Refine
Year of publication
Document Type
- Preprint (424)
- Article (317)
- Conference Proceeding (1)
- Doctoral Thesis (1)
Has Fulltext
- yes (743)
Is part of the Bibliography
- no (743)
Keywords
- Heavy Ion Experiments (13)
- Hadron-Hadron scattering (experiments) (11)
- BESIII (8)
- Heavy-ion collision (6)
- LHC (5)
- ALICE experiment (3)
- Branching fractions (3)
- Hadron-Hadron Scattering (3)
- Hadronic decays (3)
- Relativistic heavy-ion collisions (3)
- Beauty production (2)
- Charm physics (2)
- Charmonium (2)
- Cross section (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- Heavy Ions (2)
- Jets (2)
- Kollisionen schwerer Ionen (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Pb–Pb collisions (2)
- Quark-Gluon Plasma (2)
- Single electrons (2)
- pp collisions (2)
- 17-AAG (1)
- ALICE (1)
- ALICE detector (1)
- Absolute branching fraction (1)
- Angular distribution (1)
- Annihilation (1)
- Anti-nuclei (1)
- Atmospheric science (1)
- BRCA1 (1)
- BRCA2 (1)
- Bhabha (1)
- Biomarker (1)
- Bipolar disorder (1)
- Branching fraction (1)
- Business strategy in drug development (1)
- COVID-19 (1)
- Centrality Class (1)
- Centrality Selection (1)
- Chiral symmetries (1)
- Climate change (1)
- Code-based regulation (1)
- Cross section measurements (1)
- D meson (1)
- D0 and D+ mesons (1)
- Dalitz decay (1)
- Data Protection Directive (1)
- Diagnostic test (1)
- Differential diagnosis (1)
- Distributed software development (1)
- Drug therapy (1)
- D⁰ meson (1)
- Electromagnetic amplitude (1)
- Electromagnetic form factor (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Elliptic flow (1)
- Energie (1)
- Equation of state (1)
- Fibre/foam sandwich radiator (1)
- Geometrical modelling (1)
- Geometrisches Modellieren (1)
- HSP90 inhibitors (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Hadronic cross section (1)
- Hadrons (1)
- Head and neck Cancer (1)
- Heavy Ion Experiment (1)
- Heavy flavor production (1)
- Heavy ion collisions (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Hereditary breast and ovarian cancer (1)
- Initial state radiation (1)
- Invariant Mass Distribution (1)
- Ionisation energy loss (1)
- Jets and Jet Substructure (1)
- Kernreaktion Modell und Methoden (1)
- Lepton-Nucleon Scattering (experiments) (1)
- Local thermodynamical equilibrium (1)
- Lymphadenopathy (1)
- Meson production (1)
- Microplastic (1)
- Mid-rapidity (1)
- Minimum Bias (1)
- Monte Carlo (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Multiplex immunoassay (1)
- Muon anomaly (1)
- NMR spectroscopy (1)
- Nanoplastic (1)
- Neural network (1)
- Nichtgleichgewicht (1)
- Non-equilibrium effects (1)
- Nuclear-reaction models and methods (1)
- Objectoriented technology (1)
- Objektorientierte Technologie (1)
- PIA process (1)
- PIA taxonomy (1)
- Particle interactions (1)
- Particle toxicity (1)
- Partikel-Wechselwirkungen (1)
- Phase (1)
- Pion form factor (1)
- Plastic pollution (1)
- Plastics (1)
- Production Cross Section (1)
- Properties of Hadrons (1)
- Proton–proton (1)
- QGP (1)
- QMD Modell (1)
- QMD model (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- R value (1)
- RFID applications (1)
- Rapidity Range (1)
- Relativistic heavy ion physics (1)
- Relativistische Kollisionen des schwere Ions (1)
- Resolution Parameter (1)
- SARS-CoV-2 (1)
- Salivary gland diseases (1)
- Simulation (1)
- Software engineering (1)
- Softwaretechnik (1)
- Strong amplitude (1)
- Structured reporting (1)
- Systematic Uncertainty (1)
- TR (1)
- Time Projection Chamber (1)
- Tracking (1)
- Transition radiation detector (1)
- Trigger (1)
- Triple quarkonia (1)
- Triple-negative breast cancer (1)
- Ultrarelativistic Quantum Molecular Model (1)
- Ultrarelativistisches Quant Molekulares Modell (1)
- Ultrasonography (1)
- UrQMD Modell (1)
- UrQMD model (1)
- Vector Boson Production (1)
- W-exchange (1)
- Xenon-based gas mixture (1)
- Y (4260) (1)
