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In November 2005, a survey was begun of the wells in and around Hagia Sophia Church in Istanbul. The long-term goal of the survey is the understanding of the function of the tunnels and the water systems used for Hagia Sophia and its surroundings during the Byzantine and the Ottoman periods. Alternate research methods, such as geophysical research, will be used in future surveys. The 2005 survey examined the channels that run from under the narthex and continue northwards and the southwards of the building as well as channels that run towards the atrium, hippodrome, and garden in the north. The survey resulted in the first photos of the well-bottoms in the history of Hagia Sophia.
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to create sizeable public cell line repositories available to the scientific community for the generation of mutant mouse strains. The major gene trapping groups worldwide have recently joined together to centralize access to all publicly available gene trap lines by developing a user-oriented Website for the International Gene Trap Consortium (IGTC). This collaboration provides an impressive public informatics resource comprising ~45 000 well-characterized ES cell lines which currently represent ~40% of known mouse genes, all freely available for the creation of knockout mice on a non-collaborative basis. To standardize annotation and provide high confidence data for gene trap lines, a rigorous identification and annotation pipeline has been developed combining genomic localization and transcript alignment of gene trap sequence tags to identify trapped loci. This information is stored in a new bioinformatics database accessible through the IGTC Website interface. The IGTC Website (www.genetrap.org) allows users to browse and search the database for trapped genes, BLAST sequences against gene trap sequence tags, and view trapped genes within biological pathways. In addition, IGTC data have been integrated into major genome browsers and bioinformatics sites to provide users with outside portals for viewing this data. The development of the IGTC Website marks a major advance by providing the research community with the data and tools necessary to effectively use public gene trap resources for the large-scale characterization of mammalian gene function.
Kongressbericht: Auf der Tagung der Deutschen Gesellschaft für Allgemeinmedizin und Familienmedizin e.V. (DEGAM) 2004 entstand die Idee, E-Learning-Aktivitäten in der Allgemeinmedizin sichtbar zu machen und zu bündeln. Ein Kongress sollte die allgemeinmedizinischen Vertreter aus Lehre und Forschung sowie Industrievertreter zusammenbringen, um das Spektrum der Möglichkeiten und laufende Projekte kennen zu lernen. Mit motivierten Referenten, über 60 aktiven Teilnehmern und einem positiven Feedback, kann der Kongress in Frankfurt am 8. und 9. Juli 2005 als erster dieser Art in Deutschland als erfolgreich bezeichnet werden.
Background: Depression is a disorder with high prevalence in primary health care and a significant burden of illness. The delivery of health care for depression, as well as other chronic illnesses, has been criticized for several reasons and new strategies to address the needs of these illnesses have been advocated. Case management is a patient-centered approach which has shown efficacy in the treatment of depression in highly organized Health Maintenance Organization (HMO) settings and which might also be effective in other, less structured settings. Methods/Design: PRoMPT (PRimary care Monitoring for depressive Patients Trial) is a cluster randomised controlled trial with General Practice (GP) as the unit of randomisation. The aim of the study is to evaluate a GP applied case-management for patients with major depressive disorder. 70 GPs were randomised either to intervention group or to control group with the control group delivering usual care. Each GP will include 10 patients suffering from major depressive disorder according to the DSM-IV criteria. The intervention group will receive treatment based on standardized guidelines and monthly telephone monitoring from a trained practice nurse. The nurse investigates the patient's status concerning the MDD criteria, his adherence to GPs prescriptions, possible side effects of medication, and treatment goal attainment. The control group receives usual care – including recommended guidelines. Main outcome measure is the cumulative score of the section depressive disorders (PHQ-9) from the German version of the Prime MD Patient Health Questionnaire (PHQ-D). Secondary outcome measures are the Beck-Depression-Inventory, self-reported adherence (adapted from Moriskey) and the SF-36. In addition, data are collected about patients' satisfaction (EUROPEP-tool), medication, health care utilization, comorbidity, suicide attempts and days out of work. The study comprises three assessment times: baseline (T0) , follow-up after 6 months (T1) and follow-up after 12 months (T2). Discussion: Depression is now recognized as a disorder with a high prevalence in primary care but with insufficient treatment response. Case management seems to be a promising intervention which has the potential to bridge the gap of the usually time-limited and fragmented provision of care. Case management has been proven to be effective in several studies but its application in the private general medical practice setting remains unclear.
