographies of progressive South Asian Kenyans written by Nazmi Durrani. Originally published in Gujarati in the 1980s, they are available here in English for the first time, together with the original Gujarati. Also included is Naila Durrani's 1987 conference paper, 'Kenya Asian Participation in People's Resistance,' while Benegal Pereira introduces Eddie H. Pereira (1915-1995) and his resistance letters to the Colonial Times Newspaper.
Eni and Other Poems
(2017)
Eni kaleidoscopically unveils human intrigues, predicaments and woes. It brings into sharp focus the most dreaded products of cruel oppression, exploitation, and destructionthe worst forms of human degradation and sufferings. However, it also sheds beams of hope, celebrating optimism in the struggle and eventually opening the curtain to the stage of victory of the oppressed and impoverished under the shameless sky.
The African conundrum... is rooted out of the historical, philosophical and cultural bastardisation, imbalances and inequalities which many post-colonial African governments have always sought to address, though with varying degrees of success, since the 1960s. Lamentably, this African conundrum is rarely examined in a systematic manner that takes into account the geopolitical milieu of the continent, past and present. This volume seeks to interrogate and examine the extent of the impact of the geopolitical seesaw which seems poised to tip in favour of the Global North. The book grapples with the question on how Africa can wake up from its cavernous intellectual slumber to break away from both material and psychological dependency and achieve a transformative political and socio-economic self-reinvention and self-assertion. While the African conundrum is largely a result of historic oppression and a resilient colonial legacy, this book urges Africans to rethink their condition in a manner that makes Africa responsible and accountable for its own destiny. The book argues that it is through this rethinking that Africa can successfully transcend the logic of post-imperial dependency.
Campground
(2017)
Through poetry and fiction that engage the readers heart and mind, Loretta Burns explores the beauties, perils, and mysteries of day to day life. With a graceful simplicity of style and an often intimate voice, she represents a range of experiences and observations that include stories and memories of childhood, encounters with nature and music, and poignant reminders of Americas racial history. With delicate craftsmanship and an ear attuned to the eloquence of everyday language, she moves from quiet contemplation to youthful exuberance and from love to the pain of loss with sensitivity and understanding. Implicit throughout is a resilient affirmation of the fractured joy of being human.
Dissatisfaction has matured in Africa and elsewhere around the fact that often, the dominant frameworks for interpreting the continents past are not rooted on the continents value system and philosophy. This creates knowledge that does not make sense especially to local communities. The big question therefore is can Africans develop theories that can contribute towards the interpretation of the African past, using their own experiences? Framed within a concept revision substrate, the collection of papers in this thought provoking volume argues for concept revision as a step towards decolonizing knowledge in the post-colony. The various papers powerfully expose that cleansed knowledge is not only locally relevant: it is also locally accessible and globally understandable.
From Antagonism to Re-engagement : Zimbabwe's Trade Negotiations with the European Union, 2000-2016
(2017)
The book interrogates the European Union (EU) - Zimbabwe Economic Partnership Agreement (EPA) negotiations, covering trade in goods, trade-related rules and development cooperation. The negotiations coincided with EUs motives as the dominant development partner, and Zimbabwes state-stakeholder fault-lines, creating dilemmas in the pursuit of a fair EPA outcome. As a result, the economically weak Zimbabwe signed and ratified an asymmetrical interim EPA (iEPA) with an economically powerful EU in 2009 and 2012, respectively. Meanwhile, direct bilateral re-engagement which eluded the Government of National Unity (GNU), became real following ZANU-PF landslide victory on 31 July 2013, that sufficiently altered the power balance to trigger the process between the former nemesis in support of iEPA domestication, and social and economic development. ZANU-PF government stopped blaming the EU and other western nations for the countrys continued economic under-performance, signaling a softening approach on its part. Similarly, the EU and its member states softened its perception on ZANU-PF leadership leading to resumption and intensification of re-engagement despite failure to implement the Global Political Agreement-related constitutional and democratic reforms, agreed by GNU. This re-engagement was firmly endorsed when the EU and Zimbabwe signed an agreement in July 2015 to normalise bilateral relations and start cooperation.
Echoes of a Whisper
(2017)
Lughano Mwangweghos Echoes of a Whisper is an imaginative array of poetic verse steeped in Africa and tackling the fraught space of being betwixt and between, within and without, memory and the present. Love runs avidly as a theme throughout and imagery thereof is at once beautiful and absurd, adding further to a sense of suspension, a sense of unease. Mwangweghos poetry is edgy: its colour is that of tension. Yet, in such a way it speaks to both mind and soul - in places it provokes both physical and emotional reaction from the reader and the empowerment it transfers is uncanny. As his second collection of poetry, Malawian poet and short story writer Lughano Mwangwegho once again offers here writing rich in anguish and loveliness.
This book is about transnational migration (familiarly called bushfalling) and remittance flows to Cameroon. With the current dire economic state, Cameroonians increasingly aspire to go abroad to make a living. Migrants achieve this through a collective (family) strategy and with the help of migration brokers. Relations between migrants and the family that stays in Cameroon can be characterized as follows: Families raise and educate their children to become adults. In return to giving their children the gift of life, families expect reciprocity, best secured through economic success abroad and the sending of remittances by migrants. As families in Cameroon heavily contribute to the funding of migration trajectories, often by selling properties such as land or houses or borrowing money, they also expect a return on their investments. All that constitutes this study explores under the notion of the moral economy of transnational remittances. In this study, remittances are understood to be a composite of financial, material, and cultural flowsmaintaining and transforming social and kinship ties. The book proposes also a large exploration of themes in relation to transnational migration: why and how Cameroonians migrate (the role of the operational family in terms of decision and funding; the role of migration brokers through the identification of lines and the provision of the necessary papers); the moral justification for migration; the ways social relations and customs are changed by status gained through migration; the ways people explain the failure of migration projects, the difficulties to stay abroad; the matrimonial strategies to go and stay abroad. This is an empirically rich and theoretically sophisticated study that takes thinking on transnational migration informed by African strategies and experiences a step further.
This volume interrogates and theorises various forms of fundamentalism and fetishism that impinge on Africa and the African people. The book valiantly rethinks and unpacks these forms of fundamentalisms and fetishisms, offering in the process critical vistas for students, scholars and activists on matters of decoloniality and transformation. By meticulously and painstakingly unpacking pertinent issues, the book provides unparalleled intellectual milestones and platforms for the oncoming revolution and quest for justice in the form of decoloniality and transformation. Drawing from several disciplinary domains such as Development Studies, Security Studies, Political Anthropology and Sociology, Economic Anthropology and Social studies, English Studies, History, Philosophy and Religious Studies, and drawing from scholars from across different universities in the Southern African region, the book provides multiple lenses from which to understand the complex goings on in a continent that can no longer afford to simply fold hands and watch while its citizens suffer multiple forms of coloniality, fetishisms and fundamentalisms.
Glial cell line-derived neurotrophic factor (GDNF) is a ligand that activates, through co-receptor GDNF family receptor alpha-1 (GFRα1) and receptor tyrosine kinase “RET”, several signaling pathways crucial in the development and sustainment of multiple neuronal populations. We decided to study whether non-mammalian orthologs of these three proteins have conserved their function: can they activate the human counterparts? Using the baculovirus expression system, we expressed and purified Danio rerio RET, and its binding partners GFRα1 and GDNF, and Drosophila melanogaster RET and two isoforms of co-receptor GDNF receptor-like. Our results report high-level insect cell expression of post-translationally modified and dimerized zebrafish RET and its binding partners. We also found that zebrafish GFRα1 and GDNF are comparably active as mammalian cell-produced ones. We also report the first measurements of the affinity of the complex to RET in solution: at least for zebrafish, the Kd for GFRα1-GDNF binding RET is 5.9 μM. Surprisingly, we also found that zebrafish GDNF as well as zebrafish GFRα1 robustly activated human RET signaling and promoted the survival of cultured mouse dopaminergic neurons with comparable efficiency to mammalian GDNF, unlike E. coli-produced human proteins. These results contradict previous studies suggesting that mammalian GFRα1 and GDNF cannot bind and activate non-mammalian RET and vice versa.
Echolocation allows bats to orientate in darkness without using visual information. Bats emit spatially directed high frequency calls and infer spatial information from echoes coming from call reflections in objects (Simmons 2012; Moss and Surlykke 2001, 2010). The echoes provide momentary snapshots, which have to be integrated to create an acoustic image of the surroundings. The spatial resolution of the computed image increases with the quantity of received echoes. Thus, a high call rate is required for a detailed representation of the surroundings.
One important parameter that the bats extract from the echoes is an object’s distance. The distance is inferred from the echo delay, which represents the duration between call emission and echo arrival (Kössl et al. 2014). The echo delay decreases with decreasing distance and delay-tuned neurons have been characterized in the ascending auditory pathway, which runs from the inferior colliculus (Wenstrup et al. 2012; Macías et al. 2016; Wenstrup and Portfors 2011; Dear and Suga 1995) to the auditory cortex (Hagemann et al. 2010; Suga and O'Neill 1979; O'Neill and Suga 1982).