- Zustandsgleichung (1)
- accessory proteins (1)
- branching fractions (1)
- cell-free protein synthesis (1)
- charmed baryon (1)
- dE/dx (1)
- decay (1)
- decays (1)
- diphoton (1)
- e+e− annihilation (1)
- ectosomes (1)
- energy (1)
- exosomes (1)
- extracellular vesicles (1)
- gallbladder cancer (1)
- gallbladder cancer xenografts (1)
- geldanamycin (1)
- guidelines (1)
- hadron hadron Kollision (1)
- hadron hadron collision (1)
- heavy ion collisions (1)
- heavy ion experiments (1)
- intrinsically disordered region (1)
- lokales thermodynamisches Gleichgewicht (1)
- luminosity (1)
- microparticles (1)
- microvesicles (1)
- minimal information requirements (1)
- nonstructural proteins (1)
- privacy-by-design (1)
- quark gluon plasma (1)
- reproducibility (1)
- rigor (1)
- risk assessment (1)
- risk design (1)
- self-regulation (1)
- spectra (1)
- standardization (1)
- structural proteins (1)
- Λc⁺ (1)
- Σ hyperon (1)
Institute
- Physik (727)
- Frankfurt Institute for Advanced Studies (FIAS) (608)
- Informatik (583)
- Biowissenschaften (5)
- Medizin (5)
- Georg-Speyer-Haus (3)
- Informatik und Mathematik (3)
- Biochemie und Chemie (2)
- Hochschulrechenzentrum (2)
- Biochemie, Chemie und Pharmazie (1)
A Privacy Impact Assessment (PIA) is a systematic risk assessment tool, enabling organizations to maintain compliance with data protection regulations, to manage privacy risks and to provide public benefits through the success of privacy-by-design efforts. An actual practical implementation of a PIA framework has been realized in the context of RFID applications encompassing detailed steps for the PIA process; a first successful review has been completed. The PIA also allows to introduce a pro-active mitigation of privacy risks through technical and organizational controls. The better the precautionary measures realize the relevant privacy objectives, the less likely will occur with the PIA process afterwards. The recent proposal for a far-reaching revision of the EU Data Protection Directive envisages to state a specific requirement to implement a PIA process. Indeed, since risks for privacy and non-disclosure of personal data are different in not identical circumstances, the protection measures should also be different, i.e. technology should assist in trying to achieve the (at least) second-best solution for the implementation of the data protection regime by a PIA. Insofar, privacy rules can be individualized and matched with the concrete needs in the given environment.
Gallbladder cancer (GBC) is a lethal cancer with poor prognosis associated with high invasiveness and poor response to chemotherapy and radiotherapy. New therapeutic approaches are urgently needed in order to improve survival and response rates of GBC patients. We screened 130 small molecule inhibitors on a panel of seven GBC cell lines and identified the HSP90 inhibitor 17-AAG as one of the most potent inhibitory drugs across the different lines. We tested the antitumor efficacy of 17-AAG and geldanamycin (GA) in vitro and in a subcutaneous preclinical tumor model NOD-SCID mice. We also evaluated the expression of HSP90 by immunohistochemistry in human GBC tumors.
In vitro assays showed that 17-AAG and GA significantly reduced the expression of HSP90 target proteins, including EGFR, AKT, phospho-AKT, Cyclin B1, phospho-ERK and Cyclin D1. These molecular changes were consistent with reduced cell viability and cell migration and promotion of G2/M cell cycle arrest and apoptosis observed in our in vitro studies.
In vivo, 17-AAG showed efficacy in reducing subcutaneous tumors size, exhibiting a 69.6% reduction in tumor size in the treatment group compared to control mice (p < 0.05).
The HSP90 immunohistochemical staining was seen in 182/209 cases of GBC (87%) and it was strongly expressed in 70 cases (33%), moderately in 58 cases (28%), and weakly in 54 cases (26%).