Background: Diabetes model projects in different regions of Germany including interventions such as quality circles, patient education and documentation of medical findings have shown improvements of HbA1c levels, blood pressure and occurrence of hypoglycaemia in before-after studies (without control group). In 2002 the German Ministry of Health defined legal regulations for the introduction of nationwide disease management programs (DMP) to improve the quality of care in chronically ill patients. In April 2003 the first DMP for patients with type 2 diabetes was accredited. The evaluation of the DMP is essential and has been made obligatory in Germany by the Fifth Book of Social Code. The aim of the study is to assess the effectiveness of DMP by example of type 2 diabetes in the primary care setting of two German federal states (Rheinland-Pfalz and Sachsen-Anhalt). Methods/Design: The study is three-armed: a prospective cluster-randomized comparison of two interventions (DMP 1 and DMP 2) against routine care without DMP as control group. In the DMP group 1 the patients are treated according to the current situation within the German-Diabetes-DMP. The DMP group 2 represents diabetic care within ideally implemented DMP providing additional interventions (e.g. quality circles, outreach visits). According to a sample size calculation a sample size of 200 GPs (each GP including 20 patients) will be required for the comparison of DMP 1 and DMP 2 considering possible drop-outs. For the comparison with routine care 4000 patients identified by diabetic tracer medication and age (> 50 years) will be analyzed. Discussion: This study will evaluate the effectiveness of the German Diabetes-DMP compared to a Diabetes-DMP providing additional interventions and routine care in the primary care setting of two different German federal states.
Das Projekt LaMedica (http://www.lamedica.de) hat zum Ziel, eine multimediale Lehr- und Lernplattform zu entwickeln, Inhalte für die Medizin zu erstellen und diese in die Lehre zu implementieren. Es wurde eine on-line Autorenumgebung geschaffen, die sehr unterschiedliche didaktische Ansätze unterstützt: systematische und vernetzte Wissensvermittlung, fallbasiertes Lernen, Erstellung von Vorlesungen und Lernerfolgskontrolle. Die Lehrinhalte können zielgruppenspezifisch aufbereitet und dargestellt werden und richten sich insbesondere an Studenten, Ärzte in der Weiterbildung und Fachärzte. Eine on-line Medien-Datenbank unterstützt die Wiederverwendung und den Austausch von Inhalten auf der Basis eines Content-Management-Systems durch Verwendung des Learning Objects Metadata Standards (LOM). Die Förderung erfolgt durch das BMBF (FKZ NM054A).
Aims: This paper is a review of the literature on problem-related drinking of alcohol among medical doctors, and it deals with the epidemiology and results. Methods: A search of computer literature databases - PubMed and ETOH - was performed to locate articles reporting problem-related drinking among doctors, using population-based samples of doctors within the last two decades. Results: In the light of different definitions of problem-related drinking, there was found a breadth of prevalence of problem-related drinking - from heavy drinking and hazardous drinking (12%-16%) to misuse and dependence (6%-8%) - within the population-based samples of doctors. An increased risk was positively related to male doctors and doctors of the age of 40-45 years and older, and to some factors of work, lifestyle and health. Conclusion: For the future, it seems necessary to sensitise the research for problem-related drinking of doctors in Germany, e.g. initiating a representative survey, analysing the drinking of alcohol in the context of health, life-style and work-related factors.
Celiac disease
(2006)
Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years.
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential. We therefore examined the production of PGE2 in cultured growth plate chondrocytes in vitro and the effects of exogenously added PGE2 on cell proliferation. Furthermore, we analysed the expression and spatial distribution of cyclooxygenase (COX)-1 and COX-2 and PGE2 receptor types EP1, EP2, EP3 and EP4 in the growth plate in situ and in vitro. PGE2 synthesis was determined by mass spectrometry, cell proliferation by DNA [3H]-thymidine incorporation, mRNA expression of cyclooxygenases and EP receptors by RT-PCR on cultured cells and in homogenized growth plates. To determine cellular expression, frozen sections of rat tibial growth plate and primary chondrocyte cultures were stained using immunohistochemistry with polyclonal antibodies directed towards COX-1, COX-2, EP1, EP2, EP3, and EP4. Cultured growth plate chondrocytes transiently secreted PGE2 into the culture medium. Although both enzymes were expressed in chondrocytes in vitro and in vivo, it appears that mainly COX-2 contributed to PGE2-dependent proliferation. Exogenously added PGE2 stimulated DNA synthesis in a dose-dependent fashion and gave a bell-shaped curve with a maximum at 10-8 M. The EP1/EP3 specific agonist sulprostone and the EP1-selective agonist ONO-D1-004 increased DNA synthesis. The effect of PGE2 was suppressed by ONO-8711. The expression of EP1, EP2, EP3, and EP4 receptors in situ and in vitro was observed; EP2 was homogenously expressed in all zones of the growth plate in situ, whereas EP1 expression was inhomogenous, with spared cells in the reserve zone. In cultured cells these four receptors were expressed in a subset of cells only. The most intense staining for the EP1 receptor was found in polygonal cells surrounded by matrix. Expression of receptor protein for EP3 and EP4 was observed also in rat growth plates. In cultured chrondrocytes, however, only weak expression of EP3 and EP4 receptor was detected. We suggest that in growth plate chondrocytes, COX-2 is responsible for PGE2 release, which stimulates cell proliferation via the EP1 receptor.