Electrophysiological studies usually characterize neuronal processing by using artificial and simplified versions of the echolocation signals as stimuli (Hagemann et al. 2010; Hagemann et al. 2011; Hechavarría and Kössl 2014; Hechavarría et al. 2013). The high controllability of artificial stimuli simplifies the inference of the neuronal mechanisms underlying distance processing. But, it remains largely unexplored how the neurons process delay information from echolocation sequences. The main purpose of the thesis is to investigate how natural echolocation sequences are processed in the brain of the bat Carollia perspicillata. Bats actively control the sensory information that it gathers during echolocation. This allows experimenters to easily identify and record the acoustic stimuli that are behaviorally relevant for orientation. For recording echolocation sequences, a bat was placed in the mass of a swinging pendulum (Kobler et al. 1985; Beetz et al. 2016b). During the swing the bat emitted echolocation calls that were reflected in surrounding objects. An ultrasound sensitive microphone traveling with the bat and positioned above the bat’s head recorded the echolocation sequence. The echolocation sequence carried delay information of an approach flight and was used as stimulus for neuronal recordings from the auditory cortex and inferior colliculus of the bats.
Presentation of high stimulus rates to other species, such as rats, guinea pigs, suppresses cortical neuron activity (Wehr and Zador 2005; Creutzfeldt et al. 1980). Therefore, I tested if neurons of bats are suppressed when they are stimulated with high acoustic rates represented in echolocation sequences (sequence situation). Additionally, the bats were stimulated with randomized call echo elements of the sequence and an interstimulus time interval of 400 ms (element situation). To quantify neuronal suppression induced by the sequence, I compared the response pattern to the sequence situation with the concatenated response patterns to the element situation. Surprisingly, although the bats should be adapted for processing high acoustic rates, their cortical neurons are vastly suppressed in the sequence situation (Beetz et al. 2016b). However, instead of being completely suppressed during the sequence situation, the neurons partially recover from suppression at a unit specific call echo element. Multi-electrode recordings from the cortex allow assessment of the representation of echo delays along the cortical surface. At the cortical level, delay-tuned neurons are topographically organized. Cortical suppression improves sharpness of neuronal tuning and decreases the blurriness of the topographic map. With neuronal recordings from the inferior colliculus, I tested whether the echolocation sequence also induced neuronal suppression at subcortical level. The sequence induced suppression was weaker in the inferior colliculus than in the cortex. The collicular response makes the neurons able to track the acoustic events in the echolocation sequence. Collicular suppression mainly improves the signal-to-noise ratio. In conclusion, the results demonstrate that cortical suppression is not necessarily a shortcoming for temporal processing of rapidly occurring stimuli as it has previously been interpreted.
Natural environments are usually composed of multiple objects. Thus, each echolocation call reflects off multiple objects resulting in multiple echoes following the calls. At present, it is largely unexplored how neurons process echolocation sequences containing echo information from more than one object (multi-object sequences). Therefore, I stimulated bats with a multi-object sequence which contained echo information from three objects. The objects were different distances away from each other. I tested the influence of each object on the neuronal tuning by stimulating the bats with different sequences created from filtering object specific echoes from the multi-object sequence. The cortex most reliably processes echo information from the nearest object whereas echo information from distant objects is not processed due to neuronal suppression. Collicular neurons process less selectively echo information from certain objects and respond to each echo.
For proper echolocation, bats have to distinguish between own biosonar signals and the signals coming from conspecifics. This can be quite challenging when many bats echolocate adjacent to each other. In behavioral experiments, the echolocation performance of C. perspicillata was tested in the presence of potentially interfering sounds. In the presence of acoustic noise, the bats increase the sensory acquisition rate which may increase the update rate of sensory processing. Neuronal recordings from the auditory cortex and inferior colliculus could strengthen the hypothesis. Although there were signs of acoustic interference or jamming at neuronal level, the neurons were not completely suppressed and responded to the rest of the echolocation sequence.
Lieblingsbild
(2017)
Das Bild zeigt die Kryo-EM-Elektronendichtekarte des bakteriellen Kalium-Aufnahmesystems KtrAB mit ADP gebunden mit einer Auflösung von 6.6 Å. Das Bild ist mein Lieblingsbild, weil man bereits auf den ersten Blick eine dramatische Konformationsänderung im Vergleich zu einer früheren ATPgebundenen Struktur erkennen konnte, nämlich die Ausbildung langgestreckter α-Helices (hier gelb markiert), die die regulatorischen A-Untereinheiten (blau) mit den Kaliumionen-translozierenden B-Untereinheiten (grau) verbinden. ...
VJD Newsletter (1-2-2017)
(2017)
VJD Newsletter (1-5-2017)
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VJD Newsletter (1-4-2017)
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VJD Newsletter (1-3-2017)
(2017)
»Nicht schon wieder BAföG!« : die BAföG-Erstberatung des Studentenwerks bringt Licht ins Dunkle
(2017)
Das zwischenstaatliche Gewaltverbot steht im Zentrum der völkerrechtlichen Aufmerksamkeit. Auf bewaffnete Konflikte auf dem afrikanischen Kontinent trifft dies nur begrenzt zu. An dieses Defizit knüpft die Autorin ab der Zeitwende 1989/90 an. Dabei überschreitet sie die traditionellen Grenzen des Gewaltverbots und analysiert, inwieweit dies, v. a. durch die Fortentwicklung der Menschenrechtslehre, eine inhaltliche Änderungen erfahren hat, die auch die militärische Anwendung von Gewalt im Innern eines Staates ächtet (ius contra bellum internum). Ein weiterer Schwerpunkt sind Interventionen durch Regionalorganisation. Hierbei wird untersucht, ob multilaterale Interventionen schon dann gewohnheitsrechtliche Akzeptanz erfahren, wenn sie entweder formell oder materiell rechtmäßig sind. Zumindest solche, die durch den UN-Sicherheitsrat autorisiert sind, können diese sog. Baugenehmigungsthese für sich in Anspruch nehmen. Doch auch ohne UN-Mandat vermögen humanitäre Interventionen regionaler Organisationen in engen Grenzen völkerrechtmäßig sein.
[Rezension zu: Lewe, Christiane; Othold, Tim und Nicolas Oxen (Hg.): Müll. Interdisziplinäre Perspektiven auf das Übrig-Gebliebene. Bielefeld: Transcript, 2016.]”.
Der von Christiane Lewe, Tim Othold und Nicolas Oxen herausgegebene Band Müll. Interdisziplinäre Perspektiven auf das Übrig-Gebliebene eröffnet in Schlaglichtern Zugänge zu ‚übrig-gebliebener‘ Materialität in kulturwissenschaftlicher Perspektive. Ausgehend von der Annahme, bei nicht mehr gebrauchten Dingen handele es sich um das Ergebnis sozio-kultureller Zuschreibungsprozesse, interessieren sich die Beiträge für so unterschiedliche Phänomene wie die Inszenierung von Müll im Fernsehen, Gender und Schmutz, Gebäuderecycling, Self-Storage oder künstlerische Auseinandersetzungen mit Müll. Als gemeinsamer Schnittpunkt der Fallstudien stellt sich dabei das Vorhaben heraus, den als konventionell unterstellten Abwertungen des Übrig-Gebliebenen entgegenzuarbeiten. Eine literaturwissenschaftliche Perspektive fehlt hingegen.
Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells
(2017)
The adherens junction associated protein 1 (AJAP1, aka shrew-1) is presumably a type-I transmembrane protein localizing and interacting with the E-cadherin-catenin complex. In various tumors, AJAP1 expression is reduced or lost, including hepatocellular and esophageal squamous cell carcinoma, and glial-derived tumors. The aberrant expression of AJAP1 is associated with alterations in cell migration, invasion, increased tumor growth, and tumor vascularization, suggesting AJAP1 as a putative tumor suppressor. We show that AJAP1 attenuates sprouting angiogenesis by reducing endothelial migration and invasion capacities. Further, we show for the first time that endogenous AJAP1 is associated with the microtubule cytoskeleton. This linkage is independent from cell confluency and stable during angiogenic sprouting in vitro. Our work suggests that AJAP1 is a putative negative regulator of angiogenesis, reducing cell migration and invasion by interfering with the microtubule network. Based on our results and those of other authors, we suggest AJAP1 as a novel tumor suppressor and diagnostic marker.
A recent report showed PINK1 transcript levels to be up- or down-regulated by the gain or loss of Ataxin-2 function, respectively, in human blood, in a human neural cell line and in mouse tissues. These observations may have profound implications for the regulation of cell growth and may be medically exploited for the treatment of cancer and neural atrophy...
Es ist üblich, die Regisseure des festlandchinesischen Kinos in unterschiedliche Generationenkohorten einzuteilen. Sechs sind es bislang, wobei es die fünfte Generation war, die erstmals auch jenseits der Grenzen Chinas, zumal im westlichen Ausland breit rezipiert wurde. Ihre Vertreter, darunter Zhang Yimou, Chen Kaige und Tian Zhuangzhuang, schlossen ab 1982, also nach Ende der Kulturrevolution, ihr Studium an der erst vier Jahre zuvor für den Lehrbetrieb wieder geöffneten Pekinger Filmakademie ab, um Mitte bis Ende der 1980er Jahre ihre Debütfilme zu drehen. Deren prominent herausgestellte Individualität einerseits sowie unübersehbare Frontstellung zum bis dahin verbindlichen revolutionären Realismus mit seiner ungebrochenen Mao-Verherrlichung andererseits weisen sie als Produkte der auch und vor allem kulturellen Liberalisierungstendenzen unter Deng Xiaoping aus. Hiervon legt unter anderem Gelbe Erde (1984) ein deutliches Zeugnis ab, Chens immer wieder zu Recht als Initialwerk der fünften Generation gehandelter, subtil Systemkritik übender Erstling.