Our pre-clinical observations strongly suggest that the inhibition of HSP90 function by HSP90 inhibitors is a promising therapeutic strategy for gallbladder cancer that may benefit from new HSP90 inhibitors currently in development.
J/ψ production as a function of charged-particle multiplicity in p-Pb collisions at √sNN = 8.16 TeV
(2020)
Inclusive J/ψ yields and average transverse momenta in p-Pb collisions at a center-of-mass energy per nucleon pair s NN $$ \sqrt{s_{\mathrm{NN}}} $$ = 8.16 TeV are measured as a function of the charged-particle pseudorapidity density with ALICE. The J/ψ mesons are reconstructed at forward (2.03 < y cms < 3.53) and backward (−4.46 < y cms < −2.96) center-of-mass rapidity in their dimuon decay channel while the charged-particle pseudorapidity density is measured around midrapidity. The J/ψ yields at forward and backward rapidity normalized to their respective average values increase with the normalized charged-particle pseudorapidity density, the former showing a weaker increase than the latter. The normalized average transverse momenta at forward and backward rapidity manifest a steady increase from low to high charged-particle pseudorapidity density with a saturation beyond the average value.
This paper presents the measurements of π±, K±, p and p¯¯¯ transverse momentum (pT) spectra as a function of charged-particle multiplicity density in proton–proton (pp) collisions at s√ = 13 TeV with the ALICE detector at the LHC. Such study allows us to isolate the center-of-mass energy dependence of light-flavour particle production. The measurements reported here cover a pT range from 0.1 to 20 GeV/c and are done in the rapidity interval |y|<0.5. The pT-differential particle ratios exhibit an evolution with multiplicity, similar to that observed in pp collisions at s√ = 7 TeV, which is qualitatively described by some of the hydrodynamical and pQCD-inspired models discussed in this paper. Furthermore, the pT-integrated hadron-to-pion yield ratios measured in pp collisions at two different center-of-mass energies are consistent when compared at similar multiplicities. This also extends to strange and multi-strange hadrons, suggesting that, at LHC energies, particle hadrochemistry scales with particle multiplicity the same way under different collision energies and colliding systems.
The first measurement of the cross section for coherent J/ψ photoproduction as a function of |t|, the square of the momentum transferred between the incoming and outgoing target nucleus, is presented. The data were measured with the ALICE detector in ultra-peripheral Pb–Pb collisions at a centre-of-mass energy per nucleon pair √sNN = 5.02 TeV with the J/ψ produced in the central rapidity region |y| < 0.8,
which corresponds to the small Bjorken-x range (0.3 − 1.4) × 10−3.
The measured |t|-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according to the leading-twist approximation, or gluon-saturation effects from the impact-parameter dependent Balitsky–Kovchegov equation. These new results are therefore a valid tool to constrain the relevant model parameters and to investigate the transverse gluonic structure at very low Bjorken-x.
The first measurement of the coherent photoproduction of ρ0 vector mesons in ultra-peripheral Xe–Xe collisions at √sNN = 5.44 TeV is presented. This result, together with previous HERA γ p data and γ –Pb measurements from ALICE, describes the atomic number (A) dependence of this process, which is particularly sensitive to nuclear shadowing effects and to the approach to the black-disc limit of QCD at a semi-hard scale. The cross section of the Xe + Xe → ρ0 + Xe + Xe process, measured at midrapidity through the decay channel ρ0 → π+π−, is found to be dσ/dy = 131.5 ± 5.6(stat.)+17.5 −16.9(syst.) mb. The ratio of the continuum to resonant contributions for the production of pion pairs is also measured. In addition, the fraction of events accompanied by electromagnetic dissociation of either one or both colliding nuclei is reported. The dependence on A of cross section for the coherent ρ0 photoproduction at a centre-of-mass energy per nucleon of the γ A system of Wγ A,n = 65 GeV is found to be consistent with a power-law behaviour σ(γ A → ρ0 A) ∝ Aα with a slope α = 0.96 ± 0.02(syst.). This slope signals important shadowing effects, but it is still far from the behaviour expected in the black-disc limit.
