Refine
Year of publication
Language
- English (512)
Has Fulltext
- yes (512)
Is part of the Bibliography
- no (512)
Keywords
- BESIII (19)
- e +-e − Experiments (16)
- Branching fraction (12)
- Particle and Resonance Production (8)
- Quarkonium (7)
- Charm Physics (6)
- Spectroscopy (6)
- Hadronic decays (5)
- Branching fractions (4)
- Charmonium (4)
- Exotics (4)
- Heavy-ion collisions (4)
- Lepton colliders (4)
- Charmed mesons (3)
- Diffraction (3)
- Electroweak interaction (3)
- Initial state radiation (3)
- QCD (3)
- e+-e− Experiments (3)
- Absolute branching fraction (2)
- Beam Energy Scan (2)
- Bhabha (2)
- Charm physics (2)
- Chiral Magnetic Effect (2)
- Collectivity (2)
- Correlation (2)
- Cross section (2)
- Elastic scattering (2)
- Electroweak Interaction (2)
- Flavour Physics (2)
- Hadronic cross section (2)
- Leptonic, semileptonic & radiative decays (2)
- Muon anomaly (2)
- Particle decays (2)
- Pion form factor (2)
- Radiative decay (2)
- Shear viscosity (2)
- decays (2)
- Angular distribution (1)
- Annihilation (1)
- Atherosclerosis (1)
- Autophagic cell death (1)
- B-slope (1)
- BESIII detector (1)
- Beam energy scan (1)
- Biochemical simulations (1)
- Bipolar disorder (1)
- Born cross section (1)
- Born cross section measurement (1)
- Branching fraction measurement (1)
- Bromodomänen (1)
- CP violation (1)
- Canonical suppression (1)
- Cardiovascular diseases (1)
- Charged-particle multiplicity (1)
- Charm quark spatial diffusion coefficient (1)
- Charm vector (1)
- Charmed baryon (1)
- Charmonium (-like) (1)
- Chemische Sonden (1)
- Chiral magnetic effect (1)
- Circadian (1)
- Coalescence (1)
- Cold nuclear matter effects (1)
- Covariance matrix (1)
- Critical point (1)
- Cross section measurements (1)
- D meson (1)
- D0 and D+ mesons (1)
- Dalitz decay (1)
- Dark photon (1)
- Dark sector (1)
- Denosumab (1)
- Deuteron production (1)
- Di-hadron correlations (1)
- D⁰ meson (1)
- Effective form factor (1)
- Electromagnetic amplitude (1)
- Electromagnetic form factor (1)
- Electromagnetic form factors (1)
- Elliptic flow (1)
- Epigenetik (1)
- Experimental nuclear physics (1)
- Experimental particle physics (1)
- Extension study (1)
- FOS: Physical sciences (1)
- FREEDOM (1)
- Flavor changing neutral currents (1)
- Flavor symmetries (1)
- Form factors (1)
- Forward physics (1)
- Free energy (1)
- Germany (1)
- Groomed jet radius (1)
- Hadron-Hadron scattering (experiments) (1)
- Hadronization (1)
- Hadrons (1)
- Health risk analysis (1)
- Heavy Ion Experiments (1)
- Heavy Quark Production (1)
- Heavy ion collisions (1)
- Heavy-Ion Collision (1)
- Heavy-flavor decay electron (1)
- Helicity amplitude analysis (1)
- High Energy Physics - Experiment (hep-ex) (1)
- Higher moments (1)
- Hyperons (1)
- Inclusive branching fraction (1)
- Interference fragmentation function (1)
- Invisible decays (1)
- Italy (1)
- J/ψ suppression (1)
- Jet substructure (1)
- K0S (1)
- Medizinische Chemie (1)
- Membrane fusion (1)
- Membrane structures (1)
- Molecular dynamics (1)
- Multiple parton interactions (1)
- Myocardial infarction (1)
- Neolithic (1)
- Net-charge correlations (1)
- Net-charge fluctuations (1)
- Neutrinos (1)
- Osteoporosis (1)
- Particle and resonance production (1)
- Particle phenomena (1)
- Particle production (1)
- Phase (1)
- Polarization (1)
- Proton (1)
- Proton-proton collisions (1)
- Proton–proton collisions (1)
- Psychiatry (1)
- Quantum chromodynamics (1)
- Quark–gluon plasma (1)
- R value (1)
- RHIC (1)
- Rare decays (1)
- Resonances (1)
- STAR (1)
- Seasonal variation (1)
- Selection bias (1)
- Semi-leptonic decays (1)
- SoftDrop (1)
- Solar insolation (1)
- Splitting function (1)
- Strangeness enhancement (1)
- Stroke (1)
- Strong amplitude (1)
- Strukturbasiertes Design (1)
- Suicide (1)
- Sunlight (1)
- Sweden (1)
- Techniques Electromagnetic calorimeters (1)
- Thermal model (1)
- Threshold effect (1)