Für die vorzüglichen, seinerzeit als hochgradig experimentell wahrgenommenen Aufnahmen des Films zeichnete der anfangs auch als Schauspieler tätige Zhang Yimou verantwortlich, der mittlerweile in China ebenso wie im Ausland als der bei weitem bekannteste Vertreter nicht nur der fünften Generation, sondern des festlandchinesischen Kinos überhaupt gilt. Sein Regiedebüt legte er 1987 mit Rotes Kornfeld vor, der das vom so genannten Kultur-Fieber gepackte heimische Publikum begeisterte, aber auch im westlichen Ausland für Furore sorgte. Zahlreiche Auszeichnungen gingen an den Film, darunter, 1988 auf der Berlinale, der Goldene Bär, der damit erstmals einem asiatischen Film verliehen wurde.
Cleaning an ion beam from unwanted fractions is crucial for intense ion beams. This thesis will explore separation methods using a collimation channel, electric and magnetic dipoles and a velocity selector for low intensity beams on an experimental basis. In addition, statistical data of degassing events during the commissioning of a pentode extraction system for beam energies from 20 - 120keV will be presented.
Die Herztransplantation ist die Goldstandardtherapie der Herzinsuffizienz [24]. Verglichen mit der konventionellen Therapie führt sie zu einer verbesserten Überlebensrate, Belastbarkeit und Lebensqualität [15b]. Diese werden durch die internationale Gesellschaft für Herz- und Lungentransplantation (ISHLT) mit ihrer weltweit größten Datenbank für Herz- und Lungentransplantationsdaten überprüft [45]. Aufgrund des hohen Stellenwerts und der umfassenden Arbeit der ISHLT findet in dieser Dissertation der Vergleich der Daten über das Outcome von 76 Herztransplantierten der Johann-Wolfgang-Goethe-Universitätsklinik Frankfurt am Main (KGU) mit den Daten der ISHLT statt.
Es handelt sich bei dieser Arbeit um eine retrospektive Studie, die 60 Männer und 16 Frauen im Alter zwischen 18 und 68 Jahren einschließt, die an der Uniklinik Frankfurt zwischen dem 24.02.1997 und dem 04.05.2013 eine Herztransplantation erhielten. Das Ziel dieser Arbeit ist es, die Ergebnisse der Universitätsklinik Frankfurt a.M. mit den internationalen Werten zu vergleichen um genauere Informationen zur internationalen Positionierung zu erhalten. Die Resultate sollen dazu dienen, die eigenen Prozesse zu verbessern, Stärken auszubauen und Schwächen zu beheben und die Behandlung der Patienten den wissenschaftlichen Empfehlungen anzupassen.
Die Ergebnisse dieser Studie zeigten, dass die 1-Jahres-Überlebenswahrscheinlichkeit an der KGU mit 69% deutlich geringer war als international mit 81% [37a]. Dabei zeigte sich in genaueren Analysen, dass das schlechtere Kurzzeitüberleben vor allem von der Transplantationsära von Februar 1997 bis 2001, der zur Transplantation führenden Diagnose einer ischämischen Kardiomyopathie (ICM) und dem Vorhandensein eines Assist Devices vor der Transplantation verursacht wurde. Das Alter und das Geschlecht des Patienten dagegen schienen keinen Einfluss darauf zu nehmen. Im Langzeitüberleben lagen die Ergebnisse der KGU deutlich über den Werten der ISHLT. Unter der Bedingung, dass das erste postoperative Jahr überlebt wurde, ergab sich für KGU Patienten eine 10- bzw. 15-Jahres-Überlebenswahrscheinlichkeit von 74% (n=40) bzw. 60% (n=33). Die Wahrscheinlichkeit das 10. postoperative Jahr zu überleben lag für ISHLT Patienten bei 63,9%; für das 15. Jahr lag dieser Wert bei 42% [37g].
Die Langzeitkomplikationen der Malignität und der TVP traten an der KGU anteilig seltener auf als international. Die TVP-Freiheit nach 10 Jahren lag international bei 47% und an der KGU bei 75% [37e]. Für die Freiheit von Malignität lag die Wahrscheinlichkeit des 10. Jahres international bei 66% und an der KGU bei 74% [37c]. Die Wahrscheinlichkeit für die Freiheit von einem Kreatininwert über 2,5mg/dl bis zum 10. Jahr nach Transplantation war an der KGU mit 70% (n=26) ähnlich wie die internationalen Werte von 61,5% [37b]. Die Patienten der KGU erlitten des Weiteren deutlich mehr Abstoßungen im ersten Jahr. Während international zwischen 25 und 30% der Patienten eine Abstoßungsreaktion im ersten Jahr erlebten, waren es an der KGU mindestens 50%. Trotzdem war der Anteil an behandlungsbedürftigen Abstoßungen an der KGU anteilig geringer als bei dem Patientenkollektiv der ISHLT [37d]. Bei der Analyse der Immunsuppression zeigte sich, dass die KGU das Steroidweaning deutlich später und in wesentlich geringerem Ausmaß durchführt: während im 5. postoperativen Jahr 48% der ISHLT-Patienten Steroide erhalten, sind es an der KGU noch 83% (n=40) [37n]. Im Vergleich der verschiedenen Kombinationstherapien zeigte sich, dass in der Patientengruppe der KGU hauptsächlich Kombinationen mit Ciclosporin (Jahr 1 85,2%, n=46) angewendet wurden, während unter den ISHLT-Patienten hauptsächlich Tacrolimus (Jahr 1 57,5%, n=4053) eingesetzt wurde. Beide Gruppen haben gemeinsam, dass der Anteil an Sirolimus- bzw. Everolimus-Kombinationen von Jahr 1 auf Jahr 5 zunimmt. Dabei kommen diese Kombinationen prozentual gesehen international häufiger vor [37m].
Folglich konnte diese Studie nicht nur zeigen, wo die Stärken der Universitätsklinik Frankfurt liegen, sondern auch welche Punkte in naher Zukunft verbessert werden können. Somit werden konkrete Anpassungen an der Behandlung der HTx-Patienten der KGU erfolgen können.
Türkiye'de çevirmen yetiştiren kurumların sayısının hızla artmasına karşın, çevirmen adaylarının uygulamaya ilişkin yetkinliklerini artırmayı hedefleyen, nitelikli eserlerin çok az olması düşündürücüdür. Bunda, çeviribilimin nispeten genç bir bilim alanı olmasının yanı sıra, yabancı dil edincine öncelik verilmesinin ve çevirmen adaylarının çeviri edinçlerini çeviri yaparak geliştirecekleri yanılgısı (bkz. Hagemann/ Hönig 2011) önemli bir etkendir. Oysaki çevirmen adayının, metinleri çeviri odaklı çözümleyebilme yetisine sahip olması çok önemlidir. Yücel'in de belirttiği gibi, "Bu beceriyi ve bilinci geliştirmek için öğrencilerin, metinlerin nitelik ve işlevlerini bilmenin ötesinde bir metnin nasıl farklı biçimde çevrilebileceği becerisini kazanmaları gerekmektedir".
SME funding without banks?
(2017)
Wie kaum eine andere Machtform ist die autoritative Macht an Personen gebunden: an das Charisma der Autoritäten. Doch kann die "maßgebende Macht" auch ihre "transzendente Legitimation" einbüßen, nicht allein durch den Umsturz einer geltenden Ordnung, sondern vor allem durch den Tod ihrer Vermittler, der Heroen jeweiliger Kulturen. Die Stabilisierung autoritativer Macht bedarf darum hoher Symbolisierungsleistungen, beispielsweise durch Rituale der Kontinuität, die sowohl zwischen Funktion und Person differenzieren, als auch die Übertragung von Autorität ermöglichen sollen. [...] Daher mussten Unterbrechungen der autoritativen Macht - eine Zeitspanne des gefürchteten Interregnums - symbolisch überbrückt werden, etwa durch komplexe Bestattungsrituale. Im Rahmen solcher Bestattungsrituale wurden Wachsmasken und Puppen des toten Herrschers verwendet, wie sie bereits in der römischen Antike eingesetzt wurden. Totenmasken bezeugen das Überleben der Macht. [...] Ein Museum der Totenmasken kann im Dienst der Erinnerung stehen, des Kults der "grands hommes". Im Horizont dieses Kults wurde der Glaube an die persönliche Unsterblichkeit durch die Hoffnung auf Prominenz und ein dauerhaftes Nachleben im Gedächtnis künftiger Generationen ersetzt. Napoleon, Goethe oder Beethoven fungierten als die säkularen Gottheiten jener parareligiösen Strömung, die der Wissenschaftshistoriker Edgar Zilsel in einer 1918 publizierten, hellsichtigen Analyse als "Geniereligion" charakterisierte. Zu den Dogmen dieser Religion zählte die Vorstellung von einer höheren Unsterblichkeit der Genies, die sich gerade daraus ergeben sollte, dass sie zu Lebzeiten "verkannt" werden. [...] Die prominenteste Totenmaske des frühen 20. Jahrhunderts wurde indes keinem Herrscher, Revolutionär oder Genie abgenommen, sondern einer Unbekannten. Schon zur Jahrhundertwende verbreitete sich die Legende von einer unbekannten Selbstmörderin, die aus der Seine geborgen wurde; ihr friedlich und geheimnisvoll lächelndes Gesicht habe einen Mitarbeiter der Pariser Morgue so gerührt, dass er der Toten eine Gipsmaske abnahm.