Herman P. Schwan [1915–2005] was a distinguished scientist and engineer, and a founding father of the field of biomedical engineering. A man of integrity, Schwan influenced the lives of many, including his wife and children, and his many students and colleagues. Active in science until nearly the end of his life, he will be very much missed by his family and many colleagues.
High-throughput gene trapping is a random approach for inducing insertional mutations across the mouse genome. This approach uses gene trap vectors that simultaneously inactivate and report the expression of the trapped gene at the insertion site, and provide a DNA tag for the rapid identification of the disrupted gene. Gene trapping has been used by both public and private institutions to produce libraries of embryonic stem (ES) cells harboring mutations in single genes. Presently,~ 66% of the protein coding genes in the mouse genome have been disrupted by gene trap insertions. Among these, however, genes encoding signal peptides or transmembrane domains (secretory genes) are underrepresented because they are not susceptible to conventional trapping methods. Here, we describe a high-throughput gene trapping strategy that effectively targets secretory genes. We used this strategy to assemble a library of ES cells harboring mutations in 716 unique secretory genes, of which 61% were not trapped by conventional trapping, indicating that the two strategies are complementary. The trapped ES cell lines, which can be ordered from the International Gene Trap Consortium (http://www.genetrap.org), are freely available to the scientific community.
Background: Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human cells expressing both CD4 and an appropriate co-receptor. Vector transduction mimics the HIV-1 entry process and is therefore a safe tool to study HIV-1 entry. Results: Using FLY cells, which express the MLV gag and pol genes, we generated stable producer cell lines that express the HIV-1 envelope gene and a retroviral vector genome encoding the green fluorescent protein (GFP). The BH10 or 89.6 P HIV-1 Env was expressed from a bicistronic vector which allowed the rapid selection of stable cell lines. A codon-usage-optimized synthetic env gene permitted high, Rev-independent Env expression. Vectors generated by these producer cells displayed different sensitivity to entry inhibitors. Conclusion: These data illustrate that MLV/HIV-1 vectors are a valuable screening system for entry inhibitors or neutralizing antisera generated by vaccines.
Background: Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV infection does not cause a cytopathic effect in the infected cell and viral replication can only be studied by immunostaining or measurement of reverse transcriptase activity. Results: We inserted the coding sequences for green fluorescent protein (GFP) into the proline-rich region (PRR) of the ecotropic envelope protein (Env) and were able to fluorescently label MLV. This allowed us to directly monitor viral replication and attachment to target cells by flow cytometry. We used this method to study viral replication of recombinant MLVs and split viral genomes, which were generated by replacement of the MLV env gene with the red fluorescent protein (RFP) and separately cloning GFP-Env into a retroviral vector. Co-transfection of both plasmids into target cells resulted in the generation of semi-replicative vectors, and the two color labeling allowed to determine the distribution of the individual genomes in the target cells and was indicative for the occurrence of recombination events. Conclusions: Fluorescently labeled MLVs are excellent tools for the study of factors that influence viral replication and can be used to optimize MLV-based replication-competent viruses or vectors for gene therapy.