- Transversity (1)
- Triple quarkonia (1)
- Vesicle fusion (1)
- Vesicles (1)
- W-exchange (1)
- Y (4260) (1)
- Y states (1)
- branching fractions (1)
- bromodomains (1)
- center-of-mass energy (1)
- charmed baryon (1)
- charmonium-like states (1)
- chemical probes (1)
- decay (1)
- dimuon (1)
- diphoton (1)
- domestication (1)
- e+e − annihilation (1)
- e+e⁻ − Experiments (1)
- e+e− Experiments (1)
- e+e− annihilation (1)
- electron-positron collision (1)
- epigenetics (1)
- evolution (1)
- gene flow (1)
- hadron spectroscopy (1)
- hadronic events (1)
- heavy-ion collisions (1)
- helicity amplitude analysis (1)
- inclusive J/ψ decays (1)
- luminosity (1)
- medicinal chemistry (1)
- number of J/ψ events (1)
- p+p collisions (1)
- structure-based design (1)
- tetraquark (1)
- trigger efficiency (1)
- Λ+c baryon (1)
- Λc⁺ (1)
- Σ hyperon (1)
- Υ suppression (1)
- ψ(3686) (1)
Institute
- Physik (399)
- Frankfurt Institute for Advanced Studies (FIAS) (101)
- Medizin (6)
- Institut für Ökologie, Evolution und Diversität (1)
- Kulturwissenschaften (1)
- Pharmazie (1)
- Psychologie (1)
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
(2017)
Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their characteristic mtDNA signature disappeared and was replaced by haplotypes associated with European wild boars. This turnover could be accounted for by substantial gene flow from local European wild boars, although it is also possible that European wild boars were domesticated independently without any genetic contribution from the Near East. To test these hypotheses, we obtained mtDNA sequences from 2,099 modern and ancient pig samples and 63 nuclear ancient genomes from Near Eastern and European pigs. Our analyses revealed that European domestic pigs dating from 7,100 to 6,000 y BP possessed both Near Eastern and European nuclear ancestry, while later pigs possessed no more than 4% Near Eastern ancestry, indicating that gene flow from European wild boars resulted in a near-complete disappearance of Near East ancestry. In addition, we demonstrate that a variant at a locus encoding black coat color likely originated in the Near East and persisted in European pigs. Altogether, our results indicate that while pigs were not independently domesticated in Europe, the vast majority of human-mediated selection over the past 5,000 y focused on the genomic fraction derived from the European wild boars, and not on the fraction that was selected by early Neolithic farmers over the first 2,500 y of the domestication process.
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
The polarization of Λ and Λ¯ hyperons along the beam direction has been measured relative to the second and third harmonic event planes in isobar Ru+Ru and Zr+Zr collisions at √sNN = 200 GeV. This is the first experimental evidence of the hyperon polarization by the triangular flow originating from the initial density fluctuations. The amplitudes of the sine modulation for the second and third harmonic results are comparable in magnitude, increase from central to peripheral collisions, and show a mild pT dependence. The azimuthal angle dependence of the polarization follows the vorticity pattern expected due to elliptic and triangular anisotropic flow, and qualitatively disagree with most hydrodynamic model calculations based on thermal vorticity and shear induced contributions. The model results based on one of existing implementations of the shear contribution lead to a correct azimuthal angle dependence, but predict centrality and pT dependence that still disagree with experimental measurements. Thus, our results provide stringent constraints on the thermal vorticity and shear-induced contributions to hyperon polarization. Comparison to previous measurements at RHIC and the LHC for the second-order harmonic results shows little dependence on the collision system size and collision energy.