Background: Previous magnetic resonance imaging (MRI) research suggests that, prior to the onset of psychosis, high risk youths already exhibit brain abnormalities similar to those present in patients with schizophrenia.
Objectives: The goal of the present study was to describe the functional organization of endogenous activation in young adolescents who report auditory verbal hallucinations (AVH) in view of the “distributed network” hypothesis of psychosis. We recruited 20 young people aged 13–16 years who reported AVHs and 20 healthy controls matched for age, gender and handedness from local schools.
Methods: Each participant underwent a semi-structured clinical interview and a resting state (RS) neuroimaging protocol. We explored functional connectivity (FC) involving three different networks: 1) default mode network (DMN) 2) salience network (SN) and 3) central executive network (CEN). In line with previous findings on the role of the auditory cortex in AVHs as reported by young adolescents, we also investigated FC anomalies involving both the primary and secondary auditory cortices (A1 and A2, respectively).
Further, we explored between-group inter-hemispheric FC differences (laterality) for both A1 and A2. Compared to the healthy control group, the AVH group exhibited FC differences in all three networks investigated. Moreover, FC anomalies were found in a neural network including both A1 and A2. The laterality analysis revealed no between-group, inter-hemispheric differences.
Conclusions: The present study suggests that young adolescents with subclinical psychotic symptoms exhibit functional connectivity anomalies directly and indirectly involving the DMN, SN, CEN and also a neural network including both primary and secondary auditory cortical regions.
Despite the growth of Open Access, potentially illegally circumventing paywalls to access scholarly publications is becoming a more mainstream phenomenon. The web service Sci-Hub is amongst the biggest facilitators of this, offering free access to around 62 million publications. So far it is not well studied how and why its users are accessing publications through Sci-Hub. By utilizing the recently released corpus of Sci-Hub and comparing it to the data of ~28 million downloads done through the service, this study tries to address some of these questions. The comparative analysis shows that both the usage and complete corpus is largely made up of recently published articles, with users disproportionately favoring newer articles and 35% of downloaded articles being published after 2013. These results hint that embargo periods before publications become Open Access are frequently circumnavigated using Guerilla Open Access approaches like Sci-Hub. On a journal level, the downloads show a bias towards some scholarly disciplines, especially Chemistry, suggesting increased barriers to access for these. Comparing the use and corpus on a publisher level, it becomes clear that only 11% of publishers are highly requested in comparison to the baseline frequency, while 45% of all publishers are significantly less accessed than expected. Despite this, the oligopoly of publishers is even more remarkable on the level of content consumption, with 80% of all downloads being published through only 9 publishers. All of this suggests that Sci-Hub is used by different populations and for a number of different reasons, and that there is still a lack of access to the published scientific record. A further analysis of these openly available data resources will undoubtedly be valuable for the investigation of academic publishing.
The website Sci-Hub provides access to scholarly literature via full text PDF downloads. The site enables users to access articles that would otherwise be paywalled. Since its creation in 2011, SciHub has grown rapidly in popularity. However, until now, the extent of Sci-Hub’s coverage was unclear. As of March 2017, we find that Sci-Hub’s database contains 68.9% of all 81.6 million scholarly articles, which rises to 85.2% for those published in toll access journals. Coverage varies by discipline, with 92.8% coverage of articles in chemistry journals compared to 76.3% for computer science. Coverage also varies by publisher, with the coverage of the largest publisher, Elsevier, at 97.3%. Our interactive browser at greenelab.github.io/scihub allows users to explore these findings in more detail. We find Sci-Hub preferentially covers popular, paywalled content, containing 96.2% of citations to toll access journals since 2015. For recently requested articles by Unpaywall users, oaDOI provided access to 48.8% whereas Sci-Hub contained 81.5%. Together, oaDOI and Sci-Hub covered 94.1%, demonstrating that gaps in Sci-Hub’s coverage, especially for open access articles, can be filled using licit services. For the first time, nearly all scholarly literature is available gratis to anyone with an Internet connection. Sci-Hub’s scope suggests the subscription publishing model is becoming unsustainable.
Processes shaping the African Guineo-Congolian rain forest, especially in the West African part, are not well understood. Recent molecular studies, based mainly on forest tree species, confirmed the previously proposed division of the western African Guineo-Congolian rain forest into Upper Guinea (UG) and Lower Guinea (LG) separated by the Dahomey Gap (DG). Here we studied nine populations in the area of the DG and the borders of LG and UG of the widespread liana species, Chasmanthera dependens (Menispermaceae) by amplified fragment length polymorphism (AFLP), a chloroplast DNA sequence marker, and modelled the distribution based on current as well as paleoclimatic data (Holocene Climate Optimum, ca. 6 kyr BP and Last Glacial Maximum, ca. 22 kyr BP). Current population genetic structure and geographical pattern of cpDNA was related to present as well as historical modelled distributions. Results from this study show that past historical factors played an important role in shaping the distribution of C. dependens across West Africa. The Cameroon Volcanic Line seems to represent a barrier for gene flow in the present as well as in the past. Distribution modelling proposed refugia in the Dahomey Gap, supported also by higher genetic diversity. This is in contrast with the phylogeographic patterns observed in several rainforest tree species and could be explained by either diverging or more relaxed ecological requirements of this liana species.
The website Sci-Hub provides access to scholarly literature via full text PDF downloads. The site enables users to access articles that would otherwise be paywalled. Since its creation in 2011, Sci-Hub has grown rapidly in popularity. However, until now, the extent of Sci-Hub's coverage was unclear. As of March 2017, we find that Sci-Hub's database contains 68.9% of all 81.6 million scholarly articles, which rises to 85.2% for those published in closed access journals. Furthermore, Sci-Hub contains 77.0% of the 5.2 million articles published by inactive journals. Coverage varies by discipline, with 92.8% coverage of articles in chemistry journals compared to 76.3% for computer science. Coverage also varies by publisher, with the coverage of the largest publisher, Elsevier, at 97.3%. Our interactive browser at https://greenelab.github.io/scihub allows users to explore these findings in more detail. Finally, we estimate that over a six-month period in 2015–2016, Sci-Hub provided access for 99.3% of valid incoming requests. Hence, the scope of this resource suggests the subscription publishing model is becoming unsustainable. For the first time, the overwhelming majority of scholarly literature is available gratis to anyone with an Internet connection.
Peer review of research articles is a core part of our scholarly communication system. In spite of its importance, the status and purpose of peer review is often contested. What is its role in our modern digital research and communications infrastructure? Does it perform to the high standards with which it is generally regarded? Studies of peer review have shown that it is prone to bias and abuse in numerous dimensions, frequently unreliable, and can fail to detect even fraudulent research. With the advent of Web technologies, we are now witnessing a phase of innovation and experimentation in our approaches to peer review. These developments prompted us to examine emerging models of peer review from a range of disciplines and venues, and to ask how they might address some of the issues with our current systems of peer review. We examine the functionality of a range of social Web platforms, and compare these with the traits underlying a viable peer review system: quality control, quantified performance metrics as engagement incentives, and certification and reputation. Ideally, any new systems will demonstrate that they out-perform current models while avoiding as many of the biases of existing systems as possible. We conclude that there is considerable scope for new peer review initiatives to be developed, each with their own potential issues and advantages. We also propose a novel hybrid platform model that, at least partially, resolves many of the technical and social issues associated with peer review, and can potentially disrupt the entire scholarly communication system. Success for any such development relies on reaching a critical threshold of research community engagement with both the process and the platform, and therefore cannot be achieved without a significant change of incentives in research environments.
Nepal is highly vulnerable to global climate change, despite its negligible emission of global greenhouse gases. The vulnerable climate-sensitive sectors identified in Nepal's National Adaptation Programme of Action (NAPA) to Climate Change 2010 include agriculture, forestry, water, energy, public health, urbanization and infrastructure, and climate-induced disasters. In addition, analyses carried out as part of the NAPA process have indicated that the impacts of climate change in Nepal are not gender neutral. Vector-borne diseases, diarrhoeal diseases including cholera, malnutrition, cardiorespiratory diseases, psychological stress, and health effects and injuries related to extreme weather are major climate-sensitive health risks in the country. In recent years, research has been done in Nepal in order to understand the changing epidemiology of diseases and generate evidence for decision-making. Based on this evidence, the experience of programme managers, and regular surveillance data, the Government of Nepal has mainstreamed issues related to climate change in development plans, policies and programmes. In particular, the Government of Nepal has addressed climate-sensitive health risks. In addition to the NAPA report, several policy documents have been launched, including the Climate Change Policy 2011; the Nepal Health Sector Programme – Implementation Plan II (NHSP-IP 2) 2010–2015; the National Health Policy 2014; the National Health Sector Strategy 2015–2020 and its implementation plan (2016–2021); and the Health National Adaptation Plan (H-NAP): climate change and health strategy and action plan (2016–2020). However, the translation of these policies and plans of action into tangible action on the ground is still in its infancy in Nepal. Despite this, the health sector's response to addressing the impact of climate change in Nepal may be taken as a good example for other low- and middle-income countries.