ϒ production and nuclear modification at forward rapidity in Pb–Pb collisions at √sNN = 5.02TeV
(2021)
The production of ϒ mesons in Pb–Pb collisions at a centre-of-mass energy per nucleon pair √sNN = 5.02 TeV is measured with the muon spectrometer of the ALICE detector at the LHC. The yields as well as the nuclear modification factors are determined in the forward rapidity region 2.5 < y < 4.0, as a function of rapidity, transverse momentum and collision centrality. The results show that the production of the ϒ(1S) meson is suppressed by a factor of about three with respect to the production in proton–proton collisions. For the first time, a significant signal for the ϒ(2S) meson is observed at forward rapidity, indicating a suppression stronger by about a factor 2–3 with respect to the ground state. The measurements are compared with transport, hydrodynamic, comover and statistical hadronisation model calculations.
Annihilation dynamics plays a fundamental role in the baryon–antibaryon interaction (B–B) at lowenergy and its strength and range are crucial in the assessment of possible baryonic bound states. Experimental data on annihilation cross sections are available for the p–p system but not in the low relative momentum region. Data regarding the B–B interaction with strange degrees of freedom are extremely scarce, hence the modeling of the annihilation contributions is mainly based on nucleon–antinucleon (N–N) results, when available. In this letter we present a measurement of the p–p, p–⊕p– and – interaction using correlation functions in the relative momentum space in high-multiplicity triggered pp collisions at √s = 13 TeV recorded by ALICE at the LHC. In the p–p system the couplings to the mesonic channels in different partial waves are extracted by adopting a coupled-channel approach with recent χEFT potentials. The inclusion of these inelastic channels provides good agreement with the data, showing a significant presence of the annihilation term down to zero momentum. Predictions obtained using the Lednický–Lyuboshits formula and scattering parameters obtained from heavy-ion collisions, hence mainly sensitive to elastic processes, are compared with the experimental p–⊕p– and – correlations. The model describes the – data and underestimates the p–⊕p– data in the region of momenta below 200 MeV/c. The observed deviation indicates a different contribution of annihilation channels to the two systems containing strange hadrons.
The first results on K∗(892)± resonance production in inelastic pp collisions at LHC energies of √s = 5.02, 8, and 13 TeV are presented. The K∗(892)± has been reconstructed via its hadronic decay channel K∗(892)± → K0 S + π± with the ALICE detector. Measurements of transverse momentum distributions, pT-integrated yields, and mean transverse momenta for charged K∗(892) are found to be consistent with previous ALICE measurements for neutral K∗(892) within uncertainties. For pT > 1 GeV/c the K∗(892)± transverse momentum spectra become harder with increasing centre-of-mass energy from 5.02 to 13 TeV, similar to what previously observed for charged kaons and pions. For pT < 1 GeV/c the K∗(892)± yield does not evolve significantly and the abundance of K∗(892)± relative to K is rather independent of the collision energy. The transverse momentum spectra, measured for K∗(892)± at midrapidity in the interval 0 < pT < 15 GeV/c, are not well described by predictions of different versions of PYTHIA 6, PYTHIA 8 and EPOS-LHC event generators. These generators reproduce the measured pTintegrated K∗±/K ratios and describe well the momentum dependence for pT < 2 GeV/c.
The pT-differential non-linear flow modes, v4,22, v5,32, v6,33 and v6,222 for π±, K±, K0S , p + p¯¯¯, Λ + Λ¯¯¯¯ and ϕ-meson have been measured for the first time at sNN−−−√ = 5.02 TeV in Pb-Pb collisions with the ALICE detector at the Large Hadron Collider. The results were obtained with a multi-particle technique, correlating the identified hadrons with reference charged particles from a different pseudorapidity region. These non-linear observables probe the contribution from the second and third order initial spatial anisotropy coefficients to higher flow harmonics. All the characteristic features observed in previous pT-differential anisotropic flow measurements for various particle species are also present in the non-linear flow modes, i.e. increase of magnitude with increasing centrality percentile, mass ordering at low pT and particle type grouping in the intermediate pT range. Hydrodynamical calculations (iEBE-VISHNU) that use different initial conditions and values of shear and bulk viscosity to entropy density ratios are confronted with the data at low transverse momenta. These calculations exhibit a better agreement with the anisotropic flow coefficients than the non-linear flow modes. These observations indicate that non-linear flow modes can provide additional discriminatory power in the study of initial conditions as well as new stringent constraints to hydrodynamical calculations.