The 5'-terminal cloverleaf (CL)-like RNA structures are essential for the initiation of positive- and negative-strand RNA synthesis of entero- and rhinoviruses. SLD is the cognate RNA ligand of the viral proteinase 3C (3Cpro), which is an indispensable component of the viral replication initiation complex. The structure of an 18mer RNA representing the apical stem and the cGUUAg D-loop of SLD from the first 5'-CL of BEV1 was determined in solution to a root-mean-square deviation (r.m.s.d.) (all heavy atoms) of 0.59 A (PDB 1Z30). The first (antiG) and last (synA) nucleotide of the D-loop forms a novel ‘pseudo base pair’ without direct hydrogen bonds. The backbone conformation and the base-stacking pattern of the cGUUAg-loop, however, are highly similar to that of the coxsackieviral uCACGg D-loop (PDB 1RFR) and of the stable cUUCGg tetraloop (PDB 1F7Y) but surprisingly dissimilar to the structure of a cGUAAg stable tetraloop (PDB 1MSY), even though the cGUUAg BEV D-loop and the cGUAAg tetraloop differ by 1 nt only. Together with the presented binding data, these findings provide independent experimental evidence for our model [O. Ohlenschläger, J. Wöhnert, E. Bucci, S. Seitz, S. Häfner, R. Ramachandran, R. Zell and M. Görlach (2004) Structure, 12, 237–248] that the proteinase 3Cpro recognizes structure rather than sequence.
We have isolated the human protein SNEV as downregulated in replicatively senescent cells. Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing. We have used various approaches including gene complementation studies in yeast using a temperature sensitive mutant with a pleiotropic phenotype and SNEV immunodepletion from human HeLa nuclear extracts to determine its function. A human–yeast chimera was indeed capable of restoring the wild-type phenotype of the yeast mutant strain. In addition, immunodepletion of SNEV from human nuclear extracts resulted in a decrease of in vitro pre-mRNA splicing efficiency. Furthermore, as part of our analysis of protein–protein interactions within the CDC5L complex, we found that SNEV interacts with itself. The self-interaction domain was mapped to amino acids 56–74 in the protein's sequence and synthetic peptides derived from this region inhibit in vitro splicing by surprisingly interfering with spliceosome formation and stability. These results indicate that SNEV is the human orthologue of yeast PRP19, functions in splicing and that homo-oligomerization of SNEV in HeLa nuclear extract is essential for spliceosome assembly and that it might also be important for spliceosome stability.
In order to further understand how DNA polymerases discriminate against incorrect dNTPs, we synthesized two sets of dNTP analogues and tested them as substrates for DNA polymerase a (pol alpha) and Klenow fragment (exo-) of DNA polymerase I (Escherichia coli ). One set of analogues was designed to test the importance of the electronic nature of the base. The bases consisted of a benzimidazole ring with one or two exocyclic substituent(s) that are either electron-donating (methyl and methoxy) or electronwithdrawing (trifluoromethyl and dinitro). Both pol a and Klenow fragment exhibit a remarkable inability to discriminate against these analogues as compared to their ability to discriminate against incorrect natural dNTPs. Neither polymerase shows any distinct electronic or steric preferences for analogue incorporation. The other set of analogues, designed to examine the importance of hydrophobicity in dNTP incorporation, consists of a set of four regioisomers of trifluoromethyl benzimidazole. Whereas pol a and Klenow fragment exhibited minimal discrimination against the 5- and 6-regioisomers, they discriminated much more effectively against the 4- and 7-regioisomers. Since all four of these analogues will have similar hydrophobicity and stacking ability, these data indicate that hydrophobicity and stacking ability alone cannot account for the inability of pol a and Klenow fragment to discriminate against unnatural bases. After incorporation, however, both sets of analogues were not efficiently elongated. These results suggest that factors other than hydrophobicity, sterics and electronics govern the incorporation of dNTPs into DNA by pol {alpha} and Klenow fragment.
Background: Costly structures need to represent an adaptive advantage in order to be maintained over evolutionary times. Contrary to many other conspicuous shell ornamentations of gastropods, the haired shells of several Stylommatophoran land snails still lack a convincing adaptive explanation. In the present study, we analysed the correlation between the presence/absence of hairs and habitat conditions in the genus Trochulus in a Bayesian framework of character evolution. Results: Haired shells appeared to be the ancestral character state, a feature most probably lost three times independently. These losses were correlated with a shift from humid to dry habitats, indicating an adaptive function of hairs in moist environments. It had been previously hypothesised that these costly protein structures of the outer shell layer facilitate the locomotion in moist habitats. Our experiments, on the contrary, showed an increased adherence of haired shells to wet surfaces. Conclusion: We propose the hypothesis that the possession of hairs facilitates the adherence of the snails to their herbaceous food plants during foraging when humidity levels are high. The absence of hairs in some Trochulus species could thus be explained as a loss of the potential adaptive function linked to habitat shifts.