The genus Eulibitia was described by Roewer including three species from Colombia and Ecuador: Eulibitia maculata Roewer, 1912, E. annulipes Roewer, 1912 and E. sexpunctata Roewer, 1914. Herein, the genus is revisited and only the type species, Eulibitia maculata Roewer, 1912 is maintained from the previous configuration. Eulibitia sexpunctata is transferred to Ambatoiella Mello- Leitão, 1943 and E. annulipes is considered as Cosmetinae incertae sedis. Acromares lateralis Goodnight & Goodnight, 1943 and Paramessa castanea (Sørensen, 1932) are here considered junior subjective synonyms of Messatana scalaris (Sørensen, 1932) and Eulibitia maculata, respectively. Brachylibitia Mello-Leitão, 1941, currently a junior synonym of Platymessa, is regarded as a synonym of Eulibitia. Platymessa Mello-Leitão, 1941, with two species, and the monotypic genera Messatana Strand, 1942 and Paramessa Mello-Leitão, 1933, are synonymized with Eulibitia Roewer, 1912, yielding the following new combinations: Eulibitia ectroxantha (for Brachylibitia ectroxantha Mello-Leitão, 1941), E. h-inscriptum (for Platymessa h-inscripta Mello-Leitão, 1941) and E. scalaris (for Libitia (Messa) scalaris Sørensen, 1932). Eulibitia is re-diagnosed and five new species are described: E. castor sp. nov., E. pollux sp. nov., E. clytemnestra sp. nov., E. leda sp. nov. and E. helena sp. nov. A key to the nine Eulibitia species is presented; the morphology of Eulibitia is compared with that of Libitia, Libitiella and Ambatoiella.
In der vorliegenden Arbeit wurde ein integrativer Netzwerkmodellierungsansatz gewählt, um die Rolle des Endothels im Kontext der Arteriosklerose zu untersuchen. Hierbei wurden bioinformatische Analysen, laborexperimentelle Versuche und klinische Daten vereinigt und aus dieser Synthese neue klinisch relevante Gene identifiziert und beschrieben.
Das Endothel trägt maßgeblich zur Homöostase des vaskulären Systems bei und eine Dysfunktion des Endothels fördert die Entstehung der Arteriosklerose. Im Zuge der Atherogenese entstehen vermehrt reaktive Sauerstoffspezies, die Lipide in der Membran von Plasma-Lipoprotein-Partikeln und in der zellulären Plasmamembran oxidieren. Eine Gruppe solcher oxidierter Membranlipide ist oxPAPC, das in erhöhter Konzentration in arteriosklerotischen Plaques und lokal an Orten chronischer Entzündung im vaskulären System vorkommt. Weitherhin findet sich diese Gruppe von oxidierten Phospholipiden in oxidierten LDL-Partikeln, in denen oxPAPC die Bindung an Makrophagen vermittelt und hierdurch maßgeblich zur Bildung der Schaumzellen und damit zum arteriosklerotischen Prozess beiträgt. Die durch oxPAPC verursachte Veränderung der Endothelzelle ist bisher wenig erforscht. Es ist jedoch bekannt, dass oxPAPC die Transkriptionslandschaft in Endothelzellen tiefgreifend verändert. Um der Komplexität der Endothelzellveränderung gerecht zu werden, wurde ein bayesscher Ansatz angewendet.
In einem ersten Schritt wurden Expressionsprofile von humanen Aortenendothelzellen (HAEC) aus 147 Herztransplantatspendern verwendet. Diese Expressionprofile enthalten Transkriptionsinformationen der 147 HAEC, die mit oxPAPC oder Kontrollmedium behandelt worden waren. Es wurden signifikant koexprimierte Gene identifiziert und hiervon Gen-Paare berechnet, die einen differentiellen Vernetzungsgrad zwischen Kontroll- and oxPAPC-Status aufweisen. Dieses Netzwerkmodell gibt darüber Aufschluss, welche Gene miteinander in Verbindung stehen. 26759 Gene-Paare, die differentiell verbunden und signifkant koexprimiert waren, wurden hierarchisch gruppiert. Es wurden neun Gen-Gruppen mit einer erhöhten und elf Gen-Gruppen mit einer verminderten Konnektivität nach oxPAPC identifiziert. Gruppe 6 der erhöhten Konnektvitäts-Gruppen wies hierbei die höchste kohärente Konnektivität von allen Gruppen auf. Eine Analyse signifikant überrepräsentierter kanonischer Gensätze ergab, dass diese Gruppe insbesondere Serin-Glycin-Aminosäuremetabolismus, tRNA- und mTOR-Aktivierung wiederspiegelte. Der hier gewählte Netzwerkmodellierungsansatz zeigte auf, dass der Aminosäuremetabolismus durch oxidizerte Phospholipide massiven Veränderungen unterworfen ist.
Um den Mechanismus der Veränderung des Aminosäuremetabolismus näher zu untersuchen, wurden bayessche Netzwerkmodelle verwendet. Dieses Netzwerkmodell enthält im Gegensatz zum differentiellen Koexpresssionsmodell gerichtete Informationen innerhalb des Netzwerkgraphes. Die Gen-Gen Verbindungen sind kausal, wodurch sich eine Hierarchie bildet und Schlüsselfaktoren innerhalb des Netzwerks bestimmt werden können. Durch die Integrierung von Expressionsprofilen und Genomprofilen derselben HAEC-Kohorte und der Inferenz von kausalen Gen-Gen-Verbindungen ergaben sich zwei bayessche Netze: Kontroll- und oxPAPC-Netzwerk. Permutationsuntersuchungen und systematische Beurteilung im Vergleich zu Gen-Gen-Verbindungen in Online-Datenbanken zeigten eine erhöhte Prognosefähigkeit der beiden HAEC bayesschen Netze. Es wurden die Schlüsselfaktoren und deren Teilnetzwerke berechnet und auf biologische Wege hin untersucht. Hierbei wurde das mitochondriale Protein MTHFD2 als ein Schlüsselfaktor für ein Teilnetzwerk des oxPAPC bayesschen Netzes identifiziert. Dieses Teilnetz zeigte eine ähnliche Gensatzanreicherung wie GOC-AA und überlappte mit diesem signifikant.
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Three-dimensional multicellular aggregates such as spheroids provide reliable in vitro substitutes for tissues. Quantitative characterization of spheroids at the cellular level is fundamental. We present the first pipeline that provides three-dimensional, high-quality images of intact spheroids at cellular resolution and a comprehensive image analysis that completes traditional image segmentation by algorithms from other fields. The pipeline combines light sheet-based fluorescence microscopy of optically cleared spheroids with automated nuclei segmentation (F score: 0.88) and concepts from graph analysis and computational topology. Incorporating cell graphs and alpha shapes provided more than 30 features of individual nuclei, the cellular neighborhood and the spheroid morphology. The application of our pipeline to a set of breast carcinoma spheroids revealed two concentric layers of different cell density for more than 30,000 cells. The thickness of the outer cell layer depends on a spheroid’s size and varies between 50% and 75% of its radius. In differently-sized spheroids, we detected patches of different cell densities ranging from 5 × 105 to 1 × 106 cells/mm3. Since cell density affects cell behavior in tissues, structural heterogeneities need to be incorporated into existing models. Our image analysis pipeline provides a multiscale approach to obtain the relevant data for a system-level understanding of tissue architecture.
Both hemispheres contribute to motor control beyond the innervation of the contralateral alpha motoneurons. The left hemisphere has been associated with higher-order aspects of motor control like sequencing and temporal processing, the right hemisphere with the transformation of visual information to guide movements in space. In the visuomotor context, empirical evidence regarding the latter has been limited though the right hemisphere’s specialization for visuospatial processing is well-documented in perceptual tasks. This study operationalized temporal and spatial processing demands during visuomotor processing and investigated hemispheric asymmetries in neural activation during the unimanual control of a visual cursor by grip force. Functional asymmetries were investigated separately for visuomotor planning and online control during functional magnetic resonance imaging in 19 young, healthy, right-handed participants. The expected cursor movement was coded with different visual trajectories. During planning when spatial processing demands predominated, activity was right-lateralized in a hand-independent manner in the inferior temporal lobe, occipito-parietal border, and ventral premotor cortex. When temporal processing demands overweighed spatial demands, BOLD responses during planning were left-lateralized in the temporo-parietal junction. During online control of the cursor, right lateralization was not observed. Instead, left lateralization occurred in the intraparietal sulcus. Our results identify movement phase and spatiotemporal demands as important determinants of dynamic hemispheric asymmetries during visuomotor processing. We suggest that, within a bilateral visuomotor network, the right hemisphere exhibits a processing preference for planning global spatial movement features whereas the left hemisphere preferentially times local features of visual movement trajectories and adjusts movement online.
Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA, motor and non-motor tasks that rely on internal timing increase the amplitude of beta oscillations in the SMA. These independent observations suggest that the relationship between beta oscillations and BOLD activation is more complex than previously thought. Here we set out to investigate this rapport by examining beta oscillations in the SMA during movement with varying degrees of internal timing demands. In a simultaneous EEG-fMRI experiment, 20 healthy right-handed subjects performed an auditory-paced finger-tapping task. Internal timing was operationalized by including conditions with taps on every fourth auditory beat, which necessitates generation of a slow internal rhythm, while tapping to every auditory beat reflected simple auditory-motor synchronization. In the SMA, BOLD activity increased and power in both the low and the high beta band decreased expectedly during each condition compared to baseline. Internal timing was associated with a reduced desynchronization of low beta oscillations compared to conditions without internal timing demands. In parallel with this relative beta power increase, internal timing activated the SMA more strongly in terms of BOLD. This documents a task-dependent non-linear relationship between BOLD and beta-oscillations in the SMA. We discuss different roles of beta synchronization and desynchronization in active processing within the same cortical region.
Human beings are assumed to possess an approximate number system (ANS) dedicated to extracting and representing approximate numerical magnitude information. The ANS is assumed to be fundamental to arithmetic learning and has been shown to be associated with arithmetic performance. It is, however, still a matter of debate whether better arithmetic skills are reflected in the ANS. To address this issue, Chinese and German adults were compared regarding their performance in simple arithmetic tasks and in a non-symbolic numerical magnitude comparison task. Chinese participants showed a better performance in solving simple arithmetic tasks and faster reaction times in the non-symbolic numerical magnitude comparison task without making more errors than their German peers. These differences in performance could not be ascribed to differences in general cognitive abilities. Better arithmetic skills were thus found to be accompanied by a higher speed of retrieving non-symbolic numerical magnitude knowledge but not by a higher precision of non-symbolic numerical magnitude representations. The group difference in the speed of retrieving non-symbolic numerical magnitude knowledge was fully mediated by the performance in arithmetic tasks, suggesting that arithmetic skills shape non-symbolic numerical magnitude processing skills.
Dr. Z. Ece Kaya, 1978 in Istanbul geboren, ist u. a. Diplom-Politologin und promovierte Erziehungswissenschaftlerin. Ihre Arbeitsschwerpunkte sind Erziehungswissenschaften in der NS-Zeit sowie pädagogische Antworten auf Rassismus und Nationalismus. Sie arbeitet auch als Übersetzerin, Sprachlehrerin und als Theaterpädagogin. Für ihre Dissertation »Kolonialpädagogische Schriften in der NS-Zeit: ,Eine spezifisch deutsche Theorie der Kolonisation‘ – Zur Geschichte des Kolonialrassismus in der deutschen Erziehungswissenschaft « wurde sie 2017 mit dem Werner-Pünder-Preis ausgezeichnet.
In this study, we aimed to comparatively evaluate high-resolution 3D ultrasonography (hrUS), in-vivo micro-CT (μCT) and 9.4T MRI for the monitoring of tumor growth in an orthotopic renal cell carcinoma (RCC) xenograft model since there is a lack of validated, non-invasive imaging tools for this purpose. 1 × 106 Caki-2 RCC cells were implanted under the renal capsule of 16 immunodeficient mice. Local and systemic tumor growth were monitored by regular hrUS, μCT and MRI examinations. Cells engrafted in all mice and gave rise to exponentially growing, solid tumors. All imaging techniques allowed to detect orthotopic tumors and to precisely calculate their volumes. While tumors appeared homogenously radiolucent in μCT, hrUS and MRI allowed for a better visualization of intratumoral structures and surrounding soft tissue. Examination time was the shortest for hrUS, followed by μCT and MRI. Tumor volumes determined by hrUS, μCT and MRI showed a very good correlation with each other and with caliper measurements at autopsy. 10 animals developed pulmonary metastases being well detectable by μCT and MRI. In conclusion, each technique has specific strengths and weaknesses, so the one(s) best suitable for a specific experiment may be chosen individually.
We analyze older individuals’ debt and financial vulnerability using data from the Health and Retirement Study (HRS) and the National Financial Capability Study (NFCS). Specifically, in the HRS we examine three different cohorts (individuals age 56–61) in 1992, 2004, and 2010 to evaluate cross-cohort changes in debt over time. We also use two waves of the NFCS (2012 and 2015) to gain additional insights into debt management and older individuals’ capacity to shield themselves against shocks. We show that recent cohorts have taken on more debt and face more financial insecurity, mostly due to having purchased more expensive homes with smaller down payments.
In April and May 2012 data on Au+Au collisions at beam energies of Ekin = 1.23A GeV were recorded with the High Acceptance Di-Electron Spectrometer, which is located at the GSI Helmholtz Center for Heavy Ion Research in Darmstadt, Germany. At this beam energy all hadrons containing strangeness are produced below their elementary production threshold. The required energy is not available in binary NN collisions but must be provided by the system e.g. through multi-particle interactions or medium effects like a modified in-medium potential (e.g. KN/ΛN potential). Thus, a high sensitivity to these medium effects is expected in the investigated system.
The baryon-dominated systems created in relativistic heavy-ion collisions (HIC) at SIS18 energies reach densities of about 2-3 times ground state density p0 and may be similar to the properties of matter expected in the inner core of neutron stars. It is in particular the behavior of hadrons containing strangeness, i.e. kaons and hyperons, and their potentials in the dense medium which may have severe implications on astrophysical objects and processes. As ab-initio calculations of quantum chromodynamics (QCD) cannot be performed rigorously on the lattice at finite baryo-chemical potentials due to the fermion sign problem, effective descriptions have to be used in order to model properties of dense systems and the involved particles. The only way to access the in-medium potential of strange hadrons above nuclear ground state density p0 is by comparing data from relativistic HIC to such effective microscopic models. Up to now, not much data on neutral kaons and Λ hyperons are available from heavy collision systems close to their NN production threshold. These two electromagnetically uncharged strange hadrons are in particular well suited to study their potential in a dense nucleon-dominated environment as their kinematic spectra are not affected by Coulomb interactions.
Der Beitrag beschäftigt sich mit der deutschsprachigen Migrationsliteratur und mit ihrem Platz in der heutigen literarischen Szene. Es wird die Frage gestellt, warum diese Literatur aus ihrer früher eher peripheren Stelle (hinsichtlich des Interesses der LeserInnen und der Literaturwissenschaft) ins Zentrum verschoben wurde. Das Hauptanliegen des Beitrags ist jedoch die literarische Analyse dreier Werke von zwei aus der ehemaligen Sowjetunion stammenden, auf Deutsch schreibenden Schriftstellerinnen (Olga Grjasnowa und Lena Gorelik) in Bezug auf die ausgewählten spezifischen thematischen Schwerpunkte, die durch oder infolge Migration (der Hauptfiguren oder auch der SchriftstellerInnen selbst) entstanden waren.
Für die Fußnote
(2017)
Existiert eine Comic-Wissenschaft? Wer die Beiträge durchsieht, die in der hier vorliegenden Dokumentation der Tagung 'Grenzen ziehen, Grenzen überschreiten' formuliert wurden, kann feststellen, dass sie alle den wissenschaftlichen Charakter wahren, der an den Universitäten in unseren Tagen gelehrt wird. Es gibt AutorInnennamen, Titel, längere Untertitel, abstracts und Fußnoten. Es ist alles in bester Ordnung: wenn die Grenzen der Comics befragt werden, müssen ja nicht gleich die Grenzen der Wissenschaftlichkeit in den Blick geraten. Doch wird sich bei der genaueren Lektüre der Eindruck nicht abwehren lassen, dass es etwas Disparates oder sogar Desparates gibt, dass zwischen den verschiedenen wissenschaftlichen Ansätzen, Methoden und Schreibweisen Grenzen existieren, die nicht ausdrücklich benannt, reflektiert oder eben wissenschaftlich bearbeitet werden, dass die Fiktion einer Comicwissenschaft nicht darüber hinwegtäuschen kann, dass die vielen Forschungen und Studien sich immer wieder in die verschiedenen Fächer verteilen, wie sie in ihren unterschiedlichen Zugängen, Methoden, Gegenständen,Interessen, Wissensformen, Aussagen tradiert sind.
The objectives of this thesis were to understand how distinct classes of cell types interact to shape oscillatory activity in cortical circuits of the turtle. We chose the turtle cortex as a model system for cortical computations for two reasons. One is that the phylogenetic position of turtles makes their cortex functionally and anatomically particularly interesting. The second is that reptilian brains present several unique experimental advantages. Turtles have a three-layered cortex that forms the dorsalmost part of their pallium and receives direct input from visual thalamus. Thus turtle cortex, while sharing several features with mammalian cortices, constitutes a simpler system for studying cortical computations and dynamics. Freshwater turtles are semiaquatic species, that dive for hours and hibernate for months without breathing. Their brains are adapted to these behaviors so that they can operate under severe anoxia. This property allows for ex vivo wholebrain and whole-cortex (”cortical slab”) preparations in vitro, enabling the use of many sophisticated techniques for monitoring activity in parallel.
I thus set out to utilize the advantages of our model system, by using optogenetic methods to reliably evoke oscillations in an ex vivo whole-cortex preparation while observing activity in parallel with planar multi-electrode arrays (MEA), linear silicon depth-electrodes and patch-clamp recording techniques. This required several technical aspects to be solved. Prior work in turtle cortex (Prechtl, 1994; Prechtl et al., 1997; Senseman and Robbins, 2002) indicated that visual stimuli evoke complex activity patterns (e. g. wave patterns) in dorsal cortex. The goal was to examine these dynamics in detail and to provide mechanistic explanations for them whenever possible. The recent advent of optogenetics, the development of microelectrode arrays, and the possibility to combine these techniques with classical electrophysiological approaches on a resistant, accessible and stable preparation led me to explore a number of technical avenues.