Autophagy is a physiological process for the recycling and degradation of cellular materials. Forming the autophagosome from the phagophore, a cup-shaped double-membrane vesicle, is a critical step in autophagy. The origin of the cup shape of the phagophore is poorly understood. In yeast, fusion of a small number of Atg9-containing vesicles is considered a key step in autophagosome biogenesis, aided by Atg1 complexes (ULK1 in mammals) localized at the preautophagosomal structure (PAS). In particular, the S-shaped Atg17-Atg31-Atg29 subcomplex of Atg1 is critical for phagophore nucleation at the PAS. To study this process, we simulated membrane remodeling processes in the presence and absence of membrane associated Atg17. We show that at least three vesicles need to fuse to induce the phagophore shape, consistent with experimental observations. However, fusion alone is not sufficient. Interactions with 34-nm long, S-shaped Atg17 complexes are required to overcome a substantial kinetic barrier in the transition to the cup-shaped phagophore. Our finding rationalizes the recruitment of Atg17 complexes to the yeast PAS, and their unusual shape. In control simulations without Atg17, with weakly binding Atg17, or with straight instead of S-shaped Atg17, the membrane shape transition did not occur. We confirm the critical role of Atg17-membrane interactions experimentally by showing that mutations of putative membrane interaction sites result in reduction or loss of autophagic activity in yeast. Fusion of a small number of vesicles followed by Atg17-guided membrane shape-remodeling thus emerges as a viable route to phagophore formation.
Background: Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher risk of fracture than those who remained enrolled, thereby underestimating the true fracture risk for the entire trial cohort. Thus, we explored the influence of early withdrawals on nonvertebral fracture incidence during the Extension study.
Methods: To understand the potential effect of depletion of susceptible subjects on fracture incidence, we first evaluated subject characteristics in patients who were enrolled in the Extension vs those who were not. We subsequently employed a Kaplan-Meier multiple imputation (KMMI) approach to consider subjects who discontinued as if they remained enrolled with a 0%, 20%, 50%, and 100% increase in fracture risk compared with participants remaining on study.
Results: Extension enrollees were generally similar to nonparticipants in median age (71.9 and 73.1 years, respectively), mean total hip bone mineral density T-score (–1.9 and –2.0, respectively), and probability of fracture risk by Fracture Risk Assessment Tool (FRAX®) at FREEDOM baseline (16.9% and 17.7% for major osteoporotic fracture and 6.7% and 7.4% for hip fracture, respectively). When we assumed a doubled fracture risk (100% increase) after discontinuation in KMMI analyses, nonvertebral fracture rate estimates were only marginally higher than the observed rates for both the crossover group (10.32% vs 9.16%, respectively) and the long-term group (7.63% vs 6.63%, respectively).
Conclusion: The observation of continued denosumab efficacy over 8 years of treatment was robust and does not seem to be explained by depletion of susceptible subjects.
Trial registration: ClincalTrials.gov registration number NCT00523341; registered August 30, 2007
Conventional treatments for mood disorders primarily focus on reducing negative affect, but little on enhancing positive affect. Loving-kindness meditation (LKM) is a traditional meditation practice directly oriented toward enhancing unconditional and positive emotional states of kindness towards oneself and others. We report here two independent and uncontrolled studies carried out at different centers, one in Boston, USA (n = 10), and one in Frankfurt, Germany (n = 8), to examine the potential therapeutic utility of a brief LKM group intervention for symptoms of dysthymia and depression. Results at both centers suggest that LKM was associated with large-sized effects on self-reported symptoms of depression (d = 3.33 and 1.90), negative affect (d = 1.98 and 0.92), and positive affect (d = 1.63 and 0.94). Large effects were also found for clinician-reported changes in depression, rumination and specific positive emotions, and moderate effects for changes in adaptive emotion regulation strategies. The qualitative data analyses provide additional support for the potential clinical utility of the intervention. This proof-of-concept evaluation of LKM as a clinical strategy warrants further investigation.
Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
The p300/CBP‐associated factor (PCAF) and related GCN5 bromodomain‐containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine‐based L‐45 (dubbed L‐Moses) as the first potent, selective, and cell‐active PCAF bromodomain (Brd) inhibitor. Synthesis from readily available (1R,2S)‐(−)‐norephedrine furnished L‐45 in enantiopure form. L‐45 was shown to disrupt PCAF‐Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co‐crystal structure of L‐45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. Compound L‐45 shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell‐permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use.