The volume changes of lithium and sodium under pressure are discussed with respect to the packing density of the atoms and their valence. In densely packed Li I (bcc), Li II (fcc), and Li III (alpha-Hg ype), valence increases from 1 at ~ 5 GPa to ~ 2.5 at 40 GPa. The maximum valence 3 is attained in Li IV (body-centered cubic, 16 atoms per cell, packing density q = 0.965) at 47 GPa. In densely packed Na I (bcc) a linear increase of valence from 1 at ~ 10 GPa to 2.9 at 65 GPa is found which continues in Na II (fcc) up to 4.1 at 103 GPa.
A new approach to optimize multilevel logic circuits is introduced. Given a multilevel circuit, the synthesis method optimizes its area while simultaneously enhancing its random pattern testability. The method is based on structural transformations at the gate level. New transformations involving EX-OR gates as well as Reed–Muller expansions have been introduced in the synthesis of multilevel circuits. This method is augmented with transformations that specifically enhance random-pattern testability while reducing the area. Testability enhancement is an integral part of our synthesis methodology. Experimental results show that the proposed methodology not only can achieve lower area than other similar tools, but that it achieves better testability compared to available testability enhancement tools such as tstfx. Specifically for ISCAS-85 benchmark circuits, it was observed that EX-OR gate-based transformations successfully contributed toward generating smaller circuits compared to other state-of-the-art logic optimization tools.
Channel routing is an NP-complete problem. Therefore, it is likely that there is no efficient algorithm solving this problem exactly.In this paper, we show that channel routing is a fixed-parameter tractable problem and that we can find a solution in linear time for a fixed channel width.We implemented our approach for the restricted layer model. The algorithm finds an optimal route for channels with up to 13 tracks within minutes or up to 11 tracks within seconds.Such narrow channels occur for example as a leaf problem of hierarchical routers or within standard cell generators.
We present a theoretical analysis of structural FSM traversal, which is the basis for the sequential equivalence checking algorithm Record & Play presented earlier. We compare the convergence behaviour of exact and approximative structural FSM traversal with that of standard BDD-based FSM traversal. We show that for most circuits encountered in practice exact structural FSM traversal reaches the fixed point as fast as symbolic FSM traversal, while approximation can significantly reduce in the number of iterations needed. Our experiments confirm these results.
We present the FPGA implementation of an algorithm [4] that computes implications between signal values in a boolean network. The research was performed as a masterrsquos thesis [5] at the University of Frankfurt. The recursive algorithm is rather complex for a hardware realization and therefore the FPGA implementation is an interesting example for the potential of reconfigurable computing beyond systolic algorithms. A circuit generator was written that transforms a boolean network into a network of small processing elements and a global control logic which together implement the algorithm. The resulting circuit performs the computation two orders of magnitudes faster than a software implementation run by a conventional workstation.
One of the most severe short-comings of currently available equivalence checkers is their inability to verify integer multipliers. In this paper, we present a bit level reverse-engineering technique that can be integrated into standard equivalence checking flows. We propose a Boolean mapping algorithm that extracts a network of half adders from the gate netlist of an addition circuit. Once the arithmetic bit level representation of the circuit is obtained, equivalence checking can be performed using simple arithmetic operations. Experimental results show the promise of our approach.
This paper argues that short (clause-internal) scrambling to a pre-subject position has A properties in Japanese but A'-properties in German, while long scrambling (scrambling across sentence boundaries) from finite clauses, which is possible in Japanese but not in German, has A'-properties throughout. It is shown that these differences between German and Japanese can be traced back to parametric variation of phrase structure and the parameterized properties of functional heads. Due to the properties of Agreement, sentences in Japanese may contain multiple (Agro- and Agrs-) specifiers whereas German does not allow for this. In Japanese, a scrambled element may be located in a Spec AgrP, i.e. an A- or L-related position, whereas scrambled NPs in German can only appear in an AgrP-adjoined (broadly-L-related) position, which only has A'-properties. Given our assumption that successive cyclic adjunction is generally impossible, elements in German may not be long scrambled because a scrambled element that is moved to an adjunction site inside an embedded clause may not move further. In Japanese, long distance scrambling out of finite CPs is possible since scrambling may proceed in a successive cyclic manner via embedded Spec- (AgrP) positions. Our analysis of the differences between German and Japanese scrambling provides us with an account of further contrasts between the two languages such as the existence of surprising asymmetries between German and Japanese remnant-movement phenomena, and the fact that unlike German, Japanese freely allows wh-scrambling. Investigation of the properties of Japanese wh-movement also leads us to the formulation of the "Wh-cluster Hypothesis", which implies that Japanese is an LF multiple wh-fronting language.