First I had to establish gene delivery methods in reptiles. I settled on recombinant viruses, and show results from several serotypes of adeno-associated virus (AAV), i lentivirus and rabies virus. I report successful gene expression of genes of interest with several subtypes of AAV, including the commonly used AAV2/1 and AAV2/5 serotypes. Second I had to find promoters enabling global and cell-type specific gene expression in reptiles. Ubiquitous high-yield promoters such as CAG/CB7 or CMV drive high levels of expression in turtles; cell-type specific promoters such as hSyn (expression limited to neurons) and CaMKIIa (expression limited exclusively o mostly to excitatory neurons) appear similarly biased in turtles. Other cell-type specific promoters reported in the literature (fNPY, fPV, fSST) failed to express in turtles.
A second major aspect of my work focused on electrophysiological recordings using microelectrode arrays and the interpretation of extracellular signals recorded from cortex in ex vivo preparations. We observed that spike signals produced by pyramidal and inhibitory neurons were very often followed by a slower potential. We identified these slower potentials as reflections of synaptic currents, and thus of the axonal projections of the neurons, at least within the deep layers of cortex. This also resulted in a means to classify neurons as excitatory or inhibitory with much higher reliability than classical methods (e. g. spike width). The final aspect of my work concerns the use of optogenetics to dissect the mechanisms of cortical oscillations and wave propagation. I show that oscillations can be induced by light in turtle cortex after transfection with AAV2/1 carrying the gene for channelrhodopsin 2 (ChR2). By using the CaMKIIa promoter, ChR2 induced currents are limited to LII/III excitatory cells; we can therefore control excitatory drive to cortical networks. If this drive is strong enough, layer III inhibitory interneurons are recruited and fire in a concerted fashion, silencing the excitatory population. The visually evoked 20 Hz oscillations observed in chronically recorded animals (Schneider, 2015) or in anaesthetized animals (Fournier et al., in press) thus appear to result from a feedback loop between E and I cells within layers II & III. Details of these interactions are being investigated but - layer I interneurons, by contrast, do not seem to be involved. By pulsing light I could control the frequency of the oscillations within a range of several Hz around the natural oscillation frequency. Above this range, cortex could only follow the stimulus at a fraction (1/2, 1/3,...) of the light pulse frequency. Using a digital micromirror device, I limited activation of the cortical networks spatially, enabling the study of wave propagation in this system.
Reptilian cortex offers a relatively simple model system for a reductionist and comparative strategy on understanding cortical computations and dynamics. Turtle dorsal cortex could thus give fundamental insights to the primordial organization tional, computational and functional principles of cortical networks. These insights are relevant to our understanding of mammalian brains and may prove valuable to decipher fundamental questions of modern neuroscience.
Mit Baltasar Gracián vertrauten Walter Benjamin-Lesern fällt sofort auf, dass der letzte und abschließende Abschnitt von Benjamins Ursprung des deutschen Trauerspiels einen unverkennbar Gracián’schen Titel trägt: "Ponderación mysteriosa". Als fremdartiges und rätselhaftes Bruchstück stehen die spanischen Vokabeln im deutschen Text. Lange Zeit wurden sie übersehen oder in Benjamins Reflexionen subsumiert. Bernd Witte deutet in seinem Kommentar zum Trauerspielbuch die Figur der 'ponderación misteriosa' als "Sinnbild für Benjamins eschatologische Zuversicht: 'Subjektivität, die wie ein Engel in die Tiefe niederstürzt, wird von Allegorien eingeholt und wird am Himmel, wird in Gott durch 'Ponderación mysteriosa' festgehalten'". Für Witte verdichtet diese Figur den theologischen Gehalt des Trauerspielbuches, zugleich zeigt sie aber auch die "Fragwürdigkeit seines literarischen Anspruches". Mit diesem Urteil sieht Witte nicht nur Benjamins Theorie des Trauerspiels und der Allegorie als wenig bedeutsam an, sondern erschwert zudem den Zugang zu einem der produktivsten Momente der Rezeptionsgeschichte von Graciáns 'ponderación misteriosa' im 20. Jahrhundert.
Threat perceptions is a popular topic among scholars of international relations, yet the focus is oftentimes how two states perceive and misperceive threats (Robert Jervis, David Singer among others). Threats are generally understood as potential harm directed against the territorial integrity or the political regime of the states in question or both. Wandering on the borders of the mainstream realist theory and the rational choice theory – popular since when behavioralism entered into IR literature in the 1960s – and the constructivism of the reflectivist era (Wendt), the topic has been made a subject of study through such several different conceptual lenses but mostly on an international/state level of analysis a la Waltz...
The object of this study is one of the most ambitious projects of twentieth-century art history: Aby Warburg's 'Atlas Mnemosyne', conceived in the summer of 1926 – when the first mention of a 'Bilderatlas', or "atlas of images", occurs in his journal – and truncated three years later, unfinished, by his sudden death in October 1929. Mnemosyne consisted in a series of large black panels, about 170x140 cm., on which were attached black-and-white photographs of paintings, sculptures, book pages, stamps, newspaper clippings, tarot cards, coins, and other types of images. Warburg kept changing the order of the panels and the position of the images until the very end, and three main versions of the Atlas have been recorded: one from 1928 (the "1-43 version", with 682 images); one from the early months of 1929, with 71 panels and 1050 images; and the one Warburg was working on at the time of his death, also known as the "1-79 version", with 63 panels and 971 images (which is the one we will examine). But Warburg was planning to have more panels – possibly many more – and there is no doubt that Mnemosyne is a dramatically unfinished and controversial object of study.
Patterns and interpretation
(2017)
One thing for sure: digitization has completely changed the literary archive. People like me used to work on a few hundred nineteenth-century novels; today, we work on thousands of them; tomorrow, hundreds of thousands. This has had a major effect on literary history, obviously enough, but also on critical methodology; because, when we work on 200,000 novels instead of 200, we are not doing the same thing, 1,000 times bigger; we are doing a different thing. The new scale changes our relationship to our object, and in fact 'it changes the object itself'.
This paper studies a consumption-portfolio problem where money enters the agent's utility function. We solve the corresponding Hamilton-Jacobi-Bellman equation and provide closed-form solutions for the optimal consumption and portfolio strategy both in an infinite- and finite-horizon setting. For the infinite-horizon problem, the optimal stock demand is one particular root of a polynomial. In the finite-horizon case, the optimal stock demand is given by the inverse of the solution to an ordinary differential equation that can be solved explicitly. We also prove verification results showing that the solution to the Bellman equation is indeed the value function of the problem. From an economic point of view, we find that in the finite-horizon case the optimal stock demand is typically decreasing in age, which is in line with rules of thumb given by financial advisers and also with recent empirical evidence.
We study the general equilibrium implications of different fiscal policies on macroeconomic quantities, asset prices, and welfare by utilizing two endogenous growth models. The expanding variety model features only homogeneous innovations by entrants. The Schumpeterian growth model features heterogeneous innovations: "incremental" innovations by incumbents and "radical" innovations by entrants. The government levies taxes on labor income and corporate profits and supplies subsidies to consumption, capital investment, and investments in research and development by entrants and, if applicable, incumbents. With these models at hand, we provide new insights on the interplay of innovation dynamics and fiscal policy.
Se describe con medidas, dibujos e imágenes obtenidas con microscopio compuesto, una nueva especie de mosca blanca, Tetraleurodes dorsibandas Sánchez y Carapia sp. nov. (Hemiptera: Aleyrodidae) que se encontró alimentándose de Casimiroa edulis (Rutaceae) y Ehretia tinifolia (Boraginaceae) en Morelos y Oaxaca (México), respectivamente. La especie se diferencia de Tetraleurodes perileuca (Cockerell) por tener el raquis en forma de bandas, presentar estructuras en forma de mosaico irregular en la parte media de los segmentos abdominales y la presencia de setas cefálicas. Se proporciona una clave de las especies de México y se enlistan las especies del nuevo mundo.
Jede Wortschatzschicht hat ihren begrifflichen Kern, und ebenso gilt dies auch für die politische Lexik, deren Schichtung sich aus der ständigen Entwicklung der Sprache und Gesellschaft ergibt. Diese Schichtung reflektiert aktuelle gesellschaftlich-politische Ereignisse. Benennungen von diesen landeskundlichen Gegebenheiten - Politemen -, die Objekt unserer Untersuchungen sind, werden durch die Gesellschaftsentwicklung aktualisiert oder neu gebildet, d.h. sie sind durch den zeitlichen Kontext determiniert. Außerdem werden in unserem Beitrag mehrere Forschungsansätze von Sprache in der Politik, den Charakteristika und der Klassifikation der politikbezogenen Wörter behandelt.
Der viersemestrige Master-Studiengang Biochemie leitet sich aus der langjährigen Tradition in biomolekularer Forschung und Lehre in der Frankfurter Forschungslandschaft her und ist stark forschungsorientiert.
Ziel des Studienganges ist es, fachliche Kenntnisse, Fähigkeiten und Methodenkompetenzen zu vermitteln, mit denen die Absolventen in die Lage versetzt werden, in einem forschungsbezogenem Kontext selbstständig zu arbeiten.