In this article, I discuss some important properties of wh-questions and wh-scrambling in Japanese. The questions I will address are (i) which instances of (wh-) scrambling involve reconstruction and (ii) how the undoing effects of scrambling can be derived. First I will discuss the claim that (wh-) scrambling is semantically vacuous and is therefore undone at LF (Saito 1989, 1992). Then I consider the data that led Takahashi (1993) to the conclusion that at least some instances of wh-scrambling have to be analyzed as instances of "full wh-movement" i.e., overt movement of the wh-phrase in its scopal position. It will be argued that these examples are not instances of full wh-movement in Japanese, but that they also represent semantically vacuous scrambling. Those instances of scrambling that apprently cannot be undone are best explained with recourse to parsing effects. I conclude that wh-scrambling in Japanese is always triggered by a ([-wh]-) scrambling feature. In addition, long distance scrambling (scrambling out of finite CPs) is analyzed as adjunction movement, whereas short distance scrambling is movement to a specifier position of IP. Turning to the mechanisms of undoing, I will argue that only long distance scrambling is undone. This is shown to follow from Chomsky's (1995) bare phrase structure analysis, according to which multi-segmental categories derived by adjunction movement are not licensed at LF. The article is organized as follows. In section 2, the wh-scrambling phenomenon is described. In section 3, I discuss the reconstruction properties of scrambling. In addition, this section provides some basic assumptions about my analysis of Japanese scrambling in general. In section 4, I turn to the analysis of wh-scrambling as an instance of full wh-movement in Japanese. Section 5 provides discussion of multiple wh-questions in Japanese, and section 6 gives the conclusion.
Die Doppelobjekt-Konstruktion bildet einen Untersuchungsgegenstand, der in der Vergangenheit die Theoriebildung in der Syntaxforschung wesentlich beeinflusst hat. Untersuchungen zu Doppelobjekt-Konstruktionen sind u.a. folgenreich gewesen für die Kasustheorie sowie für Analysen der Verbbewegung, Satz-, VP- und Argument-Struktur. In diesem Aufsatz stelle ich eine Analyse einiger wichtiger Aspekte der Doppelobjekt-Konstruktion im Deutschen vor. Untersucht wird, in welcher Position die Objekte des Verbs basisgeneriert werden und in welchen abgeleiteten Positionen sie erscheinen. Die Beantwortung dieser Fragen liefert eine Erklärung für das asymmetrische Verhalten der beteiligten Objekte in Bezug auf ihr Bindungs- und Extraktionsverhalten.
In diesem Aufsatz diskutiere ich die Distribution von kohärenten Kontroll-Infinitiven im Deutschen. Es werden die Verbklassen bestimmt, die kohärente Infinitive lizenzieren. Dabei zeigt sich, dass ausschließlich Infinitive 'kohärent' konstruiert werden können, die die Position der Akkusativ NP (bzw. die Position des direkten Objekts) einnehmen. Kontroll-Infinitive in anderen strukturellen Positionen sind zwangsläufig 'inkohärent'. Transparente Infinitive in Sprachen wie dem Polnischen und Spanischen sind in derselben Weise in ihrer Distribution beschränkt. Ich schlage eine einheitliche Analyse der relevanten Daten vor, die weitere distributionelle Generalisierungen bezüglich des Auftretens kohärenter Infinitive korrekt prognostiziert. Für die idiolektale Variation, die unter Sprechern in Bezug auf bestimmte Verben existiert, die kohärente Infinitive lizenzieren, wird eine Erklärung formuliert, die auf der Idee basiert, dass die Bildung dieser Infinitive an die Präsenz eines Inkorporations-Merkmals gebunden ist, das beim Spracherwerb auf der Grundlage positiver Evidenz erworben wird. In this article, I discuss the distribution of so-called 'coherent (control) infinitives' in German. In section 2, I will argue that both coherent as well as incoherent control-infinitives have a sentential status. In section 3, I argue that only infinitives occupying the position of the direct object show the well-known properties associated with coherent infinitives. Control infinitives in other structural positions represent incoherent infinitives. This situation is not limited to German infinitives. Transparent infinitives in Polish and Spanish show the same structural asymmetry. In section 4, I propose a unified analysis for the data that in addition, correctly predicts further restrictions for the distribution of coherent infinitives. In section 5, I propose an account for idiolectal variation in the class of verbs that license coherent infinitives. This account is based on the idea that coherent infinitives require an incorporation-feature in their lexical entry that is acquired on the basis of positive evidence.
In diesem Aufsatz gehe ich der Frage nach, in wie viel unterschiedlichen Positionen Verben im deutschen Satz vorkommen können. Anhand syntaktischer Tests wird gezeigt, daß das Verb im Deutschen in insgesamt drei unterschiedlichen Positionen auftritt und nicht, wie in der traditionellen Grammatik angenommen wird, in nur zwei Positionen (in der rechten und in der linken Satzklammer). Es wird dafür argumentiert, daß die Anwendung des abstrakten Satzschemas, wie es heute gängigerweise in der generativen Grammatikforschung als universelles Satzmodell angenommen wird, die Erklärung einer Vielzahl syntaktischer Phänomene im Deutschen ermöglicht, die mit der traditionellen Verbstellungsanalyse, die von nur zwei Verbpositionen ausgeht, nicht erklärt werden können. Gemäß des universellen Satzschemas repräsentiert die Infl(ection)-Position eine Verbposition im Satz. Diese Position ist identisch mit der rechten Satzklammer. Eine weitere Verbposition ist die V-Position innerhalb des Mittelfelds und eine dritte potenzielle Position für das Verb entspricht der C(omplementizer-) Position (bzw. der linken Satzklammer). Der Aufsatz ist folgendermaßen gegliedert. In der Einleitung schildere ich kurz die unterschiedlichen Auffassungen, die in der Vergangenheit zur Verbstellungsproblematik im Deutschen vertreten wurden. In Abschnitt 2 nenne ich die wichtigsten Argumente, die gegen die Annahme vorgebracht wurden, daß im deutschen Satz für Verben insgesamt drei Positionen zur Verfügung stehen. Im Anschluss daran werden in den Abschnitten 3.1 bis 3.2 Argumente diskutiert, die für drei Verbpositionen sprechen. Abschnitt 3.3 behandelt die Frage, wie vor diesem Hintergrund die Daten aus Abschnitt 2, die sich als problematisch für diese Analyse erwiesen haben, erklärt werden können. In Abschnitt 4 wende ich mich weiterer unabhängiger Evidenz aus dem Bereich der historischen Syntax zu, die für drei Verbpositionen im Deutschen spricht. In Abschnitt 5 gebe ich eine kurze Zusammenfassung der wichtigsten Ergebnisse.
Ausgangspunkt der folgenden Untersuchung ist die Überlegung, daß verschiedene Versionen der Prinzipien- und Parametertheorie unterschiedliche Prognosen bezüglich strukturell ambiger Wortfolgen in Passiv-Konstruktionen des Deutschen machen. Im Rahmen einer Theorie, in der Move-alpha frei appliziert, wie etwa in der Rektions- und Bindungstheorie (Chomsky 1981, 1986a, 1986b), können multiple Derivationen für derartige Abfolgen nicht ausgeschlossen werden, wohingegen eine andere Situation vorliegt, wenn man die entsprechenden Konstruktionen im Rahmen des Minimalistischen Programms analysiert. Hier kann die Anzahl möglicher (und mit einer Wortfolge verträglicher) Derivationen mit Hilfe von Ökonomieprinzipien beschränkt werden. Auf Grundlage verschiedener syntaktischer Tests wird im weiteren gezeigt, daß bestimmte Wortfolgen nur mit einer Derivation verträglich sind, was im Einklang mit einer minimalistischen Analyse der Daten steht. Der Aufsatz ist folgendermaßen gegliedert. In Abschnitt 2 erläutere ich das Grundproblem der multiplen Derivationen, das sich im Deutschen z. B. bei Passiv-Konstruktionen ergibt, wenn man annimmt, daß NP-Bewegung und Scrambling optional erfolgen und ferner keine Beschränkungen für potentielle Derivationen gelten. In Abschnitt 3 diskutiere ich die Voraussetzungen für die Überprüfung der Prognosen der verschiedenen Varianten des Prinzipien- und Parametermodells und versuche anschließend auf Grundlage syntaktischer Tests zu belegen, daß die diskutierten Beispiele tatsächlich nicht strukturell ambig, sondern strukturell eindeutig sind, wie es die Analyse der entsprechenden Konstruktionen im Rahmen des Minimalistischen Programms vorhersagt. Abschnitt 4 beschreibt die Konsequenzen der Analyse für weitere Sprachen wie Niederländisch und Japanisch und zusätzliche Bewegungstypen. Abschnitt 5 enthält die Konklusion.