Inhaltlich erstreckt sich der Studiengang von zellulärer Biochemie über Strukturbiologie bis hin zur Biophysik/Biophysikalischen Chemie und ermöglicht den Studierenden die Setzung individueller Schwerpunkte. Für eine forschungsnahe Ausbildung auf hohem Niveau ist der Studiengang integral mit dem lokalen Forschungsumfeld verknüpft, was neben dem Heimatfachbereich Biochemie / Chemie / Pharmazie auch die Fachbereiche Physik, Biowissenschaften, Medizin als auch außeruniversitäre Institutionen wie das Max-Planck-Institut für Biophysik und das Paul-Ehrlich-Institut involviert. Den besonderen Frankfurter Schwerpunkten Strukturbiologie und Membranproteinforschung wird im Studiengang Rechnung getragen.
Das Masterstudium am hochmodernen Life-Science Campus der Goethe-Universität bietet in einer einzigartigen Mischung aus Theorie und Praxis in Biochemie und Biophysikalischer Chemie das Rüstzeug für eine Karriere in der universitären sowie industriellen Umgebung. Die Beteiligung diverser Forschungsinstitute am Masterprogramm ermöglicht eine Spezialisierung in Immunologie, Tumorbiologie oder in Membranbiochemie. Die starke Vernetzung der Universität in nationale sowie internationale Forschungsverbünde gewährleistet den Studierenden einen engen Kontakt mit international führenden Wissenschaftlern und die Möglichkeit zu weltweiten Forschungsaufenthalten. ...
Die vorliegende Untersuchung beabsichtigt die Schönheitsauffassung in der deutschen und türkischen Erzählwelt in ihrer Bedeutung, Funktionalität und kulturellen Einbettung herauszuarbeiten. Ausgehend von den Märchen der Brüder Grimm (Erstausgabe von 1812 und 1815) und den türkischen Märchen von Ignácz Kúnos (Erstfassung,1887) werden die Begriffe "schön", "Schönheit" und "Ästhetik" analysiert und zur Diskussion gestellt. Mittels einer Korpusanalyse werden so die Märchentexte einer hermeneutisch-analytischen, mythologischen und kulturtheoretisch-kritischen Betrachtung unterzogen. Ziel dabei sind die Maßstäbe der Schönheit zu hinterfragen. Was wird in der Märchenwelt als "schön" empfunden? Worin liegt die Grenze vom Schönen zum Hässlichen? Hier ist auch zu fragen, inwieweit das kulturelle Umfeld die Auffassung zum Schönen beeinträchtigt
We present a method that enables the identification and analysis of conformational Markovian transition states from atomistic or coarse-grained molecular dynamics (MD) trajectories. Our algorithm is presented by using both analytical models and examples from MD simulations of the benchmark system helix-forming peptide Ala5, and of larger, biomedically important systems: the 15-lipoxygenase-2 enzyme (15-LOX-2), the epidermal growth factor receptor (EGFR) protein, and the Mga2 fungal transcription factor. The analysis of 15-LOX-2 uses data generated exclusively from biased umbrella sampling simulations carried out at the hybrid ab initio density functional theory (DFT) quantum mechanics/molecular mechanics (QM/MM) level of theory. In all cases, our method automatically identifies the corresponding transition states and metastable conformations in a variationally optimal way, with the input of a set of relevant coordinates, by accurately reproducing the intrinsic slowest relaxation rate of each system. Our approach offers a general yet easy-to-implement analysis method that provides unique insight into the molecular mechanism and the rare but crucial (i.e., rate-limiting) transition states occurring along conformational transition paths in complex dynamical systems such as molecular trajectories.
Die Frauen
(2017)
Bei "Die Frauen" handelt es sich um eine Vorlesung aus Bertha von Suttners "Maschinenalter" (in späteren Auflagen "Maschinenzeitalter"). Das vortragende Ich hält in einer fiktiven Zukunft, in welcher der Mensch höher entwickelt ist, eine Vorlesungsreihe über die gesellschaftlichen Zustände des 19. Jahrhunderts. Die einzelnen Vorlesungen bilden die Kapitel des Buches, welches nicht nur die gesellschaftlichen Missstände des 19. Jahrhunderts darlegt, sondern eine soziale, in sich stimmige Utopie erschafft. [...] Bertha von Suttners Soziologieverständnis war stark von Auguste Comtes positivistischer Sichtweise geprägt, die auf einem absoluten Glauben an Wissenschaft und Vernunft beruht. Dieses positivistisch geprägte soziologische Programm hatte um 1900 seinen Höhepunkt erreicht und war danach für Jahrzehnte unter den Generalverdacht der Faktenhuberei und der naiven Wissenschaftsgläubigkeit gestellt worden. Mit den Positivisten teilte Suttner ein monistisches Weltbild, sah das menschliche Zusammenleben als naturgesetzliches Ganzes an und negierte eine nomothetische Wissenschaftsauffassung. Für sie hatte die Soziologie - wie die Wissenschaft überhaupt - die Aufgabe, das menschliche Zusammenleben sowohl zu beschreiben als auch zu verbessern. Die Ungleichbehandlung von Männern und Frauen betrachtete Bertha von Suttner auf Basis einer Theorie der Sozialisation. Für sie gab es keine spezifisch männlichen oder weiblichen Wesenszüge. Bei Frauen oder Männern vermehrt wahrgenommene Charaktermerkmale entstünden entweder durch Zuschreibung, oder sie seien "keine wesentlichen, im Organismus wurzelnden" Eigenschaften, sondern könnten "auf äußere Umstände und Einflüsse" wie "Erziehung und Lebensstellung" zurückgeführt werden. Diese soziologisch gefärbte Auffassung von Geschlecht ist detailliert in der fiktiven Vorlesung mit dem Titel "Die Frauen" ausgeführt. Im Text zeichnet Suttner das Bild einer zukünftigen Gesellschaft, in der Geschlecht nicht mehr als hierarchisierendes Ordnungsprinzip fungiert. Überhaupt billigte Suttner den Geschlechtern bis auf wenige physiologische Merkmale keine natürlichen Unterschiede zu. Eigenschaften wie körperliche Stärke, Mitgefühl und Mut sah sie bei beiden Geschlechtern gleichermaßen vorhanden. Suttners Auffassung stand im Gegensatz zu der allgemein vorherrschenden, welche auf Hierarchisierungen von Unterschieden beruhte. Suttner kritisiert die Zuordnung von geistigen und charakterlichen Eigenschaften zu physiologischen Eigenschaften, wie sie auch noch heute getroffen wird. Dabei geht sie wissenschaftlich-analytisch vor, indem sie Textstellen aus markanten Büchern, die 'Frauen' zum Thema haben, genau unter die Lupe nimmt und deren fehlende Objektivität und mangelhafte Argumentation darlegt. Dass bestimmte Eigenschaften bei den Frauen ihrer Zeit häufiger zu beobachten sind als bei Männern, verneint die Autorin nicht, doch erklärt sie diese Prägung mit der Sozialisation. Suttner macht aber nicht nur auf Paradoxe in der Argumentation aufmerksam, sondern zeigt die verschiedenen Formen auf, in welchen die Unterdrückung der Frau in verschiedenen Epochen zum Vorschein kommt: So argumentierten die VertreterInnen der Lehre von der Minderwertigkeit der Frau im 19. Jahrhundert nicht mehr theologisch, sondern philosophisch und 'wissenschaftlich'. Der Rang der Frau sei zwar nicht mehr der einer Sklavin, aber immer noch der einer dem Mann Untergebenen. Somit sei bloß die Form subtiler geworden, denn "die Unterordnung, die Abhängigkeit - die war geblieben." Diese Unterordnung der Frau unter den Mann als eine "Art Neben- oder vielmehr Unterabteilung des Menschentums" sieht Suttner auch in der Sprache gespiegelt: Der Begriff 'Mensch' umfasst im Maschinenzeitalter nur den Mann. Diese Reflexionen Suttners zur Sprache können als "Ansätze zu einer feministischen Sprachkritik" betrachtet werden.
Conatus und Lebensnot
(2017)
Monique David-Ménard knüpft in ihrem Beitrag an die vielschichtige und sich überschneidende, lange Rezeptionsgeschichte von französischer Philosophie und deutscher Medientheorie an, um in ihrem Beitrag zu fragen, ob und in welcher Weise eine Psychoanalyse, welche die aktuelle Wende zu den vitalistisch orientierten ontologischen Technikphilosophien nicht mitmacht, sondern die Methode der epistemologischen Brüche weiterentwickelt, mit der Medienwissenschaft im Gespräch bleiben bzw. erneut ins Gespräch kommen kann. Ausgehend von einem Vergleich des Verhältnisses von Affirmation und Passivität im Konzept des Conatus und von Eros und Thanatos in der Psychoanalyse stellt sie die These auf, dass die Einzigartigkeit der Psychoanalyse gerade darin bestehe, dass sie keine allgemeine Anthropologie darstelle, sondern eine Praxis, die darauf ausgerichtet sei, etwas sehr Spezifisches - das Triebschicksal - zu verändern. Die Übertragung erscheint aus dieser Perspektive als Dispositiv und das heißt, wie David-Ménard unterstreicht, als ein Medium unter anderen Medien.