Homing in with GPS
(2000)
This a review of the present status of heavy-ion collisions at intermediate energies. The main goal of heavy-ion physics in this energy regime is to shed some light on the nuclear equation of state (EOS), hence we present the basic concept of the EOS in nuclear matter as well as of nuclear shock waves which provide the key mechanism for the compression of nuclear matter. The main part of this article is devoted to the models currently used for describing heavy-ion reactions theoretically and to the observables useful for extracting information about the EOS from experiments. A detailed discussion of the flow effects with a broad comparison with the avaible data is presented. The many-body aspects of such reactions are investigated via the multifragmentation break up of excited nuclear systems and a comparison of model calculations with the most recent multifragmentation experiments is presented.
In the framework of the relativistic quantum dynamics approach we investigate antiproton observables in Au-Au collisions at 10.7A GeV. The rapidity dependence of the in-plane directed transverse momentum p(y) of p's shows the opposite sigh of the nucleon flow, which has indeed recently been discovered at 10.7A GeV by the E877 group. The "antiflow" of p's is also predicted at 2A GeV and at 160 A GeV and appears at all energies also for pi's and K's. These predicted p anticorrelations are a direct proof of strong p annihilation in massive heavy ion reactions.
The quantum statistical model (QSM) is used to calculate nuclear fragment distributions in chemical equilibrium. Several observable isotopic effects are predicted for intermediate energy heavy ion collisions. It is demonstrated that particle ratios for different systemsdo not depend on the breakup density-the only free parameter in our model.The importance of entropy measurements is discussed. Specific particle ratios for the system Au-Au are predicted, which can be used to determine the chemical potentials of the hot midrapidity fragment source in nearly central heavy ion collisions. Pacs-Nr. 25.70 Pq
The Monte Carlo parton string model for multiparticle production in hadron-hadron, hadron-nucleus, and nucleus-nucleus collisions at high energies is described. An adequate choice of the parameters in the model gives the possibility of recovering the main results of the dual parton model, with the advantage of treating both hadron and nuclear interactions on the same footing, reducing them to interactions between partons. Also the possibility of considering both soft and hard parton interactions is introduced.
The properties of pions from the hot and dense reaction stage of relativistic heavy ion collisions are investigated with the quantum molecular dynamics model. Pions originating from this reaction stage stem from resonance decay with enhanced mass. They carry high transverse momenta. The calculation shows a direct correlation between high pt pions, early freeze-out times and high freeze-out densities.
Dilepton spectra for p+p and p+d reactions at 4.9GeV are calculated. We consider electromagnetic bremsstrahlung also in inelastic reactions. N* and Delta* decay present the major contributions to the pho and omega meson yields.Pion annihilation yields only 1.5% of all pho's in p+d. The pho mass spectrum is strongly distorted due to phase space effects, populating dominantly dilepton masses below 770MeV.
Strong mean meson fields, which are known to exist in normal nuclei, experience a violent deformation in the course of a heavy-ion collision at relativistic energies. This may give rise to a new collective mechanism of the particle production, not reducible to the superposition of elementary nucleon-nucleon collisions.
We investigate the sensivity of pionic bounce-off and squeeze-out on the density and momentum dependence of the real part of the nucleon optical potential. For the in-plane pion bounce-off we find a strong sensivity on both the density and momentum dependence whereas the out-of-plane pion squeeze-out shows a strong sensivity only towards the momentum dependence but little sensivity towards the density dependence.
We demonstrate the importance of the Bose-statistical effects for pion production in relativistic heavy-ion collisions. The evolution of the pion phase-space density in central collisions of ultrarelativistic nuclei is studied in a simple kinetic model taking into account the effect of Bose-simulated pion production by the NN collisions in a dense cloud of mesons.